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ROCK1 Gene

protein-coding   GIFtS: 71
GCID: GC18M018529

Rho-Associated, Coiled-Coil Containing Protein Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho-Associated, Coiled-Coil Containing Protein Kinase 11 2     P160ROCK2
Renal Carcinoma Antigen NY-REN-352 3     p160-ROCK2
Rho-Associated, Coiled-Coil-Containing Protein Kinase 12 3     Rho Kinase2
Rho-Associated, Coiled-Coil-Containing Protein Kinase I2 3     Rho-Associated Protein Kinase 12
ROCK-I2 3     p160ROCK3
P160 ROCK-12 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 102511   Entrez Gene: 60932   Ensembl: ENSG000000679007   OMIM: 6017025   UniProtKB: Q134643   

Export aliases for ROCK1 gene to outside databases

Previous GC identifers: GC18M018388 GC18M018263 GC18M016785 GC18M016787 GC18M015376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ROCK1 Gene:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The
small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and
aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum
response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ROCK1 Gene:
ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) is a protein-coding gene. Diseases associated with ROCK1 include shigellosis, and giant cell tumor. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CDC42BPG.

UniProtKB/Swiss-Prot: ROCK1_HUMAN, Q13464
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and
PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma
membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts
as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a
negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning
and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate
closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes
keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis
cell-mediated matrix assembly process, essential for osteoblast mineralization

summary for ROCK1 Gene:
Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases that are
activated by RhoA GTPases, and are key modulators of processes involving cytoskeletal rearrangement such
focal adhesion formation, cell motility and tumor cell invasion. There are two isoforms of ROCK, ROCKI (aka
ROKbeta or p160ROCK) and ROCKII (aka ROKalpha), which share a high degree of structural identity in their
kinase domains (92%). The two Rho-kinase isoforms have different patterns of tissue expression; ROCKII
expression is highest in the brain and in muscle whereas ROCKI has a ubiquitous tissue distribution.
Subcellularly, ROCKII is found in the cytosol and localizes to the cleavage furrow during cytokinesis. ROCKI
is thought to colocalize with the centrosomes. ROCKs phosphorylate a number of proteins involved in actin
filament assembly and contraction (e.g. LIM Kinases, MLCK, ERM proteins). Other downstream targets of the
Rho kinases include signal transduction molecules such as IRS-1 and PI 3-K/AKT.

Gene Wiki entry for ROCK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROCK1 gene promoter:
         Nkx3-1   Nkx3-1 v4   NRSF form 1   Nkx3-1 v1   NRSF form 2   Nkx3-1 v2   AREB6   Nkx3-1 v3   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ROCK1 promoter sequence
   Search Chromatin IP Primers for ROCK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.1   Ensembl cytogenetic band:  18q11.1   HGNC cytogenetic band: 18q11.2

ROCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROCK1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M018529:  view genomic region     (about GC identifiers)

Start:
18,526,867 bp from pter      End:
18,691,812 bp from pter
Size:
164,946 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ROCK1_HUMAN, Q13464 (See protein sequence)
Recommended Name: Rho-associated protein kinase 1  
Size: 1354 amino acids; 158175 Da
Cofactor: Magnesium
Subunit: Homodimer. Interacts with RHOB, RHOC, MYLC2B and PTEN. Interacts with ITGB1BP1 (via N-terminus and PTB
domain) (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1,
LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner
Selected PDB 3D structures from and Proteopedia for ROCK1 (see all 12):
1S1C (3D)        2ESM (3D)        2ETK (3D)        2ETR (3D)        2V55 (3D)        3D9V (3D)    
Secondary accessions: B0YJ91 Q2KHM4 Q59GZ4

Explore the universe of human proteins at neXtProt for ROCK1: NX_Q13464

Explore proteomics data for ROCK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine and threonine residues1
  • Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ROCK1 (Q13464) (see all 41)
     EQDKEQS  SDIEQLR  FFKNDQW  LKQSQQK 


