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ROCK2 Gene

protein-coding   GIFtS: 67
GCID: GC02M011319

Rho-Associated, Coiled-Coil Containing Protein Kinase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho-Associated, Coiled-Coil Containing Protein Kinase 21 2     Rho-Associated Protein Kinase 22
Rho-Associated, Coiled-Coil-Containing Protein Kinase II2 3     KIAA06193
ROCK-II2 3     Rho Kinase 23
P164 ROCK-22 3     Rho-Associated, Coiled-Coil-Containing Protein Kinase 23
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 102521   Entrez Gene: 94752   Ensembl: ENSG000001343187   OMIM: 6040025   UniProtKB: O751163   

Export aliases for ROCK2 gene to outside databases

Previous GC identifers: GC02M011106 GC02M011371 GC02M011343 GC02M011272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ROCK2 Gene:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle
contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum
response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ROCK2 Gene:
ROCK2 (Rho-associated, coiled-coil containing protein kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and structural molecule activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN,
MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of
VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3
and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of
centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and
ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine
and synaptic properties in the hippocampus

summary for ROCK2 Gene:
Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are
activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such
focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka
ROKbeta or p160ROCK) and ROCKII (aka ROKalpha), which share a high degree of structural identity in their
kinase domains (92%). The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII
expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution.
Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI
is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin
filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the
Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ROCK2 gene promoter:
         FAC1   AML1a   HSF2   IRF-7A   MyoD   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROCK2 promoter sequence
   Search Chromatin IP Primers for ROCK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p24

ROCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROCK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M011319:  view genomic region     (about GC identifiers)

Start:
11,319,887 bp from pter      End:
11,488,456 bp from pter
Size:
168,570 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116 (See protein sequence)
Recommended Name: Rho-associated protein kinase 2  
Size: 1388 amino acids; 160900 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with IRS1, RHOB and RHOC (By similarity). Interacts with RHOA (activated by GTP),
PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity.
Interacts with RAF1 (By similarity)
Sequence caution: Sequence=AAX93049.1; Type=Erroneous gene model prediction; Sequence=BAA31594.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for ROCK2:
4L6Q (3D)    
Secondary accessions: Q53QZ0 Q53SJ7 Q9UQN5

Explore the universe of human proteins at neXtProt for ROCK2: NX_O75116

Explore proteomics data for ROCK2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics.
    Dephosphorylation by PTPN11 stimulates its RHOA binding activity1
  • Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ROCK2 (O75116) (see all 29)
     LPFIGFT  EQDKEQS  SDIEQLR  LKQSQQK 


    See ROCK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004841.2  
    ENSEMBL proteins: 
     ENSP00000317985   ENSP00000385509   ENSP00000261535   ENSP00000395957  
    Reactome Protein details: O75116

    ROCK2 Human Recombinant Protein Products:

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    antibodies-online proteins for ROCK2 (2 products) 

     
    antibodies-online peptides for ROCK2

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    antibodies-online antibodies for ROCK2 (144 products) 

    ROCK2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for ROCK2 
    antibodies-online kits for ROCK2 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rho-associated, coiled-coil containing protein kinase 2
    Rho kinase
    ROCK subfamily

    Selected InterPro protein domains (see all 12):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011072 HR1_rho-bd
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry O75116

    ProtoNet protein and cluster: O75116

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116
    Domain: An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization (By
    similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 REM (Hr1) repeat


    Find genes that share domains with ROCK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROCK2_HUMAN, O75116
    Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
    of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
    retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN,
    MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of
    VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3
    and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of
    centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and
    ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine
    and synaptic properties in the hippocampus
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by RHOA binding. Inhibited by Y-27632 (By similarity)

         Genatlas biochemistry entry for ROCK2:
    serine/threonine kinase ROCK2/rho kinase,isozyme of ROCK1,one the targets for the small GTPase Rho,putative
    mediator of the Rho-dependent signaling pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA16574662
    GO:0004713protein tyrosine kinase activity ----
    GO:0005198structural molecule activity NAS9933571
         
    Find genes that share ontologies with ROCK2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for ROCK2:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased HPV18 LCR reporter a  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rock2):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  vision/eye 

    Find genes that share phenotypes with ROCK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rock2tm1.1Liao for ROCK2

       genOway: Develop your customized and physiologically relevant rodent model for ROCK2

    miRNA
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    miRTarBase miRNAs that target ROCK2:
    hsa-mir-138-5p (MIRT000494), hsa-mir-124-3p (MIRT006478)

    Block miRNA regulation of human, mouse, rat ROCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ROCK2 (see all 26):
    hsa-miR-3910 hsa-miR-142-3p hsa-miR-429 hsa-miR-300 hsa-miR-139-5p hsa-miR-301a hsa-miR-519a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidROCK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROCK2_HUMAN, O75116: Cytoplasm. Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm,
    cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin
    microfilaments and the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol4
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005813centrosome IDA17015463
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031616spindle pole centrosome IEA--

    Find genes that share ontologies with ROCK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ROCK2 About   (see all 52)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56


