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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNPC3 Gene

protein-coding   GIFtS: 49
GCID: GC01P104068

RNA-Binding Region (RNP1, RRM) Containing 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RNA-Binding Region (RNP1, RRM) Containing 31 2     U11/U12 Small Nuclear Ribonucleoprotein 65 KDa Protein2 3
U11/U12 SnRNP 65K1 2     U11/U12 SnRNP 65 KDa Protein2 3
RBM402 3     SNRNP652
RNP2 3     RNA Recognition Protein2
U11/U12-65K2 3     RNA-Binding Protein 402
RNA-Binding Motif Protein 402 3     KIAA18393
RNA-Binding Region-Containing Protein 32 3     

External Ids:    HGNC: 186661   Entrez Gene: 555992   Ensembl: ENSG000001859467   UniProtKB: Q96LT93   

Export aliases for RNPC3 gene to outside databases

Previous GC identifers: GC00U991276 GC01P103782 GC01P103893 GC01P102123


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNPC3 Gene:
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes
and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is
found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals.
The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K
protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs),
suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. (provided by RefSeq, Jul
2008)

GeneCards Summary for RNPC3 Gene: 
RNPC3 (RNA-binding region (RNP1, RRM) containing 3) is a protein-coding gene. Diseases associated with RNPC3 include rabies, and ebola hemorrhagic fever. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM41.

UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
Function: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes
U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop
of m(7)G-capped U12 snRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNPC3 gene promoter:
         GATA-3   AP-2gamma   GATA-1   GATA-2   E47   FOXJ2 (long isoform)   AP-2beta   FOXJ2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNPC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p21.1

RNPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P104068:  view genomic region     (about GC identifiers)

Start:
104,068,313 bp from pter      End:
104,097,861 bp from pter
Size:
29,549 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9 (See protein sequence)
Recommended Name: RNA-binding protein 40  
Size: 517 amino acids; 58575 Da
Subunit: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with
m(7)G-capped U12 snRNA. Interacts with PDCD7
Subcellular location: Nucleus
Sequence caution: Sequence=BAA90885.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA90885.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence; Sequence=BAB47468.1;
Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RNPC3:
3EGN (3D)    
Secondary accessions: D3DT74 Q5TZ87 Q96FK7 Q96JI8 Q9NSU7 Q9NXX2

Explore the universe of human proteins at neXtProt for RNPC3: NX_Q96LT9

Explore proteomics data for RNPC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LT9

  • RNPC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNPC3 Protein Expression
    REFSEQ proteins: NP_060089.1  
    ENSEMBL proteins: 
     ENSP00000437278   ENSP00000431344   ENSP00000432886   ENSP00000436315   ENSP00000391432  
     ENSP00000435440   ENSP00000434721  

    Human Recombinant Protein Products for RNPC3: 
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    Novus Biologicals RNPC3 Protein
    Novus Biologicals RNPC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNPC3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18559850
    GO:0005689U12-type spliceosomal complex IDA15146077

    RNPC3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for RNPC3 
    Cloud-Clone Corp. CLIAs for RNPC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q96LT9

    ProtoNet protein and cluster: Q96LT9

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RNPC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM40_HUMAN, Q96LT9
    Function: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes
    U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop
    of m(7)G-capped U12 snRNA

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    RNPC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNPC3:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNPC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNPC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNPC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNPC3 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNPC3:
    hsa-miR-521
    SwitchGear 3'UTR luciferase reporter plasmidRNPC3 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of RNPC3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNPC3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for RNPC3 (Q96LT92, 3 ENSP000003914324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3MINT-61621 I2D: score=2 
    PDCD7Q8N8D13I2D: score=1 
    PRNPP041563I2D: score=1 
    --ENSP000003687484STRING: ENSP00000368748
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IC15146077

    RNPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNPC3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNPC3 (RBM40)