    See ROCK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005397.1  
    ENSEMBL proteins: 
     ENSP00000382697   ENSP00000462004  
    Reactome Protein details: Q13464

    ROCK1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ROCK1
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for ROCK1
    Novus Biologicals ROCK1 Proteins
    Novus Biologicals ROCK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ROCK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ROCK1
    R&D Systems Antibodies for ROCK1
    Cell Signaling Technology (CST) Antibodies for ROCK1 
    OriGene Antibodies for ROCK1
    OriGene Custom Antibody Services for ROCK1
    Novus Biologicals ROCK1 Antibodies
    Abcam antibodies for ROCK1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ROCK1
    LSBio Antibodies in human, mouse, rat for ROCK1

    ROCK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ROCK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ROCK1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Rho-associated, coiled-coil containing protein kinase 1
    Rho kinase
    ROCK subfamily

    Selected InterPro protein domains (see all 13):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011072 HR1_rho-bd
     IPR000961 AGC-kinase_C
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13464

    ProtoNet protein and cluster: Q13464

    2 Blocks protein domains:
    IPB000961 Protein kinase C-terminal domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ROCK1_HUMAN, Q13464
    Domain: The C-terminal auto-inhibitory domain interferes with kinase activity. RHOA binding leads to a
    conformation change and activation of the kinase. Truncated ROCK1 is constitutively activated
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 REM (Hr1) repeat


    ROCK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROCK1_HUMAN, Q13464
    Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation
    of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite
    retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and
    PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma
    membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts
    as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a
    negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning
    and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate
    closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes
    keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis
    cell-mediated matrix assembly process, essential for osteoblast mineralization
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by RHOA binding. Inhibited by Y-27632

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10436159
    GO:0004674protein serine/threonine kinase activity IDA10652353
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10652353
    GO:0005524ATP binding IEA--
         
    ROCK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for ROCK1:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 
     Increased homologous recombina  Increased telomerase activity 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Rock1) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  renal/urinary system  respiratory system  skeleton 

    ROCK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ROCK1: Rock1tm1Liao Rock1tm1.2Itl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ROCK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ROCK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ROCK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ROCK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ROCK1:
    hsa-mir-148b-3p (MIRT007315), hsa-mir-1280 (MIRT007070), hsa-mir-584-5p (MIRT004047), hsa-mir-146a-5p (MIRT000945)

    Block miRNA regulation of human, mouse, rat ROCK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ROCK1 (see all 44):
    hsa-miR-4307 hsa-miR-520f hsa-let-7a-2* hsa-miR-449a hsa-miR-124 hsa-miR-506 hsa-miR-330-3p hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidROCK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ROCK1
    Predesigned siRNA for gene silencing in human, mouse, rat ROCK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ROCK1

    Clone
    Products:
         
    OriGene clones in human, mouse for ROCK1 (see all 7)
    OriGene ORF clones in mouse, rat for ROCK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ROCK1 (NM_005406)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ROCK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROCK1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ROCK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROCK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ROCK1_HUMAN, Q13464: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (By
    similarity). Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm,
    cytoskeleton (By similarity). Cell membrane (By similarity). Cell projection, lamellipodium (By similarity). Cell
    projection, ruffle (By similarity). Note=Associated with the mother centriole and an intercentriolar linker.
    Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but
    also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A
    small proportion is associated with Golgi membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    cytoskeleton2
    extracellular2
    nucleus2
    endosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0001726ruffle ISS--
    GO:0005814centriole IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ISS--

    ROCK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ROCK1 About   (see all 63)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for ROCK1
        Wnt Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ROCK1 (see all 28)
        RhoA Pathway
    PKA Signaling
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Semaphorin Signaling

    1 Cell Signaling Technology (CST) Pathway for ROCK1
        Cytoskeletal Signaling

    1 Tocris Bioscience Pathway for ROCK1
        TGF-beta Pathway

    Selected GeneGo (Thomson Reuters) Pathways for ROCK1 (see all 13)
        Development VEGF signaling via VEGFR2 - generic cascades
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    G-protein signaling G-Protein alpha-12 signaling pathway

