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RNLS Gene

protein-coding   GIFtS: 54
GCID: GC10M090024

Renalase, FAD-Dependent Amine Oxidase

(Previous name: chromosome 10 open reading frame 59)
(Previous symbol: C10orf59)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Renalase, FAD-Dependent Amine Oxidase1 2     Chromosome 10 Open Reading Frame 591
C10orf591 2 3 5     RENALASE2
Monoamine Oxidase-C2 3     renalase2
MAO-C2 3     EC 1.4.-.-3

External Ids:    HGNC: 256411   Entrez Gene: 553282   Ensembl: ENSG000001847197   OMIM: 6093605   UniProtKB: Q5VYX03   

Export aliases for RNLS gene to outside databases

Previous GC identifer: GC10M083668


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNLS Gene:
Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney
(Xu et al., 2005 (PubMed 15841207)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RNLS Gene:
RNLS (renalase, FAD-dependent amine oxidase) is a protein-coding gene. Diseases associated with RNLS include hypertensive heart disease, and hypertension. GO annotations related to this gene include oxidoreductase activity.

UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates
cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and
epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and
preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma
catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase
and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase
has physiologically relevant catecholamine-oxidizing activity

Gene Wiki entry for RNLS (Renalase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNLS gene promoter:
         HFH-3   FOXI1   RP58   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RNLS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNLS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.31

RNLS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNLS gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090024:  view genomic region     (about GC identifiers)

Start:
90,033,621 bp from pter      End:
90,344,287 bp from pter
Size:
310,667 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0 (See protein sequence)
Recommended Name: Renalase precursor  
Size: 342 amino acids; 37847 Da
Cofactor: FAD
1 PDB 3D structure from and Proteopedia for RNLS:
3QJ4 (3D)    
Secondary accessions: Q9BS33 Q9NUP8
Alternative splicing: 2 isoforms:  Q5VYX0-1   Q5VYX0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNLS: NX_Q5VYX0

Explore proteomics data for RNLS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNLS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026879.2  NP_060833.1  

    ENSEMBL proteins: 
     ENSP00000361015   ENSP00000332530   ENSP00000387577  

    RNLS Human Recombinant Protein Products:

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    Novus Biologicals RNLS Proteins
    Novus Biologicals RNLS Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RNLS
    Cloud-Clone Corp. Proteins for RNLS

    RNLS Antibody Products:

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    LSBio Antibodies in human, mouse, rat for RNLS

    RNLS Assay Products:

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    Cloud-Clone Corp. ELISAs for RNLS
    Cloud-Clone Corp. CLIAs for RNLS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry Q5VYX0

    ProtoNet protein and cluster: Q5VYX0

    1 Blocks protein domain: IPB002938 Monooxygenase

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Similarity: Belongs to the renalase family


    RNLS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNLS_HUMAN, Q5VYX0
    Function: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates
    cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and
    epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and
    preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma
    catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase
    and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase
    has physiologically relevant catecholamine-oxidizing activity

         Enzyme Number (IUBMB): EC 1.4.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    RNLS for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnls):
     cardiovascular system  homeostasis/metabolism  nervous system 

    RNLS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnlstm1Gvd for RNLS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNLS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNLS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNLS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNLS

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNLS (see all 28):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-19b-2* hsa-miR-302e hsa-miR-138-2* hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidRNLS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNLS

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    GenScript: all cDNA clones in your preferred vector (see all 2): RNLS (NM_018363)
    Sino Biological Human cDNA Clone for RNLS
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNLS

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNLS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNLS_HUMAN, Q5VYX0: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    RNLS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNLS About    
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    noradrenaline and adrenaline degradation0.31


    1 BioSystems Pathway for RNLS
        noradrenaline and adrenaline degradation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNLS
    Interactions:

        Search GeneGlobe Interaction Network for RNLS

    1 Interacting protein for RNLS (Q5VYX03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAST1Q9Y2H93I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002931response to ischemia IEA--
    GO:0055114oxidation-reduction process ----
    GO:0071869response to catecholamine ----
    GO:0071871response to epinephrine IEA--
    GO:1902074response to salt IEA--

    RNLS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNLS

    1 HMDB Compound for RNLS    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    1 Novoseek inferred chemical compound relationship for RNLS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amine 75.3 16 18299506 (3), 15841207 (2), 20409839 (2), 19471322 (1) (see all 9)



    RNLS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNLS gene (2 alternative transcripts): 
    NM_001031709.2  NM_018363.3  

    Unigene Cluster for RNLS:

    Renalase, FAD-dependent amine oxidase
    Hs.149849  [show with all ESTs]
    Unigene Representative Sequence: NM_001031709
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371947(uc010qms.1 uc001kfd.2) ENST00000331772(uc009xtj.3 uc001kfe.3)
    ENST00000466945 ENST00000481793 ENST00000437752
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNLS (see all 28):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-19b-2* hsa-miR-302e hsa-miR-138-2* hsa-miR-519a hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidRNLS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNLS
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    GenScript: all cDNA clones in your preferred vector (see all 2): RNLS (NM_018363)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNLS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNLS
    Primer
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    OriGene qPCR primer pairs and template standards for RNLS
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      QuantiTect SYBR Green Assays in human, mouse, rat RNLS
      QuantiFast Probe-based Assays in human, mouse, rat RNLS

    Additional mRNA sequence: 

    AK002080.1 AK296262.1 BC005364.1 BX648154.1 

    8 DOTS entries:

    DT.101208  DT.92392573  DT.91759114  DT.95154169  DT.101955364  DT.91759112  DT.95367269  DT.91659451 

    Selected AceView cDNA sequences (see all 44):

