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Aliases for RNMT Gene

Aliases for RNMT Gene

  • RNA (Guanine-7-) Methyltransferase 2 3
  • MRNA (Guanine-N(7)-)-Methyltransferase 3 4
  • MRNA Cap Methyltransferase 3 4
  • EC 2.1.1.56 4 63
  • RG7MT1 3 4
  • HCMT1 3 4
  • Hcm1p 3 4
  • HMet 3 4
  • MRNA (Guanine-7-)Methyltransferase 3
  • KIAA0398 4
  • CMT1c 3
  • CMT1 3
  • Cm1p 3
  • Met 3

External Ids for RNMT Gene

Previous GeneCards Identifiers for RNMT Gene

  • GC18M013747
  • GC18P013812

Summaries for RNMT Gene

GeneCards Summary for RNMT Gene

RNMT (RNA (Guanine-7-) Methyltransferase) is a Protein Coding gene. Diseases associated with RNMT include charcot-marie-tooth disease, type 1c and bowen-conradi syndrome. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. GO annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for RNMT Gene

  • mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Gene Wiki entry for RNMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNMT Gene

Genomics for RNMT Gene

Regulatory Elements for RNMT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNMT Gene

Chromosome:
18
Start:
13,726,647 bp from pter
End:
13,764,558 bp from pter
Size:
37,912 bases
Orientation:
Plus strand

Genomic View for RNMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMT Gene

Proteins for RNMT Gene

  • Protein details for RNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43148-MCES_HUMAN
    Recommended name:
    mRNA cap guanine-N7 methyltransferase
    Protein Accession:
    O43148
    Secondary Accessions:
    • B0YJ90
    • D3DUJ5
    • O94996
    • Q9UIJ9

    Protein attributes for RNMT Gene

    Size:
    476 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    • Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap methyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for RNMT Gene

    Alternative splice isoforms for RNMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNMT Gene

Proteomics data for RNMT Gene at MOPED

Selected DME Specific Peptides for RNMT Gene

Post-translational modifications for RNMT Gene

  • Ubiquitination at Lys 163 and Lys 208
  • Modification sites at PhosphoSitePlus

Domains & Families for RNMT Gene

Protein Domains for RNMT Gene

Graphical View of Domain Structure for InterPro Entry

O43148

UniProtKB/Swiss-Prot:

MCES_HUMAN :
  • Contains 1 mRNA cap 0 methyltransferase domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
Domain:
  • Contains 1 mRNA cap 0 methyltransferase domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
genes like me logo Genes that share domains with RNMT: view

No data available for Gene Families for RNMT Gene

Function for RNMT Gene

Molecular function for RNMT Gene

GENATLAS Biochemistry:
messenger RNA (guanine-7) cap methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5)pppR-RNA.
UniProtKB/Swiss-Prot Function:
mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Enzyme Numbers (IUBMB) for RNMT Gene

Gene Ontology (GO) - Molecular Function for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IMP 9790902
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity TAS --
GO:0005515 protein binding IPI 22099306
genes like me logo Genes that share ontologies with RNMT: view
genes like me logo Genes that share phenotypes with RNMT: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNMT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNMT Gene

Localization for RNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNMT Gene COMPARTMENTS Subcellular localization image for RNMT gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9790902
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005845 mRNA cap binding complex IDA 22099306
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with RNMT: view

Pathways & Interactions for RNMT Gene

genes like me logo Genes that share pathways with RNMT: view

Gene Ontology (GO) - Biological Process for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
GO:0036265 RNA (guanine-N7)-methylation TAS 9705270
genes like me logo Genes that share ontologies with RNMT: view

No data available for SIGNOR curated interactions for RNMT Gene

Drugs & Compounds for RNMT Gene

(2) Drugs for RNMT Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for RNMT Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
rRNA
genes like me logo Genes that share compounds with RNMT: view

Transcripts for RNMT Gene

Unigene Clusters for RNMT Gene

RNA (guanine-7-) methyltransferase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNMT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for RNMT Gene

GeneLoc Exon Structure for
RNMT
ECgene alternative splicing isoforms for
RNMT

Expression for RNMT Gene

mRNA expression in normal human tissues for RNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNMT Gene

