Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNPS1 Gene

protein-coding   GIFtS: 59
GCID: GC16M002303

RNA Binding Protein S1, Serine-Rich Domain

(Previous names: RNA-binding protein S1, serine-rich domain)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RNA Binding Protein S1, Serine-Rich Domain1 2     RNA-Binding Protein With Serine-Rich Domain 12
RNA-Binding Protein S1, Serine-Rich Domain1 2     SR Protein2
SR-Related Protein LDC22 3     LDC23
E5.12     

External Ids:    HGNC: 100801   Entrez Gene: 109212   Ensembl: ENSG000002059377   OMIM: 6064475   UniProtKB: Q152873   

Export aliases for RNPS1 gene to outside databases

Previous GC identifers: GC16P002468 GC16M002328 GC16M002244 GC16M002245 GC16M002246 GC16M002168 GC16M002247 GC16M002230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNPS1 Gene:
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear
export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and
initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction,
this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains
bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine
residues. Two splice variants have been found for this gene; both variants encode the same protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNPS1 Gene: 
RNPS1 (RNA binding protein S1, serine-rich domain) is a protein-coding gene. Diseases associated with RNPS1 include polycystic kidney disease, type 1, and acinar cell carcinoma, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding.

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of
the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with
SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.
Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs
containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds
spliced mRNA 20-25 nt upstream of exon-exon junctions

Gene Wiki entry for RNPS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNPS1 gene promoter:
         CREB   p53   COMP1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNPS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNPS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RNPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPS1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002303:  view genomic region     (about GC identifiers)

Start:
2,303,100 bp from pter      End:
2,318,413 bp from pter
Size:
15,314 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287 (See protein sequence)
Recommended Name: RNA-binding protein with serine-rich domain 1  
Size: 305 amino acids; 34208 Da
Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3,
EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Forms heterodimers with ACIN1. Found in a
heterotrimeric complex with ACIN1, RNPS1 and SAP18. Component of the active spliceosome. Associates with
polysomes. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and
ALYREF/THOC4. Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts
with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes
with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
1 PDB 3D structure from and Proteopedia for RNPS1:
4A8X (3D)    
Secondary accessions: A8K1P0 B4DDU8 B4DZU7 B7ZA17 O75308 Q32P25 Q8WY42 Q9NYG3
Alternative splicing: 3 isoforms:  Q15287-1   Q15287-2   Q15287-3   

Explore the universe of human proteins at neXtProt for RNPS1: NX_Q15287

Explore proteomics data for RNPS1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53
    phosphorylation site is important for splicing and translation stimulation activity in vitro
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15287

  • RNPS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNPS1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006702.1  NP_542161.1  

    ENSEMBL proteins: 
     ENSP00000380275   ENSP00000315859   ENSP00000456352   ENSP00000455379   ENSP00000457723  
     ENSP00000455306   ENSP00000457820   ENSP00000457987   ENSP00000301730   ENSP00000454513  
     ENSP00000457110   ENSP00000454461   ENSP00000455013   ENSP00000457690   ENSP00000457378  
     ENSP00000457618   ENSP00000457296   ENSP00000455195   ENSP00000454867   ENSP00000457338  
     ENSP00000456283  
    Reactome Protein details: Q15287
    Human Recombinant Protein Products for RNPS1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for RNPS1
    OriGene Protein Over-expression Lysate for RNPS1
    OriGene MassSpec for RNPS1 
    OriGene Custom Protein Services for RNPS1
    GenScript Custom Purified and Recombinant Proteins Services for RNPS1
    Novus Biologicals RNPS1 Proteins
    Novus Biologicals RNPS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPS1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11546874
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA11546874
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--

    RNPS1 for ontologies           About GeneDecksing



    RNPS1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNPS1
    GenScript Custom Superior Antibodies Services for RNPS1
    Novus Biologicals RNPS1 Antibodies
    Abcam antibodies for RNPS1
    Cloud-Clone Corp. Antibodies for RNPS1 
    Search ThermoFisher Antibodies for RNPS1
    LSBio Antibodies in human, mouse, rat for RNPS1 

    Assay Products for RNPS1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNPS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNPS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNPS1 
    Cloud-Clone Corp. CLIAs for RNPS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q15287