    10/38 Novoseek inferred chemical compound relationships for RNPC3 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudouridine 54.3 9 1719377 (3), 17574834 (1), 18205399 (1), 19481523 (1)
    cardiolipin 49.6 11 7994907 (1), 7576002 (1), 2293908 (1), 8929771 (1) (see all 11)
    ctds 33.1 1 11703381 (1)
    uridine 33 5 10490595 (2), 10653581 (1), 19481523 (1)
    leptomycin b 31.2 2 11119609 (1)
    poly c 29.9 2 1729596 (1)
    rrna 28.3 7 9880328 (3), 7729570 (1), 9747844 (1), 9029160 (1)
    sucrose 18.4 3 2099530 (1), 9769212 (1), 8842725 (1)
    adenylate 17.2 7 17175535 (1), 12162956 (1), 1671216 (1), 12637556 (1) (see all 5)
    glycerol 14.1 5 8441402 (1), 2358436 (1), 8031233 (1), 15613301 (1)

    Search CenterWatch for drugs/clinical trials and news about RNPC3 / RBM40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNPC3 gene: 
    NM_017619.3  

    Unigene Cluster for RNPC3:

    RNA-binding region (RNP1, RRM) containing 3
    Hs.632423  [show with all ESTs]
    Unigene Representative Sequence: AK057799
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524631 ENST00000531883 ENST00000533099(uc010oul.1 uc010oum.1)
    ENST00000527062 ENST00000423855(uc010oun.2) ENST00000533834 ENST00000524641
    ENST00000525323 ENST00000532117
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNPC3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNPC3:
    hsa-miR-521
    SwitchGear 3'UTR luciferase reporter plasmidRNPC3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RNPC3 (NM_017619)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNPC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNPC3
    Sirion Biotech Customized lentivirus for stable overexpression of RNPC3 
                         Customized lentivirus expression plasmids for stable overexpression of RNPC3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNPC3
    OriGene qSTAR qPCR primer pairs in human, mouse for RNPC3
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat RNPC3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNPC3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNPC3

    Additional mRNA sequence: 

    AK000015.1 AK057799.1 AK289844.1 AY099329.1 BC010697.1 

    21 DOTS entries:

    DT.101980061  DT.100892339  DT.100892340  DT.100892341  DT.449355  DT.121339839  DT.95079594  DT.95155090 
    DT.95245085  DT.121339899  DT.120887712  DT.121339866  DT.315416  DT.75142691  DT.91672656  DT.92425866 
    DT.97818040  DT.40242558  DT.414421  DT.95255993  DT.99998484 

    24/222 AceView cDNA sequences (see all 222):

    F07523 CN482148 BX485594 BX497088 AL704039 AL705057 CR592251 Z44595 
    F03754 BC020861 AL832291 CA441626 CR601909 R96974 BM670675 BG675999 
    AI932359 M24895 AA679262 BX498546 AW274685 CB159135 CA447262 BC011179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNPC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAATG
    RNPC3 Expression
    About this image


    See RNPC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNPC3

    SOURCE GeneReport for Unigene cluster: Hs.632423

    UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
    Tissue specificity: Highly expressed in pancreas and kidney. Detected at lower levels in heart, brain, placenta,
    lung, liver, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes

        SABiosciences Custom PCR Arrays for RNPC3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNPC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNPC3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnpc31 , 5 RNA-binding region (RNP1, RRM) containing 31, 5 87.29(n)1
    89.3(a)1
      3 (49.35 cM)5
    672251  NM_026043.31  NP_080319.21 
     1136050675 
    chicken
    (Gallus gallus)
    Aves RNPC31 RNA-binding region (RNP1, RRM) containing 3 75.15(n)
    73.1(a)
      424458  XM_422302.3  XP_422302.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNPC36
    RNA-binding region (RNP1, RRM) containing 3
    69(a)
    1 ↔ 1
    4(85651506-85682053)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.336952 Xenopus laevis transcribed sequence with weak similarity more 76.22(n)    BJ051660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ092666.12   -- 71.93(n)    BQ092666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snp6
    Snipper
    29(a)
    1 → many
    2R(17948458-17957262)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G092301 U11/U12 small nuclear ribonucleoprotein 65 kDa protein 47.77(n)
    39.17(a)
      837443  NM_100793.3  NP_172394.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03266001 hypothetical protein 48.7(n)
    40.73(a)
      4332713  NM_001056528.1  NP_001049993.1 


    ENSEMBL Gene Tree for RNPC3 (if available)
    TreeFam Gene Tree for RNPC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNPC3 gene
    RBM412  

    RNPC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNPC3
    PGOHUM00000237647


