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ROBO4 Gene

protein-coding   GIFtS: 57
GCID: GC11M124753

Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)

(Previous name: roundabout homolog 4 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)1 2     MRB2
Magic Roundabout1 3     Roundabout Homolog 42
Roundabout Homolog 4 (Drosophila)1     Roundabout Homolog 4, Magic Roundabout2
ECSM42     

External Ids:    HGNC: 179851   Entrez Gene: 545382   Ensembl: ENSG000001541337   OMIM: 6075285   UniProtKB: Q8WZ753   

Export aliases for ROBO4 gene to outside databases

Previous GC identifers: GC11M126754 GC11M126266 GC11M124787 GC11M124291 GC11M124258 GC11M120696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ROBO4 Gene:
ROBO4 (roundabout, axon guidance receptor, homolog 4 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular
patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity)

Gene Wiki entry for ROBO4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ROBO4 gene promoter:
         ER-alpha   AML1a   NRSF form 1   AP-4   NRSF form 2   C/EBPalpha   HNF-1A   RORalpha1   Nkx6-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidROBO4 promoter sequence
   Search Chromatin IP Primers for ROBO4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROBO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

ROBO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROBO4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M124753:  view genomic region     (about GC identifiers)

Start:
124,753,587 bp from pter      End:
124,768,396 bp from pter
Size:
14,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75 (See protein sequence)
Recommended Name: Roundabout homolog 4 precursor  
Size: 1007 amino acids; 107457 Da
Subunit: Interacts with SLIT2 and ENAH (By similarity)
Sequence caution: Sequence=AAH64643.1; Type=Erroneous initiation; Sequence=BAA91382.1; Type=Erroneous initiation;
Sequence=BAB15082.1; Type=Erroneous initiation; Sequence=BAB55411.1; Type=Frameshift; Positions=706;
Secondary accessions: A8K154 Q14DU7 Q8TEG1 Q96JV6 Q9H718 Q9NWJ8
Alternative splicing: 3 isoforms:  Q8WZ75-1   Q8WZ75-2   Q8WZ75-3   

Explore the universe of human proteins at neXtProt for ROBO4: NX_Q8WZ75

Explore proteomics data for ROBO4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn246, Asn360, Asn389, Asn396, Asn680
  • Modification sites at PhosphoSitePlus

  • See ROBO4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061928.4  
    ENSEMBL proteins: 
     ENSP00000304945   ENSP00000437129  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8WZ75

    ProtoNet protein and cluster: Q8WZ75

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
    Similarity: Belongs to the immunoglobulin superfamily. ROBO family
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with ROBO4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROBO4_HUMAN, Q8WZ75
    Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular
    patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS14527427
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ROBO4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ROBO4:
     Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Robo4):
     cardiovascular system  cellular  homeostasis/metabolism  integument  nervous system 
     no phenotypic analysis 

    Find genes that share phenotypes with ROBO4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ROBO4

    miRNA
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    miRTarBase miRNAs that target ROBO4:
    hsa-mir-335-5p (MIRT017942)

    Block miRNA regulation of human, mouse, rat ROBO4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ROBO4:
    hsa-miR-3926 hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmidROBO4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane TAS14527427

    Find genes that share ontologies with ROBO4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ROBO4 About    
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Cytoskeleton remodeling Slit Robo signaling0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ROBO4
        Development Slit-Robo signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ROBO4
    Interactions:

        GeneGlobe Interaction Network for ROBO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ROBO4 (Q8WZ753 ENSP000003049454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENAHQ8N8S73, ENSP000003558094I2D: score=1 STRING: ENSP00000355809
    SLIT2O948133, ENSP000002737394I2D: score=1 STRING: ENSP00000273739
    PPARGENSP000002878204STRING: ENSP00000287820
    RXRAENSP000004196924STRING: ENSP00000419692
    THRBENSP000003488274STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IGI15849270
    GO:0030154cell differentiation IEA--
    GO:0030334regulation of cell migration NAS15894287
    GO:0030336negative regulation of cell migration IEA--

    Find genes that share ontologies with ROBO4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ROBO4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ROBO4 gene: 
    NM_019055.5  

    Unigene Cluster for ROBO4:

    Roundabout, axon guidance receptor, homolog 4 (Drosophila)
    Hs.524121  [show with all ESTs]
    Unigene Representative Sequence: AK074163
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306534(uc001qbg.3 uc010sas.2) ENST00000534407 ENST00000533054(uc010sat.1)
    ENST00000532216 ENST00000525182 ENST00000532300 ENST00000526899 ENST00000527279
    ENST00000529941 ENST00000533337
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate ROBO4:
    hsa-miR-3926 hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmidROBO4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF361473.1 AK000805.1 AK025195.1 AK027852.1 AK074163.1 AK289769.1 AK297845.1 AK302628.1 
    AY358083.1 BC014995.1 BC025675.1 BC039602.1 BC064643.1 BC111562.1 BC111748.1 

