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ROM1 Gene

protein-coding   GIFtS: 59
GCID: GC11P062381

Retinal Outer Segment Membrane Protein 1

  See ROM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinal Outer Segment Membrane Protein 11 2     Rod Outer Segment Membrane Protein 12
ROSP12 3 5     tetraspanin-232
TSPAN232 3     tspan-232
RP72 5     Tetraspanin-233
ROM2     Tspan-233

External Ids:    HGNC: 102541   Entrez Gene: 60942   Ensembl: ENSG000001494897   OMIM: 1807215   UniProtKB: Q033953   

Export aliases for ROM1 gene to outside databases

Previous GC identifers: GC11P064893 GC11P063956 GC11P062630 GC11P062155 GC11P062137 GC11P058709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ROM1 Gene:
This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in
the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another
photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as
an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of
the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease
retinitis pigmentosa. (provided by RefSeq, Jul 2008)

GeneCards Summary for ROM1 Gene:
ROM1 (retinal outer segment membrane protein 1) is a protein-coding gene. Diseases associated with ROM1 include meningococcal infection, and retinitis pigmentosa 7, digenic. An important paralog of this gene is PRPH2.

UniProtKB/Swiss-Prot: ROM1_HUMAN, Q03395
Function: May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or
in the maintenance of the curvature of the rim. It is essential for disk morphogenesis

Gene Wiki entry for ROM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROM1 gene promoter:
         CREB   p53   Sp1   deltaCREB   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROM1 promoter sequence
   Search Chromatin IP Primers for ROM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q13

ROM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROM1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062381:  view genomic region     (about GC identifiers)

Start:
62,379,194 bp from pter      End:
62,382,592 bp from pter
Size:
3,399 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROM1_HUMAN, Q03395 (See protein sequence)
Recommended Name: Rod outer segment membrane protein 1  
Size: 351 amino acids; 37205 Da
Subunit: Homodimer; disulfide-linked. Probably forms a complex with a PRPH2 homodimer. Other proteins could
associate with this complex in rods
Secondary accessions: B2R978

Explore the universe of human proteins at neXtProt for ROM1: NX_Q03395

Explore proteomics data for ROM1 at MOPED


See ROM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000318.1  
ENSEMBL proteins: 
 ENSP00000433566   ENSP00000432151   ENSP00000278833   ENSP00000432983  

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Cloud-Clone Corp. Proteins for ROM1

 
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antibodies-online proteins for ROM1 (5 products) 

 
antibodies-online peptides for ROM1

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antibodies-online antibodies for ROM1 (20 products) 

ROM1 Assay Products:

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antibodies-online kits for ROM1 (8 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TSPAN: Tetraspanins

4 InterPro protein domains:
 IPR000830 Peripherin/rom-1
 IPR018499 Tetraspanin/Peripherin
 IPR018498 Peripherin/rom-1_CS
 IPR008952 Tetraspanin_EC2

Graphical View of Domain Structure for InterPro Entry Q03395

ProtoNet protein and cluster: Q03395

1 Blocks protein domain: IPB000830 Peripherin/rom-1 family

UniProtKB/Swiss-Prot: ROM1_HUMAN, Q03395
Similarity: Belongs to the PRPH2/ROM1 family


Find genes that share domains with ROM1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ROM1_HUMAN, Q03395
Function: May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or
in the maintenance of the curvature of the rim. It is essential for disk morphogenesis

     Genatlas biochemistry entry for ROM1:
rod photoreceptor outer segment,membrane protein 1

Phenotypes:
     1 GenomeRNAi human phenotype for ROM1:
 Increased gamma-H2AX phosphory 

     3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rom1):
 cardiovascular system  nervous system  vision/eye 

Find genes that share phenotypes with ROM1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rom1tm1Mci for ROM1

   genOway: Develop your customized and physiologically relevant rodent model for ROM1

miRNA
Products:
    
miRTarBase miRNAs that target ROM1:
hsa-mir-26b-5p (MIRT028880), hsa-mir-124-3p (MIRT022287)

Block miRNA regulation of human, mouse, rat ROM1 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate ROM1:
hsa-miR-627 hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidROM1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ROM1
Predesigned siRNA for gene silencing in human, mouse, rat ROM1

Gene Editing
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GenScript: all cDNA clones in your preferred vector: ROM1 (NM_000327)
Sino Biological Human cDNA Clone for ROM1
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROM1

Cell Line
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROM1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ROM1_HUMAN, Q03395: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane4
cytoskeleton2

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001750photoreceptor outer segment ----
GO:0005887integral component of plasma membrane TAS1610568
GO:0016021integral component of membrane ----
GO:0042622photoreceptor outer segment membrane IEA--

Find genes that share ontologies with ROM1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ROM1
Interactions:

