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ROBO1 Gene

protein-coding   GIFtS: 65
GCID: GC03M078729

Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila)

(Previous names: roundabout (axon guidance receptor, Drosophila) homolog...)
  See ROBO1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila)1 2     Roundabout (Axon Guidance Receptor, Drosophila) Homolog 11
DUTT12 3 5     Roundabout Homolog 12
Deleted In U Twenty Twenty2 3     H-Robo-13
SAX32 5     

External Ids:    HGNC: 102491   Entrez Gene: 60912   Ensembl: ENSG000001698557   OMIM: 6024305   UniProtKB: Q9Y6N73   

Export aliases for ROBO1 gene to outside databases

Previous GC identifiers: GC03M076410 GC03M078320 GC03M078452 GC03M078567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for ROBO1 Gene:
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two
mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants
emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and
encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This
receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the
developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)

GeneCards Summary for ROBO1 Gene:
ROBO1 (roundabout, axon guidance receptor, homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with ROBO1 include articulation disorder. GO annotations related to this gene include identical protein binding and axon guidance receptor activity. An important paralog of this gene is CHL1.

UniProtKB/Swiss-Prot: ROBO1_HUMAN, Q9Y6N7
Function: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration,
including axonal navigation at the ventral midline of the neural tube and projection of axons to different
regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by
SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development

Gene Wiki entry for ROBO1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:
   Regulatory transcription factor binding sites in the ROBO1 gene promoter:
         Sox5   Cdc5   GATA-1   PPAR-gamma1   FOXC1   POU2F1   POU2F1a   FOXO4   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ROBO1 promoter sequence
   Search Chromatin IP Primers for ROBO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ROBO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p12   Ensembl cytogenetic band:  3p12.2   HGNC cytogenetic band: 3p12.3

ROBO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ROBO1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M078729:  view genomic region     (about GC identifiers)

Start:
78,646,388 bp from pter      End:
79,817,059 bp from pter
Size:
1,170,672 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: ROBO1_HUMAN, Q9Y6N7 (See protein sequence)
Recommended Name: Roundabout homolog 1 precursor  
Size: 1651 amino acids; 180930 Da
Subunit: Interacts with SLIT1 and SLIT2
Miscellaneous: Maps within a region of overlapping homozygous deletions characterized in both small cell lung
cancer cell lines (SCLC) and in a breast cancer cell line. The promoter region of ROBO1 shows complete
hypermethylation of CpG sites in the BT-20 breast tumor cell lines, some primary invasive breast carcinomasa and
some primary clear cell renal cell carcinomas (CC-RCC)
5 PDB 3D structures from and Proteopedia for ROBO1:
2EO9 (3D)        2V9Q (3D)        2V9R (3D)        2V9T (3D)        4HLJ (3D)    
Secondary accessions: B2RXI1 D3DU36 E9PD49 Q1RMC7 Q7Z300 Q9BUS7
Alternative splicing: 6 isoforms:  Q9Y6N7-1   Q9Y6N7-2   Q9Y6N7-3   Q9Y6N7-4   Q9Y6N7-5   Q9Y6N7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ROBO1: NX_Q9Y6N7

Explore proteomics data for ROBO1 at MOPED

Post-translational modifications: 

  • Ubiquitinated. May be deubiquitinated by USP33 (By similarity)1
  • Ubiquitination2 at Lys1051
  • Glycosylation2 at Asn160, Asn463, Thr660, Ser661, Asn790, Asn820, Asn827
  • Modification sites at PhosphoSitePlus

  • See ROBO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001139317.1  NP_002932.1  NP_598334.2  

    ENSEMBL proteins: 
     ENSP00000420321   ENSP00000420637   ENSP00000417992   ENSP00000418946   ENSP00000418553  
     ENSP00000419915   ENSP00000406043  
    Reactome Protein details: Q9Y6N7

    ROBO1 Human Recombinant Protein Products:

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    Novus Biologicals ROBO1 Protein
    Novus Biologicals ROBO1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ROBO1

