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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNLS Gene

protein-coding   GIFtS: 56
GCID: GC10M090024

Renalase, FAD-Dependent Amine Oxidase

(Previous name: chromosome 10 open reading frame 59)
(Previous symbol: C10orf59)
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Aliases
for RNLS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Renalase, FAD-Dependent Amine Oxidase1 2     Chromosome 10 Open Reading Frame 591
C10orf591 2 3 5     RENALASE2
Monoamine Oxidase-C2 3     renalase2
MAO-C2 3     EC 1.4.-.-3

External Ids:    HGNC: 256411   Entrez Gene: 553282   Ensembl: ENSG000001847197   OMIM: 6093605   UniProtKB: Q5VYX03   

Export aliases for RNLS gene to outside databases

Previous GC identifer: GC10M083668


Summaries
for RNLS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNLS Gene:
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney
(Xu et al., 2005 (PubMed 15841207)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RNLS Gene: 
RNLS (renalase, FAD-dependent amine oxidase) is a protein-coding gene. Diseases associated with RNLS include hypertensive heart disease, and essential hypertension, and among its related super-pathways are phenylalanine utilization. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates
cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and
epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and
preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma
catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase
and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase
has physiologically relevant catecholamine-oxidizing activity

Gene Wiki entry for RNLS (Renalase) Gene


Genomic Views
for RNLS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNLS gene promoter:
         HFH-3   FOXI1   RP58   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RNLS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

RNLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNLS gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090024:  view genomic region     (about GC identifiers)

Start:
 90,033,621 bp from pter      End:
 90,344,287 bp from pter
Size:
 310,667 bases      Orientation:
 minus strand

Proteins
for RNLS gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0 (See protein sequence)
Recommended Name: Renalase precursor  
Size: 342 amino acids; 37847 Da
Cofactor: FAD
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for RNLS:
3QJ4 (3D)    
Secondary accessions: Q9BS33 Q9NUP8
Alternative splicing: 2 isoforms:  Q5VYX0-1   Q5VYX0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNLS: NX_Q5VYX0

Explore proteomics data for RNLS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VYX0

    • RNLS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNLS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001026879.2  NP_060833.1  

    ENSEMBL proteins: 
     ENSP00000361015   ENSP00000332530   ENSP00000387577  

    Human Recombinant Protein Products for RNLS: 
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    OriGene Protein Over-expression Lysate for RNLS
    OriGene MassSpec for RNLS 
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    Novus Biologicals RNLS Proteins
    Novus Biologicals RNLS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RNLS
    Cloud-Clone Corp. Proteins for RNLS 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNLS for ontologies           About GeneDecksing



    RNLS Antibody Products: 
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    Cloud-Clone Corp. CLIAs for RNLS

    Protein Domains /
    Families
    for RNLS gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q5VYX0

    ProtoNet protein and cluster: Q5VYX0

    1 Blocks protein domain: IPB002938 Monooxygenase

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Similarity: Belongs to the renalase family


    RNLS for domains           About GeneDecksing


    Function
    for RNLS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNLS_HUMAN, Q5VYX0
    Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates
    cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and
    epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and
    preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma
    catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase
    and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase
    has physiologically relevant catecholamine-oxidizing activity

         Enzyme Number (IUBMB): EC 1.4.-.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    RNLS for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnls):
     cardiovascular system  homeostasis/metabolism  nervous system 

    RNLS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnlstm1Gvd for RNLS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNLS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNLS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNLS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNLS 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNLS
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RNLS (see all 28):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-19b-2* hsa-miR-302e hsa-miR-138-2* hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: RNLS 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of RNLS 

    Cell Line
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    In Situ Assay
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    Pathways & Interactions
    for RNLS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNLS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1phenylalanine utilization
    		noradrenaline and adrenaline degradation0.31


    1 BioSystems Pathway for RNLS
        noradrenaline and adrenaline degradation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNLS

    1 Interacting protein for RNLS (Q5VYX03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAST1Q9Y2H93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    RNLS for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNLS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNLS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNLS

    1 HMDB Compound for RNLS    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    1 Novoseek inferred chemical compound relationship for RNLS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 75.3 16 18299506 (3), 15841207 (2), 20409839 (2), 19471322 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about RNLS

    Transcripts
    for RNLS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNLS gene (2 alternative transcripts): 
    NM_001031709.2  NM_018363.3  

    Unigene Cluster for RNLS:

    Renalase, FAD-dependent amine oxidase
    Hs.149849  [show with all ESTs]
    Unigene Representative Sequence: NM_001031709
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371947(uc010qms.1 uc001kfd.2) ENST00000331772(uc009xtj.3 uc001kfe.3)
    ENST00000466945 ENST00000481793 ENST00000437752

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNLS
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RNLS (see all 28):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-19b-2* hsa-miR-302e hsa-miR-138-2* hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: RNLS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNLS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNLS
    Clone
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    OriGene ORF clones in mouse, rat for RNLS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNLS
    Sirion Biotech Customized lentivirus for stable overexpression of RNLS 
                         Customized lentivirus expression plasmids for stable overexpression of RNLS 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNLS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNLS
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    Additional mRNA sequence: 

    AK002080.1 AK296262.1 BC005364.1 BX648154.1 

    8 DOTS entries:

    DT.101208  DT.92392573  DT.91759114  DT.95154169  DT.101955364  DT.91759112  DT.95367269  DT.91659451 

    24/44 AceView cDNA sequences (see all 44):

