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Aliases for RNVU1-19 Gene

Subcategory (RNA class) for RNVU1-19 Gene

snRNA

Quality Score for this RNA gene is

5

Aliases for RNVU1-19 Gene

  • RNA, Variant U1 Small Nuclear 19 2 3 5
  • RNA, Variant U1 Small Nuclear 13 2 3
  • RNU1-126 3
  • RNU1-147 3
  • RNVU1-13 3
  • VU1.13 3
  • VU1.19 3

External Ids for RNVU1-19 Gene

Previous HGNC Symbols for RNVU1-19 Gene

  • RNVU1-13

Previous GeneCards Identifiers for RNVU1-19 Gene

  • GC01M149517

Summaries for RNVU1-19 Gene

GeneCards Summary for RNVU1-19 Gene

RNVU1-19 (RNA, Variant U1 Small Nuclear 19) is an RNA Gene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNVU1-19 Gene - the ORGUL cluster for this gene includes several descriptions:

  • U1_snRNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.

  • U1 spliceosomal RNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [1]. This family does not contain the larger yeast sequences.

Additional gene information for RNVU1-19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNVU1-19 Gene

Genomics for RNVU1-19 Gene

GeneHancer (GH) Regulatory Elements for RNVU1-19 Gene

Promoters and enhancers for RNVU1-19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I120850 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 +0.2 189 1.9 CLOCK ATF1 SMAD1 ARNT POLR2B ZNF143 GTF2B MBD2 SREBF1 NFIL3 RNVU1-19 GC01M120846
GH01I120849 Promoter 0.5 Ensembl 550.8 +1.3 1284 0.2 RNVU1-19 GC01M120846
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNVU1-19 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNVU1-19 Gene

Genomic Locations for RNVU1-19 Gene
chr1:120,850,819-120,850,985
(GRCh38/hg38)
Size:
167 bases
Orientation:
Minus strand
chr1:149,514,090-149,514,256
(GRCh37/hg19)

Genomic View for RNVU1-19 Gene

Genes around RNVU1-19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNVU1-19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNVU1-19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNVU1-19 Gene

ORGUL Member Location for RNVU1-19 Gene

ORGUL Member Location for RNVU1-19 gene

Proteins for RNVU1-19 Gene

Post-translational modifications for RNVU1-19 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNVU1-19 Gene

Domains & Families for RNVU1-19 Gene

Gene Families for RNVU1-19 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNVU1-19: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNVU1-19 Gene

Function for RNVU1-19 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNVU1-19 Gene

Localization for RNVU1-19 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNVU1-19 Gene

Pathways & Interactions for RNVU1-19 Gene

SuperPathways for RNVU1-19 Gene

No Data Available

Interacting Proteins for RNVU1-19 Gene

Gene Ontology (GO) - Biological Process for RNVU1-19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNVU1-19 Gene

Drugs & Compounds for RNVU1-19 Gene

No Compound Related Data Available

Transcripts for RNVU1-19 Gene

mRNA/cDNA for RNVU1-19 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNVU1-19 Gene

No ASD Table

Relevant External Links for RNVU1-19 Gene

GeneLoc Exon Structure for
RNVU1-19
ECgene alternative splicing isoforms for
RNVU1-19

Expression for RNVU1-19 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNVU1-19 Gene

Orthologs for RNVU1-19 Gene

Evolution for RNVU1-19 Gene

ENSEMBL:
Gene Tree for RNVU1-19 (if available)
TreeFam:
Gene Tree for RNVU1-19 (if available)

No data available for Orthologs for RNVU1-19 Gene

Paralogs for RNVU1-19 Gene

No data available for Paralogs for RNVU1-19 Gene

Variants for RNVU1-19 Gene

Sequence variations from dbSNP and Humsavar for RNVU1-19 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs112026828 -- 120,850,745(-) C/T downstream_transcript_variant
rs12094704 -- 120,852,847(-) T/C upstream_transcript_variant
rs12142111 -- 120,852,802(-) G/T upstream_transcript_variant
rs12143649 -- 120,852,510(-) T/C upstream_transcript_variant
rs199928634 -- 120,851,762(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNVU1-19 Gene

Variant ID Type Subtype PubMed ID
dgv96e212 CNV loss 25503493
dgv97e212 CNV loss 25503493
dgv98e212 CNV loss 25503493
esv2669475 CNV deletion 23128226
nsv1077691 CNV deletion 25765185
nsv1118130 CNV deletion 24896259
nsv524681 CNV gain 19592680
nsv547684 CNV loss 21841781
nsv946331 CNV duplication 23825009
nsv946845 CNV duplication 23825009
nsv951848 CNV duplication 24416366

Additional Variant Information for RNVU1-19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNVU1-19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RNVU1-19 Gene

Disorders for RNVU1-19 Gene

Additional Disease Information for RNVU1-19

No disorders were found for RNVU1-19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNVU1-19 Gene

Publications for RNVU1-19 Gene

  1. Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. (PMID: 23070852) O'Reilly D … Murphy S (Genome research 2013) 2 3 58
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PMID: 11297556) Katsamba PS … Laird-Offringa IA (The Journal of biological chemistry 2001) 1
  4. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1
  5. Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C … Nagai K (Nature 1994) 1

Products for RNVU1-19 Gene

Sources for RNVU1-19 Gene

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