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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNPEP Gene

protein-coding   GIFtS: 59
GCID: GC01P201951

Arginyl Aminopeptidase (Aminopeptidase B)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arginyl Aminopeptidase (Aminopeptidase B)1 2     Aminopeptidase B2
Arginine Aminopeptidase2 3     APB3
AP-B2 3     Arginyl Aminopeptidase3
EC 3.4.11.63 8     EC 3.4.118

External Ids:    HGNC: 100781   Entrez Gene: 60512   Ensembl: ENSG000001763937   OMIM: 6026755   UniProtKB: Q9H4A43   

Export aliases for RNPEP gene to outside databases

Previous GC identifers: GC01P199636 GC01P197385 GC01P198418 GC01P199240 GC01P198683 GC01P200218 GC01P173117


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNPEP Gene: 
RNPEP (arginyl aminopeptidase (aminopeptidase B)) is a protein-coding gene. Diseases associated with RNPEP include denture stomatitis, and stomatitis. GO annotations related to this gene include metalloexopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is LTA4H.

UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several
peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can
hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)

Gene Wiki entry for RNPEP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNPEP gene promoter:
         ATF-2   XBP-1   Tal-1beta   GATA-1   GATA-2   Evi-1   E47   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for RNPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

RNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPEP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201951:  view genomic region     (about GC identifiers)

Start:
201,951,500 bp from pter      End:
201,975,275 bp from pter
Size:
23,776 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4 (See protein sequence)
Recommended Name: Aminopeptidase B  
Size: 650 amino acids; 72596 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q9BVM9 Q9H1D4 Q9NPT7

Explore the universe of human proteins at neXtProt for RNPEP: NX_Q9H4A4

Explore proteomics data for RNPEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H4A4

  • 2 DME Specific Peptides for RNPEP (Q9H4A4)
     WFGNLVT  GPRSRVWAEPCL 

    RNPEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNPEP Protein Expression
    REFSEQ proteins: NP_064601.3  
    ENSEMBL proteins: 
     ENSP00000295640   ENSP00000356255   ENSP00000389602   ENSP00000407614  

    Human Recombinant Protein Products for RNPEP: 
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    Novus Biologicals RNPEP Proteins
    Novus Biologicals RNPEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPEP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10467730
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS10467730

    RNPEP for ontologies           About GeneDecksing



    RNPEP Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RNPEP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Arginyl aminopeptidase 
    Aminopeptidases

    5 InterPro protein domains:
     IPR015571 Pept_M1_aminopeptidase-B
     IPR014782 Peptidase_M1_N
     IPR001930 Peptidase_M1
     IPR015211 Peptidase_M1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4A4

    ProtoNet protein and cluster: Q9H4A4

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
    Similarity: Belongs to the peptidase M1 family


    RNPEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMPB_HUMAN, Q9H4A4
    Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several
    peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can
    hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)
    Catalytic activity: Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on
    arylamides of Arg and Lys

         Genatlas biochemistry entry for RNPEP:
    aminopeptidase B,72.3kDa,zinc dependent,widely expressed

         Enzyme Numbers (IUBMB): EC 3.4.11.61 2 EC 3.4.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity NAS12119107
    GO:0004301epoxide hydrolase activity NAS12119107
    GO:0005488binding ----
    GO:0008235metalloexopeptidase activity NAS12119107
    GO:0008237metallopeptidase activity ----
         
    RNPEP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNPEP:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNPEP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNPEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNPEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNPEP 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNPEP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for RNPEP (Q9H4A42, 3 ENSP000002956404) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62045 I2D: score=3 
    C12orf44Q9BSB43I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IC12119107
    GO:0019370leukotriene biosynthetic process IEA--

    RNPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNPEP for compounds           About GeneDecksing

    EMD Millipore small molecules for RNPEP:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for RNPEP

    Browse Tocris compounds for RNPEP (AMPB)

    1 HMDB Compound for RNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    10 Novoseek inferred chemical compound relationships for RNPEP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bestatin 91.2 10 7559728 (1), 16595904 (1), 7528860 (1), 1786199 (1) (see all 10)
    arphamenine b 89.8 1 8820902 (1)
    leucine 57.1 13 12685816 (2), 1912369 (2), 11732752 (2), 15187416 (1) (see all 7)
    leukotriene b4 56.2 1 10574934 (1)
    arginine 52.5 10 8100228 (1), 12616147 (1), 15187416 (1), 17332242 (1) (see all 10)
    alanine 33.4 3 8100228 (1), 12685816 (1), 11732752 (1)
    zinc 31.6 4 10574934 (1), 10215585 (1), 18571504 (1)
    proline 28.3 1 11263958 (1)
    bleomycin 27.7 1 15187416 (1)
    glutamate 19.4 2 12685816 (1), 11732752 (1)

    Search CenterWatch for drugs/clinical trials and news about RNPEP / AMPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNPEP gene: 
    NM_020216.3  

    Unigene Cluster for RNPEP:

    Arginyl aminopeptidase (aminopeptidase B)
    Hs.497391  [show with all ESTs]
    Unigene Representative Sequence: BC012166
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481780 ENST00000295640(uc001gxd.3 uc001gxe.3) ENST00000367286
    ENST00000487116 ENST00000492587 ENST00000471105 ENST00000447312 ENST00000478617
    ENST00000479726 ENST00000492849 ENST00000449524 ENST00000464707 ENST00000479531

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPEP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEP
    Sirion Biotech Customized lentivirus for stable overexpression of RNPEP 
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    Additional mRNA sequence: 

