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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ROCK2 Gene

protein-coding   GIFtS: 71
GCID: GC02M011272

Rho-Associated, Coiled-Coil Containing Protein Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho-Associated, Coiled-Coil Containing Protein Kinase 21 2     Rho-Associated Protein Kinase 22
Rho-Associated, Coiled-Coil-Containing Protein Kinase II2 3     KIAA06193
ROCK-II2 3     Rho Kinase 23
P164 ROCK-22 3     Rho-Associated, Coiled-Coil-Containing Protein Kinase 23
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 102521   Entrez Gene: 94752   Ensembl: ENSG000001343187   OMIM: 6040025   UniProtKB: O751163   

Export aliases for ROCK2 gene to outside databases

Previous GC identifers: GC02M011106 GC02M011371 GC02M011343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ROCK2 Gene:
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle
contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum
response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ROCK2 Gene: 
ROCK2 (Rho-associated, coiled-coil containing protein kinase 2) is a protein-coding gene. Diseases associated with ROCK2 include hepatopulmonary syndrome, and shigellosis, and among its related super-pathways are Development Slit-Robo signaling and Focal Adhesion. GO annotations related to this gene include protein serine/threonine kinase activity and structural molecule activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN,
MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of
VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3
and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of
centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and
ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine
and synaptic properties in the hippocampus

summary for ROCK2 Gene:
Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are
activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such
focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka
ROKbeta or p160ROCK) and ROCKII (aka ROKalpha), which share a high degree of structural identity in their
kinase domains (92%). The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII
expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution.
Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI
is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin
filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the
Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005334.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ROCK2 gene promoter:
         FAC1   AML1a   HSF2   IRF-7A   MyoD   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROCK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ROCK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p24

ROCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROCK2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M011272:  view genomic region     (about GC identifiers)

Start:
11,319,887 bp from pter      End:
11,488,456 bp from pter
Size:
168,570 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116 (See protein sequence)
Recommended Name: Rho-associated protein kinase 2  
Size: 1388 amino acids; 160900 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer. Interacts with IRS1, RHOB and RHOC (By similarity). Interacts with RHOA (activated by GTP),
PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity.
Interacts with RAF1 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein (By similarity). Nucleus. Cytoplasm,
cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin
microfilaments and the plasma membrane (By similarity)
Sequence caution: Sequence=AAX93049.1; Type=Erroneous gene model prediction; Sequence=BAA31594.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q53QZ0 Q53SJ7 Q9UQN5

Explore the universe of human proteins at neXtProt for ROCK2: NX_O75116

Explore proteomics data for ROCK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics.
    Dephosphorylation by PTPN11 stimulates its RHOA binding activity
  • UniProtKB: Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75116

  • 4/29 DME Specific Peptides for ROCK2 (O75116) (see all 29)
     LPFIGFT  EQDKEQS  SDIEQLR  LKQSQQK 

    ROCK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ROCK2 Protein Expression
    REFSEQ proteins: NP_004841.2  
    ENSEMBL proteins: 
     ENSP00000317985   ENSP00000385509   ENSP00000261535   ENSP00000395957  
    Reactome Protein details: O75116
    Human Recombinant Protein Products for ROCK2: 
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    Novus Biologicals ROCK2 Proteins
    Novus Biologicals ROCK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005813centrosome IDA17015463
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0031616spindle pole centrosome IEA--

    ROCK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rho-associated, coiled-coil containing protein kinase 2 
    Rho kinase
    ROCK subfamily

    5/13 InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011072 HR1_rho-bd
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry O75116

    ProtoNet protein and cluster: O75116

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ROCK2_HUMAN, O75116
    Domain: An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization (By
    similarity)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 REM (Hr1) repeat


    ROCK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROCK2_HUMAN, O75116
    Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
    of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
    retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN,
    MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of
    VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3
    and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of
    centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and
    ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine
    and synaptic properties in the hippocampus
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by RHOA binding. Inhibited by Y-27632 (By similarity)

