Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNPEP Gene

protein-coding   GIFtS: 53
GCID: GC01P201951

arginyl aminopeptidase (aminopeptidase B)

 Explore 17 diseases affiliated with
RNPEP via our new
 Human Malady Compendium 
Biological research products
for RNPEP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Arginyl Aminopeptidase (Aminopeptidase B)1 2     Aminopeptidase B2
Arginine Aminopeptidase2 3     APB3
AP-B2 3     Arginyl Aminopeptidase3
EC 3.4.11.63 8     EC 3.4.118

External Ids:    HGNC: 100781   Entrez Gene: 60512   Ensembl: ENSG000001763937   OMIM: 6026755   UniProtKB: Q9H4A43   

Export aliases for RNPEP gene to outside databases

Previous GC identifers: GC01P199636 GC01P197385 GC01P198418 GC01P199240 GC01P198683 GC01P200218 GC01P173117


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide
substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze
leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)

Gene Wiki entry for RNPEP


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNPEP gene promoter:
         ATF-2   XBP-1   Tal-1beta   GATA-1   GATA-2   Evi-1   E47   FOXO4   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for RNPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

RNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPEP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201951:  view genomic region     (about GC identifiers)

Start:
201,951,500 bp from pter      End:
201,975,275 bp from pter
Size:
23,776 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4 (See protein sequence)
Recommended Name: Aminopeptidase B  
Size: 650 amino acids; 72596 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: Q9BVM9 Q9H1D4 Q9NPT7

Explore the universe of human proteins at neXtProt for RNPEP: NX_Q9H4A4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H4A4

  • 2 DME Specific Peptides for RNPEP (Q9H4A4)
     WFGNLVT  GPRSRVWAEPCL 

    RNPEP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064601.3  
    ENSEMBL proteins: 
     ENSP00000295640   ENSP00000356255   ENSP00000389602   ENSP00000407614  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RNPEP
    OriGene Protein Over-expression Lysate: RNPEP
    OriGene Custom Protein Services for RNPEP 
    GenScript Custom Purified and Recombinant Proteins Services for RNPEP
    Novus Biologicals RNPEP Proteins
    Novus Biologicals RNPEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNPEP

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS10467730
    GO:0005615extracellular space IEA--
    GO:0005625soluble fraction ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS10467730


    RNPEP for ontologies           About GeneDecksing



    RNPEP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): RNPEP
    OriGene Custom Antibody Services for RNPEP 
    GenScript Custom Superior Antibodies Services for RNPEP
    Novus Biologicals RNPEP Antibodies
    Search for Antibodies for RNPEP at Abcam  
    Uscn Antibodies for RNPEP
    Search ThermoFisher Antibodies for RNPEP

    Assay Products for RNPEP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNPEP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RNPEP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RNPEP for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015571 Pept_M1_aminopeptidase-B
     IPR014782 Peptidase_M1_N
     IPR001930 Peptidase_M1
     IPR015211 Peptidase_M1_C
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H4A4

    ProtoNet protein and cluster: Q9H4A4

    1 Blocks protein family: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
    Similarity: Belongs to the peptidase M1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AMPB_HUMAN, Q9H4A4
    Function: Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide
    substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze
    leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)
    Catalytic activity: Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides
    of Arg and Lys

         Genatlas biochemistry entry for RNPEP:
    aminopeptidase B,72.3kDa,zinc dependent,widely expressed

    Enzyme Numbers (IUBMB): EC 3.4.11.61 2 EC 3.4.112

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: RNPEP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPEP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNPEP (see all 7)
    OriGene shRNA RFP: RNPEP
    OriGene siRNA: RNPEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNPEP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RNPEP (NM_020216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNPEP
    Search LifeMap BioReagents cell lines for RNPEP

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity NAS12119107
    GO:0004222metalloendopeptidase activity IEA--
    GO:0004301epoxide hydrolase activity NAS12119107
    GO:0005507copper ion binding ----
    GO:0008235metalloexopeptidase activity NAS12119107


    RNPEP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RNPEP:
     Decreased Salmonella enterica  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNPEP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for RNPEP (Q9H4A42, 3 ENSP000002956404) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62045 I2D: score=3 
    C12orf44Q9BSB43I2D: score=1 
    KCNMA1Q127913I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    SIRT7ENSP000003294664STRING: ENSP00000329466
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IC12119107
    GO:0007568aging ----
    GO:0019370leukotriene biosynthetic process IEA--
    GO:0045776negative regulation of blood pressure ----
    GO:0060041retina development in camera-type eye ----


    RNPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNPEP for compounds           About GeneDecksing

    EMD Millipore small molecules for RNPEP:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for RNPEP