    Selected BioSystems Pathways for ROCK1 (see all 21)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    G13 Signaling Pathway
    AGE/RAGE pathway

    3 Reactome Pathways for ROCK1
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    Apoptotic cleavage of cellular proteins


    Selected Kegg Pathways  (Kegg details for ROCK1) (see all 13):
        Chemokine signaling pathway
    Vascular smooth muscle contraction
    TGF-beta signaling pathway
    Axon guidance
    Focal adhesion


    ROCK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ROCK1: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ROCK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ROCK1 (Q134641, 2, 3 ENSP000003826974) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998161, 2, 3, ENSP000002519684EBI-876651,EBI-346882 MINT-6173294 MINT-6173697 MINT-6173310 MINT-6173341 I2D: score=2 STRING: ENSP00000251968
    RHOAP615861, 2, 3, ENSP000004001754EBI-876651,EBI-446668 MINT-8086576 MINT-8086663 MINT-8086602 I2D: score=6 STRING: ENSP00000400175
    SMAD2Q157962, 3, ENSP000002621604MINT-61585 I2D: score=3 STRING: ENSP00000262160
    MYBPHQ132031, 2EBI-876651,EBI-5655165 MINT-8329386 MINT-8378307
    NCLP193382, ENSP000003181954MINT-8086576 MINT-8086602 STRING: ENSP00000318195
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003383apical constriction IEA--
    GO:0006468protein phosphorylation TAS10436159
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0006939smooth muscle contraction TAS12778124

    ROCK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ROCK1
    9 ApexBio Compounds for ROCK1     About this table
    CompoundAction CAS #
    chroman 1highly potent and selective ROCK II inhibitor[1273579-40-0]
    Fasudil (HA-1077) HClCyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor[105628-07-7]
    GSK429286ASelective Rho-kinase inhibitor[864082-47-3]
    H-1152more specific, stronger and membrane-permeable inhibitor of Rho-kinase[451462-58-1]
    Hydroxyfasudilpotent Rho-kinase inhibitor[105628-72-6]
    Narciclasinemodulates the Rho/ROCK/LIM kinase/cofilin pathway[29477-83-6]
    RKI-1447potent small molecule inhibitor of ROCK1 and ROCK2[1342278-01-6]
    SLx-2119Selective ROCK2 inhibitor [911417-87-3]
    Y-27632 dihydrochloridep160ROCK inhibitor[146986-50-7]

    Compounds for ROCK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Fasudil hydrochlorideInhibitor of cyclic nucleotide dependent- and Rho-kinases[103745-39-7]
    SB 772077B dihydrochloridePotent Rho-kinase inhibitor; vasodilator[607373-46-6]
    GSK 269962Potent and selective ROCK inhibitor[850664-21-0]
    Y-27632 dihydrochlorideSelective p160ROCK inhibitor[146986-50-7]
    H 1152 dihydrochlorideSelective Rho-kinase (ROCK) inhibitor[451462-58-1]

    Selected HMDB Compounds for ROCK1 (see all 846)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    4 DrugBank Compounds for ROCK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    HYDROXYFASUDIL-- --targetinhibitor11752352 10592235
    (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE-- --target--10592235
    (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE-- --target--10592235
    5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE-- --target--10592235

    7 Novoseek inferred chemical compound relationships for ROCK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eipa 50 1 9707430 (1)
    threonine 49 4 9119047 (1), 11448997 (1), 9707430 (1), 15178765 (1)
    serine 41.4 3 9119047 (1), 11448997 (1), 9707430 (1)
    fmlp 27.4 1 10973620 (1)
    gtp 22.4 1 17947676 (1)
    adp 3.32 1 15078882 (1)
    calcium 2.73 7 12850840 (1), 17301291 (1), 12659853 (1)