    ProtoNet protein and cluster: Q15287

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    RNPS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNPS1_HUMAN, Q15287
    Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
    on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
    and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
    subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of
    the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with
    SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.
    Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs
    containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds
    spliced mRNA 20-25 nt upstream of exon-exon junctions

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9580558
    GO:0003730mRNA 3'-UTR binding IDA11546874
    GO:0005515protein binding IPI11477570
         
    RNPS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNPS1:
     Increased cell number in S and 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNPS1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNPS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNPS1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNPS1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPS1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPS1 (see all 25):
    hsa-miR-3685 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-548k hsa-miR-548v hsa-miR-1278 hsa-miR-221 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidRNPS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNPS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNPS1
    Sirion Biotech Customized adenovirus for overexpression of RNPS1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RNPS1 (see all 14)
    OriGene ORF clones in mouse, rat for RNPS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RNPS1 (NM_080594)
    Sino Biological Human cDNA Clone for RNPS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPS1
    Sirion Biotech Customized lentivirus for stable overexpression of RNPS1 
                         Customized lentivirus expression plasmids for stable overexpression of RNPS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNPS1
    Search LifeMap BioReagents cell lines for RNPS1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPS1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNPS1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    5Viral mRNA Translation
    Nonsense-Mediated Decay0.84
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNPS1
        mRNA processing


    5/18        Reactome Pathways for RNPS1 (see all 18)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Nonsense-Mediated Decay
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    2         Kegg Pathways  (Kegg details for RNPS1):
        RNA transport
    mRNA surveillance pathway


    RNPS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNPS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/308 Interacting proteins for RNPS1 (Q152871, 2, 3 ENSP000003158594) via UniProtKB, MINT, STRING, and/or I2D (see all 308)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50800 I2D: score=4 STRING: ENSP00000306330
    SRPK2P783622, 3, ENSP000003772624MINT-8337904 I2D: score=2 STRING: ENSP00000377262
    SRSF1Q079552, 3, ENSP000002589624MINT-8335594 I2D: score=2 STRING: ENSP00000258962
    SF3A2Q154282, 3, ENSP000002214944MINT-5206268 I2D: score=1 STRING: ENSP00000221494
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006351transcription, DNA-dependent TAS9580558
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    RNPS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNPS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNPS1

    4 Novoseek inferred chemical compound relationships for RNPS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 58.2 8 16537916 (1), 19061484 (1), 12215544 (1), 10668804 (1) (see all 8)
    serine 57 7 19061484 (1), 12215544 (1), 10668804 (1), 15016823 (1) (see all 6)
    camptothecin 28.4 1 9892183 (1)
    atp 7.23 4 15024032 (1), 14729963 (1)

    Search CenterWatch for drugs/clinical trials and news about RNPS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNPS1 gene (2 alternative transcripts): 
    NM_006711.3  NM_080594.2  

    Unigene Clusters for RNPS1:

    RNA binding protein S1, serine-rich domain
    Hs.355643  [show with all ESTs], Hs.733012  [show with all ESTs]
    Unigene Representative Sequences: AK092131, AK021799
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000397086(uc002cpu.3) ENST00000320225(uc002cpw.3 uc002cpx.3 uc010uwa.2)
    ENST00000566458 ENST00000562205 ENST00000566397 ENST00000565678(uc002cpt.3)
    ENST00000561718 ENST00000568631 ENST00000569598 ENST00000301730 ENST00000567147
    ENST00000565243 ENST00000565870 ENST00000561518 ENST00000564311 ENST00000570051
    ENST00000564601 ENST00000564764
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPS1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPS1 (see all 25):
    hsa-miR-3685 hsa-miR-520d-5p hsa-miR-4272 hsa-miR-548k hsa-miR-548v hsa-miR-1278 hsa-miR-221 hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidRNPS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNPS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPS1
    Clone
    Products:
         
    OriGene clones in human, mouse for RNPS1 (see all 14)
    OriGene ORF clones in mouse, rat for RNPS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RNPS1 (NM_080594)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPS1
    Sirion Biotech Customized lentivirus for stable overexpression of RNPS1 
                         Customized lentivirus expression plasmids for stable overexpression of RNPS1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNPS1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNPS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPS1

    Additional mRNA sequence: AK021799.1 

    24/48 DOTS entries (see all 48):

