Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNMTL1 Gene

protein-coding   GIFtS: 54
GCID: GC17P000685

RNA Methyltransferase Like 1

  Search for RNMTL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RNA Methyltransferase Like 11 2
Putative RNA Methyltransferase2
RNA Methyltransferase-Like Protein 12
EC 2.1.1.-3
HC905
EC 2.1.18

External Ids:    HGNC: 184851   Entrez Gene: 551782   Ensembl: ENSG000001718617   OMIM: 6126005   UniProtKB: Q9HC363   

Export aliases for RNMTL1 gene to outside databases

Previous GC identifers: GC00U991199 GC17P000633 GC17P000596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RNMTL1 Gene:
RNMTL1 (RNA methyltransferase like 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot: RMTL1_HUMAN, Q9HC36
Function: Probable RNA methyltransferase (By similarity)

Gene Wiki entry for RNMTL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNMTL1 gene promoter:
         ER-alpha   AhR   NF-1   CUTL1   C/EBPalpha   GATA-2   Arnt   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNMTL1 promoter sequence
   Search Chromatin IP Primers for RNMTL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNMTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

RNMTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNMTL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P000685:  view genomic region     (about GC identifiers)

Start:
685,513 bp from pter      End:
695,749 bp from pter
Size:
10,237 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RMTL1_HUMAN, Q9HC36 (See protein sequence)
Recommended Name: RNA methyltransferase-like protein 1  
Size: 420 amino acids; 47020 Da
Secondary accessions: Q53GN1 Q86VC3 Q96F76 Q9NVQ5

Explore the universe of human proteins at neXtProt for RNMTL1: NX_Q9HC36

Explore proteomics data for RNMTL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for RNMTL1 (Q9HC36)
     SLNSAMAA  VLLTKGCVD  KGCVDAWEPKVLR 


    See RNMTL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060616.1  
    ENSEMBL proteins: 
     ENSP00000306080   ENSP00000458328   ENSP00000460957  

    RNMTL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNMTL1
    OriGene Protein Over-expression Lysate for RNMTL1
    OriGene MassSpec for RNMTL1
    OriGene Custom Protein Services for RNMTL1
    GenScript Custom Purified and Recombinant Proteins Services for RNMTL1
    Novus Biologicals RNMTL1 Protein
    Novus Biologicals RNMTL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNMTL1

     
    Search eBioscience for Proteins for RNMTL1 

    RNMTL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNMTL1
    Novus Biologicals RNMTL1 Antibodies
    Abcam antibodies for RNMTL1
    Cloud-Clone Corp. Antibodies for RNMTL1
    ThermoFisher Antibodies for RNMTL1
    Search LSBio for Antibodies for RNMTL1

    RNMTL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNMTL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNMTL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNMTL1
    Cloud-Clone Corp. CLIAs for RNMTL1
    Search eBioscience for ELISAs for RNMTL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001537 SpoU_MeTrfase
     IPR013123 SpoU_subst-bd

    Graphical View of Domain Structure for InterPro Entry Q9HC36

    ProtoNet protein and cluster: Q9HC36

    1 Blocks protein domain: IPB001537 tRNA/rRNA methyltransferase (SpoU)

    UniProtKB/Swiss-Prot: RMTL1_HUMAN, Q9HC36
    Similarity: Belongs to the RNA methyltransferase TrmH family


    Find genes that share domains with RNMTL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RMTL1_HUMAN, Q9HC36
    Function: Probable RNA methyltransferase (By similarity)

         Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0008168methyltransferase activity ----
    GO:0008173RNA methyltransferase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with RNMTL1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNMTL1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI phenotypic allele for Rnmtl1 (no phenotypes)

    Find genes that share phenotypes with RNMTL1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNMTL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNMTL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNMTL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNMTL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNMTL1:
    hsa-let-7b-5p (MIRT032260), hsa-mir-16-5p (MIRT031612), hsa-mir-484 (MIRT042205)

    Block miRNA regulation of human, mouse, rat RNMTL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNMTL1:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidRNMTL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNMTL1
    Predesigned siRNA for gene silencing in human, mouse, rat RNMTL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNMTL1

    Clone
    Products:
         
    OriGene clones in human, mouse for RNMTL1 (see all 6)
    OriGene ORF clones in mouse, rat for RNMTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNMTL1 (NM_018146)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNMTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMTL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNMTL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNMTL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMTL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with RNMTL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNMTL1
    Interactions:

