Aliases for RNPS1 Gene
Aliases for RNPS1 Gene
External Ids for RNPS1 Gene
- HGNC: 10080
- Entrez Gene: 10921
- Ensembl: ENSG00000205937
- OMIM: 606447
- UniProtKB: Q15287
Previous GeneCards Identifiers for RNPS1 Gene
- GC16P002468
- GC16M002328
- GC16M002244
- GC16M002245
- GC16M002246
- GC16M002168
- GC16M002247
- GC16M002303
- GC16M002230
Summaries for RNPS1 Gene
-
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for RNPS1 Gene
RNPS1 (RNA Binding Protein With Serine Rich Domain 1) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding.
UniProtKB/Swiss-Prot for RNPS1 Gene
-
Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNPS1 Gene
Genomics for RNPS1 Gene
Regulatory Elements for RNPS1 Gene
Enhancers for RNPS1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RNPS1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RNPS1 gene promoter:
Regulatory Element Products
Genomic Location for RNPS1 Gene
- Chromosome:
- 16
- Start:
- 2,253,116 bp from pter
- End:
- 2,268,412 bp from pter
- Size:
- 15,297 bases
- Orientation:
- Minus strand
Genomic View for RNPS1 Gene
Genes around RNPS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
RNPS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNPS1 Gene
Proteins for RNPS1 Gene
-
Protein details for RNPS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15287-RNPS1_HUMAN
- Recommended name:
- RNA-binding protein with serine-rich domain 1
- Protein Accession:
- Q15287
- A8K1P0
- B4DDU8
- B4DZU7
- B7ZA17
- O75308
- Q32P25
- Q8WY42
- Q9NYG3
Protein attributes for RNPS1 Gene
- Size:
- 305 amino acids
- Molecular mass:
- 34208 Da
- Quaternary structure:
-
- Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.
Protein Expression for RNPS1 Gene
Post-translational modifications for RNPS1 Gene
- Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
- Ubiquitination at Lys 203
- Modification sites at PhosphoSitePlus
Other Protein References for RNPS1 Gene
- ENSEMBL proteins:
-
- ENSP00000315859
- ENSP00000380275
- ENSP00000454461
- ENSP00000454513
- ENSP00000454867
- ENSP00000455013
- ENSP00000455195
- ENSP00000455306
- ENSP00000455379
- ENSP00000456283
- ENSP00000456352
- ENSP00000457110
- ENSP00000457296
- ENSP00000457338
- ENSP00000457378
- ENSP00000457618
- ENSP00000457690
- ENSP00000457723
- ENSP00000457820
- ENSP00000457987
- ENSP00000301730
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RNPS1
- Invitrogen Antibodies for RNPS1
- antibodies-online Antibodies for RNPS1: See all 10
- GeneTex RNPS1 antibody for RNPS1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RNPS1
- Origene Custom Protein Services for RNPS1
- antibodies-online Proteins for RNPS1: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RNPS1
Assay Products
- antibodies-online Kits for RNPS1: See all 4
No data available for DME Specific Peptides for RNPS1 Gene
Domains & Families for RNPS1 Gene
Gene Families for RNPS1 Gene
Protein Domains for RNPS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNPS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15287UniProtKB/Swiss-Prot:
RNPS1_HUMAN :- The RRM domain is required for the formation of the ASAP complex.
- Belongs to the splicing factor SR family.
- Domain:
-
- The RRM domain is required for the formation of the ASAP complex.
- Contains 1 RRM (RNA recognition motif) domain.
- Family:
-
- Belongs to the splicing factor SR family.