    ROCK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for ROCK1 gene: 
    NM_005406.2  

    Unigene Cluster for ROCK1:

    Rho-associated, coiled-coil containing protein kinase 1
    Hs.306307  [show with all ESTs]
    Unigene Representative Sequence: NM_005406
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399799(uc002kte.3) ENST00000578051 ENST00000584687 ENST00000584875
    ENST00000583556 ENST00000582445
    miRNA
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    hsa-miR-4307 hsa-miR-520f hsa-let-7a-2* hsa-miR-449a hsa-miR-124 hsa-miR-506 hsa-miR-330-3p hsa-miR-556-3p
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    Additional mRNA sequence: 

    AB208965.1 AK057038.1 AK307388.1 BC113114.1 DQ786321.1 U43195.1 

    11 DOTS entries:

    DT.415971  DT.100794192  DT.100794197  DT.95156679  DT.99978158  DT.86838074  DT.91652063  DT.91944635 
    DT.99943679  DT.95123389  DT.99929329 

    Selected AceView cDNA sequences (see all 231):

    AW594257 AW593068 AI301107 BU742284 AA922029 AI831844 AA724511 AA247910 
    BM694039 AW512255 AI697252 AA714035 CD677490 BQ220803 AA491092 BM457267 
    BE326534 AU121527 CA976194 BM728671 BQ225204 AI884576 AA490260 AL135021 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ROCK1 expression in normal human tissues (normalized intensities)      ROCK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCAAGTGG
    ROCK1 Expression
    About this image


    ROCK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    ROCK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROCK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306307

    UniProtKB/Swiss-Prot: ROCK1_HUMAN, Q13464
    Tissue specificity: Detected in blood platelets

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ROCK1: 
              Cytoskeleton Regulators in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ROCK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rock11 , 5 Rho-associated coiled-coil containing protein kinase more1, 5 92.05(n)1
    96.6(a)1
      18 (4.91 cM)5
    198771  NM_009071.21  NP_033097.11 
     100644015 
    chicken
    (Gallus gallus)
    Aves ROCK11 Rho-associated, coiled-coil containing protein kinase more 81.69(n)
    87.51(a)
      373970  NM_001199448.1  NP_001186377.1 
    lizard
    (Anolis carolinensis)
    Reptilia ROCK16
    Rho-associated, coiled-coil containing protein kin...
    87(a)
    1 ↔ 1
    4(39196758-39283917)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rock11 Rho-associated, coiled-coil containing protein kinase more 76.8(n)
    82.77(a)
      100496057  XM_002934134.2  XP_002934180.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rock11 Rho-associated, coiled-coil containing protein kinase more 69.04(n)
    75.98(a)
      100329779  NM_001256634.1  NP_001243563.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CBK16
    Serine/threonine protein kinase of the the RAM sig...
    22(a)
    1 → many
    XIV(332597-334867) YNL161W


    ENSEMBL Gene Tree for ROCK1 (if available)
    TreeFam Gene Tree for ROCK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ROCK1 gene
    CDC42BPG2  DMPK2  LATS12  CDC42BPB2  STK38L2  STK382  MASTL2  CIT2  
    CDC42BPA2  LATS22  ROCK22  
    Selected SIMAP similar genes for ROCK1 using alignment to 4 protein entries:     ROCK1_HUMAN (see all proteins) (see all similar genes):
    ROCK2    CDC42BPB    PRKY    RPS6KA3    PRKACB    KIN27
    PRKACG    PRKX    DMPK    PRKACA    RPS6KA2    STK38L
    STK38    SGK1    STK11    SGK2    KIAA0999    MARK4

