Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNPEP Gene

Aliases for RNPEP Gene

  • Arginyl Aminopeptidase (Aminopeptidase B) 2 3
  • Arginine Aminopeptidase 3 4
  • EC 3.4.11.6 4 64
  • AP-B 3 4
  • Arginyl Aminopeptidase 4
  • Aminopeptidase B 3
  • EC 3.4.11 64
  • APB 4

External Ids for RNPEP Gene

Summaries for RNPEP Gene

GeneCards Summary for RNPEP Gene

RNPEP (Arginyl Aminopeptidase (Aminopeptidase B)) is a Protein Coding gene. GO annotations related to this gene include aminopeptidase activity and epoxide hydrolase activity. An important paralog of this gene is C9orf3.

UniProtKB/Swiss-Prot for RNPEP Gene

  • Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).

Gene Wiki entry for RNPEP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNPEP Gene

Genomics for RNPEP Gene

Genomic Location for RNPEP Gene

Start:
201,982,372 bp from pter
End:
202,006,147 bp from pter
Size:
23,776 bases
Orientation:
Plus strand

Genomic View for RNPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNPEP Gene

Regulatory Elements for RNPEP Gene

Proteins for RNPEP Gene

  • Protein details for RNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A4-AMPB_HUMAN
    Recommended name:
    Aminopeptidase B
    Protein Accession:
    Q9H4A4
    Secondary Accessions:
    • Q9BVM9
    • Q9H1D4
    • Q9NPT7

    Protein attributes for RNPEP Gene

    Size:
    650 amino acids
    Molecular mass:
    72596 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for RNPEP Gene

Proteomics data for RNPEP Gene at MOPED

Selected DME Specific Peptides for RNPEP Gene

Post-translational modifications for RNPEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNPEP Gene

Domains for RNPEP Gene

Gene Families for RNPEP Gene

UniProtKB/Swiss-Prot:

AMPB_HUMAN
Family:
  • Belongs to the peptidase M1 family.:
    • Q9H4A4
genes like me logo Genes that share domains with RNPEP: view

Function for RNPEP Gene

Molecular function for RNPEP Gene

GENATLAS Biochemistry: aminopeptidase B,72.3kDa,zinc dependent,widely expressed
UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal Arg and Lys from oligopeptides when P1 is not Pro. Also acts on arylamides of Arg and Lys
UniProtKB/Swiss-Prot Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).

Enzyme Numbers (IUBMB) for RNPEP Gene

Gene Ontology (GO) - Molecular Function for RNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity NAS 12119107
GO:0004301 epoxide hydrolase activity NAS 12119107
GO:0005488 binding --
GO:0008235 metalloexopeptidase activity NAS 12119107
GO:0008237 metallopeptidase activity --
genes like me logo Genes that share ontologies with RNPEP: view

Phenotypes for RNPEP Gene

GenomeRNAi human phenotypes for RNPEP:
genes like me logo Genes that share phenotypes with RNPEP: view

miRNA for RNPEP Gene

miRTarBase miRNAs that target RNPEP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNPEP Gene

Localization for RNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNPEP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNPEP Gene COMPARTMENTS Subcellular localization image for RNPEP gene
Compartment Confidence
extracellular 4
plasma membrane 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10467730
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS 10467730
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RNPEP: view

Pathways for RNPEP Gene

SuperPathways for RNPEP Gene

No Data Available

Interacting Proteins for RNPEP Gene

Gene Ontology (GO) - Biological Process for RNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IC 12119107
GO:0019370 leukotriene biosynthetic process IEA --
genes like me logo Genes that share ontologies with RNPEP: view

No data available for Pathways by source for RNPEP Gene

Compounds for RNPEP Gene

(4) ApexBio Compounds for RNPEP Gene

Compound Action Cas Number
Bestatin Specific inhibitor of aminopeptidase B and leucine aminopeptidase [58970-76-6]
Fumagillin inhibits methionine aminopeptidase-2. [23110-15-8]
SC 57461A Potent and selective inhibitor of LTA4 hydrolase. [423169-68-0]
Tosedostat (CHR2797) aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N. [238750-77-1]

