ROCK2 Gene
protein-coding GIFtS: 68
GCID: GC02M011272
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|
Rho-associated, coiled-coil containing protein kinase 2
| |
Aliases
for ROCK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho-Associated, Coiled-Coil Containing Protein Kinase 21 2 | | Rho-Associated Protein Kinase 22 | | Rho-Associated, Coiled-Coil-Containing Protein Kinase II2 3 | | KIAA06193 | | ROCK-II2 3 | | Rho Kinase 23 | | P164 ROCK-22 3 | | Rho-Associated, Coiled-Coil-Containing Protein Kinase 23 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for ROCK2 gene to outside databasesPrevious GC identifers: GC02M011106 GC02M011371 GC02M011343 |
Summaries
for ROCK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ROCK2:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction,the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. Thisprotein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation ofsmooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neuriteretraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2,NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenicendothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 duringmyogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organizationof actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus
 summary
for ROCK2: Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are
activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such
focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka
ROKbeta or p160ROCK) and ROCKII (aka ROKalpha), which share a high degree of structural identity in their
kinase domains (92%). The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII
expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution.
Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI
is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin
filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the
Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.
|
Genomic Views
for ROCK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ROCK2 gene promoter:
FAC1 AML1a HSF2 IRF-7A MyoD ZIC2/Zic2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ROCK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROCK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p24ROCK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M011272: view genomic region
(about GC identifiers)
Start:
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11,319,887 bp from pter |
End:
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11,488,456 bp from pter |
Size:
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168,570 bases |
Orientation:
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minus strand |
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Proteins
for ROCK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116 (See
protein sequence)Recommended Name: Rho-associated protein kinase 2 Size: 1388 amino acids; 160900 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with IRS1, RHOB and RHOC (By similarity). Interacts with RHOA (activated by GTP),PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interactswith RAF1 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm,cytoskeleton, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane (Bysimilarity)
Sequence caution: Sequence=AAX93049.1; Type=Erroneous gene model prediction; Sequence=BAA31594.2; Type=Erroneousinitiation; Note=Translation N-terminally shortened;
Secondary accessions: Q53QZ0 Q53SJ7 Q9UQN5Explore the universe of human proteins at neXtProt for ROCK2: NX_O75116
Post-translational modifications:
Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation byPTPN11 stimulates its RHOA binding activity1
Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75116
4/29 DME Specific Peptides for ROCK2 (O75116) (see all 29)
ROCK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004841.2
ENSEMBL proteins: ENSP00000317985 ENSP00000385509 ENSP00000261535 ENSP00000395957 Reactome Protein details: O75116
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ROCK2 for ontologies About GeneDecksing
ROCK2 Antibody Products:
Assay Products for ROCK2: |
Protein
Domains /
Families
for ROCK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ROCK2 for domains About GeneDecksing
5/13 InterPro domains/families (see all 13):Graphical View of Domain Structure for InterPro Entry O75116ProtoNet protein and cluster: O75116 2 Blocks protein families: IPB000961 Protein kinase C-terminal domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116Domain: An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization (By similarity)Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase familySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 REM (Hr1) repeat |
Function
