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RNLS Gene(Protein Coding)

Renalase, FAD-Dependent Amine Oxidase

GCID:
GC10M088180
GIFtS:
55
Genes Participants
UDN Logo

Aliases for RNLS Gene

Aliases for RNLS Gene

  • Renalase, FAD-Dependent Amine Oxidase 2 3 5
  • Monoamine Oxidase-C 3 4
  • C10orf59 3 4
  • MAO-C 3 4
  • Chromosome 10 Open Reading Frame 59 2
  • Alpha-NAD(P)H Oxidase/Anomerase 3
  • EC 1.6.3.5 4
  • RENALASE 3

External Ids for RNLS Gene

Previous HGNC Symbols for RNLS Gene

  • C10orf59

Previous GeneCards Identifiers for RNLS Gene

  • GC10M090024
  • GC10M083668
  • GC10M088273

Summaries for RNLS Gene

Entrez Gene Summary for RNLS Gene

  • Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RNLS Gene

RNLS (Renalase, FAD-Dependent Amine Oxidase) is a Protein Coding gene. Diseases associated with RNLS include Cerebral Atherosclerosis and Chronic Kidney Failure. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for RNLS Gene

  • Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Gene Wiki entry for RNLS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNLS Gene

Genomics for RNLS Gene

Products:

  1. Regulatory Element

Regulatory Elements for RNLS Gene


Promoters for RNLS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNLS on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RNLS gene promoter:

Genomic Location for RNLS Gene

Chromosome:
10
Start:
88,180,643 bp from pter
End:
88,584,530 bp from pter
Size:
403,888 bases
Orientation:
Minus strand

Genomic View for RNLS Gene

Genes around RNLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNLS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RNLS Gene

Proteins for RNLS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RNLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYX0-RNLS_HUMAN
    Recommended name:
    Renalase
    Protein Accession:
    Q5VYX0
    Secondary Accessions:
    • Q9BS33
    • Q9NUP8

    Protein attributes for RNLS Gene

    Size:
    342 amino acids
    Molecular mass:
    37847 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNLS Gene

    Alternative splice isoforms for RNLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNLS Gene

Proteomics data for RNLS Gene at MOPED

Protein Expression for RNLS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RNLS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNLS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNLS Gene

Domains & Families for RNLS Gene

Protein Domains for RNLS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VYX0

UniProtKB/Swiss-Prot:

RNLS_HUMAN :
  • Belongs to the renalase family.
Family:
  • Belongs to the renalase family.
genes like me logo Genes that share domains with RNLS: view

No data available for Gene Families for RNLS Gene

Function for RNLS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RNLS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Enzyme Numbers (IUBMB) for RNLS Gene

Phenotypes for RNLS Gene

MGI mutant phenotypes for RNLS:
inferred from 1 alleles
GenomeRNAi human phenotypes for RNLS:
genes like me logo Genes that share phenotypes with RNLS: view

Animal Models for RNLS Gene

MGI Knock Outs for RNLS:

Animal Model Products

miRNA for RNLS Gene

miRTarBase miRNAs that target RNLS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNLS Gene

Localization for RNLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNLS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNLS Gene COMPARTMENTS Subcellular localization image for RNLS gene
Compartment Confidence
extracellular 3
peroxisome 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNLS Gene

Pathways & Interactions for RNLS Gene

SuperPathways for RNLS Gene

PathCards logoMore details on SuperPathways for RNLS
No Data Available

Interacting Proteins for RNLS Gene

Selected Interacting proteins: Q5VYX0-RNLS_HUMAN for RNLS Gene via I2D

Symbol External ID(s) Details
MAST1

Gene Ontology (GO) - Biological Process for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0071869 response to catecholamine IEA --
GO:0071871 response to epinephrine IEA --
GO:1902074 response to salt IEA --
genes like me logo Genes that share ontologies with RNLS: view

No data available for Pathways by source and SIGNOR curated interactions for RNLS Gene

Drugs & Compounds for RNLS Gene

Products:

  1. Drug

(1) Drugs for RNLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for RNLS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNLS: view

Transcripts for RNLS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RNLS Gene

(11) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNLS Gene

Renalase, FAD-dependent amine oxidase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNLS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for RNLS Gene

GeneLoc Exon Structure for
RNLS
ECgene alternative splicing isoforms for
RNLS

Expression for RNLS Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RNLS Gene

mRNA expression in normal human tissues for RNLS Gene
mRNA expression by BioGPS for RNLS GenemRNA expression by GTEx for RNLS Gene

