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Aliases for RNPS1 Gene

Aliases for RNPS1 Gene

  • RNA Binding Protein S1, Serine-Rich Domain 2 3
  • RNA-Binding Protein S1, Serine-Rich Domain 2 3
  • SR-Related Protein LDC2 3 4
  • RNA-Binding Protein With Serine-Rich Domain 1 3
  • SR Protein 3
  • E5.1 3
  • LDC2 4

External Ids for RNPS1 Gene

Summaries for RNPS1 Gene

Entrez Gene Summary for RNPS1 Gene

  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for RNPS1 Gene

RNPS1 (RNA Binding Protein S1, Serine-Rich Domain) is a Protein Coding gene. Diseases associated with RNPS1 include acinar cell carcinoma. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include RNA binding and mRNA 3-UTR binding.

UniProtKB/Swiss-Prot for RNPS1 Gene

  • Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.

Gene Wiki entry for RNPS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNPS1 Gene

Genomics for RNPS1 Gene

Genomic Location for RNPS1 Gene

Start:
2,253,116 bp from pter
End:
2,268,412 bp from pter
Size:
15,297 bases
Orientation:
Minus strand

Genomic View for RNPS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNPS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNPS1 Gene

Regulatory Elements for RNPS1 Gene

Proteins for RNPS1 Gene

  • Protein details for RNPS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15287-RNPS1_HUMAN
    Recommended name:
    RNA-binding protein with serine-rich domain 1
    Protein Accession:
    Q15287
    Secondary Accessions:
    • A8K1P0
    • B4DDU8
    • B4DZU7
    • B7ZA17
    • O75308
    • Q32P25
    • Q8WY42
    • Q9NYG3

    Protein attributes for RNPS1 Gene

    Size:
    305 amino acids
    Molecular mass:
    34208 Da
    Quaternary structure:
    • Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.

    Three dimensional structures from OCA and Proteopedia for RNPS1 Gene

    Alternative splice isoforms for RNPS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNPS1 Gene

Proteomics data for RNPS1 Gene at MOPED

Post-translational modifications for RNPS1 Gene

  • Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys203

No data available for DME Specific Peptides for RNPS1 Gene

Domains for RNPS1 Gene

Gene Families for RNPS1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RNPS1 Gene

UniProtKB/Swiss-Prot:

RNPS1_HUMAN
Domain:
  • The RRM domain is required for the formation of the ASAP complex:
    • Q15287
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q15287
Family:
  • Belongs to the splicing factor SR family.:
    • Q15287
genes like me logo Genes that share domains with RNPS1: view

Function for RNPS1 Gene

Molecular function for RNPS1 Gene

UniProtKB/Swiss-Prot Function: Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.

Gene Ontology (GO) - Molecular Function for RNPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 NOT RNA binding IDA 22388736
GO:0003730 mRNA 3-UTR binding IDA 11546874
GO:0005515 protein binding IPI 11477570
genes like me logo Genes that share ontologies with RNPS1: view

Phenotypes for RNPS1 Gene

GenomeRNAi human phenotypes for RNPS1:
genes like me logo Genes that share phenotypes with RNPS1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNPS1 Gene

Localization for RNPS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNPS1 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNPS1 Gene COMPARTMENTS Subcellular localization image for RNPS1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for RNPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11546874
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11546874
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with RNPS1: view

Pathways for RNPS1 Gene

genes like me logo Genes that share pathways with RNPS1: view

Gene Ontology (GO) - Biological Process for RNPS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 22203037
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated TAS 9580558
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with RNPS1: view

Compounds for RNPS1 Gene

(4) Novoseek inferred chemical compound relationships for RNPS1 Gene

Compound -log(P) Hits PubMed IDs
arginine 58.2 8
serine 57 6
camptothecin 28.4 1
atp 7.23 2
genes like me logo Genes that share compounds with RNPS1: view

Transcripts for RNPS1 Gene

Unigene Clusters for RNPS1 Gene

RNA binding protein S1, serine-rich domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNPS1 Gene