         Genatlas biochemistry entry for ROCK2:
    serine/threonine kinase ROCK2/rho kinase,isozyme of ROCK1,one the targets for the small GTPase Rho,putative
    mediator of the Rho-dependent signaling pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA16574662
    GO:0004713protein tyrosine kinase activity ----
    GO:0005198structural molecule activity NAS9933571
         
    ROCK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ROCK2:
     Decreased focal adhesion (FA)   Decreased telomerase activity  Increased HPV18 LCR reporter a  Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Rock2):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  vision/eye 

    ROCK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rock2tm1.1Liao for ROCK2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ROCK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ROCK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ROCK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ROCK2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ROCK2:
    hsa-mir-138 (MIRT000494)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROCK2
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ROCK2 (see all 26):
    hsa-miR-3910 hsa-miR-142-3p hsa-miR-429 hsa-miR-300 hsa-miR-139-5p hsa-miR-301a hsa-miR-519a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidROCK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ROCK2
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: ROCK2 (NM_004850)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROCK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ROCK2 About   (see all 54)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Calcium signaling0.34
    5Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/12 EMD Millipore Pathways for ROCK2 (see all 12)
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Signal transduction Calcium signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling Slit-Robo signaling
    G-protein signaling G-Protein alpha-12 signaling pathway

    2 R&D Systems Pathways for ROCK2
        Wnt Signaling Pathway
    TGF-beta Signaling Pathways

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ROCK2 (see all 28)
        RhoA Pathway
    PKA Signaling
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for ROCK2
        Cytoskeletal Signaling

    1 Tocris Bioscience Pathway for ROCK2
        TGF-beta Pathway

    5/12 GeneGo (Thomson Reuters) Pathways for ROCK2 (see all 12)
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    G-protein signaling G-Protein alpha-12 signaling pathway
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling

    5/13 BioSystems Pathways for ROCK2 (see all 13)
        Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    G13 Signaling Pathway
    Integrin-mediated cell adhesion
    Spinal Cord Injury

    5/9        Reactome Pathways for ROCK2 (see all 9)
        GPCR downstream signaling
    Developmental Biology
    G alpha (12/13) signalling events
    Signaling by GPCR
    Sema4D induced cell migration and growth-cone collapse


    5/11         Kegg Pathways  (Kegg details for ROCK2) (see all 11):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    Wnt signaling pathway
    Axon guidance
    Focal adhesion


    ROCK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ROCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/862 Interacting proteins for ROCK2 (O751162, 3 ENSP000003179854) via UniProtKB, MINT, STRING, and/or I2D (see all 862)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193382, 3, ENSP000003181954MINT-7945693 MINT-8086654 I2D: score=1 STRING: ENSP00000318195
    PPP1R14BQ96C902, 3, ENSP000003101174MINT-3374782 I2D: score=1 STRING: ENSP00000310117
    MYH9P355792, ENSP000002161814MINT-7945693 MINT-7947479 STRING: ENSP00000216181
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    ARHGEF2Q929742, ENSP000003153254MINT-7945693 MINT-7947479 STRING: ENSP00000315325
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS9933571
    GO:0001843neural tube closure IEA--
    GO:0006468protein phosphorylation IDA18559669
    GO:0006939smooth muscle contraction TAS12778124
    GO:0007411axon guidance TAS--

    ROCK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ROCK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for ROCK2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for ROCK2

    Compounds for ROCK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Fasudil hydrochlorideInhibitor of cyclic nucleotide dependent- and Rho-kinases[103745-39-7]
    SB 772077B dihydrochloridePotent Rho-kinase inhibitor; vasodilator[607373-46-6]
    GSK 269962Potent and selective ROCK inhibitor[850664-21-0]
    Y-27632 dihydrochlorideSelective p160ROCK inhibitor[146986-50-7]
    H 1152 dihydrochlorideSelective Rho-kinase (ROCK) inhibitor[451462-58-1]