    Find genes that share SuperPaths with ROCK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for ROCK2
        Wnt Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ROCK2 (see all 28)
        RhoA Pathway
    PKA Signaling
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for ROCK2
        Cytoskeletal Signaling

    1 Tocris Bioscience Pathway for ROCK2
        TGF-beta Pathway

    Selected GeneGo (Thomson Reuters) Pathways for ROCK2 (see all 12)
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    G-protein signaling G-Protein alpha-12 signaling pathway
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling

    Selected BioSystems Pathways for ROCK2 (see all 13)
        Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    Integrin-mediated cell adhesion
    G13 Signaling Pathway
    Spinal Cord Injury


    2 Reactome Pathways for ROCK2
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events


    Selected Kegg Pathways  (Kegg details for ROCK2) (see all 12):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    Wnt signaling pathway
    Axon guidance
    Focal adhesion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ROCK2: 
              Primary Cilia in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ROCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ROCK2 (O751162, 3 ENSP000003179854) via UniProtKB, MINT, STRING, and/or I2D (see all 866)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193382, 3, ENSP000003181954MINT-7945693 MINT-8086654 I2D: score=1 STRING: ENSP00000318195
    PPP1R14BQ96C902, 3, ENSP000003101174MINT-3374782 I2D: score=1 STRING: ENSP00000310117
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    MYH9P355792, ENSP000002161814MINT-7945693 MINT-7947479 STRING: ENSP00000216181
    ARHGEF2Q929742, ENSP000003153254MINT-7945693 MINT-7947479 STRING: ENSP00000315325
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS9933571
    GO:0001843neural tube closure IEA--
    GO:0006468protein phosphorylation IDA18559669
    GO:0006939smooth muscle contraction TAS12778124
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with ROCK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ROCK2
    9 ApexBio Compounds for ROCK2     About this table
    CompoundAction CAS #
    chroman 1highly potent and selective ROCK II inhibitor[1273579-40-0]
    Fasudil (HA-1077) HClCyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor[105628-07-7]
    GSK429286ASelective Rho-kinase inhibitor[864082-47-3]
    H-1152more specific, stronger and membrane-permeable inhibitor of Rho-kinase[451462-58-1]
    Hydroxyfasudilpotent Rho-kinase inhibitor[105628-72-6]
    Narciclasinemodulates the Rho/ROCK/LIM kinase/cofilin pathway[29477-83-6]
    RKI-1447potent small molecule inhibitor of ROCK1 and ROCK2[1342278-01-6]
    SLx-2119Selective ROCK2 inhibitor [911417-87-3]
    Y-27632 dihydrochloridep160ROCK inhibitor[146986-50-7]

    Compounds for ROCK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Fasudil hydrochlorideInhibitor of cyclic nucleotide dependent- and Rho-kinases[103745-39-7]
    SB 772077B dihydrochloridePotent Rho-kinase inhibitor; vasodilator[607373-46-6]
    GSK 269962Potent and selective ROCK inhibitor[850664-21-0]
    Y-27632 dihydrochlorideSelective p160ROCK inhibitor[146986-50-7]
    H 1152 dihydrochlorideSelective Rho-kinase (ROCK) inhibitor[451462-58-1]

    Selected HMDB Compounds for ROCK2 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    2 DrugBank Compounds for ROCK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE-- --target--10592235
    5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE-- --target--10592235



    Find genes that share compounds with ROCK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ROCK2 gene: 
    NM_004850.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315872(uc002rbd.1) ENST00000401753 ENST00000493096 ENST00000460262
    ENST00000261535 ENST00000484951 ENST00000431087 ENST00000462366
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    hsa-miR-3910 hsa-miR-142-3p hsa-miR-429 hsa-miR-300 hsa-miR-139-5p hsa-miR-301a hsa-miR-519a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidROCK2 3' UTR sequence
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    Selected AceView cDNA sequences (see all 212):

    BF222319 BQ007869 BM664710 AW316743 BQ717709 NM_004850 BU740431 CK430964 
    BU159594 F11846 BU685004 BM833517 CD514766 BU507155 AL711092 CD724192 
    AI872746 AA320754 BQ006946 AA515709 AA354388 BE765838 BQ084100 AA353700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ROCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ROCK2 Expression
    About this image


    ROCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    ROCK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROCK2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ROCK2: 
              Primary Cilia in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ROCK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rock21 , 5 Rho-associated coiled-coil containing protein kinase more1, 5 91.04(n)1
    96.69(a)1
      12 (8.04 cM)5
    198781  NM_009072.21  NP_033098.21 
     168949785 
    chicken
    (Gallus gallus)
    Aves ROCK21 Rho-associated, coiled-coil containing protein kinase more 83.16(n)
    91.54(a)
      374182  XM_004935763.1  XP_004935820.1 
    lizard
    (Anolis carolinensis)
    Reptilia ROCK26
    Rho-associated, coiled-coil containing protein kin...
    84(a)
    1 ↔ 1
    1(147049018-147159318)
    African clawed frog
    (Xenopus laevis)
    Amphibia rocka-A-prov2 Rho-associated kinase alpha 78.23(n)    AF037073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rock22 rho-associated, coiled-coil containing protein kinase more 76.21(n)   317747  AF295804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rok1 , 3 Rho protein signal transduction protein
    serine/threonine more3
    Rho-kinase1
    43(a)3
    49.79(n)1
    46.14(a)1
      439161  NM_080535.21  NP_536796.21 
    worm
    (Caenorhabditis elegans)
    Secernentea let-5021 , 3 Rho-associated kinase3
    let-5021
    33(a)3
    52.17(n)1
    43.6(a)1
      I(4738957-4744263)3
    1720881  NM_059039.51  NP_491440.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBK16
    Serine/threonine protein kinase of the the RAM sig...
    22(a)
    1 → many
    XIV(332597-334867) YNL161W