No ASD Table

Relevant External Links for RNPS1 Gene

GeneLoc Exon Structure for
RNPS1
ECgene alternative splicing isoforms for
RNPS1

Expression for RNPS1 Gene

mRNA expression in normal human tissues for RNPS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNPS1 Gene

SOURCE GeneReport for Unigene cluster for RNPS1 Gene Hs.355643

mRNA Expression by UniProt/SwissProt for RNPS1 Gene

Q15287-RNPS1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with RNPS1: view

Orthologs for RNPS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNPS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNPS1 36
  • 99.67 (n)
  • 99.67 (a)
RNPS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNPS1 36
  • 89.62 (n)
  • 99.34 (a)
RNPS1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNPS1 36
  • 92.57 (n)
  • 100 (a)
RNPS1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnps1 36
  • 89.29 (n)
  • 100 (a)
Rnps1 16
Rnps1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNPS1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNPS1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnps1 36
  • 88.85 (n)
  • 99.67 (a)
chicken
(Gallus gallus)
Aves RNPS1 36
  • 82.13 (n)
  • 92.4 (a)
RNPS1 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNPS1 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnps1 36
  • 63.41 (n)
  • 74.88 (a)
Str.324 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13826 36
zebrafish
(Danio rerio)
Actinopterygii rnps1 36
  • 63.85 (n)
  • 70.89 (a)
rnps1 37
  • 79 (a)
OneToOne
wufa19a11 36
fruit fly
(Drosophila melanogaster)
Insecta CG34334 37
  • 10 (a)
OneToMany
RnpS1 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnp-5 37
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2775 37
  • 29 (a)
OneToOne
Species with no ortholog for RNPS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNPS1 Gene

ENSEMBL:
Gene Tree for RNPS1 (if available)
TreeFam:
Gene Tree for RNPS1 (if available)

Paralogs for RNPS1 Gene

Pseudogenes.org Pseudogenes for RNPS1 Gene

genes like me logo Genes that share paralogs with RNPS1: view

No data available for Paralogs for RNPS1 Gene

Variants for RNPS1 Gene

Sequence variations from dbSNP and Humsavar for RNPS1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs40342 -- 2,263,342(-) GAGGC(A/G)TCTGT intron-variant
rs150930 -- 2,256,007(-) gctgg(G/T)actat intron-variant
rs155242 -- 2,255,531(-) TGACC(A/G)CAGTG intron-variant
rs155243 -- 2,255,538(-) CCTCA(C/T)GTGAC intron-variant
rs155244 -- 2,256,811(-) GAACT(G/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNPS1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2557n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv457351 CNV Loss 19166990
nsv905132 CNV Loss 21882294
nsv905139 CNV Loss 21882294
dgv2567n71 CNV Loss 21882294
nsv905142 CNV Loss 21882294
nsv457353 CNV Loss 19166990
dgv2568n71 CNV Loss 21882294
nsv905144 CNV Gain 21882294

Relevant External Links for RNPS1 Gene

HapMap Linkage Disequilibrium report
RNPS1

Disorders for RNPS1 Gene

(1) MalaCards Diseases for RNPS1 Gene

Search for RNPS1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RNPS1 Gene

Relevant External Links for RNPS1

Genetic Association Database (GAD)
RNPS1
genes like me logo Genes that share disorders with RNPS1: view

No data available for UniProtKB/Swiss-Prot for RNPS1 Gene

Publications for RNPS1 Gene

  1. Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. (PMID: 10449421) Mayeda A. … Krainer A.R. (EMBO J. 1999) 3 4 23
  2. Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. (PMID: 11477570) Harada K. … Shichijo S. (Int. J. Cancer 2001) 3 4 23
  3. Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. (PMID: 11546874) Lykke-Andersen J. … Steitz J.A. (Science 2001) 3 4 23
  4. A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. (PMID: 14625303) Kataoka N. … Dreyfuss G. (J. Biol. Chem. 2004) 3 4 23
  5. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E. … Mayeda A. (Mol. Cell. Biol. 2004) 3 4 23

Products for RNPS1 Gene

Sources for RNPS1 Gene

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