for ROCK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation ofsmooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neuriteretraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2,NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenicendothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 duringmyogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibitskeratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organizationof actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampusCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by RHOA binding. Inhibited by Y-27632 (By similarity) Genatlas biochemistry entry for ROCK2:serine/threonine kinase ROCK2/rho kinase,isozyme of ROCK1,one the targets for the small GTPase Rho,putative mediator ofthe Rho-dependent signaling pathway
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ROCK2 (NM_004850) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROCK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROCK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROCK2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
ROCK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ROCK2:
Animal Models:
Mouse knock-out Rock2tm1.1Liao for ROCK2
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rock2):
ROCK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ROCK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell adhesion_Integrin-mediated cell adhesion and migration | | | 2 | Activation of cAMP-Dependent PKA | | | 3 | Sema4D in semaphorin signaling | | | 4 | Signaling by GPCR | | | 5 | G-AlphaQ Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/12 EMD Millipore Pathways for ROCK2 (see all 12)
2  R&D Systems Pathways for ROCK2
5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ROCK2 (see all 28)
1 
Cell Signaling Technology (CST) Pathway for ROCK2
1 Tocris Bioscience Pathway for ROCK2
5/12  GeneGo (Thomson Reuters) Pathways for ROCK2 (see all 12)
5/12  BioSystems Pathways for ROCK2 (see all 12)
5/9 
Reactome Pathways for ROCK2 (see all 9)
5/10 
Kegg Pathways (Kegg details for ROCK2) (see all 10):
ROCK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ROCK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/825 Interacting proteins for ROCK2 (O751162, 3 ENSP000003179854) via UniProtKB, MINT, STRING, and/or I2D (see all 825)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
ROCK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ROCK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ROCK2 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for ROCK2 |
Compounds for ROCK2 available from Tocris Bioscience About this table
10/846 HMDB Compounds for ROCK2 (see all 846) About this table
2 DrugBank Compounds for ROCK2 About this table
Search CenterWatch for drugs/clinical trials and news about ROCK2
|
Transcripts
for ROCK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ROCK2 gene: NM_004850.3 Unigene Cluster for ROCK2: Rho-associated, coiled-coil containing protein kinase 2 Hs.681743 [show with all ESTs]Unigene Representative Sequence: AB0145198 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000315872(uc002rbd.1) ENST00000401753 ENST00000493096 ENST00000460262
ENST00000261535 ENST00000484951 ENST00000431087 ENST00000462366
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ROCK2 (NM_004850) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ROCK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROCK2 |
Additional cDNA sequence: AB014519.1 AK299296.1 AK310358.1 AL049383.1 BC111801.1 D87931.1 10 DOTS entries: DT.456011 DT.120982987 DT.97797607 DT.120982998 DT.120983002 DT.316648 DT.92005556 DT.40131067 DT.95266967 DT.99936307 24/212 AceView cDNA sequences (see all 212): BX280284 CD724192 AW316743 AA305018 AI638314 AA320754 CA412615 F11846 BM664710 BU685004 CK430964 BU507155 BQ717709 AA354388 AA353700 BE765838 AL711092 BQ007869 AL079965 BQ006946 NM_004850 BQ019175 BM450170 AI872746
GeneLoc Exon Structure
|
Expression
for ROCK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ROCK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ROCK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ROCK2
SOURCE GeneReport for Unigene cluster: Hs.681743
SABiosciences Expression via Pathway-Focused PCR Arrays including ROCK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROCK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ROCK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROCK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROCK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROCK2 |
Orthologs
for ROCK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ROCK2 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ROCK26 |
Uncharacterized protein |
91(a) |
1 ↔ 1 |
3(100059926-100115191) |
lizard
(Anolis carolinensis) |
Reptilia |
ROCK26 |
-- |
83(a) |
1 ↔ 1 |
1(147084163-147154774) |
African clawed frog
(Xenopus laevis) |
Amphibia |
rocka-A-prov2 |
Rho-associated kinase alpha |
78.23(n) |
|
AF037073.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rock22 |
rho-associated, coiled-coil containing protein kinase more |
76.21(n) |
|
317747 AF295804.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rok1 , 3 |