    ENSEMBL Gene Tree for ROCK2 (if available)
    TreeFam Gene Tree for ROCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ROCK2 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    ROCK12  CDC42BPA2  LATS22  
    Selected SIMAP similar genes for ROCK2 using alignment to 5 protein entries:     ROCK2_HUMAN (see all proteins) (see all similar genes):
    ROCK1    PRKCE    CDC42BPB    PRKY    STK32A    PRKACB
    DMPK    KIN27    PRKX    RPS6KA3    PRKACG    MAPK8
    PRKACA    PRKG1    PRKG2    STK38L    PHKG1    RPS6KA2

    Find genes that share paralogs with ROCK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ROCK2 (see all 3164)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410644
    A metastatic melanoma sample4--see VAR_0410642 S P mis40--------
    rs2011876431,2
    C--11173617(-) TCAAAA/CTTTTA 1 -- int10--------
    rs718464611,2
    C--11267589(+) CAAGA-/CGTATA 1 -- int10--------
    rs757535591,2
    C,F--11267642(+) AATCAT/CTCCCC 1 -- int16Minor allele frequency- C:0.13NA CSA WA 245
    rs713938721,2
    C--11273250(+) AAACC-/CCA   
      C
    /CCCA
    CCATC
    1 -- int11NA 2
    rs1854660261,2
    --11292976(+) CAGCAA/GAGTGC 1 -- ds50010--------
    rs1163039151,2
    C,F--11293068(+) ATCTAT/CTATGG 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1886813041,2
    --11293155(+) TTAGAC/TGACTT 1 -- ds50010--------
    rs11299761,2
    C,F,H--11293281(-) TGGGAA/GGCTGA 1 -- ut313Minor allele frequency- G:0.33NA 6
    rs1156962251,2
    F--11293473(+) TATTTA/GAATAT 1 -- ut311Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for ROCK2 (11319887 - 11488456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ROCK2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658593CNV Deletion23128226
    nsv436304CNV Deletion17901297
    esv2662875CNV Deletion23128226
    esv272377CNV Insertion20981092
    esv2453181CNV Insertion19546169
    esv267549CNV Insertion20981092
    esv271091CNV Insertion20981092
    esv2592438CNV Insertion19546169
    esv272435CNV Insertion20981092
    esv2543558CNV Insertion19546169

    Human Gene Mutation Database (HGMD): ROCK2
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ROCK2:
    Birth Defects
    SeqTarget long-range PCR primers for resequencing ROCK2
    DNA2.0 Custom Variant and Variant Library Synthesis for ROCK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604002    OMIM disorders: --


    Find genes that share disorders with ROCK2           About GenesLikeMe

    Genetic Association Database (GAD): ROCK2
    Human Genome Epidemiology (HuGE) Navigator: ROCK2 (13 documents)

    Export disorders for ROCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROCK2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with ROCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. (PubMed id 9933571)1, 2, 3 Takahashi N.... Kaibuchi K. (Genomics 1999)
    2. ROCK2 allelic variants are not associated with pre-eclampsia susceptibility in the Finnish population. (PubMed id 19435756)1, 4, 9 Peterson H....Kivinen K. (Mol. Hum. Reprod. 2009)
    3. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. (PubMed id 16574662)1, 2, 9 Tanaka T.... Hamamori Y. (J. Biol. Chem. 2006)
    4. ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. (PubMed id 19131646)1, 2, 9 Wang Y....Surks H.K. (Circ. Res. 2009)
    5. A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study. (PubMed id 18971541)1, 4, 9 Rankinen T....Bouchard C. (Hypertens. Res. 2008)
    6. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. (PubMed id 21084279)1, 2 Wang H.F.... Miki Y. (Cancer Res. 2011)
    7. Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production. (PubMed id 21147781)1, 2 Herskowitz J.H.... Lah J.J. (J. Biol. Chem. 2011)
    8. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    9. Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer. (PubMed id 20939434)1, 4 Kalender M.E....Camci C. (Oncol. Res. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9475 HGNC: 10252 AceView: ROCK2 Ensembl:ENSG00000134318 euGenes: HUgn9475
    ECgene: ROCK2 Kegg: 9475 H-InvDB: ROCK2

    (According to HUGE)
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    HUGE: KIAA0619

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ROCK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROCK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ROCK2 gene:
    Search GeneIP for patents involving ROCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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