    DT.75198118  DT.100881923  DT.97813561  DT.91688578  DT.100045084  DT.100881937  DT.100045088  DT.100881945 
    DT.100881950  DT.91957712  DT.100881929  DT.100881943  DT.100881936  DT.101985517  DT.91770560  DT.97862610 
    DT.100881952  DT.120673779  DT.119658  DT.120673740  DT.100881905  DT.100881925  DT.100045085  DT.100768991 

    24/128 AceView cDNA sequences (see all 128):

    AA617951 AF274003 CR598454 CR591441 CR594976 CR617328 AK021799 NM_006711 
    CR607342 CR626285 BC001838 CR599280 CR613111 CR615513 CR610866 CR607880 
    CR590882 AA836956 CR593509 CR593506 CR600795 CR605668 CR594542 CR593829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNPS1 expression in normal human tissues (normalized intensities)      RNPS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGCAGTC
    RNPS1 Expression
    About this image


    RNPS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Larynx (Respiratory System)

    See RNPS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNPS1

    SOURCE GeneReport for Unigene clusters: Hs.355643 Hs.733012

    UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for RNPS1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNPS1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPS1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNPS1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPS1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNPS1 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnps11 , 5 ribonucleic acid binding protein S11, 5 89.29(n)1
    100(a)1
      17 (12.39 cM)5
    198261  NM_001080127.11  NP_001073596.11 
     244146755 
    chicken
    (Gallus gallus)
    Aves RNPS11 RNA binding protein S1, serine-rich domain 81.73(n)
    96.09(a)
      416756  XM_415051.3  XP_415051.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNPS16
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343649.1(3755-8654)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.3242 Transcribed sequence with moderate similarity to protein more 75.3(n)    142018711 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa19a112 wufa19a11 70.94(n)   327020  BC057251.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RnpS11 RNA-binding protein S1 46.01(n)
    46.83(a)
      41147  NM_141646.1  NP_649903.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnp-51 Protein RNP-5 46.69(n)
    48.58(a)
      175244  NM_064875.6  NP_497276.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SR451 protein arginine/serine-rich 45 48.08(n)
    46.02(a)
      838230  NM_001198085.1  NP_001185014.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01059001 hypothetical protein 49.22(n)
    46.11(a)
      4337561  NM_001060949.1  NP_001054414.2 


    ENSEMBL Gene Tree for RNPS1 (if available)
    TreeFam Gene Tree for RNPS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNPS1 gene
    8 SIMAP similar genes for RNPS1 using alignment to 16 protein entries:     RNPS1_HUMAN (see all proteins):
    CIRBP    SRSF5    RBMY1A1    PABPC1    RBMX    SRSF2
    SFRS2    SRSF1

    RNPS1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNPS1
    PGOHUM00000262454


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/380 SNPs in RNPS1 are shown (see all 380)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403719281,2
    --2303744(+) AGCTTA/TCTAGC 2 -- ut310--------
    rs115560711,2
    C,F--2303812(-) GGCCCC/TGGCTG 2 -- ut31 ese34Minor allele frequency- T:0.06WA NA 124
    rs2017445661,2
    --2303933(+) GGTATA/CAGTTA 2 -- ut310--------
    rs1882588911,2
    --2303969(+) TTTATC/TGGGAG 4 Q R mis10--------
    rs1482952041,2
    C--2304002(+) GTGGC-/GGGCGG 4 R PP fra10--------
    rs171358511,2
    C,F--2304058(+) GGGGAG/CCGGGA 4 /R syn1 ese32Minor allele frequency- C:0.36NS NA 190
    rs1605491,2
    C,F--2304108(-) TGCCCC/TTACAG 2 -- int17Minor allele frequency- T:0.14MN NA WA CSA 310
    rs1503012041,2
    --2304130(+) TTCTGA/GGCAAT 2 -- int10--------
    rs1813896781,2
    --2304188(+) CCAGAC/GTGCAG 2 -- int10--------
    rs97969491,2
    C,F,A,H--2304338(+) ATGGGG/ATCTCA 2 -- int116Minor allele frequency- A:0.34NS EA NA 1980

    HapMap Linkage Disequilibrium report for RNPS1 (2303100 - 2318413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for RNPS1 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    nsv905139CNV Loss21882294
    dgv2540n71CNV Loss21882294
    dgv2567n71CNV Loss21882294
    nsv471072CNV Loss18288195
    nsv905132CNV Loss21882294
    nsv457353CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNPS1
    DNA2.0 Custom Variant and Variant Library Synthesis for RNPS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606447    OMIM disorders: --

