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Aliases for RNU1-108P Gene

Subcategory (RNA class) for RNU1-108P Gene

snRNA

Aliases for RNU1-108P Gene

  • RNA, U1 Small Nuclear 108, Pseudogene 2 3 5

External Ids for RNU1-108P Gene

ORGUL Members for RNU1-108P Gene

Previous GeneCards Identifiers for RNU1-108P Gene

  • GC17M056747
  • GC00U935179

Summaries for RNU1-108P Gene

GeneCards Summary for RNU1-108P Gene

RNU1-108P (RNA, U1 Small Nuclear 108, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU1-108P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U1_snRNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.

  • U1 spliceosomal RNA: U1 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Its 5' end forms complementary base pairs with the 5' splice junction, thus defining the 5' donor site of an intron. There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [1]. This family does not contain the larger yeast sequences.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU1-108P Gene

Genomics for RNU1-108P Gene

Regulatory Elements for RNU1-108P Gene

Enhancers for RNU1-108P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058630 1.2 ENCODE 13 +34.8 34816 2.6 CREB3L1 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TRIM37 RAD51C SRSF1 VEZF1 TEX14 RNU1-108P SMG8 MTMR4 DHX40 ENSG00000212195
GH17F058665 1.6 FANTOM5 Ensembl ENCODE 0.8 -0.6 -560 4.0 PKNOX1 ATF1 SIN3A ZNF121 FOS ZNF548 KDM4B ZNF263 GTF2B NCOA1 TRIM37 RAD51C SRSF1 SMG8 TEX14 SUPT4H1 RNU1-108P ENSG00000266561
GH17F058669 0.7 ENCODE 0.8 -2.7 -2718 0.2 SOX13 SOX5 TFAP4 SP5 FOXA3 MNT TEAD3 TBX3 CBX1 IKZF1 SRSF1 RNU1-108P ENSG00000266561
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNU1-108P on UCSC Golden Path with GeneCards custom track

Promoters for RNU1-108P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001808467 -203 601 PKNOX1 ATF1 KDM4B GTF2B NCOA1 CREB3 MBD2 MEF2D SMARCA4 PBX2

Genomic Location for RNU1-108P Gene

Chromosome:
17
Start:
58,666,537 bp from pter
End:
58,666,697 bp from pter
Size:
161 bases
Orientation:
Minus strand

Genomic View for RNU1-108P Gene

Genes around RNU1-108P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU1-108P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU1-108P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU1-108P Gene

ORGUL Member Location for RNU1-108P Gene

ORGUL Member Location for RNU1-108P gene

Proteins for RNU1-108P Gene

Post-translational modifications for RNU1-108P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU1-108P Gene

Domains & Families for RNU1-108P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU1-108P Gene

Function for RNU1-108P Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU1-108P Gene

Localization for RNU1-108P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNU1-108P Gene

Pathways & Interactions for RNU1-108P Gene

SuperPathways for RNU1-108P Gene

No Data Available

Interacting Proteins for RNU1-108P Gene

Gene Ontology (GO) - Biological Process for RNU1-108P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU1-108P Gene

Transcripts for RNU1-108P Gene

mRNA/cDNA for RNU1-108P Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU1-108P Gene

No ASD Table

Relevant External Links for RNU1-108P Gene

GeneLoc Exon Structure for
RNU1-108P
ECgene alternative splicing isoforms for
RNU1-108P

Expression for RNU1-108P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNU1-108P Gene

genes like me logo Genes that share expression patterns with RNU1-108P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNU1-108P Gene

Orthologs for RNU1-108P Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNU1-108P Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U1 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia U1 35
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia U1 35
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm25153 35
  • 58 (a)
ManyToMany
chicken
(Gallus gallus)
Aves U1 35 35
  • 69 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea U1 35
  • 67 (a)
ManyToMany
Species where no ortholog for RNU1-108P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNU1-108P Gene

ENSEMBL:
Gene Tree for RNU1-108P (if available)
TreeFam:
Gene Tree for RNU1-108P (if available)

Paralogs for RNU1-108P Gene

No data available for Paralogs for RNU1-108P Gene

Variants for RNU1-108P Gene

Relevant External Links for RNU1-108P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU1-108P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU1-108P Gene

Disorders for RNU1-108P Gene

No disorders were found for RNU1-108P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU1-108P Gene

Publications for RNU1-108P Gene

  1. Two functionally distinct steps mediate high affinity binding of U1A protein to U1 hairpin II RNA. (PMID: 11297556) Katsamba P.S. … Laird-Offringa I.A. (J. Biol. Chem. 2001) 1
  2. The uRNA database. (PMID: 9016512) Zwieb C. (Nucleic Acids Res. 1997) 1
  3. Crystal structure at 1.92-A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. (PMID: 7984237) Oubridge C. … Nagai K. (Nature 1994) 1
  4. Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains. (PMID: 2405391) Kretzner L. … Rosbash M. (Proc. Natl. Acad. Sci. U.S.A. 1990) 1

Products for RNU1-108P Gene

Sources for RNU1-108P Gene

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