    10/846 HMDB Compounds for ROCK2 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    2 DrugBank Compounds for ROCK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE-- --target--10592235
    5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about ROCK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ROCK2 gene: 
    NM_004850.3  

    Unigene Cluster for ROCK2:

    Rho-associated, coiled-coil containing protein kinase 2
    Hs.681743  [show with all ESTs]
    Unigene Representative Sequence: AB014519
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315872(uc002rbd.1) ENST00000401753 ENST00000493096 ENST00000460262
    ENST00000261535 ENST00000484951 ENST00000431087 ENST00000462366
    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ROCK2 (see all 26):
    hsa-miR-3910 hsa-miR-142-3p hsa-miR-429 hsa-miR-300 hsa-miR-139-5p hsa-miR-301a hsa-miR-519a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidROCK2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AB014519.1 AK299296.1 AK310358.1 AL049383.1 BC111801.1 D87931.1 

    9 DOTS entries:

    DT.456011  DT.120982987  DT.97797607  DT.120982998  DT.120983002  DT.316648  DT.92005556  DT.40131067 
    DT.99936307 

    24/212 AceView cDNA sequences (see all 212):

    NM_004850 AA305018 AA353700 AW316743 BE765838 BM664710 BU685004 AA515709 
    BQ717709 BU740431 BM450170 CD724192 AA227736 BQ019175 BU159594 BF222319 
    BQ084100 AA354388 AI872746 CD514766 AA320754 AI638314 CA412615 BQ007869 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ROCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ROCK2 Expression
    About this image


    See ROCK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ROCK2

    SOURCE GeneReport for Unigene cluster: Hs.681743
        SABiosciences Expression via Pathway-Focused PCR Arrays including ROCK2: 
              Primary Cilia in human mouse rat
              Focal Adhesions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ROCK2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rock21 , 5 Rho-associated coiled-coil containing protein kinase more1, 5 91.04(n)1
    96.69(a)1
      12 (8.04 cM)5
    198781  NM_009072.21  NP_033098.21 
     168949785 
    chicken
    (Gallus gallus)
    Aves ROCK26
    Rho-associated, coiled-coil containing protein kin...
    85(a)
    1 ↔ 1
    3(96746492-96802174)
    lizard
    (Anolis carolinensis)
    Reptilia ROCK26
    Rho-associated, coiled-coil containing protein kin...
    84(a)
    1 ↔ 1
    1(147049018-147159318)
    African clawed frog
    (Xenopus laevis)
    Amphibia rocka-A-prov2 Rho-associated kinase alpha 78.23(n)    AF037073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rock22 rho-associated, coiled-coil containing protein kinase more 76.21(n)   317747  AF295804.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rok1 , 3 Rho protein signal transduction protein
    serine/threonine more3
    Rho-kinase1
    43(a)3
    49.4(n)1
    45.92(a)1
      439161  NM_080535.21  NP_536796.21 
    worm
    (Caenorhabditis elegans)
    Secernentea let-5021 , 3 Rho-associated kinase3
    Protein LET-5021
    33(a)3
    50.01(n)1
    39.44(a)1
      I(4738957-4744263)3
    1720881  NM_059039.41  NP_491440.11 


    ENSEMBL Gene Tree for ROCK2 (if available)
    TreeFam Gene Tree for ROCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ROCK2 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    ROCK12  CDC42BPA2  LATS22  
    18/52 SIMAP similar genes for ROCK2 using alignment to 5 protein entries:     ROCK2_HUMAN (see all proteins) (see all similar genes):
    ROCK1    PRKCE    CDC42BPB    PRKY    STK32A    PRKACB
    DMPK    KIN27    PRKX    RPS6KA3    PRKACG    MAPK8
    PRKACA    PRKG1    PRKG2    STK38L    PHKG1    RPS6KA2

