Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNMTL1 Gene

Aliases for RNMTL1 Gene

  • RNA Methyltransferase Like 1 2 3
  • 16S RRNA (Guanosine(1370)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Gm1370] 2-O-Methyltransferase 3 4
  • RNA Methyltransferase-Like Protein 1 3 4
  • HC90 3 6
  • MRM3 3 4
  • RRNA Methyltransferase 3, Mitochondrial 3
  • Putative RNA Methyltransferase 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • RMTL1 3

External Ids for RNMTL1 Gene

Previous GeneCards Identifiers for RNMTL1 Gene

  • GC00U991199
  • GC17P000633
  • GC17P000685
  • GC17P000596

Summaries for RNMTL1 Gene

GeneCards Summary for RNMTL1 Gene

RNMTL1 (RNA Methyltransferase Like 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for RNMTL1 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Gene Wiki entry for RNMTL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNMTL1 Gene

Genomics for RNMTL1 Gene

Regulatory Elements for RNMTL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNMTL1 Gene

Start:
782,273 bp from pter
End:
792,509 bp from pter
Size:
10,237 bases
Orientation:
Plus strand

Genomic View for RNMTL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNMTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMTL1 Gene

Proteins for RNMTL1 Gene

  • Protein details for RNMTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC36-MRM3_HUMAN
    Recommended name:
    rRNA methyltransferase 3, mitochondrial
    Protein Accession:
    Q9HC36
    Secondary Accessions:
    • Q53GN1
    • Q86VC3
    • Q96F76
    • Q9NVQ5

    Protein attributes for RNMTL1 Gene

    Size:
    420 amino acids
    Molecular mass:
    47020 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNMTL1 Gene

Proteomics data for RNMTL1 Gene at MOPED

Selected DME Specific Peptides for RNMTL1 Gene

Post-translational modifications for RNMTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNMTL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for RNMTL1 Gene

Suggested Antigen Peptide Sequences for RNMTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC36

UniProtKB/Swiss-Prot:

MRM3_HUMAN :
  • Q9HC36
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with RNMTL1: view

No data available for Gene Families for RNMTL1 Gene

Function for RNMTL1 Gene

Molecular function for RNMTL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + guanosine(1370) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methylguanosine(1370) in 16S rRNA.
UniProtKB/Swiss-Prot Function: S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for RNMTL1 Gene

Gene Ontology (GO) - Molecular Function for RNMTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0008173 RNA methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RNMTL1: view
genes like me logo Genes that share phenotypes with RNMTL1: view

Animal Model Products

CRISPR Products

miRNA for RNMTL1 Gene

miRTarBase miRNAs that target RNMTL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNMTL1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNMTL1 Gene

Localization for RNMTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMTL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNMTL1 Gene COMPARTMENTS Subcellular localization image for RNMTL1 gene
Compartment Confidence
mitochondrion 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNMTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with RNMTL1: view

Pathways for RNMTL1 Gene

SuperPathways for RNMTL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNMTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IEA --
GO:0006364 rRNA processing IEA --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with RNMTL1: view

No data available for Pathways by source for RNMTL1 Gene

Transcripts for RNMTL1 Gene

Unigene Clusters for RNMTL1 Gene

RNA methyltransferase like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNMTL1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNMTL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNMTL1 Gene

No ASD Table

Relevant External Links for RNMTL1 Gene

GeneLoc Exon Structure for
RNMTL1
ECgene alternative splicing isoforms for
RNMTL1

Expression for RNMTL1 Gene

mRNA expression in normal human tissues for RNMTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNMTL1 Gene

SOURCE GeneReport for Unigene cluster for RNMTL1 Gene Hs.182729

mRNA Expression by UniProt/SwissProt for RNMTL1 Gene

Q9HC36-MRM3_HUMAN
Tissue specificity: Expressed at same level in normal liver and hepatocarcinoma.
genes like me logo Genes that share expressions with RNMTL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNMTL1 Gene

Orthologs for RNMTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNMTL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNMTL1 35
  • 99.29 (n)
  • 99.29 (a)
RNMTL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNMTL1 35
  • 85.21 (n)
  • 85.54 (a)
RNMTL1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNMTL1 35
  • 86.43 (n)
  • 84.52 (a)
RNMTL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnmtl1 35
  • 85.31 (n)
  • 83.66 (a)
Rnmtl1 16
Rnmtl1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNMTL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNMTL1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnmtl1 35
  • 84.61 (n)
  • 83.01 (a)
chicken
(Gallus gallus)
Aves RNMTL1 35
  • 62.65 (n)
  • 57.44 (a)
RNMTL1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNMTL1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmtl1 35
  • 60.19 (n)
  • 57.32 (a)
Str.10696 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14923 35
rnmtl1a 35
  • 58.99 (n)
  • 52.62 (a)
rnmtl1a 36
  • 46 (a)
OneToMany
rnmtl1b 36
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003655 35
  • 48.76 (n)
  • 39.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14100 35
  • 46 (n)
  • 35.75 (a)
CG14100 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToOne
Species with no ortholog for RNMTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNMTL1 Gene

ENSEMBL:
Gene Tree for RNMTL1 (if available)
TreeFam:
Gene Tree for RNMTL1 (if available)

Paralogs for RNMTL1 Gene

Pseudogenes.org Pseudogenes for RNMTL1 Gene

genes like me logo Genes that share paralogs with RNMTL1: view

No data available for Paralogs for RNMTL1 Gene

Variants for RNMTL1 Gene

Sequence variations from dbSNP and Humsavar for RNMTL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1570000 -- 788,283(+) attag(C/T)tgggt intron-variant
rs3744743 -- 792,776(+) AGAGA(C/T)GGAAG downstream-variant-500B
rs3786062 -- 790,114(+) AATAA(C/T)TCGTC intron-variant
rs3786063 -- 790,176(+) AGTCA(C/T)TGCGA intron-variant
rs3833168 -- 791,520(+) TTCCT(-/GTCT/GTTT)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNMTL1 Gene

Variant ID Type Subtype PubMed ID
esv2422420 CNV Duplication 17116639
nsv457631 CNV Gain 19166990
nsv469891 CNV Complex 16826518
dgv925e1 CNV Complex 17122850
esv673 CNV CNV 17122850
nsv907457 CNV Loss 21882294
nsv907458 CNV Gain 21882294
esv35056 CNV Gain 17911159
esv2715358 CNV Deletion 23290073
esv5398 CNV Deletion 18987735
esv2715359 CNV Deletion 23290073
esv2715360 CNV Deletion 23290073
esv1058975 CNV Deletion 17803354
esv2715361 CNV Deletion 23290073

Relevant External Links for RNMTL1 Gene

HapMap Linkage Disequilibrium report
RNMTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMTL1 Gene

Disorders for RNMTL1 Gene

Relevant External Links for RNMTL1

Genetic Association Database (GAD)
RNMTL1
Human Genome Epidemiology (HuGE) Navigator
RNMTL1
genes like me logo Genes that share disorders with RNMTL1: view

No data available for UniProtKB/Swiss-Prot for RNMTL1 Gene

Publications for RNMTL1 Gene

  1. The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene. (PMID: 12296377) Xu J. … Gu J.R. (Cell Res. 2002) 2 3 4 23
  2. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. (PMID: 25009282) Rorbach J. … Minczuk M. (Mol. Biol. Cell 2014) 2 3 4
  3. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA. (PMID: 25074936) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2014) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for RNMTL1 Gene

Sources for RNMTL1 Gene

Back to Top

Content