    11 diseases for RNPS1:    About MalaCards
    polycystic kidney disease, type 1    acinar cell carcinoma    tuberous sclerosis    primary open angle glaucoma
    open-angle glaucoma    mucoepidermoid carcinoma    glaucoma    polycystic kidney disease
    kidney disease    systemic lupus erythematosus    lupus erythematosus

    1 disease from the University of Copenhagen DISEASES database for RNPS1:
    Acinar cell carcinoma

    RNPS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNPS1

    Export disorders for RNPS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNPS1 gene, integrated from 9 sources (see all 133):
    (articles sorted by number of sources associating them with RNPS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinases in vivo. (PubMed id 9580558)1, 2, 3 Loyer P.... Kidd V.J. (1998)
    2. Identification and characterisation of a novel human RNA-binding protein. (PubMed id 8543184)1, 2, 3 Badolato J.... Eisman J. (1995)
    3. Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PubMed id 15684395)1, 2, 9 Trembley J.H.... Mayeda A. (2005)
    4. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 2, 9 Sakashita E.... Mayeda A. (2004)
    5. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. (PubMed id 10449421)1, 2, 9 Mayeda A....Krainer A.R. (1999)
    6. Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. (PubMed id 11477570)1, 2, 9 Harada K.... Shichijo S. (2001)
    7. Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. (PubMed id 14517304)1, 2, 9 Li C.... Tarn W.-Y. (2003)
    8. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. (PubMed id 11546874)1, 2, 9 Lykke-Andersen J.... Steitz J.A. (2001)
    9. Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. (PubMed id 14752011)1, 2, 9 Nott A.... Moore M.J. (2004)
    10. A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. (PubMed id 14625303)1, 2, 9 Kataoka N. and Dreyfuss G. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10921 HGNC: 10080 AceView: RNPS1 Ensembl:ENSG00000205937 euGenes: HUgn10921
    ECgene: RNPS1 Kegg: 10921 H-InvDB: RNPS1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNPS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNPS1 gene:
    Search GeneIP for patents involving RNPS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNPS1  
     OriGene qPCR primer pairs and template standards for RNPS1   OriGene Protein Over-expression Lysate for RNPS1  
     OriGene MassSpec something-or-other for RNPS1   OriGene clones in human, mouse for RNPS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNPS1   OriGene Purified Protein for RNPS1  
     OriGene ORF clones in mouse, rat for RNPS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNPS1   OriGene Custom Protein Services for RNPS1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNPS1
     QIAGEN SeqTarget long-range PCR primers for resequencing RNPS1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPS1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPS1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPS1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPS1
     GenScript Custom Purified and Recombinant Proteins Services for RNPS1 GenScript cDNA clones with any tag delivered in your preferred vector for RNPS1
     GenScript Custom Assay Services for RNPS1 GenScript Custom Superior Antibodies Services for RNPS1
     GenScript Custom overexpressing Cell Line Services for RNPS1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNPS1 promoter
     Search Chromatin IP Primers for RNPS1
     RT2 qPCR Primer Assay in human, mouse / rat RNPS1
     GNC Network for RNPS1
     SABiosciences Custom PCR Arrays for RNPS1
     Search Tocris compounds for RNPS1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RNPS1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RNPS1 antibodies
     RNPS1 proteins
     RNPS1 lysates
     Antibodies for RNPS1
     See all of Abcam's Antibodies, Kits and Proteins for RNPS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RNPS1
     Antibodies for RNPS1
     ELISAs for RNPS1
     CLIAs for RNPS1
     Search LifeMap BioReagents cell lines for RNPS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPS1
     SwitchGear 3'UTR luciferase reporter plasmids for RNPS1
     SwitchGear Promoter luciferase reporter plasmids for RNPS1
     Search ThermoFisher Antibodies for RNPS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPS1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RNPS1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNPS1
    Customized:
     lentivirus for stable overexpression of RNPS1
     lentivirus expression plasmids for stable overexpression of RNPS1
     adenovirus for overexpression of RNPS1
     LSBio Antibodies in human, mouse, rat for RNPS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNPS1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4