RNMT Gene
protein-coding GIFtS: 67
GCID: GC18P013716
|
|
RNA (guanine-7-) methyltransferase
| |
Aliases
for RNMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RNA (Guanine-7-) Methyltransferase1 2 | | EC 2.1.1.563 8 | | RG7MT11 2 3 | | MET2 5 | | HCMT11 | | HCMT1c1 | | HMet1 | | MRNA (Guanine-7-)Methyltransferase2 | | Hcm1p1 | | MRNA Cap Guanine-N7 Methyltransferase2 | | MRNA (Guanine-N(7)-)-Methyltransferase2 3 | | KIAA03983 | | MRNA Cap Methyltransferase2 3 | | |
Export aliases for RNMT gene to outside databasesPrevious GC identifers: GC18M013747 GC18P013812 |
Summaries
for RNMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MCES_HUMAN, O43148Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structureof mRNAs. Binds RNA containing 5'-terminal GpppC
 summary
for RNMT: MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a
proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter
factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the
adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and
hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are
essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of
the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it
can trigger tumor growth, angiogenesis and metastasis.
Gene Wiki entry for RNMT (MRNA-methyltransferase)
|
Genomic Views
for RNMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNMT gene promoter:
STAT5A Cdc5 AREB6 MEF-2A POU2F1 POU2F1a POU2F1b aMEF-2 POU2F1c Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNMT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNMT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21RNMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P013716: view genomic region
(about GC identifiers)
Start:
|
13,726,659 bp from pter |
End:
|
13,764,557 bp from pter |
Size:
|
37,899 bases |
Orientation:
|
plus strand |
|
Proteins
for RNMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MCES_HUMAN, O43148 (See
protein sequence)Recommended Name: mRNA cap guanine-N7 methyltransferase Size: 476 amino acids; 54844 Da
Subunit: Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity.Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating inresponse to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymeraseII and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and capmethyltransferase activity
Subcellular location: Nucleus
2 PDB 3D structures from  and Proteopedia  for RNMT:3BGV (3D)
3EPP (3D)
Secondary accessions: B0YJ90 D3DUJ5 O94996 Q9UIJ9Alternative splicing: 2 isoforms: O43148-1 O43148-2 Explore the universe of human proteins at neXtProt for RNMT: NX_O43148
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43148
4/6 DME Specific Peptides for RNMT (O43148) (see all 6)
RNMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003790.1
ENSEMBL proteins: ENSP00000446426 ENSP00000372804 ENSP00000467171 ENSP00000466111 ENSP00000467475 ENSP00000466252 ENSP00000468261 ENSP00000262173 ENSP00000438624 Reactome Protein details: O43148
Human Recombinant Protein Products for RNMT:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RNMT for ontologies About GeneDecksing
RNMT Antibody Products:
Assay Products for RNMT: |
Protein
Domains /
Families
for RNMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNMT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43148ProtoNet protein and cluster: O43148 UniProtKB/Swiss-Prot: MCES_HUMAN, O43148Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase familySimilarity: Contains 1 mRNA cap 0 methyltransferase domain |
Function
for RNMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MCES_HUMAN, O43148Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structureof mRNAs. Binds RNA containing 5'-terminal GpppCCatalytic activity: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA Genatlas biochemistry entry for RNMT:messenger RNA (guanine-7) cap methyltransferase
Enzyme Number (IUBMB): EC 2.1.1.561 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RNMT for ontologies About GeneDecksing
Animal Models:
miRNA
Products: | | miRTarBase miRNAs that target RNMT:
hsa-mir-34b (MIRT004825), hsa-mir-1 (MIRT001357), hsa-mir-34c-5p (MIRT000757), hsa-mir-340 (MIRT005458), hsa-mir-30a (MIRT005167), hsa-mir-34b (MIRT000758), hsa-mir-206 (MIRT000185), hsa-mir-562 (MIRT005024), hsa-mir-199b-3p (MIRT004514), hsa-mir-34a (MIRT000759), hsa-mir-23b (MIRT004292) |
| |  | OriGene 3'-UTR Clone: RNMT
