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Aliases for RNU1-65P Gene

Subcategory (RNA class) for RNU1-65P Gene

snRNA

Aliases for RNU1-65P Gene

  • RNA, U1 Small Nuclear 65, Pseudogene 2 3 5

External Ids for RNU1-65P Gene

ORGUL Members for RNU1-65P Gene

Previous GeneCards Identifiers for RNU1-65P Gene

  • GC10P085764
  • GC00U935111

Summaries for RNU1-65P Gene

GeneCards Summary for RNU1-65P Gene

RNU1-65P (RNA, U1 Small Nuclear 65, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU1-65P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U1_snRNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.

  • U1 spliceosomal RNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [1]. This family does not contain the larger yeast sequences.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU1-65P Gene

Genomics for RNU1-65P Gene

Regulatory Elements for RNU1-65P Gene

Enhancers for RNU1-65P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G084156 1.1 Ensembl ENCODE 9.5 +153.7 153696 0.8 HDAC1 CTCF PKNOX1 ESRRA ETV1 JUN MAX CEBPG ZIC2 FOSL1 CDHR1 LRIT2 RNU1-65P ENSG00000271933 C10orf99 CERNA2
GH10G084075 0.9 Ensembl ENCODE 10.4 +73.6 73602 3.5 CTCF ZBTB40 ZNF7 ZFHX2 ZNF766 GATA2 FOS EGR2 TCF7L2 CDHR1 RNU1-65P HMGN2P8 LOC105378399
GH10G084257 0.8 ENCODE 9.3 +253.9 253908 0.2 CTCF CBX3 RB1 CREB3L1 HINFP ARNT MAX RAD21 E2F1 DIDO1 LRIT2 CDHR1 RNU1-65P GC10P084249 GC10P084248 LINC00858
GH10G084159 0.5 dbSUPER 9.5 +156.0 155998 0.6 KLF1 ZNF398 FEZF1 ZBTB8A CDHR1 LRIT2 LRIT1 RNU1-65P C10orf99 CERNA2 ENSG00000271933
GH10G083957 0.4 ENCODE 11.6 -46.0 -46013 0.2 CHD7 EZH2 RNU1-65P LOC105378398 GC10M083894
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNU1-65P on UCSC Golden Path with GeneCards custom track

Genomic Location for RNU1-65P Gene

Chromosome:
10
Start:
84,003,332 bp from pter
End:
84,003,479 bp from pter
Size:
148 bases
Orientation:
Plus strand

Genomic View for RNU1-65P Gene

Genes around RNU1-65P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU1-65P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU1-65P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU1-65P Gene

ORGUL Member Location for RNU1-65P Gene

ORGUL Member Location for RNU1-65P gene

Proteins for RNU1-65P Gene

Post-translational modifications for RNU1-65P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU1-65P Gene

Domains & Families for RNU1-65P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU1-65P Gene

Function for RNU1-65P Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU1-65P Gene

Localization for RNU1-65P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU1-65P Gene

Pathways & Interactions for RNU1-65P Gene

SuperPathways for RNU1-65P Gene

No Data Available

Interacting Proteins for RNU1-65P Gene

Gene Ontology (GO) - Biological Process for RNU1-65P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU1-65P Gene

Drugs & Compounds for RNU1-65P Gene

No Compound Related Data Available

Transcripts for RNU1-65P Gene

mRNA/cDNA for RNU1-65P Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU1-65P Gene

No ASD Table

Relevant External Links for RNU1-65P Gene

GeneLoc Exon Structure for
RNU1-65P
ECgene alternative splicing isoforms for
RNU1-65P

Expression for RNU1-65P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNU1-65P Gene

genes like me logo Genes that share expression patterns with RNU1-65P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU1-65P Gene

Orthologs for RNU1-65P Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for RNU1-65P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U1 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm23100 35
  • 70 (a)
ManyToMany
Species where no ortholog for RNU1-65P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNU1-65P Gene

ENSEMBL:
Gene Tree for RNU1-65P (if available)
TreeFam:
Gene Tree for RNU1-65P (if available)

Paralogs for RNU1-65P Gene

No data available for Paralogs for RNU1-65P Gene

Variants for RNU1-65P Gene

Relevant External Links for RNU1-65P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU1-65P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU1-65P Gene

Disorders for RNU1-65P Gene

No disorders were found for RNU1-65P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU1-65P Gene

Publications for RNU1-65P Gene

  1. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PMID: 11297556) Katsamba P.S. … Laird-Offringa I.A. (J. Biol. Chem. 2001) 1
  2. The uRNA database. (PMID: 9016512) Zwieb C. (Nucleic Acids Res. 1997) 1
  3. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C. … Nagai K. (Nature 1994) 1
  4. Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains. (PMID: 2405391) Kretzner L. … Rosbash M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 1

Products for RNU1-65P Gene

Sources for RNU1-65P Gene

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