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RNPC3 Gene

protein-coding   GIFtS: 50
GCID: GC01P104068

RNA-Binding Region (RNP1, RRM) Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA-Binding Region (RNP1, RRM) Containing 31 2     U11/U12 Small Nuclear Ribonucleoprotein 65 KDa Protein2 3
U11/U12 SnRNP 65K1 2     U11/U12 SnRNP 65 KDa Protein2 3
RBM402 3     SNRNP652
RNP2 3     RNA Recognition Protein2
U11/U12-65K2 3     RNA-Binding Protein 402
RNA-Binding Motif Protein 402 3     KIAA18393
RNA-Binding Region-Containing Protein 32 3     

External Ids:    HGNC: 186661   Entrez Gene: 555992   Ensembl: ENSG000001859467   UniProtKB: Q96LT93   

Export aliases for RNPC3 gene to outside databases

Previous GC identifers: GC00U991276 GC01P103782 GC01P103893 GC01P102123


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNPC3 Gene:
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes
and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is
found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals.
The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 65K
protein that is a component of the U12-type spliceosome. This protein contains two RNA recognition motifs (RRMs),
suggesting that it may contact one of the small nuclear RNAs of the minor spliceosome. (provided by RefSeq, Jul
2008)

GeneCards Summary for RNPC3 Gene:
RNPC3 (RNA-binding region (RNP1, RRM) containing 3) is a protein-coding gene. Diseases associated with RNPC3 include ebola hemorrhagic fever, and rabies. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBM41.

UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
Function: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes
U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop
of m(7)G-capped U12 snRNA




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNPC3 gene promoter:
         GATA-3   AP-2gamma   GATA-1   GATA-2   E47   FOXJ2 (long isoform)   AP-2beta   FOXJ2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNPC3 promoter sequence
   Search Chromatin IP Primers for RNPC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21   Ensembl cytogenetic band:  1p21.1   HGNC cytogenetic band: 1p21.1

RNPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNPC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P104068:  view genomic region     (about GC identifiers)

Start:
104,068,313 bp from pter      End:
104,097,861 bp from pter
Size:
29,549 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9 (See protein sequence)
Recommended Name: RNA-binding protein 40  
Size: 517 amino acids; 58575 Da
Subunit: Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with
m(7)G-capped U12 snRNA. Interacts with PDCD7
Sequence caution: Sequence=BAA90885.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA90885.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence; Sequence=BAB47468.1;
Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RNPC3:
3EGN (3D)    
Secondary accessions: A8K1C9 D3DT74 Q5TZ87 Q96FK7 Q96JI8 Q9NSU7 Q9NXX2
Alternative splicing: 2 isoforms:  Q96LT9-1   Q96LT9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNPC3: NX_Q96LT9

Explore proteomics data for RNPC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNPC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060089.1  
    ENSEMBL proteins: 
     ENSP00000437278   ENSP00000431344   ENSP00000432886   ENSP00000436315   ENSP00000391432  
     ENSP00000435440   ENSP00000434721  

    RNPC3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q96LT9

    ProtoNet protein and cluster: Q96LT9

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    RNPC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBM40_HUMAN, Q96LT9
    Function: Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes
    U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop
    of m(7)G-capped U12 snRNA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    RNPC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNPC3:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNPC3
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    miRNA
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    miRTarBase miRNAs that target RNPC3:
    hsa-mir-192-5p (MIRT026449)

    Block miRNA regulation of human, mouse, rat RNPC3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNPC3:
    hsa-miR-521
    SwitchGear 3'UTR luciferase reporter plasmidRNPC3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBM40_HUMAN, Q96LT9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005689U12-type spliceosomal complex IDA15146077
    GO:0005730NOT nucleolus IDA--

    RNPC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNPC3
    Interactions:

        GeneGlobe Interaction Network for RNPC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNPC3 (Q96LT92, 3 ENSP000003914324) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3MINT-61621 I2D: score=2 
    PDCD7Q8N8D13I2D: score=1 
    PRNPP041563I2D: score=1 
    DHX38ENSP000002684824STRING: ENSP00000268482
    PLRG1ENSP000003031914STRING: ENSP00000303191
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IC15146077

    RNPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNPC3 (RBM40)