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNMT | | | 8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate RNMT (see all 48): | | | hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-607 hsa-let-7d hsa-miR-429 hsa-let-7a-2* hsa-miR-30d hsa-let-7g | | | | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNMT (NM_003799) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT |
|
Pathways & Interactions
for RNMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Transcription | | | 3 | Late Phase of HIV Life Cycle | | | 4 | mRNA Splicing - Major Pathway | | | 5 | HIV Infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Tocris Bioscience Pathway for RNMT
1  BioSystems Pathway for RNMT
5/12 
Reactome Pathways for RNMT (see all 12)
1 
Kegg Pathway (Kegg details for RNMT):
RNMT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNMT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/84 Interacting proteins for RNMT (O431483 ENSP000002621734) via UniProtKB, MINT, STRING, and/or I2D (see all 84)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006370 | 7-methylguanosine mRNA capping |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016032 | viral reproduction |
TAS | -- | | GO:0036265 | RNA (guanine-N7)-methylation |
TAS | -- |
RNMT for ontologies About GeneDecksing
|
Drugs & Compounds
for RNMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RNMT for compounds About GeneDecksing
Compounds for RNMT available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Crizotinib | Potent c-MET/ALK inhibitor | [877399-52-5] | | PF 04217903 mesylate | Highly selective c-Met inhibitor | [956906-93-7] | | PHA 665752 | Potent and selective MET inhibitor | [477575-56-7] | | K 252a | Protein kinase inhibitor | [99533-80-9] | | SU 11274 | Selective inhibitor of MET kinase activity | [658084-23-2] |
2 HMDB Compounds for RNMT About this table
2 Novoseek chemical compound relationships for RNMT gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| s-adenosylmethionine |
68 |
2 |
17935775 (1), 9207015 (1) |
| rrna |
65.2 |
1 |
15136037 (1) |
Search CenterWatch for drugs/clinical trials and news about RNMT / MCES
|
Transcripts
for RNMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNMT gene: NM_003799.1 Unigene Cluster for RNMT: RNA (guanine-7-) methyltransferase Hs.592347 [show with all ESTs]Unigene Representative Sequence: AF06779111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543302(uc002ksk.1) ENST00000383314(uc010dlk.2 uc010xae.1 uc002ksl.1 uc002ksm.1)
ENST00000588457 ENST00000592764 ENST00000591746 ENST00000589866 ENST00000588417
ENST00000593007 ENST00000591922 ENST00000262173 ENST00000535051
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNMT (NM_003799) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNMT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMT |
Additional cDNA sequence: AB007858.1 AB020966.1 AB022604.1 AB022605.1 AB022606.1 AF067791.1 AK292561.1 AK296370.1 AK303842.1 BC005290.1 BC017816.1 BC036798.1 BX647977.1 11 DOTS entries: DT.100646527 DT.447268 DT.100027990 DT.95113493 DT.121105653 DT.91706823 DT.75106249 DT.95114408 DT.121105663 DT.86843028 DT.95113495 24/216 AceView cDNA sequences (see all 216): CN481684 NM_003799 CA419807 AW082788 BE221160 AW072682 BM906284 CB130278 AL597621 BM787856 BQ682848 CA392317 AI094548 AA722651 AA678116 BM466040 AW592787 Z40575 AL134828 AW083082 BE348916 AI141759 AF067791 AI677823
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNMT (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNMT
|
Expression
for RNMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGTATAAT
About this image
See RNMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNMT
SOURCE GeneReport for Unigene cluster: Hs.592347
UniProtKB/Swiss-Prot: MCES_HUMAN, O43148Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for RNMT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNMT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNMT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT |
Orthologs
for RNMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNMT gene from 10/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rnmt1 , 5 |
RNA (guanine-7-) methyltransferase1, 5 |
81.77(n)1
77.34(a)1 |
|
18 (41.22 cM)5
678971 NM_026440.41 NP_080716.11
683003555 |
chicken
(Gallus gallus) |
Aves |
RNMT1 |
RNA (guanine-7-) methyltransferase |
73.27(n)
72.34(a) |
|
421046 XM_419132.3 XP_419132.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RNMT6 |
-- |
76(a) |
1 ↔ 1 |
4(43352633-43359190) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xCMT12 |
mRNA (guanine-7-)-methyltransferase |
75.83(n) |
|
AF218795.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi09c122 |
Transcribed sequence with weak similarity to protein more |
