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RNR2 Gene

RNA gene   GIFtS: 17
GCID: GC14U990054

RNA, Ribosomal Cluster 2

(Previous names: RNA, ribosomal 2)
  See RNR2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): non-coding RNA

Quality score for this RNA gene is 2

Aliases
RNA, Ribosomal Cluster 21 2
RNA, Ribosomal 21

External Ids:    HGNC: 100831   Entrez Gene: 60532   OMIM: 1804515   

Export aliases for RNR2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNR2 Gene:
The genes encoding the rRNA components of the ribosome are organized as tandem rDNA repeating units, designated
RNR1 through RNR5, in the p12 region of chromosomes 13, 14, 15, 21 and 22. Each rDNA unit encodes a 45S rRNA
which serves as the precursor for an 18S, 5.8S and 28S rRNA. The number of rDNA repeating units varies between
individuals and from chromosome to chromosome, although usually 30 to 40 repeats are found on each chromosome.
This ribosomal repeating unit located on chromosome 14 is not currently annotated on the reference genome.
(provided by RefSeq, Mar 2009)

GeneCards Summary for RNR2 Gene:
RNR2 (RNA, ribosomal cluster 2) is an RNA gene, and is affiliated with the non-coding RNA class. Diseases associated with RNR2 include cyclic vomiting syndrome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for RNR2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNR2


Genomic Location:
Chromosome:14   

Entrez Gene cytogenetic band: 14p12   HGNC cytogenetic band: 14p12

GeneLoc information about chromosome 14        


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for RNR2:
RNA,ribosomal cluster 2

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RNR2 About    
See pathways by source

SuperPathContained pathways About
1CFTR translational fidelity class I mutations
CFTR translational fidelity class I mutations 0.60

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for RNR2
    CFTR translational fidelity (class I mutations)


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Interactions:

    GeneGlobe Interaction Network for RNR2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for RNR2:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

RNR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RNR2
DNA2.0 Custom Variant and Variant Library Synthesis for RNR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 180451    OMIM disorders: --

1 disease for RNR2:    
About MalaCards
cyclic vomiting syndrome


Find genes that share disorders with RNR2           About GenesLikeMe

Genetic Association Database (GAD): RNR2
Human Genome Epidemiology (HuGE) Navigator: RNR2 (13 documents)

Export disorders for RNR2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNR2 gene, integrated from 10 sources (see all 16):
(articles sorted by number of sources associating them with RNR2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Are pediatric and adult-onset cyclic vomiting syndrome (CVS) biologically different conditions? Relationship of adult-onset CVS with the migraine and pediatric CVS-associated common mtDNA polymorphisms 16519T and 3010A. (PubMed id 19368653)1, 4 Boles R.G....McCallum R. (Neurogastroenterol. Motil. 2009)
  2. Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. (PubMed id 11350117)1, 3 Gonzalez I.L. and Sylvester J.E. (Genomics 2001)
  3. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. (PubMed id 19920115)4 Alsbeih G.A....Abu-Amero K.K. (Clin. Cancer Res. 2009)
  4. Association study of common mitochondrial variants and cognitive ability. (PubMed id 19449098)4 Byrne E.M....Visscher P.M. (Behav. Genet. 2009)
  5. Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders. (PubMed id 19147801)4 Camilleri M....Boles R.G. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009)
  6. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. (PubMed id 19050702)4 Webb E....Houlston R.S. (Br. J. Cancer 2008)
  7. Genotyping Parkinson disease-associated mitochondrial polymorphisms. (PubMed id 15931342)4 Jiang Y....Greenlee A.R. (amp 2004)
  8. Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer. (PubMed id 7557999)1 Gonzalez I.L. and Sylvester J.E. (Genomics 1995)
  9. Sequence and structure correlation of human ribosomal transcribed spacers. (PubMed id 2319598)1 Gonzalez I.L....Sylvester J.E. (J. Mol. Biol. 1990)
  10. Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter. (PubMed id 2606358)1 Sylvester J.E....Schmickel R.D. (Gene 1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6053 HGNC: 10083 euGenes: HUgn6053 ECgene: RNR2 H-InvDB: RNR2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RNR2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNR2 gene:
Search GeneIP for patents involving RNR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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