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RNMT Gene

protein-coding   GIFtS: 67
GCID: GC18P013716

RNA (Guanine-7-) Methyltransferase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA (Guanine-7-) Methyltransferase1 2     EC 2.1.1.563 8
RG7MT12 3     MET2 5
hCMT12 3     hCMT1c2
hMet2 3     MRNA (Guanine-7-)Methyltransferase2
hcm1p2 3     MRNA Cap Guanine-N7 Methyltransferase2
MRNA (Guanine-N(7)-)-Methyltransferase2 3     KIAA03983
MRNA Cap Methyltransferase2 3     

External Ids:    HGNC: 100751   Entrez Gene: 87312   Ensembl: ENSG000001016547   OMIM: 6035145   UniProtKB: O431483   

Export aliases for RNMT gene to outside databases

Previous GC identifers: GC18M013747 GC18P013812


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNMT Gene:
RNMT (RNA (guanine-7-) methyltransferase) is a protein-coding gene. Diseases associated with RNMT include bowen-conradi syndrome, and dubowitz syndrome. GO annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap
structure of mRNAs. Binds RNA containing 5'-terminal GpppC

summary for RNMT Gene:
MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for RNMT (MRNA-methyltransferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNMT gene promoter:
         STAT5A   Cdc5   AREB6   MEF-2A   POU2F1   POU2F1a   POU2F1b   aMEF-2   POU2F1c   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNMT promoter sequence
   Search Chromatin IP Primers for RNMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21   Ensembl cytogenetic band:  18p11.21   HGNC cytogenetic band: 18p11.21

RNMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNMT gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P013716:  view genomic region     (about GC identifiers)

Start:
13,726,659 bp from pter      End:
13,764,557 bp from pter
Size:
37,899 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCES_HUMAN, O43148 (See protein sequence)
Recommended Name: mRNA cap guanine-N7 methyltransferase  
Size: 476 amino acids; 54844 Da
Subunit: Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity.
Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in
response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of
polymerase II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap
methyltransferase activity
2 PDB 3D structures from and Proteopedia for RNMT:
3BGV (3D)        3EPP (3D)    
Secondary accessions: B0YJ90 D3DUJ5 O94996 Q9UIJ9
Alternative splicing: 2 isoforms:  O43148-1   O43148-2   

Explore the universe of human proteins at neXtProt for RNMT: NX_O43148

Explore proteomics data for RNMT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys163, Lys208
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNMT (O43148) (see all 6)
     RSQSRIF  CGKGGDL  FDICSCQF  EMAKKYNM 


    See RNMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003790.1  
    ENSEMBL proteins: 
     ENSP00000446426   ENSP00000372804   ENSP00000467171   ENSP00000466111   ENSP00000467475  
     ENSP00000466252   ENSP00000468261   ENSP00000262173   ENSP00000438624  
    Reactome Protein details: O43148

    RNMT Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RNMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004971 mRNA_G-N7_MeTrfase_dom
     IPR016899 mRNA_G-N7_MeTrfase

    Graphical View of Domain Structure for InterPro Entry O43148

    ProtoNet protein and cluster: O43148

    UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
    Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase
    family
    Similarity: Contains 1 mRNA cap 0 methyltransferase domain


    RNMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCES_HUMAN, O43148
    Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap
    structure of mRNAs. Binds RNA containing 5'-terminal GpppC
    Catalytic activity: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA

         Genatlas biochemistry entry for RNMT:
    messenger RNA (guanine-7) cap methyltransferase

         Enzyme Number (IUBMB): EC 2.1.1.561 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IMP9790902
    GO:0004482mRNA (guanine-N7-)-methyltransferase activity TAS--
    GO:0005515protein binding IPI--
    GO:0008168methyltransferase activity ----
         
    RNMT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNMT
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNMT

    miRNA
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    miRTarBase miRNAs that target RNMT:
    hsa-mir-103a-3p (MIRT027113), hsa-mir-16-5p (MIRT031646), hsa-let-7b-5p (MIRT032372), hsa-let-7e-5p (MIRT051661), hsa-mir-484 (MIRT042067), hsa-mir-331-3p (MIRT043402)

    Block miRNA regulation of human, mouse, rat RNMT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNMT (see all 48):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-miR-30d hsa-let-7g
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCES_HUMAN, O43148: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005845mRNA cap binding complex IDA--
    GO:0043235receptor complex IDA--