     
    Search eBioscience for Proteins for ROBO1 

     
    antibodies-online proteins for ROBO1 (2 products) 

     
    antibodies-online peptides for ROBO1

     
    Search GeneTex for Proteins for ROBO1 

    ROBO1 Antibody Products:

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    Search for Antibodies for ROBO1 at Abcam
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    ThermoFisher Antibodies for ROBO1
    antibodies-online antibodies for ROBO1 (40 products) 

     
    GeneTex Antibodies for ROBO1:  
                        ROBO1 Antibodies

    ROBO1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ROBO1
    Cloud-Clone Corp. CLIAs for ROBO1
    Search eBioscience for ELISAs for ROBO1 
    antibodies-online kits for ROBO1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR003596 Ig_V-set_subgr

    Graphical View of Domain Structure for InterPro Entry Q9Y6N7

    ProtoNet protein and cluster: Q9Y6N7

    2 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: ROBO1_HUMAN, Q9Y6N7
    Similarity: Belongs to the immunoglobulin superfamily. ROBO family
    Similarity: Contains 3 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with ROBO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ROBO1_HUMAN, Q9Y6N7
    Function: Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration,
    including axonal navigation at the ventral midline of the neural tube and projection of axons to different
    regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by
    SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development

         Genatlas biochemistry entry for ROBO1:
    Drosophila round about homolog 1,also homolog to C elegans sex3,neural cell adhesion molecule family member,widely
    expressed,involved in axon guidance and controlling midline crossing

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12504588
    GO:0008046axon guidance receptor activity TAS9458045
    GO:0030275LRR domain binding IPI17848514
    GO:0042802identical protein binding IDA12504588
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with ROBO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ROBO1:
     Increased Salmonella enterica  

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Robo1) (see all 17):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  homeostasis/metabolism  integument  mortality/aging  muscle 
     nervous system  normal  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with ROBO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ROBO1: Robo1tm1.1Ljr Robo1tm1Phr Robo1tm1Wian

       genOway: Develop your customized and physiologically relevant rodent model for ROBO1

        Taconic Biosciences Mouse Models for ROBO1:  
                        TF2127 - Robo1

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for ROBO1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ROBO1:
    hsa-mir-217 (MIRT000481), hsa-mir-25-3p (MIRT050348), hsa-mir-423-3p (MIRT042506)

    Block miRNA regulation of human, mouse, rat ROBO1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ROBO1 (see all 46):
    hsa-miR-142-5p hsa-miR-607 hsa-miR-146a hsa-miR-29a hsa-miR-1245 hsa-miR-25 hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidROBO1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ROBO1
    Predesigned siRNA for gene silencing in human, mouse, rat ROBO1

    Clone
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    OriGene clones in human, mouse for ROBO1 (see all 22)
    OriGene ORF clones in mouse, rat for ROBO1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ROBO1 (NM_133631)
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ROBO1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROBO1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    ROBO1_HUMAN, Q9Y6N7: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18566128
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9608531
    GO:0009986cell surface IDA12504588
    GO:0030673axolemma IEA--

    Find genes that share ontologies with ROBO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section






    SuperPaths for ROBO1 About   (see all 7)  
    See pathways by source

          Powered
    by
         
    SuperPathContained pathways About
    1Signaling by Robo receptor
    Regulation of Commissural axon pathfinding by Slit and Robo0.00
    Signaling by Robo receptor
    Inactivation of Cdc42 and Rac0.00
    Role of Abl in Robo-Slit signaling0.00
    Activation of Rac0.00
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3Development Slit-Robo signaling
    Development Slit-Robo signaling0.44
    4Signaling by Slit
    Signaling by Slit
    5Netrin-1 signaling
    Netrin-1 signaling


    Find genes that share SuperPaths with ROBO1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ROBO1
        Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 GeneGo (Thomson Reuters) Pathway for ROBO1
        Development Slit-Robo signaling

    Selected Reactome Pathways for ROBO1 (see all 6)
        Regulation of Commissural axon pathfinding by Slit and Robo
    Inactivation of Cdc42 and Rac
    Netrin-1 signaling
    Role of Abl in Robo-Slit signaling
    Signaling by Robo receptor


    1 Kegg Pathway  (Kegg details for ROBO1):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including ROBO1: 
              Neurogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ROBO1