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/424 SNPs in RNPC3 are shown (see all 424)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138826351,2
    C,F--102121846(+) TAACAC/GTACCC 1 -- us2k12Minor allele frequency- G:0.04NA 122
    rs1913179061,2
    --104066599(+) GATTGA/TCTTCT 1 -- us2k10--------
    rs747317361,2
    C,F--104066728(+) ACCTCG/ATGGTA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1830184591,2
    --104066800(+) TAGATA/TCCTTA 1 -- us2k10--------
    rs1877105191,2
    --104066832(+) TTCCCA/CATGTC 1 -- us2k10--------
    rs1428149241,2
    --104066898(+) GGCATA/CATCAT 1 -- us2k10--------
    rs1473948361,2
    --104066957(+) TTGCTA/TACTAT 1 -- us2k10--------
    rs1127371811,2
    F--104066969(+) CTTCAT/ACTGCA 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs75291441,2
    C,F,A,H--104067000(+) AAAACA/GTATCT 1 -- us2k129Minor allele frequency- G:0.36NS EA NA WA CSA 2780
    rs1480604551,2
    --104067136(+) TTTCAA/TACCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNPC3 (104068313 - 104097861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for RNPC3 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871791CNV Loss21882294
    nsv830904CNV Loss17160897
    nsv523177CNV Gain19592680
    esv27438CNV Gain19812545
    dgv294n71CNV Gain21882294
    nsv526367CNV Gain19592680
    dgv14n21CNV Gain19592680
    nsv428157CNV Gain+Loss18775914
    dgv295n71CNV Gain+Loss21882294
    nsv830915CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    20/45 diseases for RNPC3 (see all 45):    About MalaCards
    rabies    ebola hemorrhagic fever    lassa fever    mixed connective tissue disease
    parainfluenza virus type 3    rubella    crimean-congo hemorrhagic fever    connective tissue disease
    hemorrhagic fever    rheumatic disease    rift valley fever    polymyositis
    collagen disease    measles    cutaneous lupus erythematosus    hemorrhagic fever with renal syndrome
    sjogren's syndrome    pemphigus vulgaris    hyperprolactinemia    nephritis

    1 disease from the University of Copenhagen DISEASES database for RNPC3:
    Night blindness

    RNPC3 for disorders           About GeneDecksing

    10/38 Novoseek inferred disease relationships for RNPC3 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 77.9 9 1873202 (1), 1374734 (1), 10645148 (1), 10323445 (1) (see all 9)
    lupus erythematosus systemic 64.3 14 10843726 (2), 1873202 (1), 1374734 (1), 8137536 (1) (see all 12)
    other connective tissue disease 57.2 2 17785335 (1), 9112226 (1)
    connective tissue diseases 54.5 5 10209523 (1), 1485812 (1), 7510759 (1), 11703381 (1) (see all 5)
    influenza 49.6 17 12755627 (2), 12642098 (1), 16756174 (1), 8648766 (1) (see all 13)
    muscular atrophy spinal 49.3 2 16473550 (1), 19286363 (1)
    autoimmune response 49.2 1 2249366 (1)
    rheumatic diseases 48.2 3 18240226 (1), 11302861 (1)
    sclerosis systemic 46.2 4 8770332 (1), 10645148 (1), 16014550 (1), 11469465 (1)
    raynauds phenomenon 45.3 1 20360189 (1)


    Export disorders for RNPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNPC3 gene, integrated from 9 sources (see all 285):
    (articles sorted by number of sources associating them with RNPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2, 3 Will C.L.... Luehrmann R. (2004)
    2. Cloning and identification of a novel human RNPC3 gene that encodes a protein with two RRM domains and is expressed in the cell nucleus. (PubMed id 14974681)1, 2, 3 Zhao E.... Mao Y. (2003)
    3. The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. (PubMed id 16096647)1, 2 Benecke H.... Will C.L. (2005)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion. (PubMed id 19447915)2 Netter C....Wahl M.C. (2009)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    10. Minor spliceosome components are predominantly localized in the nucleus. (PubMed id 18559850)1 Pessa H.K....Frilander M.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55599 HGNC: 18666 AceView: FLJ25070 Ensembl:ENSG00000185946 euGenes: HUgn55599
    ECgene: RNPC3 H-InvDB: RNPC3

    (According to HUGE)
    About This Section
    HUGE: KIAA1839

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNPC3 gene:
    Search GeneIP for patents involving RNPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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