Rho protein signal transduction protein
serine/threonine more3
Rho-kinase1 |
43(a)3
49.4(n)1
45.92(a)1 |
|
439161 NM_080535.21 NP_536796.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
let-5021 , 3 |
Rho-associated kinase3
Protein LET-5021 |
33(a)3
50.01(n)1
39.44(a)1 |
|
I(4738957-4744263)3
1720881 NM_059039.41 NP_491440.11 |
ENSEMBL Gene Tree for ROCK2 (if available)
TreeFam Gene Tree for ROCK2 (if available) |
Paralogs
for ROCK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ROCK2 gene
- CDC42BPG2 DMPK2 LATS12 STK38L2 CDC42BPB2 STK382 CIT2 ROCK12
- LATS22 CDC42BPA2
18/55 SIMAP similar genes for ROCK2 using alignment to 5 protein entries: ROCK2_HUMAN (see all proteins)
(see all similar genes):ROCK1 PRKCE CDC42BPB PRKY STK32A DMPK
KIN27 PRKX PRKACB RPS6KA3 PRKACG MAPK8
PRKACA PRKCQ PRKG2 STK38L PHKG1 RPS6KA2
ROCK2 for paralogs About GeneDecksing
|
Genomic Variants
for ROCK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ROCK2 (11319887 - 11488456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ROCK2
7 CNVs: 89480 97770 67068 97771 22655 35708 97769
2 Indels: 78434 78435
Human Gene Mutation Database (HGMD): ROCK2
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing ROCK2: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROCK2 |
|
Disorders
/ Diseases
for ROCK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ROCK2 for disorders About GeneDecksing
OMIM gene information: 604002
OMIM disorders: --
20  diseases for ROCK2: About MalaCardsmyotonic dystrophy hepatopulmonary syndrome diabetic retinopathy essential hypertension
squamous cell carcinoma shigellosis hypertension scleroderma
noma liver disease hepatocellular carcinoma twinning
breast cancer carcinoma esophagitis hypoxia
retinitis hepatitis prostatitis neuronitis
Human Genome Epidemiology (HuGE) Navigator: ROCK2 (13 documents)
Export disorders for ROCK2 gene to outside databases
|
Publications
for ROCK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ROCK2 gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with ROCK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. (PubMed id 9933571)1, 2, 3 Takahashi N.... Kaibuchi K. (1999)
- Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. (PubMed id 16574662)1, 2, 9 Tanaka T....Hamamori Y. (2006)
- ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. (PubMed id 19131646)1, 2, 9 Wang Y....Surks H.K. (2009)
- Rho kinase II phosphorylation of the lipoprotein rece ptor LR11/SORLA alters amyloid-beta production. (PubMed id 21147781)1, 2 Herskowitz J.H....Lah J.J. (2011)
- BRCA2 and nucleophosmin coregulate centrosome amplifi cation and form a complex with the Rho effector kinase ROCK2. (PubMed id 21084279)1, 2 Wang H.F....Miki Y. (2011)
- Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. (PubMed id 19997641)1, 2 Lock F.E. and Hotchin N.A. (2009)
- Regulation of RhoA-dependent ROCKII activation by Shp2. (PubMed id 18559669)1, 2 Lee H.H. and Chang Z.F. (2008)
- Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. (PubMed id 17015463)1, 2 Ma Z.... Fukasawa K. (2006)
- Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. (PubMed id 15699075)1, 2 Sebbagh M....Breard J. (2005)
- Rocks: multifunctional kinases in cell behaviour. (PubMed id 12778124)1, 2 Riento K. and Ridley A.J. (2003)
|
External Searches for ROCK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ROCK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ROCK2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ROCK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ROCK2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ROCK2 gene:
Search GeneIP for patents involving ROCK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ROCK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ROCK2 | | OriGene shRNA RFP for ROCK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROCK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ROCK2 | | | OriGene Protein Over-expression Lysate for ROCK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ROCK2 | | OriGene 3'-UTR Clone for ROCK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ROCK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ROCK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ROCK2 | | OriGene Custom Protein Services for ROCK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ROCK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROCK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROCK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROCK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROCK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROCK2 |
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| | Antibodies & Assays for ROCK2 |
| | | | Tocris compounds for ROCK2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROCK2 |
|  |  |  | | | | ThermoFisher Antibodies for ROCK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROCK2 |
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