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RNPS1 Gene

protein-coding   GIFtS: 60
GCID: GC16M002303

RNA Binding Protein S1, Serine-Rich Domain

(Previous names: RNA-binding protein S1, serine-rich domain)
  See RNPS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Binding Protein S1, Serine-Rich Domain1 2     RNA-Binding Protein With Serine-Rich Domain 12
RNA-Binding Protein S1, Serine-Rich Domain1 2     SR Protein2
SR-Related Protein LDC22 3     LDC23
E5.12     

External Ids:    HGNC: 100801   Entrez Gene: 109212   Ensembl: ENSG000002059377   OMIM: 6064475   UniProtKB: Q152873   

Export aliases for RNPS1 gene to outside databases

Previous GC identifers: GC16P002468 GC16M002328 GC16M002244 GC16M002245 GC16M002246 GC16M002168 GC16M002247 GC16M002230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNPS1 Gene:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear
export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and
initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction,
this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains
bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine
residues. Several transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2013)

GeneCards Summary for RNPS1 Gene:
RNPS1 (RNA binding protein S1, serine-rich domain) is a protein-coding gene. Diseases associated with RNPS1 include tuberous sclerosis, type 2, and acinar cell carcinoma. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding.

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
Function: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the
splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a
dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors
that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component
of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited
to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific
transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP
complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the
ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54
and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in
the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of
proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs
containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds
spliced mRNA 20-25 nt upstream of exon-exon junctions

Gene Wiki entry for RNPS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNPS1 gene promoter:
         CREB   p53   COMP1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNPS1 promoter sequence
   Search Chromatin IP Primers for RNPS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNPS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RNPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPS1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002303:  view genomic region     (about GC identifiers)

Start:
2,303,100 bp from pter      End:
2,318,413 bp from pter
Size:
15,314 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287 (See protein sequence)
Recommended Name: RNA-binding protein with serine-rich domain 1  
Size: 305 amino acids; 34208 Da
Subunit: Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with
NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and
splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively;
the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome.
Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1
and TRA2B/SFRS10
1 PDB 3D structure from and Proteopedia for RNPS1:
4A8X (3D)    
Secondary accessions: A8K1P0 B4DDU8 B4DZU7 B7ZA17 O75308 Q32P25 Q8WY42 Q9NYG3
Alternative splicing: 3 isoforms:  Q15287-1   Q15287-2   Q15287-3   

Explore the universe of human proteins at neXtProt for RNPS1: NX_Q15287

Explore proteomics data for RNPS1 at MOPED

Post-translational modifications: 

  • Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53
    phosphorylation site is important for splicing and translation stimulation activity in vitro1
  • Ubiquitination2 at Lys203
  • Modification sites at PhosphoSitePlus

  • See RNPS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001273554.1  NP_001273555.1  NP_001273556.1  NP_006702.1  NP_542161.1  

    ENSEMBL proteins: 
     ENSP00000380275   ENSP00000315859   ENSP00000456352   ENSP00000455379   ENSP00000457723  
     ENSP00000455306   ENSP00000457820   ENSP00000457987   ENSP00000301730   ENSP00000454513  
     ENSP00000457110   ENSP00000454461   ENSP00000455013   ENSP00000457690   ENSP00000457378  
     ENSP00000457618   ENSP00000457296   ENSP00000455195   ENSP00000454867   ENSP00000457338  
     ENSP00000456283  
    Reactome Protein details: Q15287

    RNPS1 Human Recombinant Protein Products:

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    Novus Biologicals RNPS1 Proteins
    Novus Biologicals RNPS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPS1

     
    Search eBioscience for Proteins for RNPS1 

     
    antibodies-online proteins for RNPS1 (9 products) 

     
    Search antibodies-online for peptides for RNPS1

    RNPS1 Antibody Products:

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    Abcam antibodies for RNPS1
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    Search ThermoFisher Antibodies for RNPS1
    antibodies-online antibodies for RNPS1 (6 products) 

    RNPS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RNPS1
    Cloud-Clone Corp. CLIAs for RNPS1
    Search eBioscience for ELISAs for RNPS1 
    antibodies-online kits for RNPS1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15287

    ProtoNet protein and cluster: Q15287

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
    Domain: The RRM domain is required for the formation of the ASAP complex
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with RNPS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNPS1_HUMAN, Q15287
    Function: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the
    splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a
    dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors
    that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component
    of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited
    to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific
    transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP
    complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the
    ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54
    and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in
    the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of
    proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
    Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs
    containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds
    spliced mRNA 20-25 nt upstream of exon-exon junctions

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723NOT RNA binding IDA--
    GO:0003730mRNA 3'-UTR binding IDA11546874
    GO:0005515protein binding IPI11477570
         
    Find genes that share ontologies with RNPS1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNPS1:
     Increased cell number in S and 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNPS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNPS1:
    hsa-mir-30c-5p (MIRT047858), hsa-mir-92a-3p (MIRT049704), hsa-mir-342-5p (MIRT038223), hsa-mir-30b-3p (MIRT038651), hsa-mir-1296-5p (MIRT036145), hsa-mir-378a-3p (MIRT043958), hsa-mir-615-3p (MIRT040364), hsa-mir-106b-5p (MIRT044270), hsa-mir-149-5p (MIRT045589)

