Subcategory (RNA class) for RNU4ATAC Gene
Quality Score for this RNA gene is
Aliases for RNU4ATAC Gene
External Ids for RNU4ATAC Gene
Previous GeneCards Identifiers for RNU4ATAC Gene
The small nuclear RNA (snRNA) encoded by this gene is part of the U12-dependent minor spliceosome complex. In addition to the encoded RNA, this ribonucleoprotein complex consists of U11, U12, U5, and U6atac snRNAs. The U12-dependent spliceosome acts on approximately 700 specific introns in the human genome. Defects in this gene are a cause of microcephalic osteodysplastic primordial dwarfism type 1 (MOPD). [provided by RefSeq, Jul 2011]
GeneCards Summary for RNU4ATAC Gene
RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)) is an RNA Gene, and is affiliated with the snRNA class. Diseases associated with RNU4ATAC include Microcephalic Osteodysplastic Primordial Dwarfism, Type I and Roifman Syndrome.
fRNAdb sequence ontologies for RNU4ATAC Gene
U4atac minor spliceosomal RNA: U4atac is an essential component of the minor U12-type spliceosome complex which is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type) . U4atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U6atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing . U4atac also contains an 3' Sm protein binding site which has been shown to be essential for splicing activity . U4atac is the functional analog of U4 (Rfam:RF00015) in the major U2-type spliceosomal complex . The drosophila U4atac snRNA has an additional predicted 3' stem loop terminal to the Sm binding site  which is not included in this model.