    AK002080 BX097218 BM695006 NM_018363 BM978857 CA407528 AI093491 BC005364 
    BG194028 BU753507 BX097852 AA232650 BI832374 AA854849 AA609946 BI832528 
    BI758544 BX648154 AI983739 AI828824 CA446666 BE464707 BM666796 BX472150 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNLS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                 -     -     -         
    SP2:                                -                 -                     
    SP3:                                                                        


    ECgene alternative splicing isoforms for RNLS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNLS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGAATGGA
    RNLS Expression
    About this image

    RNLS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNLS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149849

    UniProtKB/Swiss-Prot: RNLS_HUMAN, Q5VYX0
    Tissue specificity: Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower
    level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients
    with end-stage renal disease, as compared with healthy subjects

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNLS gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnls1 , 5 renalase, FAD-dependent amine oxidase1, 5 82.11(n)1
    72.33(a)1
      19 (29.08 cM)5
    677951  NM_001167818.11  NP_001161290.11 
     331377475 
    chicken
    (Gallus gallus)
    Aves RNLS1 renalase, FAD-dependent amine oxidase 65.57(n)
    59.58(a)
      423674  NM_001199599.1  NP_001186528.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNLS6
    renalase, FAD-dependent amine oxidase
    66(a)
    1 ↔ 1
    GL343246.1(614113-767632)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.142182 Xenopus laevis transcribed sequence with weak similarity more 71.61(n)    BX855505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnls1 renalase, FAD-dependent amine oxidase 64.52(n)
    60.53(a)
      436880  NM_001002607.1  NP_001002607.1 


    ENSEMBL Gene Tree for RNLS (if available)
    TreeFam Gene Tree for RNLS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNLS (see all 5476)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2864861,2
    H--90033165(+) TTTTAG/AAAATG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs1832321661,2
    --90033278(+) CATTTA/TAAAAT 1 -- ds50010--------
    rs1881126291,2
    --90033413(+) TAAACC/TATCGT 1 -- ds50010--------
    rs570491431,2
    --90033586(+) TCATTC/GAAAAA 1 -- ds50010--------
    rs2009111271,2
    --90033586(+) CATTC-/AAAAAA 1 -- ds50010--------
    rs21144061,2
    C,F,O,A,H--90033593(+) AAAAAA/GAATGC 1 -- ds500123Minor allele frequency- G:0.23NS EA NA WA 2474
    rs1471685611,2
    C--90033601(+) TGCCAA/GATTGA 1 -- ds50010--------
    rs1117097811,2
    C--90033613(+) AGGTT-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs65861241,2
    C,F,A--90033633(+) ATTATA/GGTTTT 1 -- ut313Minor allele frequency- G:0.01NA 142
    rs1492509951,2
    --90033678(+) AACACA/GATTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNLS (90033621 - 90283621 bp, first 250kb of RNLS)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RNLS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739328CNV Deletion23290073
    esv2739317CNV Deletion23290073
    esv2662982CNV Deletion23128226
    esv2075872CNV Deletion18987734
    esv271051CNV Insertion20981092
    nsv825500CNV Loss20364138
    nsv24973CNV Loss16902084
    nsv825501CNV Loss20364138
    nsv467414CNV Loss19166990
    nsv895879CNV Gain21882294

    Human Gene Mutation Database (HGMD): RNLS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNLS
    DNA2.0 Custom Variant and Variant Library Synthesis for RNLS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609360    OMIM disorders: --

    8 diseases for RNLS:    
    About MalaCards
    hypertensive heart disease    hypertension    essential hypertension    kidney disease
    type 1 diabetes    ischemia    alzheimer's disease    endotheliitis


    RNLS for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RNLS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure chronic 55.9 2 15841207 (1), 17846919 (1)
    renal disease 47.6 8 18277152 (4), 19471322 (1), 17565281 (1), 18299506 (1) (see all 5)
    cardiovascular diseases 30.9 1 18277152 (1)

    Genetic Association Database (GAD): RNLS
    Human Genome Epidemiology (HuGE) Navigator: RNLS (1 document)

    Export disorders for RNLS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNLS gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RNLS)
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    1. Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. (PubMed id 15841207)1, 2, 3, 9 Xu J.... Desir G.V. (J. Clin. Invest. 2005)
    2. Renalase, a new renal hormone: its role in health and disease. (PubMed id 17565281)1, 3, 9 Xu J. and Desir G.V. (Curr. Opin. Nephrol. Hypertens. 2007)
    3. FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation. (PubMed id 21699903)1, 2 Milani M.... Aliverti A. (J. Mol. Biol. 2011)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. Regulation of blood pressure and cardiovascular function by renalase. (PubMed id 19471322)1, 9 Desir G.V. (Kidney Int. 2009)
    8. Renalase, a catecholamine-metabolising enzyme? (PubMed id 17385068)2, 9 Boomsma F. and Tipton K.F. (J. Neural Transm. 2007)
    9. Synthesis of human renalase1 in Escherichia coli and its purification as a FAD-containing holoprotein. (PubMed id 20302943)1, 9 Pandini V....Aliverti A. (Protein Expr. Purif. 2010)
    10. Renalase, a novel soluble FAD-dependent protein, is synthesized in the brain and peripheral nerves. (PubMed id 20168325)1, 9 Hennebry S.C....Schlaich M. (Mol. Psychiatry 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55328 HGNC: 25641 AceView: C10orf59 Ensembl:ENSG00000184719 euGenes: HUgn55328
    ECgene: RNLS H-InvDB: RNLS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNLS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNLS gene:
    Search GeneIP for patents involving RNLS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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