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Aliases for RNR1 Gene

Subcategory (RNA class) for RNR1 Gene

non-coding RNA

Quality Score for this RNA gene is

2

Aliases for RNR1 Gene

  • RNA, Ribosomal 45S Cluster 1 2 3
  • RNA, Ribosomal Cluster 1 2
  • 45S RDNA Cluster 1 2
  • RNA, Ribosomal 1 2

External Ids for RNR1 Gene

Summaries for RNR1 Gene

Entrez Gene Summary for RNR1 Gene

  • 45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene represents the 45S ribosomal DNA cluster on chromosome 13. [provided by RefSeq, Feb 2017]

GeneCards Summary for RNR1 Gene

RNR1 (RNA, Ribosomal 45S Cluster 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with RNR1 include Idiopathic Bilateral Vestibulopathy and Nonsyndromic Hearing Loss And Deafness, Mitochondrial. Among its related pathways are Viral mRNA Translation.

Gene Wiki entry for RNR1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNR1 Gene

Genomics for RNR1 Gene

Genomic Location for RNR1 Gene

Chromosome:
13
Orientation:
Unknown strand

Genomic View for RNR1 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for Regulatory Elements and RefSeq DNA sequence for RNR1 Gene

Proteins for RNR1 Gene

Post-translational modifications for RNR1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNR1 Gene

Domains & Families for RNR1 Gene

Gene Families for RNR1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNR1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNR1 Gene

Function for RNR1 Gene

Molecular function for RNR1 Gene

GENATLAS Biochemistry:
RNA,ribosomal cluster 1

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNR1 Gene

Localization for RNR1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNR1 Gene

Pathways & Interactions for RNR1 Gene

genes like me logo Genes that share pathways with RNR1: view

Pathways by source for RNR1 Gene

1 GeneGo (Thomson Reuters) pathway for RNR1 Gene

Interacting Proteins for RNR1 Gene

Gene Ontology (GO) - Biological Process for RNR1 Gene

None

No data available for SIGNOR curated interactions for RNR1 Gene

Drugs & Compounds for RNR1 Gene

No Compound Related Data Available

Transcripts for RNR1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RNR1 Gene

No ASD Table

Relevant External Links for RNR1 Gene

ECgene alternative splicing isoforms for
RNR1

No data available for mRNA/cDNA for RNR1 Gene

Expression for RNR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNR1 Gene:

RNR1

Phenotype-based relationships between genes and organs from Gene ORGANizer for RNR1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
Organs:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • heart
  • heart valve
Limb:
  • forearm
General:
  • peripheral nervous system
  • skin
  • spinal cord
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for RNR1 Gene

Orthologs for RNR1 Gene

No data available for Orthologs and Evolution for RNR1 Gene

Paralogs for RNR1 Gene

No data available for Paralogs for RNR1 Gene

Variants for RNR1 Gene

Relevant External Links for RNR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNR1 Gene

Disorders for RNR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RNR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
idiopathic bilateral vestibulopathy
nonsyndromic hearing loss and deafness, mitochondrial
  • nonsyndromic deafness and hearing loss, maternally-inherited
congenital cytomegalovirus
  • congenital cytomegalovirus infection
nonsyndromic hearing loss and deafness
- elite association - COSMIC cancer census association via MalaCards
Search RNR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNR1

Genetic Association Database (GAD)
RNR1
Human Genome Epidemiology (HuGE) Navigator
RNR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNR1
genes like me logo Genes that share disorders with RNR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNR1 Gene

Publications for RNR1 Gene

  1. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. (PMID: 27474438) McStay B. (Genes Dev. 2016) 3 64
  2. A Portrait of Ribosomal DNA Contacts with Hi-C Reveals 5S and 45S rDNA Anchoring Points in the Folded Human Genome. (PMID: 27797956) Yu S. … Lemos B. (Genome Biol Evol 2016) 3 64
  3. The Epigenetic Pathways to Ribosomal DNA Silencing. (PMID: 27250769) Srivastava R. … Ahn S.H. (Microbiol. Mol. Biol. Rev. 2016) 3 64
  4. Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. (PMID: 25583482) Gibbons J.G. … Lemos B. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 64
  5. An overview of pre-ribosomal RNA processing in eukaryotes. (PMID: 25346433) Henras A.K. … Gleizes P.E. (Wiley Interdiscip Rev RNA 2015) 3 64

Products for RNR1 Gene

Sources for RNR1 Gene

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