    Selected Interacting proteins for ROBO1 (Q9Y6N72, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    MAPK14Q165393I2D: score=2 
    USP33Q8TEY73I2D: score=2 
    ABL1P005193I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002042cell migration involved in sprouting angiogenesis IMP19351956
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP18566128
    GO:0007155cell adhesion TAS9608531
    GO:0007156homophilic cell adhesion IDA12504588
    GO:0007399nervous system development TAS9608531

    Find genes that share ontologies with ROBO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ROBO1

    1 Novoseek inferred chemical compound relationship for ROBO1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 13.1 1 14608664 (1)



    Find genes that share compounds with ROBO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for ROBO1 gene (6 alternative transcripts): 
    NM_001145845.1  NM_002941.3  NM_133631.3  XM_006713276.1  XM_006713277.1  XM_006713278.1  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464233(uc003dqe.2) ENST00000495273 ENST00000467549 ENST00000466906
    ENST00000498428(uc011bgl.1) ENST00000472273 ENST00000484514(uc003dqf.1)
    ENST00000495961 ENST00000488735 ENST00000492990 ENST00000436010(uc010hoh.2 uc003dqc.2 uc003dqd.2 uc003dqb.2)

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    hsa-miR-142-5p hsa-miR-607 hsa-miR-146a hsa-miR-29a hsa-miR-1245 hsa-miR-25 hsa-miR-219-5p hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidROBO1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ROBO1

    1 AceView cDNA sequence:

    AW184011 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ROBO1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:              -     -                 -                                                           -                             -                           
    SP2:                                                                                                                                -                           
    SP3:                                                                                                  -                                                         
    SP4:                    -                                                                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ROBO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ROBO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGAAGCCC
    ROBO1 Expression
    About this image


    ROBO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Odontoblasts Dentin
     
     Epithelial Cells
             Early Ameloblasts Dental Enamel
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
    ROBO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ROBO1 Protein Expression

    UniProtKB/Swiss-Prot: ROBO1_HUMAN, Q9Y6N7
    Tissue specificity: Widely expressed, with exception of kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including ROBO1: 
              Neurogenesis in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ROBO1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ROBO1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ROBO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals.

    Orthologs for ROBO1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Robo11 , 5 roundabout homolog 1 (Drosophila)1, 5 88.48(n)1
    95.92(a)1
      16 (41.08 cM)5
    198761  NM_019413.21  NP_062286.21 
     726631495 
    chicken
    (Gallus gallus)
    Aves ROBO11 roundabout, axon guidance receptor, homolog 1 (Drosophila) 82.34(n)
    90.79(a)
      395292  XM_004938346.1  XP_004938403.1 
    lizard
    (Anolis carolinensis)
    Reptilia ROBO16
    roundabout, axon guidance receptor, homolog 1 (Dro...
    90(a)
    1 ↔ 1
    3(155004427-155152729)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.48192 Xenopus laevis roundabout-1 (robo1) mRNA, complete more 82.67(n)    AF461119.1 
    zebrafish
    (Danio rerio)
    Actinopterygii robo12 roundabout homolog 1 75.72(n)   30769  AF304130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lea3
    robo31
    axon guidance axon guidance receptor3
    robo31
    39(a)
    (best of 3)3
    45.75(n)1
    36.8(a)1
      2 22A13
    333141  NM_001272937.11  NP_001259866.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sax-31 , 3 Expression: hypodermis, mu_bod,
    neurons, gastrulating more3
    sax-31
    37(a)3
    47.73(n)1
    39.5(a)1
      X(3487793-3501139)3
    1806371  NM_001029819.31  NP_001024990.11 


    ENSEMBL Gene Tree for ROBO1 (if available)
    TreeFam Gene Tree for ROBO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for ROBO1 gene
    CHL12  NEO12  CNTN52  CNTN42  IGDCC42  NRCAM2  L1CAM2  ROBO22  
    CNTN22  CNTN62  NFASC2  CNTN32  DCC2  PRTG2  IGDCC32  ROBO32  
    CNTN12  
    7 SIMAP similar genes for ROBO1 using alignment to 6 protein entries:     ROBO1_HUMAN (see all proteins):
    ROBO2    TTN    ROBO3    MUSK    PTPRS    FGFR3
    NRCAM