    Block miRNA regulation of human, mouse, rat RNPS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNPS1 (see all 25):
    hsa-miR-3685 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-548k hsa-miR-548v hsa-miR-1278 hsa-miR-221 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidRNPS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNPS1
    Predesigned siRNA for gene silencing in human, mouse, rat RNPS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNPS1

    Clone
    Products:
         
    OriGene clones in human, mouse for RNPS1 (see all 13)
    OriGene ORF clones in mouse, rat for RNPS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RNPS1 (NM_080594)
    Sino Biological Human cDNA Clone for RNPS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNPS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNPS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNPS1_HUMAN, Q15287: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes
    with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11546874
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11546874
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with RNPS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNPS1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Influenza Viral RNA Transcription and Replication
    Nonsense-Mediated Decay0.89
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    5Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60


    Find genes that share SuperPaths with RNPS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNPS1
        mRNA processing


    5 Reactome Pathways for RNPS1
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    2 Kegg Pathways  (Kegg details for RNPS1):
        RNA transport
    mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNPS1
    Interactions:

        GeneGlobe Interaction Network for RNPS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNPS1 (Q152871, 2, 3 ENSP000003158594) via UniProtKB, MINT, STRING, and/or I2D (see all 360)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50800 I2D: score=4 STRING: ENSP00000306330
    SRPK2P783622, 3, ENSP000003772624MINT-8337904 I2D: score=2 STRING: ENSP00000377262
    SRSF1Q079552, 3, ENSP000002589624MINT-8335594 I2D: score=2 STRING: ENSP00000258962
    SF3A2Q154282, 3, ENSP000002214944MINT-5206268 I2D: score=1 STRING: ENSP00000221494
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IMP--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-templated TAS9580558
    GO:0006366transcription from RNA polymerase II promoter TAS--

    Find genes that share ontologies with RNPS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNPS1

    4 Novoseek inferred chemical compound relationships for RNPS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 58.2 8 16537916 (1), 19061484 (1), 12215544 (1), 10668804 (1) (see all 8)
    serine 57 7 19061484 (1), 12215544 (1), 10668804 (1), 15016823 (1) (see all 6)
    camptothecin 28.4 1 9892183 (1)
    atp 7.23 4 15024032 (1), 14729963 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNPS1 gene (5 alternative transcripts): 
    NM_001286625.1  NM_001286626.1  NM_001286627.1  NM_006711.4  NM_080594.3  

    Unigene Cluster for RNPS1:

    RNA binding protein S1, serine-rich domain
    Hs.355643  [show with all ESTs]
    Unigene Representative Sequence: AK092131
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000397086(uc002cpu.3) ENST00000320225(uc002cpw.3 uc002cpx.3 uc010uwa.2)
    ENST00000566458 ENST00000562205 ENST00000566397 ENST00000565678(uc002cpt.3)
    ENST00000561718 ENST00000568631 ENST00000569598 ENST00000301730 ENST00000567147
    ENST00000565243 ENST00000565870 ENST00000561518 ENST00000564311 ENST00000570051
    ENST00000564601 ENST00000564764
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNPS1 (see all 25):
    hsa-miR-3685 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-548k hsa-miR-548v hsa-miR-1278 hsa-miR-221 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidRNPS1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RNPS1 (NM_080594)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPS1
    Primer
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    OriGene qPCR primer pairs and template standards for RNPS1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNPS1
      QuantiTect SYBR Green Assays in human, mouse, rat RNPS1
      QuantiFast Probe-based Assays in human, mouse, rat RNPS1

    Additional mRNA sequence: 

    AB445101.1 AF015608.1 AF247662.1 AF274003.1 AK091886.1 AK092131.1 AK289955.1 AK293343.1 
    AK303100.1 AK316132.1 BC001659.2 BC001838.2 BC108316.1 L37368.1 

    Selected DOTS entries (see all 45):

    DT.75198118  DT.100881923  DT.97813561  DT.91688578  DT.100045084  DT.100881937  DT.100045088  DT.100881945 
    DT.100881950  DT.100881929  DT.100881943  DT.100881936  DT.101985517  DT.91770560  DT.120673779  DT.100881952 
    DT.100881905  DT.100881925  DT.119658  DT.91957712  DT.100768991  DT.100881930  DT.120673724  DT.91919987 

    Selected AceView cDNA sequences (see all 128):

    CR599280 CR590882 CR594976 CR600795 CR594542 CR593829 NM_080594 CR623779 
    CR608607 AK021799 BC001838 CR607880 CR593506 CR607876 CR626285 AA836956 
    CR626163 CR593509 CR613111 AF274003 AA617951 CR591441 CR605668 NM_006711 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNPS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCAGTC
    RNPS1 Expression
    About this image


    RNPS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Larynx (Respiratory System)
    RNPS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNPS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.355643

    UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNPS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnps11 , 5 ribonucleic acid binding protein S11, 5 89.29(n)1
    100(a)1
      17 (12.39 cM)5
    198261  NM_001080127.11  NP_001073596.11 
     244146755 
    chicken
    (Gallus gallus)
    Aves RNPS11 RNA binding protein S1, serine-rich domain 82.13(n)
    92.4(a)
      416756  XM_004945441.1  XP_004945498.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNPS16
    RNA binding protein S1, serine-rich domain
    86(a)
    1 ↔ 1
    GL343649.1(3755-8654)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.3242 Transcribed sequence with moderate similarity to protein more 75.3(n)    142018711 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa19a112 wufa19a11 70.94(n)   327020  BC057251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RnpS16
    CG343346
    --
    19(a)
    10(a)
    many → 1
    many → 1
    3R(5377765-5379469)
    X(22274648-22277203)
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-56
    Protein RNP-5 (rnp-5) mRNA, complete cds
    21(a)
    1 ↔ 1
    III(852801-853909) WBGene00004388


    ENSEMBL Gene Tree for RNPS1 (if available)
    TreeFam Gene Tree for RNPS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNPS1 gene
    8 SIMAP similar genes for RNPS1 using alignment to 16 protein entries:     RNPS1_HUMAN (see all proteins):
    CIRBP    SRSF5    RBMY1A1    PABPC1    RBMX    SFRS2
    SRSF2    SRSF1

    Find genes that share paralogs with RNPS1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNPS1
    PGOHUM00000262454


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNPS1 (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403719281,2
    --2303744(+) AGCTTA/TCTAGC 2 -- ut310--------
    rs115560711,2
    C,F--2303812(-) GGCCCC/TGGCTG 2 -- ut31 ese34Minor allele frequency- T:0.06WA NA 124
    rs2017445661,2
    --2303933(+) GGTATA/CAGTTA 2 -- ut310--------
    rs1882588911,2
    --2303969(+) TTTATC/TGGGAG 4 Q R mis10--------
    rs1482952041,2
    C--2304002(+) GTGGC-/GGGCGG 4 R PP fra10--------
    rs171358511,2
    C,F--2304058(+) GGGGAG/CCGGGA 4 /R syn1 ese32Minor allele frequency- C:0.36NS NA 190
    rs1605491,2
    C,F--2304108(-) TGCCCC/TTACAG 2 -- int17Minor allele frequency- T:0.14MN NA WA CSA 310
    rs1503012041,2
    --2304130(+) TTCTGA/GGCAAT 2 -- int10--------
    rs1813896781,2
    --2304188(+) CCAGAC/GTGCAG 2 -- int10--------
    rs97969491,2
    C,F,A,H--2304338(+) ATGGGG/ATCTCA 2 -- int116Minor allele frequency- A:0.34NS EA NA 1980

    HapMap Linkage Disequilibrium report for RNPS1 (2303100 - 2318413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNPS1 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    nsv905139CNV Loss21882294
    dgv2540n71CNV Loss21882294
    dgv2567n71CNV Loss21882294
    nsv471072CNV Loss18288195
    nsv905132CNV Loss21882294
    nsv457353CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606447    OMIM disorders: --

    3 diseases for RNPS1:    
    About MalaCards
    tuberous sclerosis, type 2    acinar cell carcinoma    polycystic kidney disease, type 1

    1 disease from the University of Copenhagen DISEASES database for RNPS1:
    Acinar cell carcinoma

    Find genes that share disorders with RNPS1           About GenesLikeMe

    Genetic Association Database (GAD): RNPS1

    Export disorders for RNPS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNPS1 gene, integrated from 10 sources (see all 139):
    (articles sorted by number of sources associating them with RNPS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinases in vivo. (PubMed id 9580558)1, 2, 3 Loyer P.... Kidd V.J. (J. Cell Sci. 1998)
    2. Identification and characterisation of a novel human RNA-binding protein. (PubMed id 8543184)1, 2, 3 Badolato J.... Eisman J. (Gene 1995)
    3. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PubMed id 15684395)1, 2, 9 Trembley J.H.... Mayeda A. (Mol. Cell. Biol. 2005)
    4. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 2, 9 Sakashita E.... Mayeda A. (Mol. Cell. Biol. 2004)
    5. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. (PubMed id 10449421)1, 2, 9 Mayeda A....Krainer A.R. (EMBO J. 1999)
    6. Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. (PubMed id 11477570)1, 2, 9 Harada K.... Shichijo S. (Int. J. Cancer 2001)
    7. Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. (PubMed id 14517304)1, 2, 9 Li C.... Tarn W.-Y. (Mol. Cell. Biol. 2003)
    8. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. (PubMed id 11546874)1, 2, 9 Lykke-Andersen J.... Steitz J.A. (Science 2001)
    9. Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. (PubMed id 14752011)1, 2, 9 Nott A.... Moore M.J. (Genes Dev. 2004)
    10. A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. (PubMed id 14625303)1, 2, 9 Kataoka N. and Dreyfuss G. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10921 HGNC: 10080 AceView: RNPS1 Ensembl:ENSG00000205937 euGenes: HUgn10921
    ECgene: RNPS1 Kegg: 10921 H-InvDB: RNPS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNPS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNPS1 gene:
    Search GeneIP for patents involving RNPS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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