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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ROBO4 Gene

protein-coding   GIFtS: 53
GCID: GC11M124753

roundabout, axon guidance receptor, homolog 4 (Drosophila)

(Previous name: roundabout homolog 4 (Drosophila) )
 Explore 15 diseases affiliated with
ROBO4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ROBO4    

Aliases
for ROBO4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)1 2     Roundabout Homolog 4 (Drosophila)1
ECSM41 2     Roundabout Homolog 42
MRB1 2     Roundabout Homolog 4, Magic Roundabout2
FLJ207981     Magic Roundabout3

External Ids:    HGNC: 179851   Entrez Gene: 545382   Ensembl: ENSG000001541337   OMIM: 6075285   UniProtKB: Q8WZ753   

Export aliases for ROBO4 gene to outside databases

Previous GC identifers: GC11M126754 GC11M126266 GC11M124787 GC11M124291 GC11M124258 GC11M120696


Summaries
for ROBO4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular
patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity)

Gene Wiki entry for ROBO4


Genomic Views
for ROBO4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ROBO4 gene promoter:
         ER-alpha   AML1a   NRSF form 1   AP-4   NRSF form 2   C/EBPalpha   HNF-1A   RORalpha1   Nkx6-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ROBO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ROBO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ROBO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

ROBO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROBO4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M124753:  view genomic region     (about GC identifiers)

Start:
 124,753,587 bp from pter      End:
 124,768,396 bp from pter
Size:
 14,810 bases      Orientation:
 minus strand

Proteins
for ROBO4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75 (See protein sequence)
Recommended Name: Roundabout homolog 4 precursor  
Size: 1007 amino acids; 107457 Da
Subunit: Interacts with SLIT2 and ENAH (By similarity)
Sequence caution: Sequence=AAH64643.1; Type=Erroneous initiation; Sequence=BAA91382.1; Type=Erroneous initiation;
Sequence=BAB15082.1; Type=Erroneous initiation; Sequence=BAB55411.1; Type=Frameshift; Positions=706;
Secondary accessions: A8K154 Q14DU7 Q8TEG1 Q96JV6 Q9H718 Q9NWJ8
Alternative splicing: 3 isoforms:  Q8WZ75-1   Q8WZ75-2   Q8WZ75-3   

Explore the universe of human proteins at neXtProt for ROBO4: NX_Q8WZ75

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WZ75

    • ROBO4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061928.4  
    ENSEMBL proteins: 
     ENSP00000304945   ENSP00000437129  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ROBO4
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    Novus Biologicals ROBO4 Proteins
    Novus Biologicals ROBO4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ROBO4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral to membrane TAS14527427


    ROBO4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ROBO4

    Protein Domains /
    Families
    for ROBO4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ROBO4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8WZ75

    ProtoNet protein and cluster: Q8WZ75

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
    Similarity: Belongs to the immunoglobulin superfamily. ROBO family
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for ROBO4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
    Function: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular
    patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROBO4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ROBO4:
    hsa-miR-3926 hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmid: ROBO4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ROBO4 (see all 7)
    OriGene shRNA RFP: ROBO4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROBO4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ROBO4

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROBO4 

    Cell Line
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    Search LifeMap BioReagents cell lines for ROBO4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROBO4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS14527427
    GO:0005515protein binding ----


    ROBO4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ROBO4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Robo4):
     cardiovascular system  cellular  homeostasis/metabolism  integument  no phenotypic analysis 

    ROBO4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ROBO4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Slit-Robo signaling
    		Cytoskeleton remodeling Slit-Robo signaling1.00
    		Development_Slit-Robo signaling0.92

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ROBO4
        Cytoskeleton remodeling Slit-Robo signaling


    1 GeneGo (Thomson Reuters) Pathway for ROBO4
        Development Slit-Robo signaling



    ROBO4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ROBO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ROBO4 (Q8WZ753 ENSP000003049454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENAHQ8N8S73, ENSP000003558094I2D: score=1 STRING: ENSP00000355809
    SLIT2O948133, ENSP000002737394I2D: score=1 STRING: ENSP00000273739
    PPARGENSP000002878204STRING: ENSP00000287820
    RXRAENSP000004196924STRING: ENSP00000419692
    THRBENSP000003488274STRING: ENSP00000348827
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IGI15849270
    GO:0030154cell differentiation IEA--
    GO:0030334regulation of cell migration NAS15894287
    GO:0030336negative regulation of cell migration IEA--


    ROBO4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ROBO4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ROBO4
    Search CenterWatch for drugs/clinical trials and news about ROBO4 

    Transcripts
    for ROBO4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ROBO4 gene: 
    NM_019055.5  

    Unigene Cluster for ROBO4:

    Roundabout, axon guidance receptor, homolog 4 (Drosophila)
    Hs.524121  [show with all ESTs]
    Unigene Representative Sequence: AK074163
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306534(uc001qbg.3 uc010sas.2) ENST00000534407 ENST00000528277(uc001qbi.3 uc001qbh.2)
    ENST00000533054(uc010sat.1) ENST00000532216 ENST00000525182 ENST00000532300
    ENST00000526899 ENST00000527279 ENST00000529941 ENST00000533337

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ROBO4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ROBO4:
    hsa-miR-3926 hsa-miR-579
    SwitchGear 3'UTR luciferase reporter plasmid: ROBO4 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: ROBO4
    OriGene siRNA: ROBO4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ROBO4
    Clone
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    GenScript: all cDNA clones in your preferred vector: ROBO4 (NM_019055)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROBO4 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ROBO4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ROBO4

    Additional cDNA sequence: 

