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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNPS1 Gene

protein-coding GIFtS: 59
GCID: GC16M002303

RNA Binding Protein S1, Serine-Rich Domain

(Previous names: RNA-binding protein S1, serine-rich domain)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RNA Binding Protein S1, Serine-Rich Domain¹ ²		RNA-Binding Protein With Serine-Rich Domain 1²
RNA-Binding Protein S1, Serine-Rich Domain¹ ²		SR Protein²
SR-Related Protein LDC2² ³		LDC2³
E5.1²

External Ids:	HGNC: 10080¹	Entrez Gene: 10921²	Ensembl: ENSG00000205937⁷	OMIM: 606447⁵	UniProtKB: Q15287³

Export aliases for RNPS1 gene to outside databases

Previous GC identifers: GC16P002468 GC16M002328 GC16M002244 GC16M002245 GC16M002246 GC16M002168 GC16M002247 GC16M002230

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNPS1 Gene:

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear

export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and

initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction,

this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains

bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine

residues. Two splice variants have been found for this gene; both variants encode the same protein. (provided by

RefSeq, Jul 2008)

GeneCards Summary for RNPS1 Gene:

RNPS1 (RNA binding protein S1, serine-rich domain) is a protein-coding gene. Diseases associated with RNPS1 include polycystic kidney disease, type 1, and acinar cell carcinoma, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding.

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287

Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction

on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear

and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during

subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of

the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with

SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner.

Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs

containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds

spliced mRNA 20-25 nt upstream of exon-exon junctions

Gene Wiki entry for RNPS1 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NT_010393.16 NC_018927.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNPS1 gene promoter:
CREB p53 COMP1 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNPS1 promoter sequence

Search SABiosciences Chromatin IP Primers for RNPS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RNPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPS1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002303: view genomic region (about GC identifiers)

Start:	2,303,100 bp from pter	End:	2,318,413 bp from pter
Size:	15,314 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287 (See protein sequence)

Recommended Name: RNA-binding protein with serine-rich domain 1

Size: 305 amino acids; 34208 Da

Subunit: Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3,

EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and ALYREF/THOC4. Forms heterodimers with ACIN1. Found in a

heterotrimeric complex with ACIN1, RNPS1 and SAP18. Component of the active spliceosome. Associates with

polysomes. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and

ALYREF/THOC4. Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Interacts

with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10

Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes

with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles

1 PDB 3D structure from and Proteopedia for RNPS1:

4A8X (3D)

Secondary accessions: A8K1P0 B4DDU8 B4DZU7 B7ZA17 O75308 Q32P25 Q8WY42 Q9NYG3

Alternative splicing: 3 isoforms: Q15287-1 Q15287-2 Q15287-3

Explore the universe of human proteins at neXtProt for RNPS1: NX_Q15287

Explore proteomics data for RNPS1 at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53

phosphorylation site is important for splicing and translation stimulation activity in vitro

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q15287

RNPS1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_006702.1 NP_542161.1

ENSEMBL proteins:

ENSP00000380275 ENSP00000315859 ENSP00000456352 ENSP00000455379 ENSP00000457723

ENSP00000455306 ENSP00000457820 ENSP00000457987 ENSP00000301730 ENSP00000454513

ENSP00000457110 ENSP00000454461 ENSP00000455013 ENSP00000457690 ENSP00000457378

ENSP00000457618 ENSP00000457296 ENSP00000455195 ENSP00000454867 ENSP00000457338

ENSP00000456283

Reactome Protein details: Q15287
Human Recombinant Protein Products for RNPS1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for RNPS1 OriGene Protein Over-expression Lysate for RNPS1 OriGene MassSpec for RNPS1 OriGene Custom Protein Services for RNPS1
	GenScript Custom Purified and Recombinant Proteins Services for RNPS1
	Novus Biologicals RNPS1 Proteins Novus Biologicals RNPS1 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RNPS1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11546874
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	11546874
GO:0005829	cytosol	TAS	--
GO:0016607	nuclear speck	IEA	--

RNPS1 for ontologies About GeneDecksing

RNPS1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RNPS1
	GenScript Custom Superior Antibodies Services for RNPS1
	Novus Biologicals RNPS1 Antibodies
	Abcam antibodies for RNPS1
	Cloud-Clone Corp. Antibodies for RNPS1
	Search ThermoFisher Antibodies for RNPS1
	LSBio Antibodies in human, mouse, rat for RNPS1

Assay Products for RNPS1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RNPS1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNPS1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RNPS1 Cloud-Clone Corp. CLIAs for RNPS1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

RBM: RNA binding motif (RRM) containing

2 InterPro protein domains:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q15287

ProtoNet protein and cluster: Q15287

1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: RNPS1_HUMAN, Q15287

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 1 RRM (RNA recognition motif) domain

RNPS1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RNPS1_HUMAN, Q15287