    11 DOTS entries:

    DT.456057  DT.100823944  DT.95306865  DT.315596  DT.100711708  DT.100712884  DT.100699016  DT.100823942 
    DT.100823945  DT.120733444  DT.120733451 

    Selected AceView cDNA sequences (see all 123):

    BE218677 BM556872 BU683353 AI265775 T87725 CD671574 BQ711089 BX280065 
    AA630260 AA303624 AY358083 BC064643 R99441 BM709423 BC039602 BU733363 
    AA358843 BC025675 BC014995 R99429 AK074163 AA876225 BU687982 BM921911 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ROBO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAACAAAG
    ROBO4 Expression
    About this image


    ROBO4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Spleen (Hematopoietic System)
    ROBO4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROBO4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524121

    UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
    Tissue specificity: Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different
    tumor types

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ROBO4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Robo41 , 5 roundabout homolog 4 (Drosophila)1, 5 81.61(n)1
    78.05(a)1
      9 (20.76 cM)5
    741441  NM_028783.21  NP_083059.21 
     374018975 
    chicken
    (Gallus gallus)
    Aves ROBO46
    roundabout, axon guidance receptor, homolog 4 (Dro...
    37(a)
    1 ↔ 1
    24(241553-246273) ENSGALG00000000850
    lizard
    (Anolis carolinensis)
    Reptilia ROBO46
    roundabout, axon guidance receptor, homolog 4 (Dro...
    36(a)
    1 ↔ 1
    GL343367.1(455851-533339)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX733227.12   -- 71.37(n)    BX733227.1 
    zebrafish
    (Danio rerio)
    Actinopterygii robo46
    roundabout homolog 4
    28(a)
    1 ↔ 1
    10(32256930-32292860) ENSDARG00000009387


    ENSEMBL Gene Tree for ROBO4 (if available)
    TreeFam Gene Tree for ROBO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ROBO4 gene
    1 SIMAP similar gene for ROBO4 using alignment to 2 protein entries:     ROBO4_HUMAN (see all proteins):
    MUSK

    Find genes that share paralogs with ROBO4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ROBO4 (see all 529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824416741,2
    --124753652(+) TGCCTA/CCCTCC 1 -- int10--------
    rs1870705661,2
    --124753697(+) ACCGTA/GCCCAG 1 -- int10--------
    rs1918848521,2
    --124753834(+) TCCCAC/TTTCCC 1 -- int10--------
    rs1477011081,2
    C--124753873(+) TTGAGA/GAGGTG 1 -- int10--------
    rs1491579611,2
    --124753936(+) CCTTCC/TTATAT 1 -- int10--------
    rs1814638161,2
    --124753966(+) ATGAAC/TCTCAT 1 -- int10--------
    rs1860534511,2
    --124754026(+) TGAATA/GCCTGA 1 -- int10--------
    rs752089821,2
    C,F--124754140(+) GTATCA/GAATTT 1 -- ut313Minor allele frequency- G:0.08WA NA EA 358
    rs1999297301,2
    C--124754180(+) TGGTG-/CCTTTT 1 -- ut310--------
    rs1903609281,2
    C--124754207(+) CCTCCC/TTTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ROBO4 (124753587 - 124768396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ROBO4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv531CNV Insertion18451855
    nsv520150CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ROBO4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607528    OMIM disorders: --


    Find genes that share disorders with ROBO4           About GenesLikeMe

    Genetic Association Database (GAD): ROBO4
    Human Genome Epidemiology (HuGE) Navigator: ROBO4 (3 documents)

    Export disorders for ROBO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ROBO4 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ROBO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. (PubMed id 18270976)1, 4 Anitha A....Mori N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    2. Association study between Gilles de la Tourette Syndrome and two genes in the Robo-Slit pathway located in the chromosome 11q24 linked/associated region. (PubMed id 17671968)1, 4 Miranda D.M....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. (PubMed id 11944987)1, 2 Huminiecki L.... Bicknell R. (Genomics 2002)
    8. In silico cloning of novel endothelial-specific genes. (PubMed id 11076864)1, 3 Huminiecki L. and Bicknell R. (Genome Res. 2000)
    9. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. (PubMed id 16685377)1, 9 GrAPne J....Bhargava S. (Oncol. Rep. 2006)
    10. Slit2-Robo4 pathway modulates lipopolysaccharide-induced endothelial inflammation and its expression is dysregulated during endotoxemia. (PubMed id 24272999)1 Zhao H....Ganju R.K. (J. Immunol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54538 HGNC: 17985 AceView: ROBO4 Ensembl:ENSG00000154133 euGenes: HUgn54538
    ECgene: ROBO4 H-InvDB: ROBO4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ROBO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ROBO4 gene:
    Search GeneIP for patents involving ROBO4

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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