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Aliases for RNMT Gene

Aliases for RNMT Gene

  • RNA (Guanine-7-) Methyltransferase 2 3
  • MRNA (Guanine-N(7)-)-Methyltransferase 3 4
  • MRNA Cap Methyltransferase 3 4
  • EC 2.1.1.56 4 63
  • RG7MT1 3 4
  • HCMT1 3 4
  • Hcm1p 3 4
  • HMet 3 4
  • Met 3 6
  • MRNA Cap Guanine-N7 Methyltransferase 3
  • MRNA (Guanine-7-)Methyltransferase 3
  • KIAA0398 4
  • HCMT1c 3

External Ids for RNMT Gene

Previous GeneCards Identifiers for RNMT Gene

  • GC18M013747
  • GC18P013812

Summaries for RNMT Gene

GeneCards Summary for RNMT Gene

RNMT (RNA (Guanine-7-) Methyltransferase) is a Protein Coding gene. Diseases associated with RNMT include bowen-conradi syndrome and dubowitz syndrome. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for RNMT Gene

  • mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Gene Wiki entry for RNMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNMT Gene

Genomics for RNMT Gene

Regulatory Elements for RNMT Gene

Genomic Location for RNMT Gene

Start:
13,726,660 bp from pter
End:
13,764,558 bp from pter
Size:
37,899 bases
Orientation:
Plus strand

Genomic View for RNMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMT Gene

Proteins for RNMT Gene

  • Protein details for RNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43148-MCES_HUMAN
    Recommended name:
    mRNA cap guanine-N7 methyltransferase
    Protein Accession:
    O43148
    Secondary Accessions:
    • B0YJ90
    • D3DUJ5
    • O94996
    • Q9UIJ9

    Protein attributes for RNMT Gene

    Size:
    476 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    • Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. Interacts with RAM/FAM103A1, the interaction significantly enhances RNA-binding and cap methyltransferase activity.

    Three dimensional structures from OCA and Proteopedia for RNMT Gene

    Alternative splice isoforms for RNMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNMT Gene

Proteomics data for RNMT Gene at MOPED

Selected DME Specific Peptides for RNMT Gene

Post-translational modifications for RNMT Gene

  • Ubiquitination at Lys163 and Lys208
  • Modification sites at PhosphoSitePlus

Other Protein References for RNMT Gene

Domains for RNMT Gene

Protein Domains for RNMT Gene

Graphical View of Domain Structure for InterPro Entry

O43148

UniProtKB/Swiss-Prot:

MCES_HUMAN :
  • O43148
Domain:
  • Contains 1 mRNA cap 0 methyltransferase domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
genes like me logo Genes that share domains with RNMT: view

No data available for Gene Families for RNMT Gene

Function for RNMT Gene

Molecular function for RNMT Gene

GENATLAS Biochemistry: messenger RNA (guanine-7) cap methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5)pppR-RNA.
UniProtKB/Swiss-Prot Function: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs. Binds RNA containing 5-terminal GpppC.

Enzyme Numbers (IUBMB) for RNMT Gene

Gene Ontology (GO) - Molecular Function for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IMP 9790902
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity TAS --
GO:0005515 protein binding IPI 22099306
GO:0008168 methyltransferase activity --
genes like me logo Genes that share ontologies with RNMT: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNMT Gene

Localization for RNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNMT Gene COMPARTMENTS Subcellular localization image for RNMT gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9790902
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005845 mRNA cap binding complex IDA 22099306
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with RNMT: view

Pathways for RNMT Gene

genes like me logo Genes that share pathways with RNMT: view

Gene Ontology (GO) - Biological Process for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
GO:0008152 metabolic process --
GO:0010467 gene expression TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RNMT: view

Compounds for RNMT Gene

(2) HMDB Compounds for RNMT Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(2) Novoseek inferred chemical compound relationships for RNMT Gene

Compound -log(P) Hits PubMed IDs
s-adenosylmethionine 68 2
rrna 65.2 1
genes like me logo Genes that share compounds with RNMT: view

Transcripts for RNMT Gene

Unigene Clusters for RNMT Gene

RNA (guanine-7-) methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for RNMT Gene