    AF361473.1 AK000805.1 AK025195.1 AK027852.1 AK074163.1 AK289769.1 AK297845.1 AK302628.1 
    AY358083.1 BC014995.1 BC025675.1 BC039602.1 BC064643.1 BC111562.1 BC111748.1 

    11 DOTS entries:

    DT.456057  DT.100823944  DT.95306865  DT.315596  DT.100711708  DT.100712884  DT.100699016  DT.100823942 
    DT.100823945  DT.120733444  DT.120733451 

    24/123 AceView cDNA sequences (see all 123):

    AI265775 BM556872 CD671574 T87725 AA303624 AA630260 BX280065 BC064643 
    AY358083 R99441 BU683353 BQ711089 AA876225 R99429 BC014995 AK074163 
    BC025675 AA358843 BM709423 BU733363 BC039602 BE218677 BQ068218 AI129190 

    GeneLoc Exon Structure


    Expression
    for ROBO4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ROBO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAACAAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ROBO4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ROBO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ROBO4

    SOURCE GeneReport for Unigene cluster: Hs.524121

    UniProtKB/Swiss-Prot: ROBO4_HUMAN, Q8WZ75
    Tissue specificity: Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor
    types

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROBO4

    Orthologs
    for ROBO4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ROBO4 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ROBO46
    		 Uncharacterized protein
    		 39(a)
    		 1 ↔ 1
    		 24(248566-253905)
    lizard
    (Anolis carolinensis)    		 Reptilia ROBO46
    		 --
    		 35(a)
    		 1 ↔ 1
    		 GL343367.1(469519-518213)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia BX733227.12   -- 71.37(n)    BX733227.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii robo41 roundabout homolog 4 45.96(n)
    33.76(a)    		   560765  XM_684163.4  XP_689255.3 


    ENSEMBL Gene Tree for ROBO4 (if available)
    TreeFam Gene Tree for ROBO4 (if available) 

    Paralogs
    for ROBO4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ROBO4 gene
    CDON2  ROBO22  NEO12  ROBO12  IGDCC42  BOC2  DCC2  PRTG2  
    IGDCC32  ROBO32  
    1 SIMAP similar gene for ROBO4 using alignment to 2 protein entries:     ROBO4_HUMAN (see all proteins):
    MUSK

    ROBO4 for paralogs           About GeneDecksing



    Genomic Variants
    for ROBO4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 NCBI SNPs in ROBO4 are shown (see all 372)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1824416741,2
    		--124753652(+) TGCCTA/CCCTCC 1 -- int10--------
    rs1870705661,2
    		--124753697(+) ACCGTA/GCCCAG 1 -- int10--------
    rs1918848521,2
    		--124753834(+) TCCCAC/TTTCCC 1 -- int10--------
    rs1477011081,2
    		--124753873(+) TTGAGA/GAGGTG 1 -- int10--------
    rs1491579611,2
    		--124753936(+) CCTTCC/TTATAT 1 -- int10--------
    rs1814638161,2
    		--124753966(+) ATGAAC/TCTCAT 1 -- int10--------
    rs1860534511,2
    		--124754026(+) TGAATA/GCCTGA 1 -- int10--------
    rs752089821,2
    		F,--124754140(+) GTATCA/GAATTT 1 -- ut313Minor allele frequency- G:0.08WA NA EA 358
    rs1999297301,2
    		--124754180(+) TGGTG-/CCTTTT 1 -- ut310--------
    rs1903609281,2
    		--124754207(+) CCTCCC/TTTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ROBO4 (124753587 - 124768396 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ROBO4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ROBO4
    DNA2.0 Custom Variant and Variant Library Synthesis for ROBO4

    Disorders / Diseases
    for ROBO4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ROBO4 for disorders           About GeneDecksing

    OMIM gene information: 607528    OMIM disorders: --

    15 diseases for ROBO4:    About MalaCards
    horizontal gaze palsy with progressive scoliosis    gilles de la tourette syndrome    gaze palsy    vesicoureteral reflux
    proliferative diabetic retinopathy    tourette syndrome    diabetic retinopathy    scoliosis
    pulmonary fibrosis    keratitis    hermaphroditism    fibrosis
    influenza    colorectal cancer    sepsis

    Human Genome Epidemiology (HuGE) Navigator: ROBO4 (3 documents)

    Export disorders for ROBO4 gene to outside databases

    Publications
    for ROBO4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ROBO4 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with ROBO4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. (PubMed id 11944987)1, 2 Huminiecki L.... Bicknell R. (2002)
    6. In silico cloning of novel endothelial-specific genes. (PubMed id 11076864)1, 3 Huminiecki L. and Bicknell R. (2000)
    7. Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. (PubMed id 16685377)1, 9 Grone J....Bhargava S. (2006)
    8. Slit2/Robo4 signaling modulates HIV-1 gp120-induced ly mphatic hyperpermeability. (PubMed id 22241990)1 Zhang X....Groopman J.E. (2012)
    9. Expression and roles of Slit/Robo in human ovarian ca ncer. (PubMed id 21465248)1 Dai C.F....Zheng J. (2011)
    10. Robo4-dependent Slit signaling stabilizes the vascula ture during pathologic angiogenesis and cytokine storm. (PubMed id 21423011)1 London N.R. and Li D.Y. (2011)

    External Searches for ROBO4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ROBO4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54538 HGNC: 17985 AceView: ROBO4 Ensembl:ENSG00000154133 euGenes: HUgn54538
    ECgene: ROBO4 H-InvDB: ROBO4

    Other Databases showing ROBO4 gene

    (According to HUGE)
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    Specialized Databases showing ROBO4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ROBO4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ROBO4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ROBO4 gene:
    Search GeneIP for patents involving ROBO4

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