    ROCK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ROCK1
    PGOHUM00000259265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ROCK1 (see all 2681)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410584
    A lung neuroendocrine carcinoma sample4--see VAR_0410582 P S mis40--------
    rs26637071,2
    C--18529357(-) GGAACA/GTGAAA 1 -- ds50010--------
    rs1112877281,2
    C,F--18529408(-) TGGGCC/TACTCT 1 -- ds50013Minor allele frequency- T:0.02CSA NS WA 638
    rs1923229491,2
    --18529493(+) AACCCA/GACATC 1 -- ds50010--------
    rs113901551,2
    C--18529511(+) GGAGA-/CACTCT 1 -- ds50010--------
    rs739597541,2
    C,F--18529593(+) GCTTCC/GCTGAT 1 -- ds50012Minor allele frequency- G:0.00WA NS 540
    rs1123898101,2
    C--18529602(-) TTTCTA/GCACAT 1 -- ds50011Minor allele frequency- G:0.00NS 538
    rs1116270741,2
    C,F--18529700(-) TAAAAC/TGTGGT 1 -- ds50011Minor allele frequency- T:0.00NS 520
    rs2014063381,2
    C--18529719(+) AAATAC/TACTTT 1 -- ut310--------
    rs2019935211,2
    C--18529823(+) GCAGTA/CAAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ROCK1 (18526867 - 18691812 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ROCK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv270844CNV Insertion20981092
    esv273128CNV Insertion20981092
    nsv833594CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): ROCK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ROCK1
    DNA2.0 Custom Variant and Variant Library Synthesis for ROCK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601702    OMIM disorders: --

    Selected diseases for ROCK1 (see all 38):    About MalaCards
    shigellosis    giant cell tumor    myotonic dystrophy    epididymitis
    scleroderma    clear cell renal cell carcinoma    transitional cell carcinoma    fibrosarcoma
    diarrhea    hyperglycemia    ovarian cancer    kidney disease
    coronary artery disease    cervical cancer    endotheliitis    renal cell carcinoma
    chronic lymphocytic leukemia    osteosarcoma    cervicitis    atherosclerosis


    ROCK1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for ROCK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 21.1 8 16371346 (2), 11230737 (2)
    ovarian cancer 0 10 16371346 (3), 15355639 (3)
    tumors 0 1 16371346 (1)
    cancer 0 4 16371346 (1), 12794027 (1), 18204440 (1)
    heart failure 0 3 16983089 (2), 17482681 (1)

    Genetic Association Database (GAD): ROCK1
    Human Genome Epidemiology (HuGE) Navigator: ROCK1 (9 documents)

    Export disorders for ROCK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROCK1 gene, integrated from 10 sources (see all 325):
    (articles sorted by number of sources associating them with ROCK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. (PubMed id 8617235)1, 2, 3 Ishizaki T.... Narumiya S. (EMBO J. 1996)
    2. ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. (PubMed id 19131646)1, 2, 9 Wang Y....Surks H.K. (Circ. Res. 2009)
    3. Different molecular mechanisms for Rho family GTPase-dependent, Ca2+- independent contraction of smooth muscle. (PubMed id 9722579)1, 2, 9 Van Eyk J.E.... Mak A.S. (J. Biol. Chem. 1998)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. No association between Rho-associated coiled-coil forming protein serine/threonine kinase1 gene and schizophrenia in the Japanese population. (PubMed id 19404162)1, 4 Nakataki M....Ohmori T. (Psychiatr. Genet. 2009)
    7. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. (PubMed id 19181962)1, 2 Kroll J.... Augustin H.G. (Am. J. Physiol. 2009)
    8. Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation. (PubMed id 19997641)1, 2 Lock F.E. and Hotchin N.A. (PLoS ONE 2009)
    9. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. (PubMed id 19036714)1, 2 Ongusaha P.P.... Lee S.W. (Sci. Signal. 2008)
    10. The diaphanous-related formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. (PubMed id 18694941)1, 2 Hannemann S.... Fackler O.T. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6093 HGNC: 10251 AceView: ROCK1 Ensembl:ENSG00000067900 euGenes: HUgn6093
    ECgene: ROCK1 Kegg: 6093 H-InvDB: ROCK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ROCK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROCK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ROCK1 gene:
    Search GeneIP for patents involving ROCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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