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Aliases for RNU2-4P Gene

Subcategory (RNA class) for RNU2-4P Gene

snRNA

Aliases for RNU2-4P Gene

  • RNA, U2 Small Nuclear 4, Pseudogene 2 3 5
  • RNA, U2 Small Nuclear Pseudogene 2 2 3
  • RNU2P2 3
  • U2/7 3
  • U2 3

External Ids for RNU2-4P Gene

Previous HGNC Symbols for RNU2-4P Gene

  • RNU2P2

Previous GeneCards Identifiers for RNU2-4P Gene

  • GC17M038832
  • GC17M041467
  • GC17M037225

Summaries for RNU2-4P Gene

GeneCards Summary for RNU2-4P Gene

RNU2-4P (RNA, U2 Small Nuclear 4, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU2-4P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U2_snRNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

  • U2 spliceosomal RNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenosine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

View fRNAdb secondary structures for RNU2-4P

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU2-4P Gene

Genomics for RNU2-4P Gene

Regulatory Elements for RNU2-4P Gene

Enhancers for RNU2-4P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F043455 1.1 Ensembl ENCODE 11.3 -69.9 -69877 4.4 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 SP5 NFYC DHX8 RAMP2-AS1 HMGN2P15 ETV4 MIR2117 RNU6-470P ARL4D RNU6-1137P LINC00910 RNU2-4P
GH17F043351 0.5 ENCODE 11.1 +35.5 35503 0.5 PKNOX1 RNU6-1137P DHX8 RNU2-4P LINC00910 RNU6-406P MIR2117 GC17P043358 LINC00854
GH17F043350 0.3 FANTOM5 11.1 +36.5 36450 0.3 HDAC1 PKNOX1 ATF1 MLX GATA2 CREM USF2 JUNB ZEB2 RAD51 RNU6-1137P DHX8 RNU2-4P LINC00910 RNU6-406P MIR2117 GC17P043358 LINC00854
GH17F043516 0.7 ENCODE 10.6 -130.1 -130086 1.2 PKNOX1 SIN3A FEZF1 NFXL1 ZNF2 ZNF366 SCRT2 ETV6 EGR2 ZNF263 ETV4 DHX8 RNU6-1137P LINC00910 RNU2-4P ARL4D SOST GC17P043522 PIR45394 GC17M043486
GH17F043383 0.2 ENCODE 0.8 +2.7 2743 2.1 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF143 SP5 MXD4 RPL29P31 NBR2 RNU2-4P GC17P043374
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNU2-4P on UCSC Golden Path with GeneCards custom track

Genomic Location for RNU2-4P Gene

Chromosome:
17
Start:
43,387,226 bp from pter
End:
43,387,517 bp from pter
Size:
292 bases
Orientation:
Minus strand

Genomic View for RNU2-4P Gene

Genes around RNU2-4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU2-4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU2-4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU2-4P Gene

ORGUL Member Location for RNU2-4P Gene

ORGUL Member Location for RNU2-4P gene

Proteins for RNU2-4P Gene

Post-translational modifications for RNU2-4P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-4P Gene

Domains & Families for RNU2-4P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-4P Gene

Function for RNU2-4P Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-4P Gene

Localization for RNU2-4P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU2-4P Gene

Pathways & Interactions for RNU2-4P Gene

SuperPathways for RNU2-4P Gene

No Data Available

Interacting Proteins for RNU2-4P Gene

Gene Ontology (GO) - Biological Process for RNU2-4P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU2-4P Gene

Transcripts for RNU2-4P Gene

fRNAdb Secondary structures for RNU2-4P Gene

  • RF00004;U2;ABBA01028418.1/3128-3319

mRNA/cDNA for RNU2-4P Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-4P Gene

No ASD Table

Relevant External Links for RNU2-4P Gene

GeneLoc Exon Structure for
RNU2-4P
ECgene alternative splicing isoforms for
RNU2-4P

Expression for RNU2-4P Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNU2-4P Gene

Orthologs for RNU2-4P Gene

Evolution for RNU2-4P Gene

ENSEMBL:
Gene Tree for RNU2-4P (if available)
TreeFam:
Gene Tree for RNU2-4P (if available)

No data available for Orthologs for RNU2-4P Gene

Paralogs for RNU2-4P Gene

No data available for Paralogs for RNU2-4P Gene

Variants for RNU2-4P Gene

Relevant External Links for RNU2-4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU2-4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU2-4P Gene

Disorders for RNU2-4P Gene

No disorders were found for RNU2-4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU2-4P Gene

Publications for RNU2-4P Gene

  1. Human genes for U2 small nuclear RNA are tandemly repeated. (PMID: 6201719) Van Arsdell S.W. … Weiner A.M. (Mol. Cell. Biol. 1984) 2 3 64
  2. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PMID: 22751105) Chu L. … Tomasson M.H. (J. Clin. Invest. 2012) 3 64
  3. Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines. (PMID: 11350032) Berglund J.A. … Schultz S.C. (RNA 2001) 1
  4. A conserved pseudouridine modification in eukaryotic U2 snRNA induces a change in branch-site architecture. (PMID: 11424937) Newby M.I. … Greenbaum N.L. (RNA 2001) 1
  5. The uRNA database. (PMID: 9016512) Zwieb C. (Nucleic Acids Res. 1997) 1

Products for RNU2-4P Gene

Sources for RNU2-4P Gene

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