    Browse Tocris compounds for RNPEP

    1 HMDB Compound for RNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--
    10 Novoseek chemical compound relationships for RNPEP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bestatin 91.2 10 7559728 (1), 16595904 (1), 7528860 (1), 1786199 (1) (see all 10)
    arphamenine b 89.8 1 8820902 (1)
    leucine 57.1 13 12685816 (2), 1912369 (2), 11732752 (2), 15187416 (1) (see all 7)
    leukotriene b4 56.2 1 10574934 (1)
    arginine 52.5 10 8100228 (1), 12616147 (1), 15187416 (1), 17332242 (1) (see all 10)
    alanine 33.4 3 8100228 (1), 12685816 (1), 11732752 (1)
    zinc 31.6 4 10574934 (1), 10215585 (1), 18571504 (1)
    proline 28.3 1 11263958 (1)
    bleomycin 27.7 1 15187416 (1)
    glutamate 19.4 2 12685816 (1), 11732752 (1)

    Search CenterWatch for drugs/clinical trials and news about RNPEP / AMPB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNPEP gene: 
    NM_020216.3  

    Unigene Cluster for RNPEP:

    Arginyl aminopeptidase (aminopeptidase B)
    Hs.497391  [show with all ESTs]
    Unigene Representative Sequence: BC012166
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481780 ENST00000295640(uc001gxd.3 uc001gxe.3) ENST00000367286
    ENST00000487116 ENST00000492587 ENST00000471105 ENST00000447312 ENST00000478617
    ENST00000479726 ENST00000492849 ENST00000449524 ENST00000464707 ENST00000479531


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: RNPEP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPEP
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNPEP:
    hsa-miR-129-3p hsa-miR-2278 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidRNPEP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNPEP (see all 7)
    OriGene shRNA RFP: RNPEP
    OriGene siRNA: RNPEP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPEP
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RNPEP (NM_020216)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEP 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNPEP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNPEP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPEP

    Additional cDNA sequence: 

    AJ242586.1 AJ296161.1 AK026644.1 AK097372.1 AL390139.1 BC001064.2 BC012166.1 Z36876.1 

    24 DOTS entries:

    DT.320481  DT.100054556  DT.101967810  DT.100881976  DT.100881973  DT.121353929  DT.86847437  DT.100881994 
    DT.121354053  DT.92467434  DT.100881990  DT.309958  DT.40228307  DT.92467423  DT.95140135  DT.92467422 
    DT.92467440  DT.95146155  DT.100054081  DT.101958342  DT.121354060  DT.97860929  DT.91786150  DT.95264483 

    24/371 AceView cDNA sequences (see all 371):

    BU688441 BU179905 AI339641 BQ101147 W15547 BG393142 BM783350 BU687009 
    BC012166 BG656381 BE326836 BQ100844 BQ932990 BQ691499 AI357246 BU630482 
    BM664468 BM783352 AI346163 BM783378 AA424607 AA399641 AI304679 BM696190 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RNPEP (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^
    SP1:                                -     -     -     -                 -                 -                       -                                             
    SP2:                                -     -     -     -           -     -                                         -                                             
    SP3:                                                  -                 -                 -                       -                                             
    SP4:                                                  -           -     -                 -                       -                                             
    SP5:        -     -     -     -     -     -     -     -                 -                 -                                                                     

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RNPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RNPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNPEP

    SOURCE GeneReport for Unigene cluster: Hs.497391
        SABiosciences Custom PCR Arrays for RNPEP
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNPEP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNPEP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPEP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for RNPEP gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RNPEP1 arginyl aminopeptidase (aminopeptidase B) 72.79(n)
    74.2(a)
      421165  XM_419245.3  XP_419245.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNPEP6
    --
    71(a)
    1 ↔ 1
    4(132379092-132393260)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87652 Xenopus laevis transcribed sequence with moderate similarity more 77.97(n)    BJ070677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnpep1 arginyl aminopeptidase (aminopeptidase B) 64.98(n)
    65.58(a)
      437014  NM_001002741.1  NP_001002741.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    9(a)
    possible ortholog
    GroupUn.3968(7247-9381)
    worm
    (Caenorhabditis elegans)
    Secernentea Y67D8C.96
    Y53F4B.206
    (see all 7)
    Protein Y53F4B.20
    (see all 7)
    9(a)
    8(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    IV(3077470-3086920)
    II(15084400-15089576)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G637706
    AT5G135206
    leukotriene-A4 hydrolase
    9(a)
    33(a)
    possible ortholog
    1 ↔ many
    1(23657506-23664677)
    5(4341948-4344671)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    aminopeptidase, putative, expressed
    9(a)
    32(a)
    possible ortholog
    1 ↔ many
    8(28170517-28179029)
    3(34371027-34375231)
    E. coli
    (Escherichia coli)
    Gamma proteobacteria pepN6
    aminopeptidase N
    10(a)
    possible ortholog
    Chromosome(989845-992457)