    RNMT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNMT About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    mRNA Capping0.93
    RNA Polymerase II Transcription0.60
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3mRNA Splicing - Major Pathway
    mRNA processing0.44
    4Gene Expression
    Gene Expression0.40
    5mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RNMT (see all 62)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Tocris Bioscience Pathway for RNMT
        Akt Pathway

    1 BioSystems Pathway for RNMT
        mRNA processing


    3 Reactome Pathways for RNMT
        mRNA Capping
    RNA Pol II CTD phosphorylation and interaction with CE
    RNA Pol II CTD phosphorylation and interaction with CE


    1 Kegg Pathway  (Kegg details for RNMT):
        mRNA surveillance pathway


    RNMT for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNMT
    Interactions:

        Search GeneGlobe Interaction Network for RNMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNMT (O431483 ENSP000002621734) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119403, ENSP000003130074I2D: score=1 STRING: ENSP00000313007
    SUPT6HQ7KZ853, ENSP000003191044I2D: score=1 STRING: ENSP00000319104
    KPNA2P522923, ENSP000003324554I2D: score=1 STRING: ENSP00000332455
    RNGTTO609423, ENSP000003584974I2D: score=3 STRING: ENSP00000358497
    POLR2BP308763, ENSP000003127354I2D: score=4 STRING: ENSP00000312735
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:00063707-methylguanosine mRNA capping TAS--
    GO:0008152metabolic process ----
    GO:0010467gene expression TAS--
    GO:0016032viral process TAS--

    RNMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RNMT available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CrizotinibPotent c-MET/ALK inhibitor[877399-52-5]
    PF 04217903 mesylateHighly selective c-Met inhibitor[956906-93-7]
    PHA 665752Potent and selective MET inhibitor[477575-56-7]
    SU 11274Selective inhibitor of MET kinase activity[658084-23-2]

    2 HMDB Compounds for RNMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    2 Novoseek inferred chemical compound relationships for RNMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-adenosylmethionine 68 2 17935775 (1), 9207015 (1)
    rrna 65.2 1 15136037 (1)



    RNMT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNMT gene: 
    NM_003799.1  

    Unigene Cluster for RNMT:

    RNA (guanine-7-) methyltransferase
    Hs.592347  [show with all ESTs]
    Unigene Representative Sequence: AF067791
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543302(uc002ksk.1) ENST00000383314(uc010dlk.2 uc010xae.1 uc002ksl.1 uc002ksm.1)
    ENST00000588457 ENST00000592764 ENST00000591746 ENST00000589866 ENST00000588417
    ENST00000593007 ENST00000591922 ENST00000262173 ENST00000535051
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNMT (see all 48):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-miR-30d hsa-let-7g
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    Primer
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    Additional mRNA sequence: 

    AB007858.1 AB020966.1 AB022604.1 AB022605.1 AB022606.1 AF067791.1 AK292561.1 AK296370.1 
    AK303842.1 BC005290.1 BC017816.1 BC036798.1 BX647977.1 

    11 DOTS entries:

    DT.100646527  DT.447268  DT.100027990  DT.95113493  DT.121105653  DT.91706823  DT.75106249  DT.95114408 
    DT.121105663  DT.86843028  DT.95113495 

    Selected AceView cDNA sequences (see all 216):

    BU155434 BQ682848 BQ231229 AW592787 AW082788 AB022606 AB007858 AI141759 
    CR602543 AA566003 AL554971 Z41602 Z40575 BM906284 CB130278 NM_003799 
    AA722651 AW072682 BE221160 BM787856 AL597621 AI094548 CN481684 BC036798 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNMT (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:              -                                                                                       
    SP2:                                                                                                      
    SP3:                                                                          -                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for RNMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTATAAT
    RNMT Expression
    About this image

    RNMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592347

    UniProtKB/Swiss-Prot: MCES_HUMAN, O43148
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNMT gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnmt1 , 5 RNA (guanine-7-) methyltransferase1, 5 81.77(n)1
    77.34(a)1
      18 (41.22 cM)5
    678971  NM_026440.41  NP_080716.11 
     683003555 
    chicken
    (Gallus gallus)
    Aves RNMT1 RNA (guanine-7-) methyltransferase 74.15(n)
    73.63(a)
      421046  XM_419132.4  XP_419132.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNMT6
    RNA (guanine-7-) methyltransferase
    53(a)
    1 ↔ 1
    4(43347803-43373018)
    African clawed frog
    (Xenopus laevis)
    Amphibia xCMT12 mRNA (guanine-7-)-methyltransferase 75.83(n)    AF218795.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi09c122 Transcribed sequence with weak similarity to protein more 79.23(n)    57097207 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)35Bd1 , 3 mRNA (guanine-N7)-methyltransferase3
    lethal (2) 35Bd1
    43(a)3
    53.92(n)1
    46.54(a)1
      35B83
    348771  NM_078844.41  NP_523568.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C25A1.33
    tag-721
    Yeast ABD1 protein like3
    tag-721
    40(a)3
    51.51(n)1
    42.99(a)1
      I(10167719-10169953)3
    1828751  NM_060273.61  NP_492674.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ABD1(YBR236C)4 Methyltransferase, catalyzes the transfer of a methyl more   --   2(691693-690383) 852538  NP_009795.1 