        Search GeneGlobe Interaction Network for RNMTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNMTL1 (Q9HC361, 2, 3 ENSP000003060804) via UniProtKB, MINT, STRING, and/or I2D (see all 276)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTHL1P785491, 3, ENSP000002190664EBI-1045440,EBI-1049350 I2D: score=2 STRING: ENSP00000219066
    NUDT1P366391, 3, ENSP000003395034EBI-1045440,EBI-1048967 I2D: score=2 STRING: ENSP00000339503
    PUF60Q9UHX11, 3, ENSP000003220164EBI-1045440,EBI-1053259 I2D: score=2 STRING: ENSP00000322016
    TRIP6Q156541, 3, ENSP000002004574EBI-1045440,EBI-742327 I2D: score=2 STRING: ENSP00000200457
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--

    Find genes that share ontologies with RNMTL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNMTL1 (RMTL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNMTL1 gene: 
    NM_018146.2  

    Unigene Cluster for RNMTL1:

    RNA methyltransferase like 1
    Hs.182729  [show with all ESTs]
    Unigene Representative Sequence: BM559404
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304478(uc002frw.3) ENST00000574916 ENST00000574509 ENST00000571157

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNMTL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNMTL1:
    hsa-miR-612 hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidRNMTL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNMTL1
    Predesigned siRNA for gene silencing in human, mouse, rat RNMTL1
    Clone
    Products:
         
    OriGene clones in human, mouse for RNMTL1 (see all 6)
    OriGene ORF clones in mouse, rat for RNMTL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNMTL1 (NM_018146)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNMTL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMTL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RNMTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNMTL1
      QuantiTect SYBR Green Assays in human, mouse, rat RNMTL1
      QuantiFast Probe-based Assays in human, mouse, rat RNMTL1

    Additional mRNA sequence: 

    AF177344.2 AK001443.1 AK222900.1 AK225128.1 BC011550.1 BC050614.1 

    7 DOTS entries:

    DT.414899  DT.95154338  DT.100716834  DT.75156332  DT.100884745  DT.120918839  DT.100884764 

    Selected AceView cDNA sequences (see all 135):

    CR626756 CR610396 CR613251 CF130226 BI915503 CB147544 AA315930 BU621472 
    CB528524 CR592397 CA488414 BM465798 BF223090 CA487721 CR598330 CR606431 
    BI767361 CR626293 AF177344 NM_018146 BI915279 BI909292 CR591937 BX366873 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNMTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGCAAGCA
    RNMTL1 Expression
    About this image


    RNMTL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebellum
    RNMTL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNMTL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182729

    UniProtKB/Swiss-Prot: RMTL1_HUMAN, Q9HC36
    Tissue specificity: Expressed at same level in normal liver and hepatocarcinoma

        Custom PCR Arrays for RNMTL1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RNMTL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNMTL1
    QuantiTect SYBR Green Assays in human, mouse, rat RNMTL1
    QuantiFast Probe-based Assays in human, mouse, rat RNMTL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMTL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RNMTL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnmtl11 , 5 RNA methyltransferase like 11, 5 85.31(n)1
    83.66(a)1
      11 (45.92 cM)5
    673901  NM_183263.51  NP_899086.21 
     762437155 
    chicken
    (Gallus gallus)
    Aves RNMTL11 RNA methyltransferase like 1 62.65(n)
    57.44(a)
      417620  XM_415864.4  XP_415864.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNMTL16
    RNA methyltransferase like 1
    56(a)
    1 ↔ 1
    GL344108.1(45549-51393)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106962 Transcribed sequence with weak similarity to protein more 76.92(n)    BX692556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.149232 Transcribed sequence with weak similarity to protein more 73.44(n)    BM035786.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG141001 CG14100 46(n)
    35.75(a)
      40132  NM_140873.4  NP_649130.2 


    ENSEMBL Gene Tree for RNMTL1 (if available)
    TreeFam Gene Tree for RNMTL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNMTL1 gene

    Find genes that share paralogs with RNMTL1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RNMTL1
    PGOHUM00000238693 PGOHUM00000233140