Function for RNPS1 Gene
Molecular function for RNPS1 Gene
- UniProtKB/Swiss-Prot Function:
- Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | NOT RNA binding | IDA,TAS | 22388736 |
| GO:0003730 | mRNA 3-UTR binding | IDA | 11546874 |
| GO:0005515 | protein binding | IPI | 11477570 |
Phenotypes for RNPS1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RNPS1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RNPS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNPS1 gene
- Search ViGene Biosciences for RNPS1
CRISPR Products
-
OriGene CRISPR knockouts for RNPS1
- GenScript: Design CRISPR guide RNA sequences for RNPS1
miRNA for RNPS1 Gene
- miRTarBase miRNAs that target RNPS1
-
- hsa-mir-1296-5p (MIRT036145)
- hsa-mir-342-5p (MIRT038223)
- hsa-mir-30b-3p (MIRT038651)
- hsa-mir-615-3p (MIRT040364)
- hsa-mir-378a-3p (MIRT043958)
- hsa-mir-106b-5p (MIRT044270)
- hsa-mir-149-5p (MIRT045589)
- hsa-mir-30c-5p (MIRT047858)
- hsa-mir-92a-3p (MIRT049704)
- hsa-mir-3163 (MIRT283249)
- hsa-mir-218-5p (MIRT439752)
- hsa-mir-7151-3p (MIRT468982)
- hsa-mir-5095 (MIRT468983)
- hsa-mir-6742-5p (MIRT468984)
- hsa-mir-92a-2-5p (MIRT468985)
- hsa-mir-4483 (MIRT468986)
- hsa-mir-1293 (MIRT468987)
- hsa-mir-6766-5p (MIRT468988)
- hsa-mir-6756-5p (MIRT468989)
- hsa-mir-6745 (MIRT468990)
- hsa-mir-363-5p (MIRT468991)
- hsa-mir-6729-5p (MIRT468992)
- hsa-mir-6881-5p (MIRT468993)
- hsa-mir-4649-5p (MIRT468994)
- hsa-mir-5589-5p (MIRT468995)
- hsa-mir-4487 (MIRT468996)
- hsa-mir-558 (MIRT468997)
- hsa-mir-3160-3p (MIRT468998)
- hsa-mir-6776-5p (MIRT468999)
- hsa-mir-524-5p (MIRT546708)
- hsa-mir-520d-5p (MIRT546709)
- hsa-mir-548v (MIRT546710)
- hsa-mir-187-5p (MIRT546711)
- hsa-mir-1283 (MIRT546712)
- hsa-mir-888-5p (MIRT546713)
- hsa-mir-548m (MIRT546714)
- hsa-mir-5582-3p (MIRT546715)
- hsa-mir-3662 (MIRT546716)
- hsa-mir-548f-3p (MIRT546717)
- hsa-mir-548e-3p (MIRT546718)
- hsa-mir-548az-3p (MIRT546719)
- hsa-mir-548ar-3p (MIRT546720)
- hsa-mir-548a-3p (MIRT546721)
- hsa-mir-221-3p (MIRT546722)
- hsa-mir-222-3p (MIRT546723)
- hsa-mir-539-5p (MIRT560145)
- hsa-mir-616-5p (MIRT560146)
- hsa-mir-373-5p (MIRT560147)
- hsa-mir-371b-5p (MIRT560148)
- hsa-mir-1278 (MIRT560149)
- hsa-mir-888-3p (MIRT560150)
- hsa-mir-590-3p (MIRT560151)
- hsa-mir-4311 (MIRT560152)
- hsa-mir-195-5p (MIRT726710)
- hsa-mir-16-5p (MIRT726711)
- hsa-mir-15a-5p (MIRT726712)
- hsa-mir-15b-5p (MIRT726713)
miRNA Products
- Search ViGene Biosciences for RNPS1
Clone Products
- Sino Biological Human cDNA Clone for RNPS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RNPS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNPS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RNPS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNPS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNPS1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNPS1 Gene
Localization for RNPS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNPS1 Gene
- Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,TAS | 11546874 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 11546874 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016607 | nuclear speck | IEA | -- |
Pathways & Interactions for RNPS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
| 2 | RNA Polymerase II Transcription Termination | ||
| 3 | Viral mRNA Translation | ||
| 4 | Transport of Mature Transcript to Cytoplasm | ||
| 5 | mRNA surveillance pathway | ||
Pathways by source for RNPS1 Gene
1 BioSystems pathway for RNPS1 Gene
12 Reactome pathways for RNPS1 Gene
2 KEGG pathways for RNPS1 Gene
Interacting Proteins for RNPS1 Gene
Selected Interacting proteins:
Q15287-RNPS1_HUMAN
ENSP00000301730
for RNPS1 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 22203037 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006351 | transcription, DNA-templated | TAS | 9580558 |
| GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
No data available for SIGNOR curated interactions for RNPS1 Gene
Transcripts for RNPS1 Gene
mRNA/cDNA for RNPS1 Gene
- (8) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (128) Selected AceView cDNA sequences:
- (26) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNPS1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNPS1
- GenScript: Design CRISPR guide RNA sequences for RNPS1
miRNA Products
- Search ViGene Biosciences for RNPS1
Clone Products
- Sino Biological Human cDNA Clone for RNPS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RNPS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNPS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for RNPS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (9.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNPS1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RNPS1 Gene:
RNPS1SOURCE GeneReport for Unigene cluster for RNPS1 Gene:
Hs.355643mRNA Expression by UniProt/SwissProt for RNPS1 Gene:
Q15287-RNPS1_HUMAN
Tissue specificity:
Ubiquitous.
