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RNPEP Gene

protein-coding   GIFtS: 60
GCID: GC01P201951

Arginyl Aminopeptidase (Aminopeptidase B)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginyl Aminopeptidase (Aminopeptidase B)1 2     Aminopeptidase B2
Arginine Aminopeptidase2 3     APB3
AP-B2 3     Arginyl Aminopeptidase3
EC 3.4.11.63 8     EC 3.4.118

External Ids:    HGNC: 100781   Entrez Gene: 60512   Ensembl: ENSG000001763937   OMIM: 6026755   UniProtKB: Q9H4A43   

Export aliases for RNPEP gene to outside databases

Previous GC identifers: GC01P199636 GC01P197385 GC01P198418 GC01P199240 GC01P198683 GC01P200218 GC01P173117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNPEP Gene:
RNPEP (arginyl aminopeptidase (aminopeptidase B)) is a protein-coding gene. GO annotations related to this gene include aminopeptidase activity and epoxide hydrolase activity. An important paralog of this gene is LTA4H.

UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several
peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can
hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)

Gene Wiki entry for RNPEP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNPEP gene promoter:
         ATF-2   XBP-1   Tal-1beta   GATA-1   GATA-2   Evi-1   E47   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPEP promoter sequence
   Search Chromatin IP Primers for RNPEP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

RNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPEP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201951:  view genomic region     (about GC identifiers)

Start:
201,951,500 bp from pter      End:
201,975,275 bp from pter
Size:
23,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4 (See protein sequence)
Recommended Name: Aminopeptidase B  
Size: 650 amino acids; 72596 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q9BVM9 Q9H1D4 Q9NPT7

Explore the universe of human proteins at neXtProt for RNPEP: NX_Q9H4A4

Explore proteomics data for RNPEP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for RNPEP (Q9H4A4)
     WFGNLVT  GPRSRVWAEPCL 


    See RNPEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064601.3  
    ENSEMBL proteins: 
     ENSP00000295640   ENSP00000356255   ENSP00000389602   ENSP00000407614  

    RNPEP Human Recombinant Protein Products:

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    Novus Biologicals RNPEP Proteins
    Novus Biologicals RNPEP Lysates
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPEP

     
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    antibodies-online proteins for RNPEP (8 products) 

     
    antibodies-online peptides for RNPEP

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    antibodies-online kits for RNPEP (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Arginyl aminopeptidase
    Aminopeptidases

    5 InterPro protein domains:
     IPR015571 Pept_M1_aminopeptidase-B
     IPR014782 Peptidase_M1_N
     IPR001930 Peptidase_M1
     IPR015211 Peptidase_M1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4A4

    ProtoNet protein and cluster: Q9H4A4

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
    Similarity: Belongs to the peptidase M1 family


    Find genes that share domains with RNPEP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMPB_HUMAN, Q9H4A4
    Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several
    peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can
    hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)
    Catalytic activity: Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on
    arylamides of Arg and Lys

         Genatlas biochemistry entry for RNPEP:
    aminopeptidase B,72.3kDa,zinc dependent,widely expressed

         Enzyme Numbers (IUBMB): EC 3.4.11.61 2 EC 3.4.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity NAS12119107
    GO:0004301epoxide hydrolase activity NAS12119107
    GO:0005488binding ----
    GO:0008235metalloexopeptidase activity NAS12119107
    GO:0008237metallopeptidase activity ----
         
    Find genes that share ontologies with RNPEP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNPEP:
     Decreased Salmonella enterica  

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target RNPEP:
    hsa-mir-186-5p (MIRT045299)

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    3 qRT-PCR Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMPB_HUMAN, Q9H4A4: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    nucleus3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10467730
    GO:0005615extracellular space ----
    GO:0005886plasma membrane TAS10467730
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with RNPEP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNPEP
    Interactions:

        Search GeneGlobe Interaction Network for RNPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for RNPEP (Q9H4A42, 3 ENSP000002956404) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62045 I2D: score=3 
    ATG101Q9BSB43I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IC12119107
    GO:0019370leukotriene biosynthetic process IEA--

