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Aliases for RNU1-22P Gene

Subcategory (RNA class) for RNU1-22P Gene

snRNA

Aliases for RNU1-22P Gene

  • RNA, U1 Small Nuclear 22, Pseudogene 2 3 5

External Ids for RNU1-22P Gene

ORGUL Members for RNU1-22P Gene

Previous GeneCards Identifiers for RNU1-22P Gene

  • GC00U933874
  • GC16P003137
  • GC16P003138
  • GC16P003140
  • GC16P003154
  • GC16P003168
  • GC16P003211
  • GC16P003236
  • GC16P003293
  • GC16P003331
  • GC16P003384

Summaries for RNU1-22P Gene

GeneCards Summary for RNU1-22P Gene

RNU1-22P (RNA, U1 Small Nuclear 22, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU1-22P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U1_snRNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.

  • U1 spliceosomal RNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [1]. This family does not contain the larger yeast sequences.

View fRNAdb secondary structures for RNU1-22P

Additional gene information for RNU1-22P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU1-22P Gene

Genomics for RNU1-22P Gene

Regulatory Elements for RNU1-22P Gene

Enhancers for RNU1-22P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H003083 1.1 ENCODE dbSUPER 0.7 +0.3 313 5 ELF3 ARID4B DMAP1 DNMT3B THRB RAD21 RARA TCF12 GLIS2 SCRT2 LOC105371058 ZNF205 RNU1-22P
GH16H003081 0.4 dbSUPER 0.7 -4.3 -4331 1 IKZF1 RUNX3 LOC105371058 ZNF213-AS1 ZNF205 RNU1-22P GC16P003476
GH16H003082 0.2 dbSUPER 0.7 -2.9 -2919 0 ZNF205 RNU1-22P GC16P003476
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNU1-22P on UCSC Golden Path with GeneCards custom track

Promoters for RNU1-22P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082596 757 201 ZNF792 DMAP1 KAT8 ZGPAT IKZF1 MBD1 ETV4 KDM1A SMAD4

Genomic Location for RNU1-22P Gene

Chromosome:
16
Start:
3,086,143 bp from pter
End:
3,086,300 bp from pter
Size:
158 bases
Orientation:
Plus strand

Genomic View for RNU1-22P Gene

Genes around RNU1-22P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU1-22P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU1-22P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU1-22P Gene

ORGUL Member Location for RNU1-22P Gene

ORGUL Member Location for RNU1-22P gene

Proteins for RNU1-22P Gene

Post-translational modifications for RNU1-22P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU1-22P Gene

Domains & Families for RNU1-22P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU1-22P Gene

Function for RNU1-22P Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for RNU1-22P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU1-22P Gene

Localization for RNU1-22P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNU1-22P Gene

Pathways & Interactions for RNU1-22P Gene

SuperPathways for RNU1-22P Gene

No Data Available

Interacting Proteins for RNU1-22P Gene

Gene Ontology (GO) - Biological Process for RNU1-22P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU1-22P Gene

Drugs & Compounds for RNU1-22P Gene

No Compound Related Data Available

Transcripts for RNU1-22P Gene

fRNAdb Secondary structures for RNU1-22P Gene

  • RF00003;U1;AADB02017055.1/261796-261639

mRNA/cDNA for RNU1-22P Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for RNU1-22P
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNU1-22P Gene

No ASD Table

Relevant External Links for RNU1-22P Gene

GeneLoc Exon Structure for
RNU1-22P
ECgene alternative splicing isoforms for
RNU1-22P

Expression for RNU1-22P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNU1-22P Gene

genes like me logo Genes that share expression patterns with RNU1-22P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU1-22P Gene

Orthologs for RNU1-22P Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNU1-22P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U1 34
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm26505 34
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia U1 34
  • 62 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia U1 34
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia U1 34
  • 58 (a)
ManyToMany
Species where no ortholog for RNU1-22P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNU1-22P Gene

ENSEMBL:
Gene Tree for RNU1-22P (if available)
TreeFam:
Gene Tree for RNU1-22P (if available)

Paralogs for RNU1-22P Gene

No data available for Paralogs for RNU1-22P Gene

Variants for RNU1-22P Gene

Relevant External Links for RNU1-22P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU1-22P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU1-22P Gene

Disorders for RNU1-22P Gene

No disorders were found for RNU1-22P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU1-22P Gene

Publications for RNU1-22P Gene

  1. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PMID: 11297556) Katsamba PS … Laird-Offringa IA (The Journal of biological chemistry 2001) 1
  2. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1
  3. Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C … Nagai K (Nature 1994) 1
  4. Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains. (PMID: 2405391) Kretzner L … Rosbash M (Proceedings of the National Academy of Sciences of the United States of America 1990) 1

Products for RNU1-22P Gene

Sources for RNU1-22P Gene

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