Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNPEPL1 Gene

protein-coding   GIFtS: 52
GCID: GC02P241505

Arginyl Aminopeptidase (Aminopeptidase B)-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Arginyl Aminopeptidase (Aminopeptidase B)-Like 11 2
RNPEP-Like 12 3
Argininyl Aminopeptidase-Like 12
Arginyl Aminopeptidase-Like 12
EC 3.4.11.-3

External Ids:    HGNC: 100791   Entrez Gene: 571402   Ensembl: ENSG000001423277   OMIM: 6052875   UniProtKB: Q9HAU83   

Export aliases for RNPEPL1 gene to outside databases

Previous GC identifers: GC02M239958 GC02M240803 GC02P241527 GC02P241829 GC02P241228 GC02P241156 GC02P233256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RNPEPL1 Gene:
RNPEPL1 (arginyl aminopeptidase (aminopeptidase B)-like 1) is a protein-coding gene. Diseases associated with RNPEPL1 include breast and colorectal cancer, and diabetes mellitus. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is LTA4H.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNPEPL1 gene promoter:
         COUP-TF1   COUP-TF   COUP   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPEPL1 promoter sequence
   Search Chromatin IP Primers for RNPEPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNPEPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

RNPEPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPEPL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P241505:  view genomic region     (about GC identifiers)

Start:
241,505,221 bp from pter      End:
241,520,789 bp from pter
Size:
15,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RNPL1_HUMAN, Q9HAU8 (See protein sequence)
Recommended Name: Arginyl aminopeptidase-like 1  
Size: 494 amino acids; 55518 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=BAA91823.1; Type=Erroneous initiation;
Secondary accessions: Q5XKC3 Q6NX56 Q96AC9 Q9H033 Q9NVD0

Explore the universe of human proteins at neXtProt for RNPEPL1: NX_Q9HAU8

Explore proteomics data for RNPEPL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNPEPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060696.4  
    ENSEMBL proteins: 
     ENSP00000414661   ENSP00000270357   ENSP00000403319  

    RNPEPL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNPEPL1
    OriGene Protein Over-expression Lysate for RNPEPL1
    OriGene MassSpec for RNPEPL1
    OriGene Custom Protein Services for RNPEPL1
    GenScript Custom Purified and Recombinant Proteins Services for RNPEPL1
    Novus Biologicals RNPEPL1 Protein
    Novus Biologicals RNPEPL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPEPL1

    RNPEPL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNPEPL1
    Novus Biologicals RNPEPL1 Antibodies
    Abcam antibodies for RNPEPL1
    Cloud-Clone Corp. Antibodies for RNPEPL1
    Search ThermoFisher Antibodies for RNPEPL1
    LSBio Antibodies in human, mouse, rat for RNPEPL1

    RNPEPL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNPEPL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNPEPL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNPEPL1
    Cloud-Clone Corp. CLIAs for RNPEPL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Arginyl aminopeptidase-like 1
    Aminopeptidases

    4 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR001930 Peptidase_M1
     IPR015211 Peptidase_M1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9HAU8

    ProtoNet protein and cluster: Q9HAU8

    UniProtKB/Swiss-Prot: RNPL1_HUMAN, Q9HAU8
    Similarity: Belongs to the peptidase M1 family


    RNPEPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Number (IUBMB): EC 3.4.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0005488binding ----
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    RNPEPL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNPEPL1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNPEPL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNPEPL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNPEPL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNPEPL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNPEPL1:
    hsa-mir-124-3p (MIRT002699)

    Block miRNA regulation of human, mouse, rat RNPEPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNPEPL1 (see all 22):
    hsa-miR-3678-3p hsa-miR-148b hsa-miR-128 hsa-miR-301a hsa-miR-759 hsa-miR-4314 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidRNPEPL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNPEPL1
    Predesigned siRNA for gene silencing in human, mouse, rat RNPEPL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNPEPL1

    Clone
    Products:
         
    OriGene clones in human, mouse for RNPEPL1 (see all 7)
    OriGene ORF clones in mouse, rat for RNPEPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNPEPL1 (NM_018226)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPEPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEPL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNPEPL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNPEPL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNPEPL1
    Interactions:

        Search GeneGlobe Interaction Network for RNPEPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for RNPEPL1 (ENSP000002703574) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ME1ENSP000003587194STRING: ENSP00000358719
    ME2ENSP000003210704STRING: ENSP00000321070
    ME3ENSP000003526574STRING: ENSP00000352657
    PFKLENSP000002698484STRING: ENSP00000269848
    PFKMENSP000003528424STRING: ENSP00000352842
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0019370leukotriene biosynthetic process IEA--

    RNPEPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNPEPL1 (RNPL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNPEPL1 gene: 
    NM_018226.4  

    Unigene Cluster for RNPEPL1:

    Arginyl aminopeptidase (aminopeptidase B)-like 1
    Hs.5345  [show with all ESTs]
    Unigene Representative Sequence: NM_018226
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451363 ENST00000270357(uc002vzi.3 uc002vzj.3) ENST00000486058
    ENST00000481757 ENST00000493398 ENST00000464550 ENST00000460884 ENST00000498042
    ENST00000471657 ENST00000437406
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNPEPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNPEPL1 (see all 22):
    hsa-miR-3678-3p hsa-miR-148b hsa-miR-128 hsa-miR-301a hsa-miR-759 hsa-miR-4314 hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidRNPEPL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNPEPL1
    Predesigned siRNA for gene silencing in human, mouse, rat RNPEPL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RNPEPL1 (see all 7)
    OriGene ORF clones in mouse, rat for RNPEPL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNPEPL1 (NM_018226)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPEPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEPL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNPEPL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPEPL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNPEPL1
      QuantiTect SYBR Green Assays in human, mouse, rat RNPEPL1
      QuantiFast Probe-based Assays in human, mouse, rat RNPEPL1

    Additional mRNA sequence: 

    AF300795.1 AK001668.1 AK130185.1 AL512754.1 BC017301.2 BC067258.1 BC082975.1 

    7 DOTS entries:

    DT.445550  DT.100774179  DT.91756364  DT.100774177  DT.100774176  DT.120929831  DT.99999618 

    Selected AceView cDNA sequences (see all 203):

    CO245960 BC017301 CF132256 NM_018226 BU154916 BE889102 BU183275 AI161167 
    BG698893 BG741321 AI521099 BM015509 BM462002 T16044 BQ051551 BQ956073 
    BE906394 BQ220551 AI868489 BE563549 BG032190 BE296124 BM810538 AI418829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNPEPL1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a · 14b
    SP1:                                                        -                 -           -     -                                       
    SP2:                                                                          -           -     -                                       
    SP3:        -     -     -     -     -     -           -     -     -     -     -           -     -                                       
    SP4:                                                                                      -     -     -                                 
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for RNPEPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNPEPL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGAGAGG
    RNPEPL1 Expression
    About this image


    RNPEPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    RNPEPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNPEPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5345

    UniProtKB/Swiss-Prot: RNPL1_HUMAN, Q9HAU8
    Tissue specificity: Ubiquitous. Expressed at relatively higher levels in heart and skeletal muscle

        Custom PCR Arrays for RNPEPL1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNPEPL1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPEPL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNPEPL1
    QuantiTect SYBR Green Assays in human, mouse, rat RNPEPL1
    QuantiFast Probe-based Assays in human, mouse, rat RNPEPL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNPEPL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnpepl11 , 5 arginyl aminopeptidase (aminopeptidase B)-like 11, 5 88.98(n)1
    93.75(a)1
      1 (46.60 cM)5
    1086571  NM_181405.41  NP_852070.31 
     929107835 
    chicken
    (Gallus gallus)
    Aves RNPEPL11 arginyl aminopeptidase (aminopeptidase B)-like 1 77.51(n)
    84.76(a)
      424946  XM_422753.4  XP_422753.4 
    lizard
    (Anolis carolinensis)
    Reptilia RNPEPL16
    arginyl aminopeptidase (aminopeptidase B)-like 1
    81(a)
    1 ↔ 1
    GL343245.1(1795795-1819981)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984352 similar to arginyl aminopeptidase (aminopeptidase B)-like more 71.71(n)    BC045064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005358951 arginyl aminopeptidase-like 1-like 67.26(n)
    67.36(a)
      100535895  XM_003200489.2  XP_003200537.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAP26
    Leucyl aminopeptidase yscIV (leukotriene A4 hydrol...
    18(a)
    1 → many
    XIV(542963-544978) YNL045W


    ENSEMBL Gene Tree for RNPEPL1 (if available)
    TreeFam Gene Tree for RNPEPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNPEPL1 gene
    LTA4H2  RNPEP2  C9orf32  
    2 SIMAP similar genes for RNPEPL1 using alignment to 4 protein entries:     RNPL1_HUMAN (see all proteins):
    RNPEP    LTA4H