    ENSEMBL Gene Tree for RNMT (if available)
    TreeFam Gene Tree for RNMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNMT gene
    1 SIMAP similar gene for RNMT using alignment to 7 protein entries:     MCES_HUMAN (see all proteins):
    hCMT1c

    RNMT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNMT (see all 799)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457399701,2
    C--13678068(+) GATTAC/GAGGCA 1 -- us2k10--------
    rs1841984381,2
    --13678085(+) ACCACC/GCCTGG 1 -- us2k10--------
    rs1166113061,2
    C,F--13678220(+) GCACCC/TGGTGT 1 -- us2k12Minor allele frequency- T:0.02WA NA 238
    rs12842001,2
    C,F,A,H--13678588(-) AGCGTC/TGTGCT 1 -- us2k129Minor allele frequency- T:0.13NA NS EA WA CSA 2523
    rs1452489471,2
    --13678601(+) AAATGC/TTGCCT 1 -- us2k10--------
    rs1428561881,2
    C--13678652(+) CTGAC-/AAGAAGGA 1 -- us2k10--------
    rs38098981,2
    C,F,A--13678829(-) ATCAGT/GGTCAA 1 -- us2k1 tfbs314Minor allele frequency- G:0.31EA NA NS WA 1862
    rs739580291,2
    C,F--13678916(+) GGGGTG/AATGGC 1 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1873434971,2
    --13678932(+) AAAGTC/GTGTTG 1 -- us2k10--------
    rs38098971,2
    C,F,A--13678980(-) GCATTG/AGTCTG 1 -- us2k111Minor allele frequency- A:0.31EA NA NS WA 1838

    HapMap Linkage Disequilibrium report for RNMT (13726659 - 13764557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNMT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv8144CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNMT
    DNA2.0 Custom Variant and Variant Library Synthesis for RNMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603514    OMIM disorders: --

    6 diseases for RNMT:    
    About MalaCards
    bowen-conradi syndrome    dubowitz syndrome    newcastle disease    spina bifida
    vaccinia    malaria

    3 diseases from the University of Copenhagen DISEASES database for RNMT:
    Dubowitz Syndrome     Bowen-Conradi syndrome     Vaccinia

    RNMT for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNMT
    Human Genome Epidemiology (HuGE) Navigator: RNMT (2 documents)

    Export disorders for RNMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNMT gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with RNMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PubMed id 9705270)1, 2, 3 Pillutla R.C.... Shatkin A.J. (J. Biol. Chem. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    4. Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. (PubMed id 15767670)1, 2 Shafer B.... Shatkin A.J. (Mol. Cell. Biol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. (PubMed id 11114884)1, 2 Wen Y. and Shatkin A.J. (Genes Dev. 2000)
    7. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. (PubMed id 10347220)1, 2 Saha N.... Shuman S. (J. Biol. Chem. 1999)
    8. The Candida albicans gene for mRNA 5'-cap methyltransferase: identification of the additional residues essential for catalysis. (PubMed id 10589710)1, 2 Yamada-Okabe T....Yamada-Okabe H. (Microbiology 1999)
    9. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PubMed id 9828141)1, 3 Pillutla R.C....Shatkin A.J. (Genomics 1998)
    10. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)methyltransferase, an mRNA cap methylase. (PubMed id 9790902)1, 2 Tsukamoto T.... Kiyohisa M. (Biochem. Biophys. Res. Commun. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8731 HGNC: 10075 AceView: RNMT Ensembl:ENSG00000101654 euGenes: HUgn8731
    ECgene: RNMT Kegg: 8731 H-InvDB: RNMT

    (According to HUGE)
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    HUGE: KIAA0398

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNMT gene:
    Search GeneIP for patents involving RNMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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