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Aliases for RNMT Gene

Aliases for RNMT Gene

  • RNA Guanine-7 Methyltransferase 2 3 5
  • MRNA (Guanine-N(7)-)-Methyltransferase 3 4
  • MRNA Cap Guanine-N7 Methyltransferase 2 3
  • RNA (Guanine-7-) Methyltransferase 2 3
  • MRNA Cap Methyltransferase 3 4
  • EC 2.1.1.56 4 61
  • RG7MT1 3 4
  • HCMT1 3 4
  • Hcm1p 3 4
  • HMet 3 4
  • MRNA (Guanine-7-)Methyltransferase 3
  • KIAA0398 4
  • CMT1c 3
  • CMT1 3
  • Cm1p 3
  • MET 3

External Ids for RNMT Gene

Previous GeneCards Identifiers for RNMT Gene

  • GC18M013747
  • GC18P013812

Summaries for RNMT Gene

GeneCards Summary for RNMT Gene

RNMT (RNA Guanine-7 Methyltransferase) is a Protein Coding gene. Diseases associated with RNMT include Dubowitz Syndrome. Among its related pathways are mRNA Capping and HIV Life Cycle. GO annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for RNMT Gene

  • mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Gene Wiki entry for RNMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNMT Gene

Genomics for RNMT Gene

Regulatory Elements for RNMT Gene

Enhancers for RNMT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F013725 0.2 ENCODE 17.1 +0.0 14 3.2 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 RNMT ENSG00000267756 ENSG00000266969 FAM210A
GH18F013717 1.1 ENCODE 16.7 -9.2 -9169 0.4 RNMT RN7SL362P
GH18F013800 1.2 Ensembl ENCODE 9 +74.5 74517 0.9 ARID4B KLF17 ZNF2 RAD21 ZNF48 ZEB1 ZNF335 GLIS2 ZNF143 SP3 RNMT MC5R GC18P013764 PIR43169
GH18F013379 1.4 FANTOM5 ENCODE 8.6 -344.9 -344911 4.0 MAX REST MNT ZIC2 RAD21 NR2F2 ZNF121 EED ETV6 FOXP2 LDLRAD4 RNMT PTPN2 CEP192 ENSG00000267393 LDLRAD4-AS1
GH18F013807 0.6 ENCODE 8 +83.0 83017 3.4 RNMT MC5R GC18P013764 PIR43169
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNMT on UCSC Golden Path with GeneCards custom track

Promoters for RNMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000522803 -47 3201 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for RNMT Gene

Chromosome:
18
Start:
13,726,647 bp from pter
End:
13,764,558 bp from pter
Size:
37,912 bases
Orientation:
Plus strand

Genomic View for RNMT Gene

Genes around RNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMT Gene

Proteins for RNMT Gene

  • Protein details for RNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43148-MCES_HUMAN
    Recommended name:
    mRNA cap guanine-N7 methyltransferase
    Protein Accession:
    O43148
    Secondary Accessions:
    • B0YJ90
    • D3DUJ5
    • O94996
    • Q9UIJ9

    Protein attributes for RNMT Gene

    Size:
    476 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    • Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap methyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for RNMT Gene

    Alternative splice isoforms for RNMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNMT Gene

Selected DME Specific Peptides for RNMT Gene

O43148:
  • EQADMMLRNAC
  • RSQSRIF
  • CGKGGDL
  • EMAKKYNM
  • FDICSCQF
  • YPLFGCKYDF

Post-translational modifications for RNMT Gene

  • Ubiquitination at Lys 163 and Lys 208
  • Modification sites at PhosphoSitePlus

Domains & Families for RNMT Gene

Protein Domains for RNMT Gene

Graphical View of Domain Structure for InterPro Entry

O43148

UniProtKB/Swiss-Prot:

MCES_HUMAN :
  • Contains 1 mRNA cap 0 methyltransferase domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
Domain:
  • Contains 1 mRNA cap 0 methyltransferase domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
genes like me logo Genes that share domains with RNMT: view

No data available for Gene Families for RNMT Gene

Function for RNMT Gene

Molecular function for RNMT Gene

GENATLAS Biochemistry:
messenger RNA (guanine-7) cap methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5)pppR-RNA.
UniProtKB/Swiss-Prot Function:
mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Enzyme Numbers (IUBMB) for RNMT Gene

Gene Ontology (GO) - Molecular Function for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IMP 9790902
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity IMP,TAS --
GO:0005515 protein binding IPI 22099306
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RNMT: view
genes like me logo Genes that share phenotypes with RNMT: view

