Aliases for ROBO1 Gene
External Ids for ROBO1 Gene
Previous GeneCards Identifiers for ROBO1 Gene
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for ROBO1 Gene
ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1 (Drosophila)) is a Protein Coding gene. Diseases associated with ROBO1 include articulation disorder. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include identical protein binding and axon guidance receptor activity. An important paralog of this gene is PRTG.
UniProtKB/Swiss-Prot for ROBO1 Gene
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.