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Aliases for RNU11 Gene

Subcategory (RNA class) for RNU11 Gene

snRNA

Quality Score for this RNA gene is

5.4

Aliases for RNU11 Gene

  • RNA, U11 Small Nuclear 2 3
  • RNU11-1 3
  • U11 3

External Ids for RNU11 Gene

Previous GeneCards Identifiers for RNU11 Gene

  • GC00U990630
  • GC01U901037
  • GC01P028849
  • GC01P028975
  • GC01P027228

Summaries for RNU11 Gene

GeneCards Summary for RNU11 Gene

RNU11 (RNA, U11 Small Nuclear) is an RNA Gene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU11 Gene - the ORGUL cluster for this gene includes several descriptions:

  • U11_snRNA: U11 snRNA plays a role in splicing of the minor U12-dependent class of eukaryotic nuclear introns, similar to U1 snRNA in the major class spliceosome it base pairs to the conserved 5' splice site sequence.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • U11 spliceosomal RNA: The U11 small nuclear (snRNA), together with U4atac/U6atac, U5, and U12 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU11 Gene

Genomics for RNU11 Gene

Regulatory Elements for RNU11 Gene

Genomic Location for RNU11 Gene

Start:
28,648,600 bp from pter
End:
28,648,734 bp from pter
Size:
135 bases
Orientation:
Plus strand

Genomic View for RNU11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNU11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU11 Gene

ORGUL Member Location for RNU11 Gene

ORGUL Member Location for RNU11 gene

Proteins for RNU11 Gene

Post-translational modifications for RNU11 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU11 Gene

Domains for RNU11 Gene

Gene Families for RNU11 Gene

HGNC:
  • snRNA :ncRNAs / Small nuclear RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNU11: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU11 Gene

Function for RNU11 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNU11 Gene

Localization for RNU11 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU11 Gene

Pathways for RNU11 Gene

SuperPathways for RNU11 Gene

No Data Available

Interacting Proteins for RNU11 Gene

Gene Ontology (GO) - Biological Process for RNU11 Gene

None

No data available for Pathways by source for RNU11 Gene

Transcripts for RNU11 Gene

mRNA/cDNA for RNU11 Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNU11 Gene

RNA, U11 small nuclear:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNU11

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNU11 Gene

No ASD Table

Relevant External Links for RNU11 Gene

GeneLoc Exon Structure for
RNU11
ECgene alternative splicing isoforms for
RNU11

Expression for RNU11 Gene

mRNA expression in normal human tissues for RNU11 Gene

mRNA differential expression in normal tissues according to GTEx for RNU11 Gene

This gene is overexpressed in Muscle - Skeletal (6.4).

SOURCE GeneReport for Unigene cluster for RNU11 Gene Hs.640266

genes like me logo Genes that share expressions with RNU11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for RNU11 Gene

Orthologs for RNU11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNU11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U11 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnu11 16
Rnu11 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia U11 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia U11 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves U11 36
  • 74 (a)
OneToMany
U11 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia U11 36
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii U11 36
  • 68 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea U11 36
  • 65 (a)
OneToMany
Species with no ortholog for RNU11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNU11 Gene

ENSEMBL:
Gene Tree for RNU11 (if available)
TreeFam:
Gene Tree for RNU11 (if available)

Paralogs for RNU11 Gene

No data available for Paralogs for RNU11 Gene

Variants for RNU11 Gene

Sequence variations from dbSNP and Humsavar for RNU11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7368197 -- 28,647,287(+) ATAtt(G/T)ttttt upstream-variant-2KB
rs9426296 -- 28,648,889(+) ATTCA(G/T)ACCTG downstream-variant-500B
rs9426392 -- 28,649,045(+) TTGGC(A/G)ACTGT downstream-variant-500B
rs10127601 -- 28,648,324(+) AGCCG(C/T)TCTTC upstream-variant-2KB
rs11801300 -- 28,648,222(+) CCGGT(A/G)TTCCA upstream-variant-2KB

Relevant External Links for RNU11 Gene

HapMap Linkage Disequilibrium report
RNU11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNU11 Gene

Disorders for RNU11 Gene

No disorders were found for RNU11 Gene.

No data available for UniProtKB/Swiss-Prot for RNU11 Gene

Publications for RNU11 Gene

  1. Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc. (PMID: 2973606) Montzka K.A. … Steitz J.A. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3
  2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will C.L. … Luehrmann R. (RNA 2004) 3
  3. An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. (PMID: 20347424) Verbeeren J. … Frilander M.J. (Mol. Cell 2010) 3

Products for RNU11 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate RNU11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RNU11
    • Block miRNA regulation of RNU11 using miScript Target Protectors

    Sources for RNU11 Gene

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