GeneLoc Exon Structure for
RNMT
ECgene alternative splicing isoforms for
RNMT

Expression for RNMT Gene

mRNA expression in normal human tissues for RNMT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNMT Gene

SOURCE GeneReport for Unigene cluster for RNMT Gene Hs.592347

mRNA Expression by UniProt/SwissProt for RNMT Gene

O43148-MCES_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RNMT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNMT Gene

Orthologs for RNMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNMT 35
  • 99.51 (n)
  • 99.16 (a)
RNMT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNMT 35
  • 89.68 (n)
  • 86.53 (a)
RNMT 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
RNMT 35
  • 91.53 (n)
  • 90.13 (a)
mouse
(Mus musculus)
Mammalia Rnmt 35
  • 81.77 (n)
  • 77.34 (a)
Rnmt 16
Rnmt 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNMT 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnmt 35
  • 82.34 (n)
  • 79.03 (a)
chicken
(Gallus gallus)
Aves RNMT 35
  • 74.15 (n)
  • 73.63 (a)
RNMT 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNMT 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xCMT1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmt 35
  • 71.24 (n)
  • 73.67 (a)
Str.2305 35
zebrafish
(Danio rerio)
Actinopterygii rnmt 35
  • 62.91 (n)
  • 62.3 (a)
rnmt 36
  • 60 (a)
OneToOne
wufi09c12 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003460 35
  • 49.58 (n)
  • 44.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bd 35
  • 53.92 (n)
  • 46.54 (a)
l(2)35Bd 36
  • 39 (a)
OneToOne
l(2)35Bd 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-72 35
  • 51.51 (n)
  • 42.99 (a)
tag-72 36
  • 35 (a)
OneToOne
C25A1.3 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABD1 36
  • 25 (a)
OneToOne
ABD1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6979 36
  • 46 (a)
OneToOne
Species with no ortholog for RNMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNMT Gene

ENSEMBL:
Gene Tree for RNMT (if available)
TreeFam:
Gene Tree for RNMT (if available)

Paralogs for RNMT Gene

Selected SIMAP similar genes for RNMT Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNMT: view

No data available for Paralogs for RNMT Gene

Variants for RNMT Gene

Sequence variations from dbSNP and Humsavar for RNMT Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1043925 -- 13,764,017(+) AGACC(A/T)CCTTC utr-variant-3-prime
rs1284190 -- 13,731,314(-) TCTCC(C/T)GCCTC intron-variant
rs1284191 -- 13,731,173(-) TGCCT(C/T)GGCCT intron-variant
rs1284192 -- 13,729,592(-) ATCAG(A/G)GAACA intron-variant, upstream-variant-2KB
rs1284193 -- 13,729,466(-) ATGGA(A/T)ATTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNMT Gene

Variant ID Type Subtype PubMed ID
esv8144 CNV Gain 19470904

Relevant External Links for RNMT Gene

HapMap Linkage Disequilibrium report
RNMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMT Gene

Disorders for RNMT Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RNMT Gene including...

Search for RNMT Gene in MalaCards »

(3) University of Copenhagen DISEASES for RNMT Gene

Relevant External Links for RNMT

Genetic Association Database (GAD)
RNMT
Human Genome Epidemiology (HuGE) Navigator
RNMT
genes like me logo Genes that share disorders with RNMT: view

No data available for UniProtKB/Swiss-Prot for RNMT Gene

Publications for RNMT Gene

  1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PMID: 9705270) Pillutla R.C. … Shatkin A.J. (J. Biol. Chem. 1998) 2 3 4
  2. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)methyltransferase, an mRNA cap methylase. (PMID: 9790902) Tsukamoto T. … Kiyohisa M. (Biochem. Biophys. Res. Commun. 1998) 3 4
  3. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PMID: 9828141) Pillutla R.C. … Shatkin A.J. (Genomics 1998) 2 3
  4. Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. (PMID: 10347220) Saha N. … Shuman S. (J. Biol. Chem. 1999) 3 4
  5. The Candida albicans gene for mRNA 5'-cap methyltransferase: identification of the additional residues essential for catalysis. (PMID: 10589710) Yamada-Okabe T. … Yamada-Okabe H. (Microbiology 1999) 3 4

Products for RNMT Gene

  • Addgene plasmids for RNMT

Sources for RNMT Gene

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