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RNLS Gene(Protein Coding)

Renalase, FAD Dependent Amine Oxidase

GCID:
GC10M088180
GIFtS:
47
Genes Participants
UDN Logo

Aliases for RNLS Gene

Aliases for RNLS Gene

  • Renalase, FAD Dependent Amine Oxidase 2 3 5
  • Monoamine Oxidase-C 3 4
  • C10orf59 3 4
  • MAO-C 3 4
  • Chromosome 10 Open Reading Frame 59 2
  • Alpha-NAD(P)H Oxidase/Anomerase 3
  • EC 1.6.3.5 4
  • RENALASE 3

External Ids for RNLS Gene

Previous HGNC Symbols for RNLS Gene

  • C10orf59

Previous GeneCards Identifiers for RNLS Gene

  • GC10M090024
  • GC10M083668
  • GC10M088273

Summaries for RNLS Gene

Entrez Gene Summary for RNLS Gene

  • Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RNLS Gene

RNLS (Renalase, FAD Dependent Amine Oxidase) is a Protein Coding gene. Diseases associated with RNLS include Chronic Kidney Failure. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot for RNLS Gene

  • Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Gene Wiki entry for RNLS Gene

Additional gene information for RNLS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNLS Gene

Genomics for RNLS Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for RNLS Gene

Promoters and enhancers for RNLS Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10I088582 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 555.3 +1.5 1493 1.7 PKNOX1 SIN3A KLF5 RAD21 YY1 ZNF207 ZNF143 SMARCA5 SMAD5 USF2 RNLS GC10P088584 LIPJ GC10M088413
GH10I088878 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -299.7 -299686 10.9 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 STAMBPL1 RPL11P3 KIF20B FAS ACTA2-AS1 ENSG00000201548 RNLS LIPJ LIPM LIPN
GH10I088892 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.3 -313.8 -313799 12.6 HDGF PKNOX1 FEZF1 IRF4 ATF7 FOS RUNX3 RXRA JUNB PPARG STAMBPL1 ACTA2-AS1 ANKRD22 FAS LIPM KIF20B ENSG00000201548 RNLS LIPJ IFIT1B
GH10I088792 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.9 -208.3 -208261 0.8 CTCF MAX EBF1 RAD21 YY1 POLR2A HNF4G SMARCC2 RCOR1 RUNX3 LIPN ENSG00000201548 LIPJ RNLS ANKRD22 FAS RCBTB2P1 LIPM
GH10I087850 Enhancer 1.1 Ensembl ENCODE dbSUPER 9.8 +733.5 733532 0.4 CTCF MAX MZF1 RAD21 RFX5 ZNF239 ZNF143 SMC3 ZNF600 NFE2 ENSG00000201548 LIPJ RNLS GC10P087845 PTEN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNLS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNLS gene promoter:

Genomic Locations for RNLS Gene

Genomic Locations for RNLS Gene
chr10:88,180,643-88,584,530
(GRCh38/hg38)
Size:
403,888 bases
Orientation:
Minus strand
chr10:90,033,621-90,344,287
(GRCh37/hg19)

Genomic View for RNLS Gene

Genes around RNLS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNLS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNLS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RNLS Gene

Proteins for RNLS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RNLS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYX0-RNLS_HUMAN
    Recommended name:
    Renalase
    Protein Accession:
    Q5VYX0
    Secondary Accessions:
    • Q9BS33
    • Q9NUP8

    Protein attributes for RNLS Gene

    Size:
    342 amino acids
    Molecular mass:
    37847 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNLS Gene

    Alternative splice isoforms for RNLS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNLS Gene

Protein Expression for RNLS Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RNLS Gene

No Post-translational modifications

Other Protein References for RNLS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNLS Gene

Domains & Families for RNLS Gene

Gene Families for RNLS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for RNLS Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNLS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VYX0

UniProtKB/Swiss-Prot:

RNLS_HUMAN :
  • Belongs to the renalase family.
Family:
  • Belongs to the renalase family.
genes like me logo Genes that share domains with RNLS: view

Function for RNLS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RNLS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.

Enzyme Numbers (IUBMB) for RNLS Gene

Phenotypes From GWAS Catalog for RNLS Gene

Gene Ontology (GO) - Molecular Function for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0016651 oxidoreductase activity, acting on NAD(P)H TAS --
GO:0051379 epinephrine binding IDA 23964689
GO:0070404 NADH binding IDA 25531177
GO:0097621 monoamine oxidase activity IMP 15841207
genes like me logo Genes that share ontologies with RNLS: view
genes like me logo Genes that share phenotypes with RNLS: view

Animal Models for RNLS Gene

MGI Knock Outs for RNLS:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNLS Gene

Localization for RNLS Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNLS Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNLS gene
Compartment Confidence
extracellular 5
peroxisome 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with RNLS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNLS Gene

Pathways & Interactions for RNLS Gene

SuperPathways for RNLS Gene

PathCards logo More details on SuperPathways for RNLS
No Data Available

Gene Ontology (GO) - Biological Process for RNLS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0010459 negative regulation of heart rate IDA 15841207
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway TAS --
GO:0045776 negative regulation of blood pressure IDA 15841207
GO:0055114 oxidation-reduction process IMP,IEA 15841207
genes like me logo Genes that share ontologies with RNLS: view