Primer Products
-
OriGene qPCR primer pairs for RNPS1
-
OriGene qPCR primer pairs and template standards for RNPS1
No data available for mRNA differential expression in normal tissues for RNPS1 Gene
Orthologs for RNPS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RNPS1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RNPS1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RNPS1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RNPS1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Rnps1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rnps1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RNPS1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RNPS1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RNPS1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rnps1 34 |
|
||
| Str.324 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | rnps1 34 35 |
|
||
| wufa19a11 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13826 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | RnpS1 35 |
|
OneToMany | |
| CG34334 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | rnp-5 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2775 35 |
|
OneToOne |
- Species where no ortholog for RNPS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RNPS1 Gene
(8) SIMAP similar genes for RNPS1 Gene using alignment to 16 proteins:
Pseudogenes.org Pseudogenes for RNPS1 Gene
No data available for Paralogs for RNPS1 Gene
Variants for RNPS1 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10721 | -- | 2,253,495(-) | TCTGA(C/T)CTCAA | nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs111259177 | -- | 2,269,380(+) | CAAAG(C/T)GCTCG | intron-variant, upstream-variant-2KB | |
| rs111319345 | -- | 2,264,873(+) | AGCAA(C/T)AAGTG | intron-variant | |
| rs111367774 | -- | 2,259,054(+) | GGAGG(C/T)GGAGG | intron-variant | |
| rs111373276 | -- | 2,256,548(+) | TGAGA(A/C)TCCGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv952902 | CNV | deletion | 24416366 |
| nsv571201 | CNV | loss | 21841781 |
| nsv471072 | CNV | loss | 18288195 |
| nsv457353 | CNV | loss | 19166990 |
| nsv457351 | CNV | loss | 19166990 |
| nsv1052260 | CNV | gain | 25217958 |
| esv2422427 | CNV | duplication | 17116639 |
| dgv4863n54 | CNV | loss | 21841781 |
| dgv4859n54 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.15;
23.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RNPS1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNPS1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNPS1 Gene
Disorders for RNPS1 Gene
Relevant External Links for RNPS1
No disorders were found for RNPS1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNPS1 Gene
Publications for RNPS1 Gene
- Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. (PMID: 15684395) Trembley J.H. … Mayeda A. (Mol. Cell. Biol. 2005) 3 4 22 64
- A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex. (PMID: 14625303) Kataoka N. … Dreyfuss G. (J. Biol. Chem. 2004) 3 4 22 64
- Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E. … Mayeda A. (Mol. Cell. Biol. 2004) 3 4 22 64
- Splicing enhances translation in mammalian cells: an additional function of the exon junction complex. (PMID: 14752011) Nott A. … Moore M.J. (Genes Dev. 2004) 3 4 22 64
- Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. (PMID: 14517304) Li C. … Tarn W.-Y. (Mol. Cell. Biol. 2003) 3 4 22 64
Products for RNPS1 Gene
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- antibodies-online Antibodies for RNPS1: See all 10
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- Search antibodies-online for peptides
- GeneTex RNPS1 antibody for RNPS1
- Search GeneTex for Proteins for RNPS1
- ViGene Biosciences adenoviral particle packaged cDNA for RNPS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNPS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNPS1 gene
- Search ViGene Biosciences for RNPS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for RNPS1
- VectorBuilder custom plasmid, inducible vectors for RNPS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNPS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RNPS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab