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Aliases for RNU2-1 Gene

Subcategory (RNA class) for RNU2-1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for RNU2-1 Gene

  • RNA, U2 Small Nuclear 1 2 3 5
  • RNU2 3
  • U2 3

External Ids for RNU2-1 Gene

Previous GeneCards Identifiers for RNU2-1 Gene

  • GC17M8A0032
  • GC11M062609
  • GC01P053219
  • GC01P051335
  • GC07P116543
  • GC17U901855

Summaries for RNU2-1 Gene

Entrez Gene Summary for RNU2-1 Gene

  • The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. [provided by RefSeq, Mar 2009]

GeneCards Summary for RNU2-1 Gene

RNU2-1 (RNA, U2 Small Nuclear 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are mRNA Splicing - Major Pathway.

Gene Wiki entry for RNU2-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNU2-1 Gene

Genomics for RNU2-1 Gene

Regulatory Elements for RNU2-1 Gene

Enhancers for RNU2-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043215 1 ENCODE 0.4 +16.5 16545 3.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF143 PAF1 MXD4 NBR2 RND2 VAT1 TMEM106A RNU2-1
GH17G043210 0.9 ENCODE 0.3 +21.4 21380 4.4 ELF3 HDGF TBP PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 NBR2 RND2 VAT1 PTGES3L PSMC3IP TMEM106A RNU2-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNU2-1 on UCSC Golden Path with GeneCards custom track

Promoters for RNU2-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000283448 77 1401

Genomic Location for RNU2-1 Gene

Chromosome:
17
Start:
43,233,787 bp from pter
End:
43,233,977 bp from pter
Size:
191 bases
Orientation:
Minus strand

Genomic View for RNU2-1 Gene

Genes around RNU2-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU2-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU2-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU2-1 Gene

Proteins for RNU2-1 Gene

Post-translational modifications for RNU2-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-1 Gene

Domains & Families for RNU2-1 Gene

Gene Families for RNU2-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNU2-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-1 Gene

Function for RNU2-1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-1 Gene

Localization for RNU2-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU2-1 Gene

Pathways & Interactions for RNU2-1 Gene

SuperPathways for RNU2-1 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RNU2-1: view

Pathways by source for RNU2-1 Gene

1 BioSystems pathway for RNU2-1 Gene

Interacting Proteins for RNU2-1 Gene

Gene Ontology (GO) - Biological Process for RNU2-1 Gene

None

No data available for SIGNOR curated interactions for RNU2-1 Gene

Drugs & Compounds for RNU2-1 Gene

No Compound Related Data Available

Transcripts for RNU2-1 Gene

mRNA/cDNA for RNU2-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-1 Gene

No ASD Table

Relevant External Links for RNU2-1 Gene

GeneLoc Exon Structure for
RNU2-1
ECgene alternative splicing isoforms for
RNU2-1

Expression for RNU2-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU2-1 Gene

Orthologs for RNU2-1 Gene

Evolution for RNU2-1 Gene

ENSEMBL:
Gene Tree for RNU2-1 (if available)
TreeFam:
Gene Tree for RNU2-1 (if available)

No data available for Orthologs for RNU2-1 Gene

Paralogs for RNU2-1 Gene

No data available for Paralogs for RNU2-1 Gene

Variants for RNU2-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNU2-1 Gene

Variant ID Type Subtype PubMed ID
dgv1466n106 OTHER inversion 24896259
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
esv6011 OTHER inversion 19470904
nsv1079031 OTHER inversion 25765185
nsv1146669 OTHER inversion 26484159
nsv1160487 CNV duplication 26073780
nsv510712 CNV deletion 20534489
nsv962328 CNV duplication 23825009

Relevant External Links for RNU2-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU2-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for RNU2-1 Gene

Disorders for RNU2-1 Gene

Relevant External Links for RNU2-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNU2-1

No disorders were found for RNU2-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNU2-1 Gene

Publications for RNU2-1 Gene

  1. Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes. (PMID: 2411549) Htun H. … Dahlberg J.E. (EMBO J. 1985) 2 3 64
  2. Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for primary central nervous system lymphoma. (PMID: 26250566) Baraniskin A. … Schroers R. (Neuro-oncology 2015) 3 64
  3. Binding affinity and cooperativity control U2Ba8^/snRNA/U2A' RNP formation. (PMID: 24866816) Williams S.G. … Hall K.B. (Biochemistry 2014) 3 64
  4. Analysis of U2 small nuclear RNA fragments in the bile differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. (PMID: 24482036) Baraniskin A. … Hahn S.A. (Dig. Dis. Sci. 2014) 3 64
  5. Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum. (PMID: 23527303) MaziA"res J. … Michot B. (PLoS ONE 2013) 3 64

Products for RNU2-1 Gene

Sources for RNU2-1 Gene

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