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Aliases for RNU2-1 Gene

Subcategory (RNA class) for RNU2-1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for RNU2-1 Gene

  • RNA, U2 Small Nuclear 1 2 3
  • RNU2 3
  • U2 3

External Ids for RNU2-1 Gene

Previous GeneCards Identifiers for RNU2-1 Gene

  • GC17M8A0032
  • GC11M062609
  • GC01P053219
  • GC01P051335
  • GC07P116543
  • GC17U901855

Summaries for RNU2-1 Gene

Entrez Gene Summary for RNU2-1 Gene

  • The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. [provided by RefSeq, Mar 2009]

GeneCards Summary for RNU2-1 Gene

RNU2-1 (RNA, U2 Small Nuclear 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are mRNA Splicing - Major Pathway.

Gene Wiki entry for RNU2-1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNU2-1 Gene

Genomics for RNU2-1 Gene

Regulatory Elements for RNU2-1 Gene

Genomic Location for RNU2-1 Gene

43,233,787 bp from pter
43,233,977 bp from pter
191 bases
Minus strand

Genomic View for RNU2-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNU2-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU2-1 Gene

Proteins for RNU2-1 Gene

Post-translational modifications for RNU2-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-1 Gene

Domains & Families for RNU2-1 Gene

Gene Families for RNU2-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNU2-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-1 Gene

Function for RNU2-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-1 Gene

Localization for RNU2-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU2-1 Gene

Pathways & Interactions for RNU2-1 Gene

SuperPathways for RNU2-1 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RNU2-1: view

Pathways by source for RNU2-1 Gene

1 BioSystems pathway for RNU2-1 Gene

Interacting Proteins for RNU2-1 Gene

Gene Ontology (GO) - Biological Process for RNU2-1 Gene


No data available for SIGNOR curated interactions for RNU2-1 Gene

Drugs & Compounds for RNU2-1 Gene

No Compound Related Data Available

Transcripts for RNU2-1 Gene

mRNA/cDNA for RNU2-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-1 Gene

No ASD Table

Relevant External Links for RNU2-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNU2-1 Gene

No Expression Related Data Available

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNU2-1 Gene

Orthologs for RNU2-1 Gene

Evolution for RNU2-1 Gene

Gene Tree for RNU2-1 (if available)
Gene Tree for RNU2-1 (if available)

No data available for Orthologs for RNU2-1 Gene

Paralogs for RNU2-1 Gene

No data available for Paralogs for RNU2-1 Gene

Variants for RNU2-1 Gene

Relevant External Links for RNU2-1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU2-1 Gene

Disorders for RNU2-1 Gene

Relevant External Links for RNU2-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RNU2-1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNU2-1 Gene

Publications for RNU2-1 Gene

  1. P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes. (PMID: 16308568) Medlin J. … Murphy S. (EMBO J. 2005) 23 67
  2. The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA. (PMID: 12574128) Medlin J.E. … Murphy S. (EMBO J. 2003) 23 67
  3. Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. (PMID: 10882116) Yu A. … Weiner A.M. (Mol. Cell 2000) 23 67
  4. Striking bimodal methylation of the repeat unit of the tandem array encoding human U2 snRNA (the RNU2 locus). (PMID: 10644450) Jiang C. … Liao D. (Genomics 1999) 23 67
  5. Induction of fragility at the human RNU2 locus by cytosine arabinoside is dependent upon a transcriptionally competent U2 small nuclear RNA gene and the expression of p53. (PMID: 9661701) MacArthur H.L. … Bacchetti S. (Somat. Cell Mol. Genet. 1997) 23 67

Products for RNU2-1 Gene

Sources for RNU2-1 Gene

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