Animal Models for RNMT Gene

MGI Knock Outs for RNMT:
  • Rnmt tm1b(KOMP)Mbp

Animal Model Products

  • Taconic Biosciences Mouse Models for RNMT

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNMT Gene

Localization for RNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNMT Gene COMPARTMENTS Subcellular localization image for RNMT gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9790902
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 nucleolus IDA --
GO:0005845 mRNA cap binding complex IDA 22099306
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with RNMT: view

Pathways & Interactions for RNMT Gene

genes like me logo Genes that share pathways with RNMT: view

Pathways by source for RNMT Gene

1 BioSystems pathway for RNMT Gene
1 KEGG pathway for RNMT Gene

Gene Ontology (GO) - Biological Process for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping IMP,TAS --
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0036265 RNA (guanine-N7)-methylation IEA --
genes like me logo Genes that share ontologies with RNMT: view

No data available for SIGNOR curated interactions for RNMT Gene

Drugs & Compounds for RNMT Gene

(2) Drugs for RNMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for RNMT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNMT: view

Transcripts for RNMT Gene

Unigene Clusters for RNMT Gene

RNA (guanine-7-) methyltransferase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for RNMT Gene

GeneLoc Exon Structure for
RNMT
ECgene alternative splicing isoforms for
RNMT

Expression for RNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNMT Gene

This gene is overexpressed in Breast (21.2) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNMT Gene



Protein tissue co-expression partners for RNMT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNMT Gene:

RNMT

SOURCE GeneReport for Unigene cluster for RNMT Gene:

Hs.592347

mRNA Expression by UniProt/SwissProt for RNMT Gene:

O43148-MCES_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNMT: view

Primer Products

No data available for mRNA differential expression in normal tissues for RNMT Gene

Orthologs for RNMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNMT 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia RNMT 34
  • 91.53 (n)
-- 35
  • 90 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNMT 34 35
  • 89.68 (n)
rat
(Rattus norvegicus)
Mammalia Rnmt 34
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Rnmt 34 16 35
  • 81.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNMT 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNMT 34 35
  • 74.15 (n)
lizard
(Anolis carolinensis)
Reptilia RNMT 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmt 34
  • 71.24 (n)
Str.2305 34
African clawed frog
(Xenopus laevis)
Amphibia xCMT1 34
zebrafish
(Danio rerio)
Actinopterygii rnmt 34 35
  • 62.91 (n)
wufi09c12 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bd 36 34 35
  • 53.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003460 34
  • 49.58 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-72 34 35
  • 51.51 (n)
C25A1.3 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABD1 35 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6979 35
  • 46 (a)
OneToOne
Species where no ortholog for RNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNMT Gene

ENSEMBL:
Gene Tree for RNMT (if available)
TreeFam:
Gene Tree for RNMT (if available)

Paralogs for RNMT Gene

(1) SIMAP similar genes for RNMT Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNMT: view

No data available for Paralogs for RNMT Gene

Variants for RNMT Gene

Sequence variations from dbSNP and Humsavar for RNMT Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1043925 -- 13,764,017(+) AGACC(A/T)CCTTC nc-transcript-variant, utr-variant-3-prime
rs10502424 -- 13,744,985(+) GTCAG(G/T)ATCTA intron-variant
rs10535272 -- 13,732,736(+) GGGAG(-/CC)CCCCC intron-variant
rs10592900 -- 13,745,707(+) GACTG(-/TACTC)TACAG intron-variant
rs11080684 -- 13,726,817(+) CCACC(A/C)CTGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNMT Gene

Variant ID Type Subtype PubMed ID
esv8144 CNV gain 19470904
nsv576529 CNV gain 21841781

Variation tolerance for RNMT Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMT Gene

Disorders for RNMT Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNMT Gene - From: DISEASES

Disorder Aliases PubMed IDs
dubowitz syndrome
  • dubowitz's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RNMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNMT

Genetic Association Database (GAD)
RNMT
Human Genome Epidemiology (HuGE) Navigator
RNMT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNMT
genes like me logo Genes that share disorders with RNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNMT Gene

Publications for RNMT Gene

  1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PMID: 9705270) Pillutla R.C. … Shatkin A.J. (J. Biol. Chem. 1998) 2 3 4 64
  2. RAM/Fam103a1 is required for mRNA cap methylation. (PMID: 22099306) Gonatopoulos-Pournatzis T. … Cowling V.H. (Mol. Cell 2011) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B. … Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009) 3 46 64
  5. Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. (PMID: 15767670) Shafer B. … Shatkin A.J. (Mol. Cell. Biol. 2005) 3 4 64

Products for RNMT Gene

Sources for RNMT Gene

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