    ROCK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3164 SNPs in ROCK2 are shown (see all 3164)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410644
    A metastatic melanoma sample4--see VAR_0410642 S P mis40--------
    rs2011876431,2
    C--11173617(-) TCAAAA/CTTTTA 1 -- int10--------
    rs718464611,2
    C--11267589(+) CAAGA-/CGTATA 1 -- int10--------
    rs757535591,2
    C,F--11267642(+) AATCAT/CTCCCC 1 -- int16Minor allele frequency- C:0.13NA CSA WA 245
    rs713938721,2
    C--11273250(+) AAACC-/CCA   
      C
    /CCCA
    CCATC
    1 -- int11NA 2
    rs1854660261,2
    --11292976(+) CAGCAA/GAGTGC 1 -- ds50010--------
    rs1163039151,2
    C,F--11293068(+) ATCTAT/CTATGG 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1886813041,2
    --11293155(+) TTAGAC/TGACTT 1 -- ds50010--------
    rs11299761,2
    C,F,H--11293281(-) TGGGAA/GGCTGA 1 -- ut313Minor allele frequency- G:0.33NA 6
    rs1156962251,2
    F--11293473(+) TATTTA/GAATAT 1 -- ut311Minor allele frequency- G:0.01NA 120

    HapMap Linkage Disequilibrium report for ROCK2 (11319887 - 11488456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for ROCK2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658593CNV Deletion23128226
    nsv436304CNV Deletion17901297
    esv2662875CNV Deletion23128226
    esv272377CNV Insertion20981092
    esv2453181CNV Insertion19546169
    esv267549CNV Insertion20981092
    esv271091CNV Insertion20981092
    esv2592438CNV Insertion19546169
    esv272435CNV Insertion20981092
    esv2543558CNV Insertion19546169


    Human Gene Mutation Database (HGMD): ROCK2
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ROCK2:
    Birth Defects
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604002    OMIM disorders: --

    20/22 diseases for ROCK2 (see all 22):    About MalaCards
    hepatopulmonary syndrome    shigellosis    myotonic dystrophy    scleroderma
    behcet's disease    diabetic retinopathy    essential hypertension    hypertension
    esophageal squamous cell carcinoma    liver disease    hypoxia    endotheliitis
    esophagitis    retinitis    hepatocellular carcinoma    pancreatic cancer
    squamous cell carcinoma    breast cancer    pancreatitis    hepatitis


    ROCK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ROCK2
    Human Genome Epidemiology (HuGE) Navigator: ROCK2 (13 documents)

    Export disorders for ROCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ROCK2 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with ROCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. (PubMed id 9933571)1, 2, 3 Takahashi N.... Kaibuchi K. (1999)
    2. ROCK2 allelic variants are not associated with pre-ec lampsia susceptibility in the Finnish population. (PubMed id 19435756)1, 4, 9 Peterson H....Kivinen K. (2009)
    3. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. (PubMed id 16574662)1, 2, 9 Tanaka T....Hamamori Y. (2006)
    4. ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. (PubMed id 19131646)1, 2, 9 Wang Y....Surks H.K. (2009)
    5. A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study. (PubMed id 18971541)1, 4, 9 Rankinen T....Bouchard C. (2008)
    6. Rho kinase II phosphorylation of the lipoprotein rece ptor LR11/SORLA alters amyloid-beta production. (PubMed id 21147781)1, 2 Herskowitz J.H....Lah J.J. (2011)
    7. BRCA2 and nucleophosmin coregulate centrosome amplifi cation and form a complex with the Rho effector kinase ROCK2. (PubMed id 21084279)1, 2 Wang H.F....Miki Y. (2011)
    8. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer. (PubMed id 20939434)1, 4 Kalender M.E....Camci C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9475 HGNC: 10252 AceView: ROCK2 Ensembl:ENSG00000134318 euGenes: HUgn9475
    ECgene: ROCK2 Kegg: 9475 H-InvDB: ROCK2

    (According to HUGE)
    About This Section
    HUGE: KIAA0619

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ROCK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROCK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ROCK2 gene:
    Search GeneIP for patents involving ROCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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