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Aliases for RNPEPL1 Gene

Aliases for RNPEPL1 Gene

  • Arginyl Aminopeptidase (Aminopeptidase B)-Like 1 2 3
  • RNPEP-Like 1 4
  • EC 3.4.11.- 4

External Ids for RNPEPL1 Gene

Summaries for RNPEPL1 Gene

GeneCards Summary for RNPEPL1 Gene

RNPEPL1 (Arginyl Aminopeptidase (Aminopeptidase B)-Like 1) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is C9orf3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNPEPL1 Gene

Genomics for RNPEPL1 Gene

Genomic Location for RNPEPL1 Gene

Start:
240,565,804 bp from pter
End:
240,581,372 bp from pter
Size:
15,569 bases
Orientation:
Plus strand

Genomic View for RNPEPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNPEPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNPEPL1 Gene

Regulatory Elements for RNPEPL1 Gene

Proteins for RNPEPL1 Gene

  • Protein details for RNPEPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAU8-RNPL1_HUMAN
    Recommended name:
    Arginyl aminopeptidase-like 1
    Protein Accession:
    Q9HAU8
    Secondary Accessions:
    • Q5XKC3
    • Q6NX56
    • Q96AC9
    • Q9H033
    • Q9NVD0

    Protein attributes for RNPEPL1 Gene

    Size:
    494 amino acids
    Molecular mass:
    55518 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91823.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RNPEPL1 Gene

Proteomics data for RNPEPL1 Gene at MOPED

Post-translational modifications for RNPEPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNPEPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNPEPL1 Gene

Domains for RNPEPL1 Gene

Gene Families for RNPEPL1 Gene

Protein Domains for RNPEPL1 Gene

UniProtKB/Swiss-Prot:

RNPL1_HUMAN
Family:
  • Belongs to the peptidase M1 family.:
    • Q9HAU8
genes like me logo Genes that share domains with RNPEPL1: view

Function for RNPEPL1 Gene

Enzyme Numbers (IUBMB) for RNPEPL1 Gene

Gene Ontology (GO) - Molecular Function for RNPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0005488 binding --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNPEPL1: view

Phenotypes for RNPEPL1 Gene

GenomeRNAi human phenotypes for RNPEPL1:
genes like me logo Genes that share phenotypes with RNPEPL1: view

miRNA for RNPEPL1 Gene

miRTarBase miRNAs that target RNPEPL1

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNPEPL1 Gene

Localization for RNPEPL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNPEPL1 Gene COMPARTMENTS Subcellular localization image for RNPEPL1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for RNPEPL1 Gene

Pathways for RNPEPL1 Gene

SuperPathways for RNPEPL1 Gene

No Data Available

Interacting Proteins for RNPEPL1 Gene

Gene Ontology (GO) - Biological Process for RNPEPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0019370 leukotriene biosynthetic process IEA --
genes like me logo Genes that share ontologies with RNPEPL1: view

No data available for Pathways by source for RNPEPL1 Gene

Transcripts for RNPEPL1 Gene

Unigene Clusters for RNPEPL1 Gene

Arginyl aminopeptidase (aminopeptidase B)-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNPEPL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - -
SP3: - - - - - - - - - - - - -
SP4: - - -
SP5:
SP6: - -
SP7: -
SP8: -

Relevant External Links for RNPEPL1 Gene

GeneLoc Exon Structure for
RNPEPL1
ECgene alternative splicing isoforms for
RNPEPL1

Expression for RNPEPL1 Gene

mRNA expression in normal human tissues for RNPEPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNPEPL1 Gene

This gene is overexpressed in Whole Blood (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNPEPL1 Gene

SOURCE GeneReport for Unigene cluster for RNPEPL1 Gene Hs.5345

mRNA Expression by UniProt/SwissProt for RNPEPL1 Gene

Q9HAU8-RNPL1_HUMAN
Tissue specificity: Ubiquitous. Expressed at relatively higher levels in heart and skeletal muscle.
genes like me logo Genes that share expressions with RNPEPL1: view

Orthologs for RNPEPL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNPEPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNPEPL1 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNPEPL1 36
  • 91.58 (n)
  • 95.83 (a)
RNPEPL1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNPEPL1 36
  • 92.32 (n)
  • 96.34 (a)
RNPEPL1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnpepl1 36
  • 88.98 (n)
  • 93.75 (a)
Rnpepl1 16
Rnpepl1 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNPEPL1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNPEPL1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnpepl1 36
  • 88.8 (n)
  • 93.47 (a)
chicken
(Gallus gallus)
Aves RNPEPL1 36
  • 77.51 (n)
  • 84.76 (a)
RNPEPL1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNPEPL1 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398435 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnpepl1 36
  • 66.16 (n)
  • 69.95 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535895 36
  • 67.26 (n)
  • 67.36 (a)
RNPEPL1 37
  • 50 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP2 37
  • 18 (a)
OneToMany
Species with no ortholog for RNPEPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNPEPL1 Gene

ENSEMBL:
Gene Tree for RNPEPL1 (if available)
TreeFam:
Gene Tree for RNPEPL1 (if available)

Paralogs for RNPEPL1 Gene

Paralogs for RNPEPL1 Gene

Selected SIMAP similar genes for RNPEPL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNPEPL1: view

Variants for RNPEPL1 Gene

Sequence variations from dbSNP and Humsavar for RNPEPL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8662 -- 240,578,353(+) CCCCT(A/G/T)GGGTT utr-variant-3-prime
rs1127191 -- 240,578,464(+) GCCCT(C/T)TGGCC utr-variant-3-prime
rs1127196 -- 240,578,543(+) TGTCT(C/T)TTGTA utr-variant-3-prime
rs1127202 -- 240,578,629(+) GGCCC(A/C)CCATG utr-variant-3-prime
rs1127207 -- 240,578,688(+) ATGGG(C/G)TATCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNPEPL1 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
essv1993 CNV CNV 17122850
nsv834586 CNV Loss 17160897
nsv10226 CNV Gain 18304495
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876148 CNV Loss 21882294
dgv4474n71 CNV Loss 21882294
dgv4475n71 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv876160 CNV Loss 21882294
dgv4476n71 CNV Loss 21882294
nsv876163 CNV Loss 21882294
nsv470529 CNV Loss 18288195
nsv482062 CNV Gain 20164927

Relevant External Links for RNPEPL1 Gene

HapMap Linkage Disequilibrium report
RNPEPL1

Disorders for RNPEPL1 Gene

Relevant External Links for RNPEPL1

Genetic Association Database (GAD)
RNPEPL1
Human Genome Epidemiology (HuGE) Navigator
RNPEPL1
genes like me logo Genes that share disorders with RNPEPL1: view

No data available for UniProtKB/Swiss-Prot for RNPEPL1 Gene

Publications for RNPEPL1 Gene

  1. Arginyl aminopeptidase-like 1 (RNPEPL1) is an alternatively processed aminopeptidase with specificity for methionine, glutamine, and citrulline residues. (PMID: 19508204) Thompson M.W. … Seipelt R.L. (Protein Pept. Lett. 2009) 2 3 23
  2. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PMID: 11017071) Horikawa Y. … Bell G.I. (Nat. Genet. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for RNPEPL1 Gene

Sources for RNPEPL1 Gene

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