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Aliases for RNU6-1 Gene

Subcategory (RNA class) for RNU6-1 Gene

snRNA

Quality Score for this RNA gene is

3

Aliases for RNU6-1 Gene

  • RNA, U6 Small Nuclear 1 2 3 5
  • RNA, U6A Small Nuclear 2 3
  • RNU6A 3
  • RNU6 3
  • U6-1 3
  • U6 3

External Ids for RNU6-1 Gene

Previous HGNC Symbols for RNU6-1 Gene

  • RNU6A

Previous GeneCards Identifiers for RNU6-1 Gene

  • GC15U900950
  • GC15M065922
  • GC15M068132
  • GC07M122819

Summaries for RNU6-1 Gene

GeneCards Summary for RNU6-1 Gene

RNU6-1 (RNA, U6 Small Nuclear 1) is an RNA Gene, and is affiliated with the snRNA class. Diseases associated with RNU6-1 include Poikiloderma With Neutropenia. Among its related pathways are RNA transport and mRNA Splicing - Major Pathway.

Additional gene information for RNU6-1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNU6-1 Gene

Genomics for RNU6-1 Gene

GeneHancer (GH) Regulatory Elements for RNU6-1 Gene

Promoters and enhancers for RNU6-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I067838 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 550.8 -0.1 -56 3.3 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 LOC101929076 RNU6-1 GC15M067840 SKOR1 MAP2K5 IQCH-AS1 FEM1B PIAS1 CALML4 ENSG00000259410
GH15I068227 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 -389.2 -389198 3.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B ZNF766 CLN6 ENSG00000260007 PIAS1 FEM1B RNU6-1 LOC101929076 SKOR1 IQCH-AS1 CALML4
GH15I067782 Enhancer 1.7 UCNEbase FANTOM5 Ensembl ENCODE 12.1 +56.1 56054 3.6 HDGF PKNOX1 NFIB BMI1 RAD21 ZNF335 ZNF366 ZNF143 ATF7 ETV6 MAP2K5 LOC101929076 SKOR1 RNU6-1 IQCH-AS1 PIAS1 HNRNPA1P5
GH15I067880 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.6 -43.2 -43217 5.3 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT SIN3A FEZF1 DMAP1 SKOR1 PIAS1 IQCH-AS1 LOC101929076 RNU6-1 MAP2K5 CALML4 FEM1B GC15M067840 GC15M067974
GH15I067967 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 -128.4 -128397 1.5 MEIS2 KLF1 PKNOX1 USF1 MZF1 BMI1 RAD21 ZNF335 ZFHX2 EGR1 PIAS1 RNU6-1 LOC101929076 SKOR1 ENSG00000260657 C15orf61 GC15M067974 GC15M067967 GC15M067840
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNU6-1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNU6-1 gene promoter:

Genomic Locations for RNU6-1 Gene

Genomic Locations for RNU6-1 Gene
chr15:67,839,939-67,840,045
(GRCh38/hg38)
Size:
107 bases
Orientation:
Minus strand
chr15:68,132,277-68,132,383
(GRCh37/hg19)

Genomic View for RNU6-1 Gene

Genes around RNU6-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU6-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU6-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU6-1 Gene

Proteins for RNU6-1 Gene

Post-translational modifications for RNU6-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU6-1 Gene

Domains & Families for RNU6-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNU6-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU6-1 Gene

Function for RNU6-1 Gene

Phenotypes From GWAS Catalog for RNU6-1 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU6-1 Gene

Localization for RNU6-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNU6-1 Gene

Pathways & Interactions for RNU6-1 Gene

genes like me logo Genes that share pathways with RNU6-1: view

Pathways by source for RNU6-1 Gene

2 KEGG pathways for RNU6-1 Gene
1 Qiagen pathway for RNU6-1 Gene

Interacting Proteins for RNU6-1 Gene

Gene Ontology (GO) - Biological Process for RNU6-1 Gene

None

No data available for SIGNOR curated interactions for RNU6-1 Gene

Drugs & Compounds for RNU6-1 Gene

No Compound Related Data Available

Transcripts for RNU6-1 Gene

mRNA/cDNA for RNU6-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNU6-1 Gene