    Selected Novoseek inferred chemical compound relationships for RNPC3 gene (see all 38)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pseudouridine 54.3 9 1719377 (3), 17574834 (1), 18205399 (1), 19481523 (1)
    cardiolipin 49.6 11 7994907 (1), 7576002 (1), 2293908 (1), 8929771 (1) (see all 11)
    ctds 33.1 1 11703381 (1)
    uridine 33 5 10490595 (2), 10653581 (1), 19481523 (1)
    leptomycin b 31.2 2 11119609 (1)
    poly c 29.9 2 1729596 (1)
    rrna 28.3 7 9880328 (3), 7729570 (1), 9747844 (1), 9029160 (1)
    sucrose 18.4 3 2099530 (1), 9769212 (1), 8842725 (1)
    adenylate 17.2 7 17175535 (1), 12162956 (1), 1671216 (1), 12637556 (1) (see all 5)
    glycerol 14.1 5 8441402 (1), 2358436 (1), 8031233 (1), 15613301 (1)



    RNPC3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNPC3 gene: 
    NM_017619.3  

    Unigene Cluster for RNPC3:

    RNA-binding region (RNP1, RRM) containing 3
    Hs.632423  [show with all ESTs]
    Unigene Representative Sequence: AK057799
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524631 ENST00000531883 ENST00000533099(uc010oul.1 uc010oum.1)
    ENST00000527062 ENST00000423855(uc010oun.2) ENST00000533834 ENST00000524641
    ENST00000525323 ENST00000532117
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RNPC3:
    hsa-miR-521
    SwitchGear 3'UTR luciferase reporter plasmidRNPC3 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for RNPC3
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      QuantiTect SYBR Green Assays in human, mouse, rat RNPC3
      QuantiFast Probe-based Assays in human, mouse, rat RNPC3

    Additional mRNA sequence: 

    AK000015.1 AK057799.1 AK289844.1 AY099329.1 BC010697.1 

    21 DOTS entries:

    DT.101980061  DT.100892339  DT.100892340  DT.100892341  DT.449355  DT.121339839  DT.95079594  DT.95155090 
    DT.95245085  DT.121339899  DT.120887712  DT.121339866  DT.315416  DT.75142691  DT.91672656  DT.92425866 
    DT.97818040  DT.40242558  DT.414421  DT.95255993  DT.99998484 

    Selected AceView cDNA sequences (see all 222):

    AI367972 CA447262 BG675999 BX484623 BX497088 BX485594 CR601909 BC020861 
    AA679262 AB058742 AU137618 BX498546 BC010697 CR616713 H45506 CR593744 
    NM_020978 CN482148 AW978322 AI932359 CA441626 BM670675 AW274685 CR615091 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNPC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTTAATG
    RNPC3 Expression
    About this image

    RNPC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNPC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632423

    UniProtKB/Swiss-Prot: RBM40_HUMAN, Q96LT9
    Tissue specificity: Highly expressed in pancreas and kidney. Detected at lower levels in heart, brain, placenta,
    lung, liver, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNPC3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnpc31 , 5 RNA-binding region (RNP1, RRM) containing 31, 5 87.29(n)1
    89.3(a)1
      3 (49.35 cM)5
    672251  NM_001038696.11  NP_001033785.11 
     1136050675 
    chicken
    (Gallus gallus)
    Aves RNPC31 RNA-binding region (RNP1, RRM) containing 3 74.33(n)
    72.48(a)
      424458  XM_422302.4  XP_422302.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNPC36
    RNA-binding region (RNP1, RRM) containing 3
    70(a)
    1 ↔ 1
    4(85651506-85682053)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.336952 Xenopus laevis transcribed sequence with weak similarity more 76.22(n)    BJ051660.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BQ092666.12   -- 71.93(n)    BQ092666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snp6
    Snipper
    24(a)
    1 → many
    2R(17948458-17957262)


    ENSEMBL Gene Tree for RNPC3 (if available)
    TreeFam Gene Tree for RNPC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNPC3 gene
    RBM412  

    RNPC3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNPC3
    PGOHUM00000237647