(1) HMDB Compounds for RNPEP Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(10) Novoseek inferred chemical compound relationships for RNPEP Gene

Compound -log(P) Hits PubMed IDs
bestatin 91.2 10
arphamenine b 89.8 1
leucine 57.1 10
leukotriene b4 56.2 1
arginine 52.5 10
genes like me logo Genes that share compounds with RNPEP: view

Transcripts for RNPEP Gene

Unigene Clusters for RNPEP Gene

Arginyl aminopeptidase (aminopeptidase B):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNPEP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: -
SP11:
SP12:
SP13:

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RNPEP Gene

GeneLoc Exon Structure for
RNPEP
ECgene alternative splicing isoforms for
RNPEP

Expression for RNPEP Gene

mRNA expression in normal human tissues for RNPEP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNPEP Gene

SOURCE GeneReport for Unigene cluster for RNPEP Gene Hs.497391

genes like me logo Genes that share expressions with RNPEP: view

Orthologs for RNPEP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNPEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNPEP 36
  • 99.33 (n)
  • 99.08 (a)
RNPEP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNPEP 36
  • 84.44 (n)
  • 86.36 (a)
RNPEP 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNPEP 36
  • 89.36 (n)
  • 89.47 (a)
RNPEP 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnpep 36
  • 87.08 (n)
  • 88.62 (a)
Rnpep 16
Rnpep 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNPEP 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNPEP 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnpep 36
  • 86.37 (n)
  • 88.12 (a)
chicken
(Gallus gallus)
Aves RNPEP 36
  • 72.79 (n)
  • 74.2 (a)
RNPEP 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNPEP 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8765 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnpep 36
  • 67.05 (n)
  • 69.34 (a)
Str.7070 36
zebrafish
(Danio rerio)
Actinopterygii rnpep 36
  • 65.04 (n)
  • 65.47 (a)
rnpep 37
  • 64 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP2 37
  • 30 (a)
OneToMany
Species with no ortholog for RNPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNPEP Gene

ENSEMBL:
Gene Tree for RNPEP (if available)
TreeFam:
Gene Tree for RNPEP (if available)

Paralogs for RNPEP Gene

Paralogs for RNPEP Gene

Selected SIMAP similar genes for RNPEP Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNPEP: view

Variants for RNPEP Gene

Sequence variations from dbSNP and Humsavar for RNPEP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2493781 -- 201,994,861(-) ttcta(A/C)taaaa intron-variant
rs4364934 -- 201,999,499(+) ATCAC(A/G)CCATT intron-variant
rs4589165 -- 201,999,556(+) AATAA(C/T)AAAAT intron-variant
rs4950747 -- 201,983,967(+) tcact(C/G)tcgtc intron-variant
rs4950748 -- 201,984,030(+) ggttc(C/G)agcga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNPEP Gene

Variant ID Type Subtype PubMed ID
nsv873102 CNV Gain 21882294

Relevant External Links for RNPEP Gene

HapMap Linkage Disequilibrium report
RNPEP

Disorders for RNPEP Gene

(2) Novoseek inferred disease relationships for RNPEP Gene

Disease -log(P) Hits PubMed IDs
tumors 1.3 1
melanoma 0 1

Relevant External Links for RNPEP

Genetic Association Database (GAD)
RNPEP
genes like me logo Genes that share disorders with RNPEP: view

No data available for UniProtKB/Swiss-Prot for RNPEP Gene

Publications for RNPEP Gene

  1. Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation. (PMID: 8344358) Belhacene N. … Auberger P. (Eur. J. Immunol. 1993) 3 23
  2. Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization. (PMID: 9533033) Aurich-Costa J. … Cohen P. (Cytogenet. Cell Genet. 1997) 2 3
  3. Aminopeptidase B (EC 3.4.11.6). (PMID: 10467730) Foulon T. … Cohen P. (Int. J. Biochem. Cell Biol. 1999) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors. (PMID: 21862451) Benyamin B. … Whitfield J.B. (Hum. Mol. Genet. 2011) 3 49

Products for RNPEP Gene

Sources for RNPEP Gene

Back to Top

Content