    Find genes that share ontologies with RNPEP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for RNPEP
    4 ApexBio Compounds for RNPEP     About this table
    CompoundAction CAS #
    BestatinSpecific inhibitor of aminopeptidase B and leucine aminopeptidase[58970-76-6]
    Fumagillininhibits methionine aminopeptidase-2[23110-15-8]
    SC 57461APotent and selective inhibitor of LTA4 hydrolase[423169-68-0]
    Tosedostat (CHR2797)aminopeptidase inhibitor for LAP, PuSA and Aminopeptidase N[238750-77-1]

    Browse Tocris compounds for RNPEP (AMPB)

    1 HMDB Compound for RNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    10 Novoseek inferred chemical compound relationships for RNPEP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bestatin 91.2 10 7559728 (1), 16595904 (1), 7528860 (1), 1786199 (1) (see all 10)
    arphamenine b 89.8 1 8820902 (1)
    leucine 57.1 13 12685816 (2), 1912369 (2), 11732752 (2), 15187416 (1) (see all 7)
    leukotriene b4 56.2 1 10574934 (1)
    arginine 52.5 10 8100228 (1), 12616147 (1), 15187416 (1), 17332242 (1) (see all 10)
    alanine 33.4 3 8100228 (1), 12685816 (1), 11732752 (1)
    zinc 31.6 4 10574934 (1), 10215585 (1), 18571504 (1)
    proline 28.3 1 11263958 (1)
    bleomycin 27.7 1 15187416 (1)
    glutamate 19.4 2 12685816 (1), 11732752 (1)



    Find genes that share compounds with RNPEP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNPEP gene: 
    NM_020216.3  

    Unigene Cluster for RNPEP:

    Arginyl aminopeptidase (aminopeptidase B)
    Hs.497391  [show with all ESTs]
    Unigene Representative Sequence: BC012166
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481780 ENST00000295640(uc001gxd.3 uc001gxe.3) ENST00000367286
    ENST00000487116 ENST00000492587 ENST00000471105 ENST00000447312 ENST00000478617
    ENST00000479726 ENST00000492849 ENST00000449524 ENST00000464707 ENST00000479531

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNPEP
      QuantiFast Probe-based Assays in human, mouse, rat RNPEP

    Additional mRNA sequence: 

    AJ242586.1 AJ296161.1 AK026644.1 AK097372.1 AL390139.1 BC001064.2 BC012166.1 Z36876.1 

    24 DOTS entries:

    DT.320481  DT.100054556  DT.101967810  DT.100881976  DT.100881973  DT.121353929  DT.86847437  DT.100881994 
    DT.121354053  DT.92467434  DT.100881990  DT.309958  DT.40228307  DT.92467423  DT.95140135  DT.92467422 
    DT.92467440  DT.95146155  DT.100054081  DT.101958342  DT.121354060  DT.97860929  DT.91786150  DT.95264483 

    Selected AceView cDNA sequences (see all 371):

    BM783378 BQ686233 CB157750 AI436271 BM664468 AW450372 AI261255 BU630482 
    BQ100933 AA424607 AI934976 BG010313 AW069640 BU615656 BQ681649 NM_020216 
    AI079800 BE326836 AA977066 CA309818 BU687009 CD742996 BC001064 AI292166 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNPEP (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^
    SP1:                                -     -     -     -                 -                 -                       -                                             
    SP2:                                -     -     -     -           -     -                                         -                                             
    SP3:                                                  -                 -                 -                       -                                             
    SP4:                                                  -           -     -                 -                       -                                             
    SP5:        -     -     -     -     -     -     -     -                 -                 -                                                                     

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RNPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNPEP Expression
    About this image

    RNPEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNPEP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497391
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNPEP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnpep1 , 5 arginyl aminopeptidase (aminopeptidase B)1, 5 87.08(n)1
    88.62(a)1
      1 (58.43 cM)5
    2156151  NM_145417.31  NP_663392.21 
     1352627125 
    chicken
    (Gallus gallus)
    Aves RNPEP1 arginyl aminopeptidase (aminopeptidase B) 72.79(n)
    74.2(a)
      421165  XM_419245.4  XP_419245.4 
    lizard
    (Anolis carolinensis)
    Reptilia RNPEP6
    arginyl aminopeptidase (aminopeptidase B)
    63(a)
    1 ↔ 1
    4(132378828-132394128)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87652 Xenopus laevis transcribed sequence with moderate similarity more 77.97(n)    BJ070677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnpep1 arginyl aminopeptidase (aminopeptidase B) 65.04(n)
    65.47(a)
      437014  NM_001002741.2  NP_001002741.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAP26
    Leucyl aminopeptidase yscIV (leukotriene A4 hydrol...
    30(a)
    1 → many
    XIV(542963-544978) YNL045W


    ENSEMBL Gene Tree for RNPEP (if available)
    TreeFam Gene Tree for RNPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNPEP gene
    LTA4H2  RNPEPL12  C9orf32  
    2 SIMAP similar genes for RNPEP using alignment to 5 protein entries:     AMPB_HUMAN (see all proteins):
    RNPEPL1    LTA4H

    Find genes that share paralogs with RNPEP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNPEP (see all 590)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409664011,2
    --173115652(+) GCACTA/CGGCCC 1 -- us2k10--------
    rs109202941,2
    C,F,A--173115676(+) TCTATA/GGAATC 1 -- us2k15Minor allele frequency- G:0.28WA NA EA 362
    rs108008041,2
    C,F,A,H--173115774(+) ATGAAT/CTGGGG 1 -- us2k18Minor allele frequency- C:0.46NA WA CSA EA 370
    rs124029991,2
    H--173115884(+) CAGTTC/TTGAGG 1 -- us2k10--------
    rs1137269821,2
    C,F--173115917(+) ATGCAG/CGGAGG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs75293871,2
    C,F,A,H--173115924(+) GAGGCA/GGAAGT 1 -- us2k123Minor allele frequency- G:0.43NS EA NA WA CSA 2354
    rs2011316751,2
    C--173116000(+) AAATC-/TTTTTTT 1 -- us2k10--------
    rs49508041,2
    C,A--173116092(+) CCTCCC/G/TGGGCC 1 -- us2k112NA WA CSA EA 374
    rs1442956511,2
    C--173116171(+) TTTTTA/TAAAAT 1 -- us2k10--------
    rs49508051,2
    C,F,A--173116177(+) AAAATT/GTTTTT 1 -- us2k17Minor allele frequency- G:0.43NA WA CSA EA 366

    HapMap Linkage Disequilibrium report for RNPEP (201951500 - 201975275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNPEP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873102CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNPEP
    DNA2.0 Custom Variant and Variant Library Synthesis for RNPEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602675    OMIM disorders: --


    Find genes that share disorders with RNPEP           About GenesLikeMe

    2 Novoseek inferred disease relationships for RNPEP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.3 1 16985214 (1)
    melanoma 0 1 15500947 (1)

    Genetic Association Database (GAD): RNPEP

    Export disorders for RNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNPEP gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with RNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors. (PubMed id 21862451)1, 4 Benyamin B....Whitfield J.B. (Hum. Mol. Genet. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Aminopeptidase B (EC 3.4.11.6). (PubMed id 10467730)1, 3 Foulon T....Cohen P. (amp 1999)
    4. Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization. (PubMed id 9533033)1, 3 Aurich-Costa J....Cohen P. (Cytogenet. Cell Genet. 1997)
    5. Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation. (PubMed id 8344358)1, 9 Belhacene N....Auberger P. (Eur. J. Immunol. 1993)
    6. Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype. (PubMed id 23500679)1 Puertas M.d.e.l. .C....RamA-rez-ExpA^sito M.J. (Exp. Gerontol. 2013)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6051 HGNC: 10078 AceView: RNPEP Ensembl:ENSG00000176393 euGenes: HUgn6051
    ECgene: RNPEP H-InvDB: RNPEP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNPEP gene:
    Search GeneIP for patents involving RNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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