    AJ242586.1 AJ296161.1 AK026644.1 AK097372.1 AL390139.1 BC001064.2 BC012166.1 Z36876.1 

    24 DOTS entries:

    DT.320481  DT.100054556  DT.101967810  DT.100881976  DT.100881973  DT.121353929  DT.86847437  DT.100881994 
    DT.121354053  DT.92467434  DT.100881990  DT.309958  DT.40228307  DT.92467423  DT.95140135  DT.92467422 
    DT.92467440  DT.95146155  DT.100054081  DT.101958342  DT.121354060  DT.97860929  DT.91786150  DT.95264483 

    24/371 AceView cDNA sequences (see all 371):

    AI934976 NM_020216 CA309818 AI079800 BM907905 BQ898593 BQ681649 AL390139 
    BG676081 AW450372 BG773725 BQ679142 BM664468 BQ100933 BU615656 CB105357 
    BM696190 AI357246 CR600517 AA361401 BM783352 CA415323 AI796238 AA290978 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RNPEP (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^
    SP1:                                -     -     -     -                 -                 -                       -                                             
    SP2:                                -     -     -     -           -     -                                         -                                             
    SP3:                                                  -                 -                 -                       -                                             
    SP4:                                                  -           -     -                 -                       -                                             
    SP5:        -     -     -     -     -     -     -     -                 -                 -                                                                     

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RNPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNPEP Expression
    About this image


    See RNPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNPEP

    SOURCE GeneReport for Unigene cluster: Hs.497391
        SABiosciences Custom PCR Arrays for RNPEP
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNPEP gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnpep1 , 5 arginyl aminopeptidase (aminopeptidase B)1, 5 87.08(n)1
    88.62(a)1
      1 (58.43 cM)5
    2156151  NM_145417.31  NP_663392.21 
     1352627125 
    chicken
    (Gallus gallus)
    Aves RNPEP1 arginyl aminopeptidase (aminopeptidase B) 72.79(n)
    74.2(a)
      421165  XM_419245.3  XP_419245.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNPEP6
    arginyl aminopeptidase (aminopeptidase B)
    63(a)
    1 ↔ 1
    4(132378828-132394128)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87652 Xenopus laevis transcribed sequence with moderate similarity more 77.97(n)    BJ070677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnpep1 arginyl aminopeptidase (aminopeptidase B) 64.98(n)
    65.58(a)
      437014  NM_001002741.1  NP_001002741.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAP26
    Leucyl aminopeptidase yscIV (leukotriene A4 hydrol...
    29(a)
    1 → many
    XIV(542963-544978)


    ENSEMBL Gene Tree for RNPEP (if available)
    TreeFam Gene Tree for RNPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNPEP gene
    LTA4H2  RNPEPL12  C9orf32  
    2 SIMAP similar genes for RNPEP using alignment to 5 protein entries:     AMPB_HUMAN (see all proteins):
    RNPEPL1    LTA4H

    RNPEP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/590 SNPs in RNPEP are shown (see all 590)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409664011,2
    --173115652(+) GCACTA/CGGCCC 1 -- us2k10--------
    rs109202941,2
    C,F,A--173115676(+) TCTATA/GGAATC 1 -- us2k15Minor allele frequency- G:0.28WA NA EA 362
    rs108008041,2
    C,F,A,H--173115774(+) ATGAAT/CTGGGG 1 -- us2k18Minor allele frequency- C:0.46NA WA CSA EA 370
    rs124029991,2
    H--173115884(+) CAGTTC/TTGAGG 1 -- us2k10--------
    rs1137269821,2
    C,F--173115917(+) ATGCAG/CGGAGG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs75293871,2
    C,F,A,H--173115924(+) GAGGCA/GGAAGT 1 -- us2k123Minor allele frequency- G:0.43NS EA NA WA CSA 2354
    rs2011316751,2
    C--173116000(+) AAATC-/TTTTTTT 1 -- us2k10--------
    rs49508041,2
    C,A--173116092(+) CCTCCC/G/TGGGCC 1 -- us2k112NA WA CSA EA 374
    rs1442956511,2
    C--173116171(+) TTTTTA/TAAAAT 1 -- us2k10--------
    rs49508051,2
    C,F,A--173116177(+) AAAATT/GTTTTT 1 -- us2k17Minor allele frequency- G:0.43NA WA CSA EA 366

    HapMap Linkage Disequilibrium report for RNPEP (201951500 - 201975275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNPEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873102CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602675    OMIM disorders: --

    17 diseases for RNPEP:    About MalaCards
    denture stomatitis    stomatitis    clear cell renal cell carcinoma    bacterial vaginosis
    vaginitis    mantle cell lymphoma    renal cell carcinoma    pheochromocytoma
    choriocarcinoma    type 1 diabetes    neuroblastoma    melanoma
    pancreatic cancer    hypertension    pancreatitis    endotheliitis
    breast cancer


    RNPEP for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RNPEP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.3 1 16985214 (1)
    melanoma 0 1 15500947 (1)

    Genetic Association Database (GAD): RNPEP

    Export disorders for RNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNPEP gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with RNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with met abolic risk factors. (PubMed id 21862451)1, 4 Benyamin B....Whitfield J.B. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Aminopeptidase B (EC 3.4.11.6). (PubMed id 10467730)1, 3 Foulon T....Cohen P. (1999)
    4. Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization. (PubMed id 9533033)1, 3 Aurich-Costa J....Cohen P. (1997)
    5. Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation. (PubMed id 8344358)1, 9 Belhacene N....Auberger P. (1993)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    7. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6051 HGNC: 10078 AceView: RNPEP Ensembl:ENSG00000176393 euGenes: HUgn6051
    ECgene: RNPEP H-InvDB: RNPEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNPEP gene:
    Search GeneIP for patents involving RNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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