Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNU2-1 Gene

RNA gene   GIFtS: 17
GCID: GC17U901855

RNA, U2 Small Nuclear 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Subcategory (RNA class): non-coding RNA

Quality score for this RNA gene is 2

Aliases
RNA, U2 Small Nuclear 11 2
RNU22 5
U22

External Ids:    HGNC: 101421   Entrez Gene: 60662   OMIM: 1806905   

Export aliases for RNU2-1 gene to outside databases

Previous GC identifers: GC17M8A0032 GC11M062609 GC01P053219 GC01P051335 GC07P116543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RNU2-1 Gene:
The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear
mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6
snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP
that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2
snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution
to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains
a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. (provided by RefSeq, Mar
2009)

GeneCards Summary for RNU2-1 Gene:
RNU2-1 (RNA, U2 small nuclear 1) is an RNA gene, and is affiliated with the non-coding RNA class. Diseases associated with RNU2-1 include cockayne syndrome, and lung cancer.

Gene Wiki entry for RNU2-1 (RNU2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the RNU2-1 gene promoter:
         STAT5B   POU2F1   POU2F1a   Olf-1   HNF-3beta   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RNU2-1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNU2-1


Genomic Location:
Chromosome:17   

Entrez Gene cytogenetic band: 17q12   HGNC cytogenetic band: 17q12

GeneLoc information about chromosome 17        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
snRNA: ncRNAs / Small nuclear RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNU2-1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNU2-1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNU2-1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNU2-1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat RNU2-1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RNU2-1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat RNU2-1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RNU2-1

Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for RNU2-1
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNU2-1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNU2-1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RNU2-1
Browse ESI BIO Cell Lines and PureStem Progenitors for RNU2-1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNU2-1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus
  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RNU2-1 About    
See pathways by source

SuperPathContained pathways About
1mRNA Splicing - Major Pathway
mRNA processing0.44


1 BioSystems Pathway for RNU2-1
    mRNA processing


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNU2-1
Interactions:

    GeneGlobe Interaction Network for RNU2-1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RNU2-1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RNU2-1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RNU2-1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse OriGene RNAi
Predesigned siRNA for gene silencing in human, mouse, rat RNU2-1
Clone
Products:
     
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for RNU2-1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNU2-1
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNU2-1
Primer
Products:
    
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RNU2-1
  Search QuantiTect SYBR Green Assays in human, mouse, rat RNU2-1
  QuantiFast Probe-based Assays in human, mouse, rat RNU2-1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

Expression evidence for RNU2-1:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

RNU2-1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for RNU2-1
Primer
Products:
Browse OriGene qPCR
Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RNU2-1
Search QuantiTect SYBR Green Assays in human, mouse, rat RNU2-1
QuantiFast Probe-based Assays in human, mouse, rat RNU2-1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNU2-1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus
  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RNU2-1
DNA2.0 Custom Variant and Variant Library Synthesis for RNU2-1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 180690    OMIM disorders: --

2 diseases for RNU2-1:    
About MalaCards
cockayne syndrome    lung cancer


RNU2-1 for disorders           About GeneDecksing


Export disorders for RNU2-1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RNU2-1 gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with RNU2-1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes. (PubMed id 2411549)1, 3 Htun H....Dahlberg J.E. (EMBO J. 1985)
  2. Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum. (PubMed id 23527303)1 MaziA"res J....Michot B. (PLoS ONE 2013)
  3. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
  4. Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complex. (PubMed id 23426875)1 Zhao C....Greenbaum N.L. (RNA 2013)
  5. Composition and three-dimensional EM structure of double affinity- purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (EMBO J. 2007)
  6. The multifunctional human p100 protein 'hooks' methylated ligands. (PubMed id 17632523)1 Shaw N....Rao Z. (amp 2007)
  7. The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. (PubMed id 15456888)1 Lin K.T....Tarn W.Y. (Mol. Cell. Biol. 2004)
  8. Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing. (PubMed id 14701755)1 Jacobs E.Y....Weiner A.M. (Mol. Cell. Biol. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution. (PubMed id 9608047)1 Liao D....Weiner A.M. (J. Mol. Evol. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 6066 HGNC: 10142 euGenes: HUgn6066 ECgene: RNU2-1 H-InvDB: RNU2-1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for RNU2-1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for RNU2-1 gene:
Search GeneIP for patents involving RNU2-1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   Browse OriGene RNAi products  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   Browse OriGene clones  
 Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RNU2-1   OriGene Custom Protein Services for RNU2-1  

 
 
 Block miRNA regulation of human, mouse, rat RNU2-1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNU2-1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNU2-1 Predesigned siRNA for gene silencing in human, mouse, rat RNU2-1
 QuantiFast Probe-based Assays in human, mouse, rat RNU2-1 Search QuantiTect SYBR Green Assays in human, mouse, rat RNU2-1
 Custom PCR Arrays for RNU2-1 Search Chromatin IP Primers for RNU2-1
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNU2-1  GeneGlobe Interaction Network for RNU2-1
 Regulatory tfbs in RNU2-1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for RNU2-1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for RNU2-1
 GenScript Custom Assay Services for RNU2-1 GenScript Custom overexpressing Cell Line Services for RNU2-1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for RNU2-1
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Biologicals
 Novus Tissue Slides
 Search for Antibodies for RNU2-1 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for RNU2-1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for RNU2-1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNU2-1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for RNU2-1
 Browse SwitchGear Promoter luciferase reporter plasmids for RNU2-1
 Search ThermoFisher Antibodies for RNU2-1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNU2-1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNU2-1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNU2-1
 Search LSBio for Antibodies for RNU2-1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RNU2-1 gene at Home site.
Version: 3.12.162 20 Aug 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4