Protein differential expression in normal tissues from HIPED for RNLS Gene

This gene is overexpressed in Ovary (29.6), Skin (21.2), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNLS Gene



SOURCE GeneReport for Unigene cluster for RNLS Gene Hs.149849

mRNA Expression by UniProt/SwissProt for RNLS Gene

Q5VYX0-RNLS_HUMAN
Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
genes like me logo Genes that share expression patterns with RNLS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RNLS Gene

Orthologs for RNLS Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNLS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RNLS 35
  • 89.67 (n)
  • 84.8 (a)
dog
(Canis familiaris)
 Mammalia RNLS 35
  • 80.13 (n)
  • 78.48 (a)
RNLS 36
  • 78 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rnls 35
  • 82.11 (n)
  • 72.33 (a)
Rnls 16
Rnls 36
  • 72 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia RNLS 35
  • 99.32 (n)
  • 98.54 (a)
RNLS 36
  • 93 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Rnls 35
  • 82.59 (n)
  • 78.53 (a)
oppossum
(Monodelphis domestica)
 Mammalia RNLS 36
  • 64 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RNLS 36
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RNLS 35
  • 65.57 (n)
  • 59.58 (a)
RNLS 36
  • 55 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RNLS 36
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rnls 35
  • 66.27 (n)
  • 63.2 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14218 35
zebrafish
(Danio rerio)
 Actinopterygii rnls 35
  • 64.52 (n)
  • 60.53 (a)
rnls 36
  • 59 (a)
 OneToOne
Species with no ortholog for RNLS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNLS Gene

ENSEMBL:
Gene Tree for RNLS (if available)
TreeFam:
Gene Tree for RNLS (if available)

Paralogs for RNLS Gene

No data available for Paralogs for RNLS Gene

Variants for RNLS Gene

Sequence variations from dbSNP and Humsavar for RNLS Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_023310 -
rs1418481 -- 88,460,921(-) TTCCC(C/T)GAGAC intron-variant
rs1418482 -- 88,423,651(+) ACTTA(C/T)TGGAT intron-variant
rs1426620 -- 88,400,841(+) AATGC(C/T)CCTAT intron-variant
rs1536252 -- 88,495,714(-) CCCAT(C/T)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNLS Gene

Variant ID Type Subtype PubMed ID
nsv467414 CNV Loss 19166990
nsv895879 CNV Gain 21882294
esv2662982 CNV Deletion 23128226
esv2739317 CNV Deletion 23290073
esv2075872 CNV Deletion 18987734
esv2739328 CNV Deletion 23290073
nsv825500 CNV Loss 20364138
esv271051 CNV Insertion 20981092
nsv825501 CNV Loss 20364138
nsv24973 CNV Loss 16902084

Variation tolerance for RNLS Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.13; 90.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNLS Gene

Human Gene Mutation Database (HGMD)
RNLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNLS Gene

Disorders for RNLS Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNLS Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
cerebral atherosclerosis
  • intracranial arteriosclerosis
chronic kidney failure
  • chronic renal disease
- elite association - COSMIC cancer census association via MalaCards
Search RNLS in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNLS

Genetic Association Database (GAD)
RNLS
Human Genome Epidemiology (HuGE) Navigator
RNLS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNLS
genes like me logo Genes that share disorders with RNLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNLS Gene

Publications for RNLS Gene

  1. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. (PMID: 15841207) Xu J. … Desir G.V. (J. Clin. Invest. 2005) 2 3 4 23 67
  2. Renalase, a new renal hormone: its role in health and disease. (PMID: 17565281) Xu J. … Desir G.V. (Curr. Opin. Nephrol. Hypertens. 2007) 2 3 23
  3. Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves. (PMID: 20168325) Hennebry S.C. … Schlaich M. (Mol. Psychiatry 2010) 3 23
  4. Synthesis of human renalase1 in Escherichia coli and its purification as a FAD-containing holoprotein. (PMID: 20302943) Pandini V. … Aliverti A. (Protein Expr. Purif. 2010) 3 23
  5. Regulation of blood pressure and cardiovascular function by renalase. (PMID: 19471322) Desir G.V. (Kidney Int. 2009) 3 23

Products for RNLS Gene

Sources for RNLS Gene

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