No data available for Pathways by source and SIGNOR curated interactions for RNLS Gene

Drugs & Compounds for RNLS Gene

Products:

  1. Drug

(1) Drugs for RNLS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0

(1) Additional Compounds for RNLS Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNLS: view

Transcripts for RNLS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RNLS Gene

(15) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNLS Gene

Renalase, FAD-dependent amine oxidase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNLS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - -
SP3:

Relevant External Links for RNLS Gene

GeneLoc Exon Structure for
RNLS
ECgene alternative splicing isoforms for
RNLS

Expression for RNLS Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNLS Gene

mRNA expression in normal human tissues for RNLS Gene
mRNA expression by BioGPS for RNLS GenemRNA expression by GTEx for RNLS Gene

Protein differential expression in normal tissues from HIPED for RNLS Gene

This gene is overexpressed in Ovary (29.6), Skin (21.2), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNLS Gene



NURSA nuclear receptor signaling pathways regulating expression of RNLS Gene:

RNLS

SOURCE GeneReport for Unigene cluster for RNLS Gene:

Hs.149849

mRNA Expression by UniProt/SwissProt for RNLS Gene:

Q5VYX0-RNLS_HUMAN
Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.

Evidence on tissue expression from TISSUES for RNLS Gene

  • Kidney(4.6)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with RNLS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNLS Gene

Orthologs for RNLS Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNLS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RNLS 33 34
  • 99.32 (n)
cow
(Bos Taurus)
 Mammalia RNLS 33
  • 89.67 (n)
rat
(Rattus norvegicus)
 Mammalia Rnls 33
  • 82.59 (n)
mouse
(Mus musculus)
 Mammalia Rnls 33 16 34
  • 82.11 (n)
dog
(Canis familiaris)
 Mammalia RNLS 33 34
  • 80.13 (n)
oppossum
(Monodelphis domestica)
 Mammalia RNLS 34
  • 64 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RNLS 34
  • 64 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RNLS 33 34
  • 65.57 (n)
lizard
(Anolis carolinensis)
 Reptilia RNLS 34
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia rnls 33
  • 66.27 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14218 33
zebrafish
(Danio rerio)
 Actinopterygii rnls 33 34
  • 64.52 (n)
Species where no ortholog for RNLS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNLS Gene

ENSEMBL:
Gene Tree for RNLS (if available)
TreeFam:
Gene Tree for RNLS (if available)

Paralogs for RNLS Gene

No data available for Paralogs for RNLS Gene

Variants for RNLS Gene

Sequence variations from dbSNP and Humsavar for RNLS Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000017616 -- 88,414,203(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000020488 -- 88,501,497(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000027976 -- 88,284,904(-) C/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000046677 -- 88,537,647(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000046874 -- 88,557,202(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNLS Gene

Variant ID Type Subtype PubMed ID
dgv270e212 CNV loss 25503493
dgv271e212 CNV loss 25503493
esv2075872 CNV deletion 18987734
esv2662982 CNV deletion 23128226
esv3375666 CNV insertion 20981092
esv3624124 CNV loss 21293372
esv3624125 CNV gain 21293372
esv3624126 CNV gain 21293372
esv3624131 CNV loss 21293372
esv3624132 CNV gain 21293372
esv3624134 CNV gain 21293372
esv3891883 CNV loss 25118596
nsv1037657 CNV loss 25217958
nsv1054984 CNV loss 25217958
nsv1134038 CNV deletion 24896259
nsv24973 CNV deletion 16902084
nsv467414 CNV loss 19166990
nsv477695 CNV novel sequence insertion 20440878
nsv551838 CNV loss 21841781
nsv551839 CNV loss 21841781
nsv825500 CNV loss 20364138
nsv825501 CNV loss 20364138

Variation tolerance for RNLS Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.13; 90.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNLS Gene

Human Gene Mutation Database (HGMD)
RNLS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNLS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNLS Gene

Disorders for RNLS Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNLS Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
chronic kidney failure
  • chronic kidney disease
- elite association - COSMIC cancer census association via MalaCards
Search RNLS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNLS

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNLS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNLS Gene

Publications for RNLS Gene

  1. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. (PMID: 15841207) Xu J … Desir GV (The Journal of clinical investigation 2005) 2 3 4 22 58
  2. Renalase, a new renal hormone: its role in health and disease. (PMID: 17565281) Xu J … Desir GV (Current opinion in nephrology and hypertension 2007) 2 3 22 58
  3. Metabolic function for human renalase: oxidation of isomeric forms of β-NAD(P)H that are inhibitory to primary metabolism. (PMID: 25531177) Beaupre BA … Moran GR (Biochemistry 2015) 3 4 58
  4. Renalase is an α-NAD(P)H oxidase/anomerase. (PMID: 23964689) Beaupre BA … Moran GR (Journal of the American Chemical Society 2013) 3 4 58
  5. FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation. (PMID: 21699903) Milani M … Aliverti A (Journal of molecular biology 2011) 3 4 58

Products for RNLS Gene

Sources for RNLS Gene

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