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Aliases for RNU2-28P Gene

Subcategory (RNA class) for RNU2-28P Gene

snRNA

Aliases for RNU2-28P Gene

  • RNA, U2 Small Nuclear 28, Pseudogene 2 3 5

External Ids for RNU2-28P Gene

ORGUL Members for RNU2-28P Gene

Previous GeneCards Identifiers for RNU2-28P Gene

  • GC03P081560
  • GC00U936121

Summaries for RNU2-28P Gene

GeneCards Summary for RNU2-28P Gene

RNU2-28P (RNA, U2 Small Nuclear 28, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU2-28P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U2_snRNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

  • U2 spliceosomal RNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenosine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

Additional gene information for RNU2-28P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU2-28P Gene

Genomics for RNU2-28P Gene

GeneHancer (GH) Regulatory Elements for RNU2-28P Gene

Promoters and enhancers for RNU2-28P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I081491 Enhancer 0.9 FANTOM5 Ensembl ENCODE 0.4 -17.2 -17200 0.8 ZNF366 ZNF512 PRDM1 YY1 GBE1 RNU2-28P GC03M081468
GH03I081490 Enhancer 0.9 Ensembl ENCODE 0.4 -18.7 -18675 0.8 CTCF ATF1 ZNF644 RAD21 ZNF143 SMC3 ATF7 BCLAF1 HOMEZ CREM GC03M081468 RNU2-28P GBE1
GH03I081485 Enhancer 0.8 Ensembl ENCODE 0.3 -23.9 -23851 1.2 SRF BACH1 JUNB DPF2 BATF ATF2 IRF4 ZNF217 IKZF1 NFATC1 GC03M081468 RNU2-28P
GH03I081496 Enhancer 0.5 ENCODE 0.4 -12.4 -12353 1.3 SMARCE1 ZNF217 CTBP1 GATA3 GATAD2B DPF2 CUX1 RNU2-28P GC03M081468 GBE1
GH03I081472 Enhancer 0.3 ENCODE 0.3 -36.6 -36637 1 JUN GC03M081468 RNU2-28P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNU2-28P on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNU2-28P Gene

Genomic Locations for RNU2-28P Gene
chr3:81,509,476-81,509,664
(GRCh38/hg38)
Size:
189 bases
Orientation:
Plus strand

Genomic View for RNU2-28P Gene

Genes around RNU2-28P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU2-28P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU2-28P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU2-28P Gene

ORGUL Member Location for RNU2-28P Gene

ORGUL Member Location for RNU2-28P gene

Proteins for RNU2-28P Gene

Post-translational modifications for RNU2-28P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-28P Gene

Domains & Families for RNU2-28P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-28P Gene

Function for RNU2-28P Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-28P Gene

Localization for RNU2-28P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNU2-28P Gene

Pathways & Interactions for RNU2-28P Gene

SuperPathways for RNU2-28P Gene

No Data Available

Interacting Proteins for RNU2-28P Gene

Gene Ontology (GO) - Biological Process for RNU2-28P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU2-28P Gene

Drugs & Compounds for RNU2-28P Gene

No Compound Related Data Available

Transcripts for RNU2-28P Gene

mRNA/cDNA for RNU2-28P Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-28P Gene

No ASD Table

Relevant External Links for RNU2-28P Gene

GeneLoc Exon Structure for
RNU2-28P
ECgene alternative splicing isoforms for
RNU2-28P

Expression for RNU2-28P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNU2-28P Gene

genes like me logo Genes that share expression patterns with RNU2-28P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU2-28P Gene

Orthologs for RNU2-28P Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNU2-28P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U2 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia U2 34
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U2 34
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia U2 34
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia U2 34
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25052 34
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia U2 34
  • 55 (a)
OneToOne
Species where no ortholog for RNU2-28P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNU2-28P Gene

ENSEMBL:
Gene Tree for RNU2-28P (if available)
TreeFam:
Gene Tree for RNU2-28P (if available)

Paralogs for RNU2-28P Gene

No data available for Paralogs for RNU2-28P Gene

Variants for RNU2-28P Gene

Additional Variant Information for RNU2-28P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU2-28P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU2-28P Gene

Disorders for RNU2-28P Gene

No disorders were found for RNU2-28P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU2-28P Gene

Publications for RNU2-28P Gene

  1. Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines. (PMID: 11350032) Berglund JA … Schultz SC (RNA (New York, N.Y.) 2001) 1
  2. A conserved pseudouridine modification in eukaryotic U2 snRNA induces a change in branch-site architecture. (PMID: 11424937) Newby MI … Greenbaum NL (RNA (New York, N.Y.) 2001) 1
  3. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1
  4. The spliceosomal snRNAs of Caenorhabditis elegans. (PMID: 2339054) Thomas J … Blumenthal T (Nucleic acids research 1990) 1

Products for RNU2-28P Gene

Sources for RNU2-28P Gene

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