    ENSEMBL Gene Tree for RNPEP (if available)
    TreeFam Gene Tree for RNPEP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNPEP gene
    LTA4H2  RNPEPL12  C9orf32  
    2 SIMAP similar genes for RNPEP using alignment to 5 protein entries:     AMPB_HUMAN (see all proteins):
    RNPEPL1    LTA4H

    RNPEP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 NCBI SNPs in RNPEP are shown (see all 111    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75149961,2
    C,F,A,H,--173127767(+) ACTTCT/CATAAG 1 -- int188Minor allele frequency- C:0.03NS EA NA PA EU CA WA 4400
    rs727448611,2
    --173127871(+) AGTTGA/GAATAG 1 -- int10--------
    rs761999181,2
    C,F,--173128162(+) CCTTCC/TGGACT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs1119037451,2
    C--173128628(+) CAAAAA/CAAAAA 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs604834271,2
    --173128743(+) TGAGCC/TGAGAT 1 -- int10--------
    rs104492631,2
    --173128774(+) tgggcA/Gacaga 1 -- int10--------
    rs24937811,2
    H--173129876(-) ttctaC/Ataaaa 1 -- int14Minor allele frequency- A:0.00NS EA 382
    rs49508131,2
    H--173130014(+) GTCTGT/GGTGGA 1 -- int14Minor allele frequency- G:0.00NS EA 410
    rs64279251,2
    C,A,--173130069(+) CTTTGG/ACTGCA 1 -- int13Minor allele frequency- A:0.19CSA WA NA 240
    rs168494881,2
    C,--173130097(+) GCATCT/GTTCCA 1 -- int13Minor allele frequency- G:0.01NA 134

    HapMap Linkage Disequilibrium report for RNPEP (201951500 - 201975275 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNPEP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNPEP
    DNA2.0 Custom Variant and Variant Library Synthesis for RNPEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNPEP for disorders           About GeneDecksing

    OMIM gene information: 602675    OMIM disorders: --

    17 diseases for RNPEP:    About MalaCards
    denture stomatitis    clear cell renal cell carcinoma    bacterial vaginosis    mantle cell lymphoma
    renal cell carcinoma    stomatitis    vaginitis    pheochromocytoma
    choriocarcinoma    pancreatic cancer    melanoma    breast cancer
    pancreatitis    hypertension    carcinoma    neuroblastoma
    malaria

    2 Novoseek disease relationships for RNPEP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.3 1 16985214 (1)
    melanoma 0 1 15500947 (1)


    Export disorders for RNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNPEP gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with RNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Aminopeptidase B (EC 3.4.11.6). (PubMed id 10467730)1, 3 Foulon T....Cohen P. (1999)
    3. Assignment of the aminopeptidase B gene (RNPEP) to human chromosome 1 band q32 by in situ hybridization. (PubMed id 9533033)1, 3 Aurich-Costa J....Cohen P. (1997)
    4. Characterization and purification of T lymphocyte aminopeptidase B: a putative marker of T cell activation. (PubMed id 8344358)1, 9 Belhacene N....Auberger P. (1993)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with met abolic risk factors. (PubMed id 21862451)1 Benyamin B....Whitfield J.B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6051 HGNC: 10078 AceView: RNPEP Ensembl:ENSG00000176393 euGenes: HUgn6051
    ECgene: RNPEP H-InvDB: RNPEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNPEP gene:
    Search GeneIP for patents involving RNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for RNPEP
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for RNPEP   OriGene shRNA RFP for RNPEP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNPEP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNPEP  
     OriGene Protein Over-expression Lysate for RNPEP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RNPEP   OriGene 3'-UTR Clone for RNPEP  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNPEP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RNPEP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNPEP   OriGene Custom Protein Services for RNPEP  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNPEP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNPEP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPEP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNPEP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPEP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPEP
     GenScript Custom Purified and Recombinant Proteins Services for RNPEP GenScript cDNA clones with any tag delivered in your preferred vector for RNPEP
     GenScript Custom Assay Services for RNPEP GenScript Custom Superior Antibodies Services for RNPEP
     GenScript Custom overexpressing Cell Line Services for RNPEP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNPEP promoter
     Search Chromatin IP Primers for RNPEP
     RT2 qPCR Primer Assay in human, mouse, rat RNPEP
     Search GNC Networks for RNPEP
     SABiosciences Custom PCR Arrays for RNPEP
     Search Tocris compounds for RNPEP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for RNPEP
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RNPEP antibodies
     RNPEP proteins
     RNPEP lysates
     Search for Antibodies for RNPEP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RNPEP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RNPEP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RNPEP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPEP
     SwitchGear 3'UTR luciferase reporter plasmids for RNPEP
     SwitchGear Promoter luciferase reporter plasmids for RNPEP
     Search ThermoFisher Antibodies for RNPEP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPEP
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNPEP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4