No ASD Table

Relevant External Links for RNU6-1 Gene

GeneLoc Exon Structure for
RNU6-1
ECgene alternative splicing isoforms for
RNU6-1

Expression for RNU6-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNU6-1 Gene

genes like me logo Genes that share expression patterns with RNU6-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU6-1 Gene

Orthologs for RNU6-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNU6-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia U6 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U6 34
  • 100 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm26427 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia U6 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia U6 34
  • 100 (a)
OneToOne
Species where no ortholog for RNU6-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNU6-1 Gene

ENSEMBL:
Gene Tree for RNU6-1 (if available)
TreeFam:
Gene Tree for RNU6-1 (if available)

Paralogs for RNU6-1 Gene

No data available for Paralogs for RNU6-1 Gene

Variants for RNU6-1 Gene

Sequence variations from dbSNP and Humsavar for RNU6-1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000069308 -- 67,840,202(-) C/A upstream_transcript_variant
rs1000342983 -- 67,840,481(-) G/C upstream_transcript_variant
rs1000882100 -- 67,840,717(-) C/A/T upstream_transcript_variant
rs1002781917 -- 67,839,687(-) C/A downstream_transcript_variant
rs1002788196 -- 67,839,907(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNU6-1 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
dgv135n111 CNV deletion 26073780
esv1002005 CNV deletion 20482838
esv1972594 CNV deletion 18987734
esv2523863 CNV deletion 19546169
esv2672070 CNV deletion 23128226
esv2733339 CNV deletion 23290073
esv2758743 CNV gain+loss 17122850
esv2758896 CNV gain+loss 17122850
esv2758920 CNV gain+loss 17122850
esv2759205 CNV gain 17122850
esv3259 CNV loss 18987735
esv3545926 CNV deletion 23714750
esv3574862 CNV loss 25503493
esv3574863 CNV loss 25503493
esv3584226 CNV gain 25503493
esv3643383 CNV gain 21293372
esv3643384 CNV loss 21293372
esv3643385 CNV gain 21293372
esv3890859 CNV loss 25118596
esv3891198 CNV gain 25118596
esv8509 CNV loss 19470904
esv996651 CNV deletion 20482838
nsv1041463 CNV gain 25217958
nsv1068280 CNV deletion 25765185
nsv1160555 CNV deletion 26073780
nsv1578 CNV insertion 18451855
nsv2385 CNV insertion 18451855
nsv3041 CNV insertion 18451855
nsv428427 CNV gain 18775914
nsv469845 CNV loss 16826518
nsv470101 CNV loss 18288195
nsv512148 CNV loss 21212237
nsv524931 CNV gain 19592680
nsv545381 CNV gain 21841781
nsv545382 CNV loss 21841781
nsv569803 CNV gain 21841781
nsv578188 CNV loss 21841781
nsv7462 OTHER inversion 18451855
nsv826912 CNV gain 20364138
nsv828360 CNV loss 20364138
nsv829809 CNV loss 17160897
nsv832764 CNV gain 17160897
nsv833704 CNV gain 17160897
nsv953938 CNV deletion 24416366
nsv956356 CNV deletion 24416366
nsv9662 CNV gain 18304495

Additional Variant Information for RNU6-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU6-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RNU6-1 Gene

Disorders for RNU6-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNU6-1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
poikiloderma with neutropenia
  • pn
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNU6-1

genes like me logo Genes that share disorders with RNU6-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNU6-1 Gene

Publications for RNU6-1 Gene

  1. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 44 58
  2. Multiple, dispersed human U6 small nuclear RNA genes with varied transcriptional efficiencies. (PMID: 12711679) Domitrovich AM … Kunkel GR (Nucleic acids research 2003) 2 3 58
  3. Upstream elements required for efficient transcription of a human U6 RNA gene resemble those of U1 and U2 genes even though a different polymerase is used. (PMID: 3360322) Kunkel GR … Pederson T (Genes & development 1988) 2 3 58
  4. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PMID: 23319000) Luykx JJ … Ophoff RA (Molecular psychiatry 2014) 3 58
  5. Identification of suitable reference genes for hepatic microRNA quantitation. (PMID: 24606728) Lamba V … Lamba JK (BMC research notes 2014) 3 58

Products for RNU6-1 Gene

Sources for RNU6-1 Gene

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