    Search GeneGlobe Interaction Network for ROM1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ROM1 (Q033953 ENSP000002788334) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PRPH2P239423, ENSP000002303814I2D: score=1 STRING: ENSP00000230381
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007155cell adhesion IEA--
GO:0007601visual perception IEA--

Find genes that share ontologies with ROM1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ROM1

4 Novoseek inferred chemical compound relationships for ROM1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
thiosemicarbazide 70.8 1 1398965 (1)
cysteine 3.77 1 10980553 (1)
glycogen 2.77 2 1415249 (1), 7860071 (1)
cholesterol 0 2 15924998 (1), 12196538 (1)



Find genes that share compounds with ROM1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ROM1 gene: 
NM_000327.3  

Unigene Cluster for ROM1:

Retinal outer segment membrane protein 1
Hs.281564  [show with all ESTs]
Unigene Representative Sequence: NM_000327
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000525801 ENST00000534093 ENST00000529273 ENST00000278833(uc001ntv.3)
ENST00000525947
miRNA
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2 qRT-PCR Assays for microRNAs that regulate ROM1:
hsa-miR-627 hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidROM1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ROM1
Predesigned siRNA for gene silencing in human, mouse, rat ROM1
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ROM1 (NM_000327)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ROM1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROM1
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ROM1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ROM1
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  QuantiFast Probe-based Assays in human, mouse, rat ROM1

Additional mRNA sequence: 

AK313674.1 BC008100.1 BC036268.1 DQ426890.1 L07894.1 

8 DOTS entries:

DT.114339  DT.95150862  DT.100028703  DT.97841260  DT.100028702  DT.100749773  DT.91964993  DT.40263656 

Selected AceView cDNA sequences (see all 117):

BU727958 T29277 BQ636274 BU736816 AL712083 AI674433 BI828739 BQ636777 
BU731899 BQ023128 BQ638887 L07894 BU726671 BM705245 BQ447764 BQ636375 
BU838626 BQ637001 BM687980 BC008100 BC036268 BQ640606 BI757792 BU726597 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ROM1    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b
SP1:        -     -     -                     
SP2:                                          
SP3:                    -                     


ECgene alternative splicing isoforms for ROM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ROM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGAAGGCCTG
ROM1 Expression
About this image


ROM1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Rod Cells Outer Nuclear Layer
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Epithelial Cells
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
ROM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ROM1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.281564

UniProtKB/Swiss-Prot: ROM1_HUMAN, Q03395
Tissue specificity: Retina (photoreceptor). In rim region of ROS (rod outer segment) disks

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROM1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ROM1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rom11 , 5 rod outer segment membrane protein 11, 5 85.09(n)1
84.62(a)1
  19 (6.03 cM)5
198811  NM_009073.41  NP_033099.31 
 89273825 
chicken
(Gallus gallus)
Aves CRDS26
Gallus gallus photoreceptor outer segment membrane...
30(a)
many ↔ many
5(25259854-25270250) ENSGALG00000009185
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
31(a)
many ↔ many
1(39531216-39537775)
zebrafish
(Danio rerio)
Actinopterygii rom1b6
rom1a6
retinal outer segment membrane protein 1a
38(a)
33(a)
1 ↔ many
1 ↔ many
14(48610355-48634803) ENSDARG00000026926
5(70122247-70140978) ENSDARG00000019752


ENSEMBL Gene Tree for ROM1 (if available)
TreeFam Gene Tree for ROM1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ROM1 gene
PRPH22  
1 SIMAP similar gene for ROM1 using alignment to 4 protein entries:     ROM1_HUMAN (see all proteins):
PRPH2

Find genes that share paralogs with ROM1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ROM1 (see all 63)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs112311611,2
C,F,A,H--62298521(+) CCCAGA/GAGTGT 1 -- us2k1 tfbs322Minor allele frequency- G:0.21NS EA NA CSA WA 2347
rs2006867661,2
--62298705(+) TCCTGC/GAGAGC 1 -- us2k10--------
rs2001434131,2
--62298874(+) GCTGTG/TGGGGC 1 -- us2k10--------
rs128088291,2
C,F--62298960(+) GTCCCG/ACTAGG 1 -- us2k111Minor allele frequency- A:0.29NA CSA WA EA EU 827
rs769557901,2
C,F--62298987(+) TGAGGG/TGCTGG 1 -- us2k11Minor allele frequency- T:0.07EA 120
rs115535761,2
C,F,H--62299101(-) CCCCCA/GGGACT 1 -- us2k122Minor allele frequency- G:0.30NS EA NA CSA WA EU 7053
rs2016938621,2
--62299107(+) GGGGGG/TGCTGC 1 -- us2k10--------
rs1469803301,2
C--62299108(+) GGGGGG/CCTGCA 1 -- us2k11Minor allele frequency- C:0.00NA 4150
rs1382227591,2
C,F--62299110(+) GGGGCT/CGCAAG 1 -- us2k12Minor allele frequency- C:0.00NA EU 5039
rs1842281801,2
C--62299142(+) TAACCA/TGAAGC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ROM1 (62379194 - 62382592 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ROM1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv897622CNV Loss21882294
nsv825939CNV Gain20364138
nsv832182CNV Gain+Loss17160897