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNPC3 (see all 424)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138826351,2
    C,F--102121846(+) TAACAC/GTACCC 1 -- us2k12Minor allele frequency- G:0.04NA 122
    rs1913179061,2
    --104066599(+) GATTGA/TCTTCT 1 -- us2k10--------
    rs747317361,2
    C,F--104066728(+) ACCTCG/ATGGTA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1830184591,2
    --104066800(+) TAGATA/TCCTTA 1 -- us2k10--------
    rs1877105191,2
    --104066832(+) TTCCCA/CATGTC 1 -- us2k10--------
    rs1428149241,2
    --104066898(+) GGCATA/CATCAT 1 -- us2k10--------
    rs1473948361,2
    --104066957(+) TTGCTA/TACTAT 1 -- us2k10--------
    rs1127371811,2
    F--104066969(+) CTTCAT/ACTGCA 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs75291441,2
    C,F,A,H--104067000(+) AAAACA/GTATCT 1 -- us2k129Minor allele frequency- G:0.36NS EA NA WA CSA 2780
    rs1480604551,2
    --104067136(+) TTTCAA/TACCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNPC3 (104068313 - 104097861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNPC3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871791CNV Loss21882294
    nsv830904CNV Loss17160897
    nsv523177CNV Gain19592680
    esv27438CNV Gain19812545
    dgv294n71CNV Gain21882294
    nsv526367CNV Gain19592680
    dgv14n21CNV Gain19592680
    nsv428157CNV Gain+Loss18775914
    dgv295n71CNV Gain+Loss21882294
    nsv830915CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Selected diseases for RNPC3 (see all 50):    
    About MalaCards
    ebola hemorrhagic fever    rabies    lassa fever    parainfluenza virus type 3
    mixed connective tissue disease    rubella    connective tissue disease    crimean-congo hemorrhagic fever
    rift valley fever    rheumatic disease    hemorrhagic fever    collagen disease
    polymyositis    measles    hemorrhagic fever with renal syndrome    cutaneous lupus erythematosus
    sjogren's syndrome    hyperprolactinemia    influenza    pemphigus vulgaris

    1 disease from the University of Copenhagen DISEASES database for RNPC3:
    Night blindness

    RNPC3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RNPC3 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 77.9 9 1873202 (1), 1374734 (1), 10645148 (1), 10323445 (1) (see all 9)
    lupus erythematosus systemic 64.3 14 10843726 (2), 1873202 (1), 1374734 (1), 8137536 (1) (see all 12)
    other connective tissue disease 57.2 2 17785335 (1), 9112226 (1)
    connective tissue diseases 54.5 5 10209523 (1), 1485812 (1), 7510759 (1), 11703381 (1) (see all 5)
    influenza 49.6 17 12755627 (2), 12642098 (1), 16756174 (1), 8648766 (1) (see all 13)
    muscular atrophy spinal 49.3 2 16473550 (1), 19286363 (1)
    autoimmune response 49.2 1 2249366 (1)
    rheumatic diseases 48.2 3 18240226 (1), 11302861 (1)
    sclerosis systemic 46.2 4 8770332 (1), 10645148 (1), 16014550 (1), 11469465 (1)
    raynauds phenomenon 45.3 1 20360189 (1)


    Export disorders for RNPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNPC3 gene, integrated from 10 sources (see all 285):
    (articles sorted by number of sources associating them with RNPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PubMed id 15146077)1, 2, 3 Will C.L.... Luehrmann R. (RNA 2004)
    2. Cloning and identification of a novel human RNPC3 gene that encodes a protein with two RRM domains and is expressed in the cell nucleus. (PubMed id 14974681)1, 2, 3 Zhao E.... Mao Y. (Biochem. Genet. 2003)
    3. The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein. (PubMed id 16096647)1, 2 Benecke H.... Will C.L. (EMBO J. 2005)
    4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion. (PubMed id 19447915)2 Netter C.... Wahl M.C. (RNA 2009)
    9. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (Neuropathol. Appl. Neurobiol. 2009)
    10. Minor spliceosome components are predominantly localized in the nucleus. (PubMed id 18559850)1 Pessa H.K....Frilander M.J. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55599 HGNC: 18666 AceView: FLJ25070 Ensembl:ENSG00000185946 euGenes: HUgn55599
    ECgene: RNPC3 H-InvDB: RNPC3

    (According to HUGE)
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    HUGE: KIAA1839

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNPC3 gene:
    Search GeneIP for patents involving RNPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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