    Find genes that share paralogs with ROBO1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for ROBO1 (see all 22326)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360556891,2,,4
    C,FA breast cancer sample4 --78611125(-) AGAGAA/CGTGTT 6 E D mis14Minor allele frequency- C:0.03NA WA 200
    VAR_0190714
    A breast cancer sample4--see VAR_0190712 S N mis40--------
    rs1383721091,2
    Cuntested179506945(+) AAAACA/G/TGACCA 1 -- int10--------
    rs1929954081,2
    C--78601134(+) CTTTAA/CAAATC 3 -- ds50010--------
    rs674675731,2
    C,F--78601174(+) TAGAAA/CTAGAT 3 -- ds50015Minor allele frequency- C:0.31WA CSA NA EA 362
    rs1848020551,2
    --78601229(+) TAATAG/TACCCT 3 -- ds50010--------
    rs1897261331,2
    --78601275(+) TTCACG/TTCTAG 3 -- ds50010--------
    rs1497367051,2
    --78601291(+) GACTGA/CTCTTA 3 -- ds50010--------
    rs1814263651,2
    --78601311(+) TTTCAC/GAGGAC 3 -- ds50010--------
    rs1414706121,2
    --78601412(+) AAGACA/GGAACG 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for ROBO1 (78646388 - 78896388 bp, first 250kb of ROBO1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ROBO1 (see all 51):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725557CNV Deletion23290073
    esv2725548CNV Deletion23290073
    esv2725545CNV Deletion23290073
    esv2208607CNV Deletion18987734
    esv2432577CNV Deletion19546169
    esv2725558CNV Deletion23290073
    esv2725553CNV Deletion23290073
    esv2725549CNV Deletion23290073
    esv2123767CNV Deletion18987734
    esv2725556CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ROBO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ROBO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 602430    OMIM disorders: --

    1 disease for ROBO1:    
    About MalaCards
    articulation disorder

    2 inferred disease relationships from the University of Copenhagen DISEASES database for ROBO1:
    Dyslexia     Articulation disorder

    Find genes that share disorders with ROBO1           About GenesLikeMe

    3 Novoseek inferred disease relationships for ROBO1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 26.9 1 15374951 (1)
    colorectal cancer 0 2 17204444 (1), 16685377 (1)
    tumors 0 9 16685377 (3), 15979925 (1), 17968499 (1), 18201275 (1)

    Genetic Association Database (GAD): ROBO1
    Human Genome Epidemiology (HuGE) Navigator: ROBO1 (12 documents)

    Export disorders for ROBO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for ROBO1 gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with ROBO1)

    1. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. (PubMed id 9458045)1, 2, 3 Kidd T.... Tear G. (Cell 1998)
    2. The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression. (PubMed id 9608531)1, 2, 3 Sundaresan V.... Rabbitts P. (Mol. Cell. Neurosci. 1998)
    3. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. (PubMed id 10892742)1, 2, 9 Bashaw G.J.... Goodman C.S. (Cell 2000)
    4. Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. (PubMed id 21041608)1, 4 van Winkel R. (Arch. Gen. Psychiatry 2011)
    5. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. (PubMed id 19023125)1, 4 Potkin S.G....Macciardi F. (Schizophr Bull 2009)
    8. On the replication of genetic associations: timing can be everything! (PubMed id 18387595)1, 4 Lasky-Su J....Lange C. (Am. J. Hum. Genet. 2008)
    9. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    10. Structural insights into the Slit-Robo complex. (PubMed id 17848514)1, 2 Morlot C.... McCarthy A.A. (Proc. Natl. Acad. Sci. U.S.A. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6091 HGNC: 10249 AceView: ROBO1.1 Ensembl:ENSG00000169855 euGenes: HUgn6091
    ECgene: ROBO1 Kegg: 6091 H-InvDB: ROBO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ROBO1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ROBO1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ROBO1 gene:
    Search GeneIP for patents involving ROBO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    CRISPR knockouts from OriGene)
    About This Section


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