This gene is overexpressed in Breast (21.2) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNMT Gene



SOURCE GeneReport for Unigene cluster for RNMT Gene Hs.592347

mRNA Expression by UniProt/SwissProt for RNMT Gene

O43148-MCES_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNMT: view

Protein tissue co-expression partners for RNMT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNMT Gene

Orthologs for RNMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNMT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNMT 35
  • 89.68 (n)
  • 86.53 (a)
RNMT 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNMT 35
  • 91.53 (n)
  • 90.13 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnmt 35
  • 81.77 (n)
  • 77.34 (a)
Rnmt 16
Rnmt 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNMT 35
  • 99.51 (n)
  • 99.16 (a)
RNMT 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnmt 35
  • 82.34 (n)
  • 79.03 (a)
oppossum
(Monodelphis domestica)
Mammalia RNMT 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNMT 35
  • 74.15 (n)
  • 73.63 (a)
RNMT 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNMT 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmt 35
  • 71.24 (n)
  • 73.67 (a)
Str.2305 35
African clawed frog
(Xenopus laevis)
Amphibia xCMT1 35
zebrafish
(Danio rerio)
Actinopterygii rnmt 35
  • 62.91 (n)
  • 62.3 (a)
wufi09c12 35
rnmt 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bd 37
  • 43 (a)
l(2)35Bd 35
  • 53.92 (n)
  • 46.54 (a)
l(2)35Bd 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003460 35
  • 49.58 (n)
  • 44.51 (a)
worm
(Caenorhabditis elegans)
Secernentea C25A1.3 37
  • 40 (a)
tag-72 35
  • 51.51 (n)
  • 42.99 (a)
tag-72 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABD1 36
  • 25 (a)
OneToOne
ABD1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6979 36
  • 46 (a)
OneToOne
Species with no ortholog for RNMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNMT Gene

ENSEMBL:
Gene Tree for RNMT (if available)
TreeFam:
Gene Tree for RNMT (if available)

Paralogs for RNMT Gene

(1) SIMAP similar genes for RNMT Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNMT: view

No data available for Paralogs for RNMT Gene

Variants for RNMT Gene

Sequence variations from dbSNP and Humsavar for RNMT Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1043925 -- 13,764,017(+) AGACC(A/T)CCTTC utr-variant-3-prime
rs1284190 -- 13,731,314(-) TCTCC(C/T)GCCTC intron-variant
rs1284191 -- 13,731,173(-) TGCCT(C/T)GGCCT intron-variant
rs1284192 -- 13,729,592(-) ATCAG(A/G)GAACA intron-variant
rs1284193 -- 13,729,466(-) ATGGA(A/T)ATTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNMT Gene

Variant ID Type Subtype PubMed ID
esv8144 CNV Gain 19470904

Variation tolerance for RNMT Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNMT Gene

HapMap Linkage Disequilibrium report
RNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMT Gene

Disorders for RNMT Gene

MalaCards: The human disease database

(3) MalaCards diseases for RNMT Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 1c
  • charcot-marie-tooth disease type 1c
bowen-conradi syndrome
  • bowen hutterite syndrome
dubowitz syndrome
  • dubowitz's syndrome
- elite association
Search RNMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNMT

Genetic Association Database (GAD)
RNMT
Human Genome Epidemiology (HuGE) Navigator
RNMT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNMT
genes like me logo Genes that share disorders with RNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNMT Gene

Publications for RNMT Gene

  1. Predicting atomic details of the unfolding pathway for YibK, a knotted protein from the SPOUT superfamily. (PMID: 19916572) Tuszynska I. … Bujnicki J.M. (J. Biomol. Struct. Dyn. 2010) 23 67
  2. The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. (PMID: 20047967) Wurm J.P. … Wohnert J. (Nucleic Acids Res. 2010) 23 67
  3. Scintillation proximity assay for measurement of RNA methylation. (PMID: 19181706) Baker M.R. … Rife J.P. (Nucleic Acids Res. 2009) 23 67
  4. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. (PMID: 19181850) Raffa G.D. … Gatti M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  5. Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. (PMID: 19808971) Schaefer M. … Lyko F. (Cancer Res. 2009) 23 67

Products for RNMT Gene

Sources for RNMT Gene

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