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNMTL1 (see all 254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561261381,2
    C,F--687646(+) AATCCA/GCACGC 1 -- int11Minor allele frequency- G:0.08WA 118
    rs600095521,2
    C,F--687684(+) TTTACC/TGTGCT 1 -- int12Minor allele frequency- T:0.03WA 120
    rs1843434071,2
    --687742(+) TGTGCC/TTGTCA 1 -- int10--------
    rs673493101,2
    C,F--687811(+) GGCAGG/ATGTGC 1 -- int13Minor allele frequency- A:0.50NA 6
    rs1873698291,2
    --687821(+) CTTACA/GGTGGC 1 -- int10--------
    rs116555291,2
    C,F,H--687843(+) GAACTT/CCATCA 1 -- int112Minor allele frequency- C:0.03NA NS EA 986
    rs1921986651,2
    --688002(+) GCCTCC/TGTATA 1 -- int10--------
    rs739755221,2
    C,F--688050(+) AAGGAC/TTTCTA 1 -- int12Minor allele frequency- T:0.10WA 120
    rs1854219751,2
    --688085(+) TTTTGC/GCCATC 1 -- int10--------
    rs116544741,2
    C,F,H--688134(+) CGCCTA/GATACC 1 -- int115Minor allele frequency- G:0.03NA NS EA 1564

    HapMap Linkage Disequilibrium report for RNMTL1 (685513 - 695749 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNMTL1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv5398CNV Deletion18987735
    esv2715360CNV Deletion23290073
    esv2715358CNV Deletion23290073
    esv1058975CNV Deletion17803354
    esv2715359CNV Deletion23290073
    esv2715361CNV Deletion23290073
    esv2422420CNV Duplication17116639
    nsv907457CNV Loss21882294
    nsv457631CNV Gain19166990
    esv35056CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNMTL1
    DNA2.0 Custom Variant and Variant Library Synthesis for RNMTL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612600    OMIM disorders: --


    Find genes that share disorders with RNMTL1           About GenesLikeMe

    Genetic Association Database (GAD): RNMTL1
    Human Genome Epidemiology (HuGE) Navigator: RNMTL1 (1 document)

    Export disorders for RNMTL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNMTL1 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RNMTL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene. (PubMed id 12296377)1, 2, 3, 9 Xu J.... Gu J.R. (Cell Res. 2002)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55178 HGNC: 18485 AceView: FLJ10581 Ensembl:ENSG00000171861 euGenes: HUgn55178
    ECgene: RNMTL1 H-InvDB: RNMTL1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNMTL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNMTL1 gene:
    Search GeneIP for patents involving RNMTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNMTL1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RNMTL1  
     OriGene MassSpec something-or-other for RNMTL1   OriGene clones in human, mouse for RNMTL1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNMTL1   OriGene Purified Protein for RNMTL1  
     OriGene ORF clones in mouse, rat for RNMTL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNMTL1   OriGene Custom Protein Services for RNMTL1  

     
     
     Block miRNA regulation of human, mouse, rat RNMTL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNMTL1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNMTL1 Predesigned siRNA for gene silencing in human, mouse, rat RNMTL1
     QuantiFast Probe-based Assays in human, mouse, rat RNMTL1 QuantiTect SYBR Green Assays in human, mouse, rat RNMTL1
     Custom PCR Arrays for RNMTL1 Search Chromatin IP Primers for RNMTL1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNMTL1  Search GeneGlobe Interaction Network for RNMTL1
     Regulatory tfbs in RNMTL1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNMTL1 GenScript cDNA clones with any tag delivered in your preferred vector for RNMTL1
     GenScript Custom Assay Services for RNMTL1 GenScript Custom overexpressing Cell Line Services for RNMTL1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNMTL1 (RMTL1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNMTL1 antibodies
     RNMTL1 proteins
     RNMTL1 lysates
     Antibodies for RNMTL1
     See all of Abcam's Antibodies, Kits and Proteins for RNMTL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNMTL1
     Antibodies for RNMTL1
     ELISAs for RNMTL1
     CLIAs for RNMTL1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNMTL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMTL1
     SwitchGear 3'UTR luciferase reporter plasmids for RNMTL1
     SwitchGear Promoter luciferase reporter plasmids for RNMTL1
     ThermoFisher Antibodies for RNMTL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMTL1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNMTL1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNMTL1
     Search LSBio for Antibodies for RNMTL1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RNMTL1
      Search eBioscience for proteins for RNMTL1
      Search eBioscience for elisas for RNMTL1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNMTL1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4