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RNA, U2 small nuclear 1(Previous names: RNA, U2 small nuclear )
(Previous symbol: RNU2)
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Aliases
for RNU2-1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): non-coding RNA
Quality score for this RNA gene is 2
| Aliases |
|---|
| RNA, U2 Small Nuclear 11 2 | | RNU21 2 5 | | U21 2 | | RNA, U2 Small Nuclear1 |
Export aliases for RNU2-1 gene to outside databasesPrevious GC identifers: GC17M8A0032 GC11M062609 GC01P053219 GC01P051335 |
Summaries
for RNU2-1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNU2-1:
The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNAprecursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) andnumerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts withthe 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locusrepresents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeatunits within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2snRNA. Arrays of six to more than 30 repeats have been reported. (provided by RefSeq, Mar 2009)
Gene Wiki entry for RNU2-1 (RNU2)
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Genomic Views
for RNU2-1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNU2-1 gene promoter:
STAT5B POU2F1 POU2F1a Olf-1 HNF-3beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNU2-1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNU2-1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 HGNC cytogenetic band: 17q12-q21RNU2-1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P116543: view genomic region
(about GC identifiers)
Start:
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116,543,373 bp from pter |
End:
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116,543,409 bp from pter |
Size:
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37 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 115,938,833-115,938,869 |
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Proteins
for RNU2-1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for RNU2-1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for RNU2-1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for RNU2-1 | |  | Search LifeMap BioReagents cell lines for RNU2-1 |
Pathways & Interactions
for RNU2-1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
1  BioSystems Pathway for RNU2-1
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNU2-1
|
Drugs & Compounds
for RNU2-1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNU2-1
Search CenterWatch for drugs/clinical trials and news about RNU2-1
|
Transcripts
for RNU2-1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
GeneLoc Exon Structure
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Expression
for RNU2-1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for RNU2-1:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SABiosciences Custom PCR Arrays for RNU2-1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RNU2-1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNU2-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNU2-1 |
Orthologs
for RNU2-1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
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Paralogs
for RNU2-1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNU2-1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RNU2-1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNU2-1 for disorders About GeneDecksing
OMIM gene information: 180690
OMIM disorders: --
1  disease for RNU2-1: About MalaCardscockayne syndrome
Export disorders for RNU2-1 gene to outside databases
|
Publications
for RNU2-1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNU2-1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with RNU2-1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes. (PubMed id 2411549)1, 3 Htun H....Dahlberg J.E. (1985)
- Implication of the SMN complex in the biogenesis and s teady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (2013)
- Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. (PubMed id 17332742)1 Behzadnia N.... Luehrmann R. (2007)
- The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. (PubMed id 15456888)1 Lin K.T....Tarn W.Y. (2004)
- Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing. (PubMed id 14701755)1 Jacobs E.Y....Weiner A.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution. (PubMed id 9608047)1 Liao D....Weiner A.M. (1998)
- Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion. (PubMed id 9034341)1 Liao D....Weiner A.M. (1997)
- Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus. (PubMed id 7828589)1 Pavelitz T....Weiner A.M. (1995)
- Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles. (PubMed id 2176635)1 Hausner T.P....Weiner A.M. (1990)
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External Searches for RNU2-1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RNU2-1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNU2-1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNU2-1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNU2-1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNU2-1 gene:
Search GeneIP for patents involving RNU2-1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNU2-1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNU2-1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNU2-1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNU2-1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNU2-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNU2-1 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNU2-1 |
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 |  |  |  | |
| | | | Search Tocris compounds for RNU2-1 |
| |  |  |  |  | | | | |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for RNU2-1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNU2-1 |
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