Human Gene Mutation Database (HGMD): ROM1
Locus Specific Mutation Databases (LSDB): ROM1

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ROM1
DNA2.0 Custom Variant and Variant Library Synthesis for ROM1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 180721   
OMIM disorders: 608133  
UniProtKB/Swiss-Prot: ROM1_HUMAN, Q03395
  • Retinitis pigmentosa 7 (RP7) [MIM:608133]: A retinal dystrophy belonging to the group of pigmentary
    retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination
    and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically
    have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose
    their far peripheral visual field and eventually central vision as well. Note=The disease may be caused by
    mutations affecting distinct genetic loci, including the gene represented in this entry. A digenic form of
    retinitis pigmentosa 7 results from a mutation in the PRPH2 gene and a null mutation of the ROM1 gene has been
    reported (PubMed:8202715)

  • 16 diseases for ROM1:    
    About MalaCards
    meningococcal infection    retinitis pigmentosa 7, digenic    rom1-related retinitis pigmentosa    reactive arthritis
    best vitelliform macular dystrophy    peripheral retinal degeneration    fundus flavimaculatus    carbamoyl phosphate synthetase i deficiency disease
    rheumatic disease    eye disease    retinal degeneration    vitelliform macular dystrophy
    retinal disease    macular dystrophy    retinitis pigmentosa    leber congenital amaurosis

    5 diseases from the University of Copenhagen DISEASES database for ROM1:
    Retinitis pigmentosa     Peripheral retinal degeneration     Vitelliform macular dystrophy     Fundus dystrophy
    Carbamoyl phosphate synthetase I deficiency disease

    Find genes that share disorders with ROM1           About GenesLikeMe

    7 Novoseek inferred disease relationships for ROM1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 84 20 16916875 (4), 8595413 (2), 9331261 (2), 11151159 (1) (see all 14)
    macular dystrophy, vitelliform 83.1 1 7860071 (1)
    fundus flavimaculatus 74 1 11151159 (1)
    retinal degeneration 67.1 2 8595413 (1), 1610568 (1)
    meningococcal diseases 65.4 4 8132350 (1), 1377227 (1), 7750732 (1), 7562997 (1)
    retinopathy 64.3 12 12724643 (3), 7904211 (3), 1415249 (1), 8504299 (1) (see all 7)
    atrophy 0 1 10895316 (1)

    Genetic Association Database (GAD): ROM1
    Human Genome Epidemiology (HuGE) Navigator: ROM1 (1 document)

    Export disorders for ROM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROM1 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with ROM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation. (PubMed id 8504299)1, 2, 3, 9 Bascom R.A.... McInnes R.R. (Hum. Mol. Genet. 1993)
    2. Dominant and digenic mutations in the peripherin/RDS and ROM1 genes in retinitis pigmentosa. (PubMed id 9331261)1, 2, 9 Dryja T.P.... Berson E.L. (Invest. Ophthalmol. Vis. Sci. 1997)
    3. Mutation analysis of the ROM1 gene in retinitis pigmentosa. (PubMed id 8595413)1, 2, 9 Bascom R.A.... McInnes R.R. (Hum. Mol. Genet. 1995)
    4. Cloning of the cDNA for a novel photoreceptor membrane protein (rom- 1) identifies a disk rim protein family implicated in human retinopathies. (PubMed id 1610568)1, 2, 9 Bascom R.A....McInnes R.R. (Neuron 1992)
    5. Polymorphisms and rare sequence variants at the ROM1 locus. (PubMed id 7904211)1, 2, 9 Bascom R.A....McInnes R.R. (Hum. Mol. Genet. 1993)
    6. Digenic retinitis pigmentosa due to mutations at the unlinked peripherin/RDS and ROM1 loci. (PubMed id 8202715)1, 2, 9 Kajiwara K.... Dryja T.P. (Science 1994)
    7. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    8. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Disulfide-mediated oligomerization of Peripherin/Rds and Rom-1 in photoreceptor disk membranes. Implications for photoreceptor outer segment morphogenesis and degeneration. (PubMed id 10681511)1, 9 Loewen C.J. and Molday R.S. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6094 HGNC: 10254 AceView: ROM1 Ensembl:ENSG00000149489 euGenes: HUgn6094
    ECgene: ROM1 H-InvDB: ROM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ROM1 Pharmacogenomics, SNPs, Pathways
    Mutations of the ROM1 genehttp://www.retina-international.org/files/sci-news/rommut.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ROM1 gene:
    Search GeneIP for patents involving ROM1

    GeneCards and IP:
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