Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNVU1-19 Gene

Subcategory (RNA class) for RNVU1-19 Gene

snRNA

Quality Score for this RNA gene is

5

Aliases for RNVU1-19 Gene

  • RNA, Variant U1 Small Nuclear 19 2 3 5
  • RNA, Variant U1 Small Nuclear 13 2 3
  • RNU1-126 3
  • RNU1-147 3
  • RNVU1-13 3
  • VU1.13 3
  • VU1.19 3

External Ids for RNVU1-19 Gene

Previous HGNC Symbols for RNVU1-19 Gene

  • RNVU1-13

Previous GeneCards Identifiers for RNVU1-19 Gene

  • GC01M149517

Summaries for RNVU1-19 Gene

GeneCards Summary for RNVU1-19 Gene

RNVU1-19 (RNA, Variant U1 Small Nuclear 19) is an RNA Gene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNVU1-19 Gene - the ORGUL cluster for this gene includes several descriptions:

  • U1_snRNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.

  • U1 spliceosomal RNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [1]. This family does not contain the larger yeast sequences.

Additional gene information for RNVU1-19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNVU1-19 Gene

Genomics for RNVU1-19 Gene

Regulatory Elements for RNVU1-19 Gene

Enhancers for RNVU1-19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H120849 0.9 ENCODE 0.7 +0.2 189 1 ATF1 ARNT ZNF143 GTF2B SREBF1 NFIL3 MBD2 NBN SUZ12 GTF2E2 RNVU1-19 GC01M120846
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNVU1-19 on UCSC Golden Path with GeneCards custom track

Promoters for RNVU1-19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000253961 185 1601 ATF1 ARNT ZNF143 GTF2B SREBF1 MBD2 NFIL3 NBN SUZ12 GTF2E2
ENSR00000012521 1285 201

Genomic Location for RNVU1-19 Gene

Chromosome:
1
Start:
120,850,819 bp from pter
End:
120,850,985 bp from pter
Size:
167 bases
Orientation:
Minus strand

Genomic View for RNVU1-19 Gene

Genes around RNVU1-19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNVU1-19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNVU1-19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNVU1-19 Gene

ORGUL Member Location for RNVU1-19 Gene

ORGUL Member Location for RNVU1-19 gene

Proteins for RNVU1-19 Gene

Post-translational modifications for RNVU1-19 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNVU1-19 Gene

Domains & Families for RNVU1-19 Gene

Gene Families for RNVU1-19 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNVU1-19: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNVU1-19 Gene

Function for RNVU1-19 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNVU1-19 Gene

Localization for RNVU1-19 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNVU1-19 Gene

Pathways & Interactions for RNVU1-19 Gene

SuperPathways for RNVU1-19 Gene

No Data Available

Interacting Proteins for RNVU1-19 Gene

Gene Ontology (GO) - Biological Process for RNVU1-19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNVU1-19 Gene

Drugs & Compounds for RNVU1-19 Gene

No Compound Related Data Available

Transcripts for RNVU1-19 Gene

mRNA/cDNA for RNVU1-19 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNVU1-19 Gene

No ASD Table

Relevant External Links for RNVU1-19 Gene

GeneLoc Exon Structure for
RNVU1-19
ECgene alternative splicing isoforms for
RNVU1-19

Expression for RNVU1-19 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNVU1-19 Gene

Orthologs for RNVU1-19 Gene

Evolution for RNVU1-19 Gene

ENSEMBL:
Gene Tree for RNVU1-19 (if available)
TreeFam:
Gene Tree for RNVU1-19 (if available)

No data available for Orthologs for RNVU1-19 Gene

Paralogs for RNVU1-19 Gene

No data available for Paralogs for RNVU1-19 Gene

Variants for RNVU1-19 Gene

Sequence variations from dbSNP and Humsavar for RNVU1-19 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111383389 -- 120,850,511(-) CATCT(C/T)TTAAA downstream-variant-500B
rs112017954 -- 120,850,512(-) ACATC(C/T)CTTAA downstream-variant-500B
rs112086289 -- 120,852,279(-) TTTTC(A/C)AGTAT upstream-variant-2KB
rs112653280 -- 120,851,340(-) AGGAG(A/G)AAAAG upstream-variant-2KB
rs12022682 -- 120,851,467(-) tgaag(A/C/G/T)agggt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNVU1-19 Gene

Variant ID Type Subtype PubMed ID
dgv96e212 CNV loss 25503493
dgv97e212 CNV loss 25503493
dgv98e212 CNV loss 25503493
esv2669475 CNV deletion 23128226
nsv1077691 CNV deletion 25765185
nsv1118130 CNV deletion 24896259
nsv524681 CNV gain 19592680
nsv547684 CNV loss 21841781
nsv946331 CNV duplication 23825009
nsv946845 CNV duplication 23825009
nsv951848 CNV duplication 24416366

Relevant External Links for RNVU1-19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNVU1-19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RNVU1-19 Gene

Disorders for RNVU1-19 Gene

Relevant External Links for RNVU1-19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNVU1-19

No disorders were found for RNVU1-19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNVU1-19 Gene

Publications for RNVU1-19 Gene

  1. Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. (PMID: 23070852) O'Reilly D … Murphy S (Genome research 2013) 2 3 60
  2. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PMID: 11297556) Katsamba PS … Laird-Offringa IA (The Journal of biological chemistry 2001) 1
  3. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1
  4. Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C … Nagai K (Nature 1994) 1
  5. Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains. (PMID: 2405391) Kretzner L … Rosbash M (Proceedings of the National Academy of Sciences of the United States of America 1990) 1

Products for RNVU1-19 Gene

Sources for RNVU1-19 Gene

Content
Loading form....