79.23(n) |
|
57097207 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(2)35Bd1 , 3 |
mRNA (guanine-N7)-methyltransferase3
lethal (2) 35Bd1 |
43(a)3
53.12(n)1
45.8(a)1 |
|
35B83
348771 NM_078844.31 NP_523568.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
C25A1.33
tag-721 |
Yeast ABD1 protein like3
Protein TAG-721 |
40(a)3
51.51(n)1
42.99(a)1 |
|
I(10167719-10169953)3
1828751 NM_060273.51 NP_492674.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ABD1(YBR236C)4
ABD11 |
Methyltransferase, catalyzes the transfer of a methyl more4
Abd1p1 |
50.62(n)1
36.95(a)1 |
|
2(691693-690383)4
8525381, 4 NP_009795.31 NP_009795.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G206501 |
mRNA cap guanine-N7 methyltransferase 1 |
51.32(n)
41.24(a) |
|
821612 NM_112956.5 NP_188701.2 |
rice
(Oryza sativa) |
Liliopsida |
Os08g01800001 |
hypothetical protein |
46.99(n)
39.45(a) |
|
4344818 NM_001067671.1 NP_001061136.1 |
ENSEMBL Gene Tree for RNMT (if available)
TreeFam Gene Tree for RNMT (if available) |
Paralogs
for RNMT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNMT (13726659 - 13764557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNMT
1 Indel: 60257 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNMT |
|
Disorders
/ Diseases
for RNMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNMT for disorders About GeneDecksing
OMIM gene information: 603514
OMIM disorders: --
6  diseases for RNMT: About MalaCardsbowen-conradi syndrome spina bifida dubowitz syndrome newcastle disease
vaccinia homocysteine
2 diseases from the University of Copenhagen DISEASES database for RNMT:Vaccinia Newcastle disease Human Genome Epidemiology (HuGE) Navigator: RNMT (2 documents)
Export disorders for RNMT gene to outside databases
|
Publications
for RNMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNMT gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with RNMT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PubMed id 9705270)1, 2, 3 Pillutla R.C.... Shatkin A.J. (1998)
- Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. (PubMed id 15767670)1, 2 Shafer B.... Shatkin A.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. (PubMed id 11114884)1, 2 Wen Y. and Shatkin A.J. (2000)
- Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. (PubMed id 10347220)1, 2 Saha N.... Shuman S. (1999)
- The Candida albicans gene for mRNA 5'-cap methyltransferase: identification of the additional residues essential for catalysis. (PubMed id 10589710)1, 2 Yamada-Okabe T....Yamada-Okabe H. (1999)
- Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PubMed id 9828141)1, 3 Pillutla R.C....Shatkin A.J. (1998)
- Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)methyltransferase, an mRNA cap methylase. (PubMed id 9790902)1, 2 Tsukamoto T.... Kiyohisa M. (1998)
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for RNMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RNMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing RNMT gene
(According to HUGE)
About This Section
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Specialized Databases showing RNMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RNMT | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for RNMT gene:
Search GeneIP for patents involving RNMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RNMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for RNMT | | OriGene shRNA RFP for RNMT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNMT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNMT | | | OriGene Protein Over-expression Lysate for RNMT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNMT | | OriGene 3'-UTR Clone for RNMT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNMT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNMT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNMT | | OriGene Custom Protein Services for RNMT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNMT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNMT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNMT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNMT |
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| | | | Tocris compounds for RNMT |
| |  |  |  |  | | | | | | Recombinant Protein for RNMT |
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 | | | RNMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNMT |
|  |  |  |  | | | | ThermoFisher Antibodies for RNMT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNMT |
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