    RNPEPL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNPEPL1 (see all 338)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360464
    A colorectal cancer sample4--see VAR_0360462 V M mis40--------
    rs577200441,2
    C,F--241506058(+) GCCGCG/ACCTCC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs587306541,2
    C,F--241506123(+) CTCCCT/CTGGGC 1 -- us2k14Minor allele frequency- C:0.08WA NA 242
    rs1156023351,2
    C,F--241506145(+) AGGTGC/GCACAG 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1160229541,2
    C,F--241506183(+) GGCCGC/TGGAGA 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1149171261,2
    C,F--241506341(+) CAGCCA/GGGAAC 1 -- us2k12Minor allele frequency- G:0.08WA NA 238
    rs1835768761,2
    --241506392(+) TGCCAA/TCGAAA 1 -- us2k10--------
    rs1444401721,2
    --241506430(+) CCACCA/GGGCAG 1 -- us2k10--------
    rs1483903991,2
    --241506524(+) GACTGC/TGTAAG 1 -- us2k10--------
    rs1879117421,2
    --241506595(+) AGGGCA/GCGTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNPEPL1 (241505221 - 241520789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNPEPL1 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876116CNV Loss21882294
    dgv4476n71CNV Loss21882294
    dgv4475n71CNV Loss21882294
    nsv876163CNV Loss21882294
    nsv876157CNV Loss21882294
    dgv4471n71CNV Loss21882294
    nsv876144CNV Loss21882294
    dgv4472n71CNV Loss21882294
    nsv834586CNV Loss17160897
    nsv470529CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RNPEPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RNPEPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605287    OMIM disorders: --

    3 diseases for RNPEPL1:    
    About MalaCards
    breast and colorectal cancer    diabetes mellitus    colorectal cancer


    RNPEPL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNPEPL1
    Human Genome Epidemiology (HuGE) Navigator: RNPEPL1 (2 documents)

    Export disorders for RNPEPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNPEPL1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with RNPEPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arginyl aminopeptidase-like 1 (RNPEPL1) is an alternatively processed aminopeptidase with specificity for methionine, glutamine, and citrulline residues. (PubMed id 19508204)1, 3, 9 Thompson M.W....Seipelt R.L. (Protein Pept. Lett. 2009)
    2. Family-based association study for bipolar affective disorder. (PubMed id 20414141)1, 4 Secolin R....Lopes-Cendes I. (Psychiatr. Genet. 2010)
    3. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    4. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PubMed id 11017071)1, 2 Horikawa Y....Bell G.I. (Nat. Genet. 2000)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57140 HGNC: 10079 AceView: RNPEPL1 Ensembl:ENSG00000142327 euGenes: HUgn57140
    ECgene: RNPEPL1 H-InvDB: RNPEPL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNPEPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNPEPL1 gene:
    Search GeneIP for patents involving RNPEPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNPEPL1  
     OriGene qPCR primer pairs and template standards for RNPEPL1   OriGene Protein Over-expression Lysate for RNPEPL1  
     OriGene MassSpec something-or-other for RNPEPL1   OriGene clones in human, mouse for RNPEPL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNPEPL1   OriGene Purified Protein for RNPEPL1  
     OriGene ORF clones in mouse, rat for RNPEPL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNPEPL1   OriGene Custom Protein Services for RNPEPL1  

     
     
     Block miRNA regulation of human, mouse, rat RNPEPL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNPEPL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNPEPL1 Predesigned siRNA for gene silencing in human, mouse, rat RNPEPL1
     QuantiFast Probe-based Assays in human, mouse, rat RNPEPL1 QuantiTect SYBR Green Assays in human, mouse, rat RNPEPL1
     Custom PCR Arrays for RNPEPL1 Search Chromatin IP Primers for RNPEPL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNPEPL1  Search GeneGlobe Interaction Network for RNPEPL1
     Regulatory tfbs in RNPEPL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNPEPL1 GenScript cDNA clones with any tag delivered in your preferred vector for RNPEPL1
     GenScript Custom Assay Services for RNPEPL1 GenScript Custom overexpressing Cell Line Services for RNPEPL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNPEPL1 (RNPL1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNPEPL1 antibodies
     RNPEPL1 proteins
     RNPEPL1 lysates
     Antibodies for RNPEPL1
     See all of Abcam's Antibodies, Kits and Proteins for RNPEPL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNPEPL1
     Antibodies for RNPEPL1
     ELISAs for RNPEPL1
     CLIAs for RNPEPL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNPEPL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEPL1
     SwitchGear 3'UTR luciferase reporter plasmids for RNPEPL1
     SwitchGear Promoter luciferase reporter plasmids for RNPEPL1
     Search ThermoFisher Antibodies for RNPEPL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEPL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNPEPL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNPEPL1
     LSBio Antibodies in human, mouse, rat for RNPEPL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNPEPL1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4