    CA407528 AK002080 NM_018363 BX097218 BM695006 BM978857 BC005364 BG197548 
    BX472150 AI093491 BX648154 AI828824 BI832374 AA609946 BE464707 AI983739 
    AA232650 BI832528 BU753507 CA446666 BM666796 BI758544 BX097852 BG194028 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNLS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                 -     -     -         
    SP2:                                -                 -                     
    SP3:                                                                        


    ECgene alternative splicing isoforms for RNLS

    Expression
    for RNLS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGAATGGA
    RNLS Expression
    About this image


    See RNLS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNLS

    SOURCE GeneReport for Unigene cluster: Hs.149849

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower
    level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients
    with end-stage renal disease, as compared with healthy subjects

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    Orthologs
    for RNLS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNLS gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnls1 , 5 renalase, FAD-dependent amine oxidase1, 5 82.11(n)1
    72.33(a)1    		   19 (29.08 cM)5
    677951  NM_001167818.11  NP_001161290.11 
     331377475 
    chicken
    (Gallus gallus)    		 Aves RNLS1 renalase, FAD-dependent amine oxidase 65.77(n)
    59.58(a)    		   423674  NM_001199599.1  NP_001186528.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNLS6
    		 Uncharacterized protein
    		 66(a)
    		 1 ↔ 1
    		 GL343246.1(614113-767632)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.142182 Xenopus laevis transcribed sequence with weak similarity more 71.61(n)    BX855505.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rnls1 renalase, FAD-dependent amine oxidase 64.31(n)
    60.59(a)    		   436880  NM_001002607.1  NP_001002607.1 


    ENSEMBL Gene Tree for RNLS (if available)
    TreeFam Gene Tree for RNLS (if available)

    Paralogs
    for RNLS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RNLS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5476 SNPs in RNLS are shown (see all 5476)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2864861,2
    		H--90033165(+) TTTTAG/AAAATG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs1832321661,2
    		--90033278(+) CATTTA/TAAAAT 1 -- ds50010--------
    rs1881126291,2
    		--90033413(+) TAAACC/TATCGT 1 -- ds50010--------
    rs570491431,2
    		--90033586(+) TCATTC/GAAAAA 1 -- ds50010--------
    rs2009111271,2
    		--90033586(+) CATTC-/AAAAAA 1 -- ds50010--------
    rs21144061,2
    		C,F,O,A,H--90033593(+) AAAAAA/GAATGC 1 -- ds500123Minor allele frequency- G:0.23NS EA NA WA 2474
    rs1471685611,2
    		C--90033601(+) TGCCAA/GATTGA 1 -- ds50010--------
    rs1117097811,2
    		C--90033613(+) AGGTT-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs65861241,2
    		C,F,A--90033633(+) ATTATA/GGTTTT 1 -- ut313Minor allele frequency- G:0.01NA 142
    rs1492509951,2
    		--90033678(+) AACACA/GATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNLS (90033621 - 90283621 bp, first 250kb of RNLS)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RNLS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739328CNV Deletion23290073
    esv2739317CNV Deletion23290073
    esv2662982CNV Deletion23128226
    esv2075872CNV Deletion18987734
    esv271051CNV Insertion20981092
    nsv825500CNV Loss20364138
    nsv24973CNV Loss16902084
    nsv825501CNV Loss20364138
    nsv467414CNV Loss19166990
    nsv895879CNV Gain21882294


    Human Gene Mutation Database (HGMD): RNLS
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for RNLS

    Disorders / Diseases
    for RNLS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 609360    OMIM disorders: --

    7 diseases for RNLS:    About MalaCards
    hypertensive heart disease    essential hypertension    kidney disease    hypertension
    type 1 diabetes    ischemia    alzheimer's disease


    RNLS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for RNLS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure chronic 55.9 2 15841207 (1), 17846919 (1)
    renal disease 47.6 8 18277152 (4), 19471322 (1), 17565281 (1), 18299506 (1) (see all 5)
    cardiovascular diseases 30.9 1 18277152 (1)

    Genetic Association Database (GAD): RNLS
    Human Genome Epidemiology (HuGE) Navigator: RNLS (1 document)

    Export disorders for RNLS gene to outside databases

    Publications
    for RNLS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNLS gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with RNLS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. (PubMed id 15841207)1, 2, 3, 9 Xu J.... Desir G.V. (2005)
    2. Renalase, a new renal hormone: its role in health and disease. (PubMed id 17565281)1, 3, 9 Xu J. and Desir G.V. (2007)
    3. FAD-binding site and NADP reactivity in human renalas e: a new enzyme involved in blood pressure regulation. (PubMed id 21699903)1, 2 Milani M....Aliverti A. (2011)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. Regulation of blood pressure and cardiovascular funct ion by renalase. (PubMed id 19471322)1, 9 Desir G.V. (2009)
    8. Renalase, a catecholamine-metabolising enzyme? (PubMed id 17385068)2, 9 Boomsma F. and Tipton K.F. (2007)
    9. Synthesis of human renalase1 in Escherichia coli and its purification as a FAD-containing holoprotein. (PubMed id 20302943)1, 9 Pandini V....Aliverti A. (2010)
    10. Renalase, a novel soluble FAD-dependent protein, is s ynthesized in the brain and peripheral nerves. (PubMed id 20168325)1, 9 Hennebry S.C....Schlaich M. (2010)

    External Searches for RNLS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNLS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55328 HGNC: 25641 AceView: C10orf59 Ensembl:ENSG00000184719 euGenes: HUgn55328
    ECgene: RNLS H-InvDB: RNLS

    Other Databases showing RNLS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNLS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNLS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNLS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNLS gene:
    Search GeneIP for patents involving RNLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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