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Aliases for RNH1 Gene

Aliases for RNH1 Gene

  • Ribonuclease/Angiogenin Inhibitor 1 2 3 4 5
  • Placental Ribonuclease Inhibitor 3 4
  • Placental RNase Inhibitor 3 4
  • RAI 3 4
  • RNH 3 4
  • Ribonuclease/Angiogenin Inhibitor 2
  • Testicular Tissue Protein Li 164 3
  • PRI 4

External Ids for RNH1 Gene

Previous HGNC Symbols for RNH1 Gene

  • RNH

Previous GeneCards Identifiers for RNH1 Gene

  • GC11M000310

Summaries for RNH1 Gene

Entrez Gene Summary for RNH1 Gene

  • Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

GeneCards Summary for RNH1 Gene

RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include ribonuclease inhibitor activity.

UniProtKB/Swiss-Prot for RNH1 Gene

  • Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Wiki entry for RNH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNH1 Gene

Genomics for RNH1 Gene

Regulatory Elements for RNH1 Gene

Enhancers for RNH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNH1 on UCSC Golden Path with GeneCards custom track

Promoters for RNH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNH1 Gene

Chromosome:
11
Start:
494,512 bp from pter
End:
507,300 bp from pter
Size:
12,789 bases
Orientation:
Minus strand

Genomic View for RNH1 Gene

Genes around RNH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNH1 Gene

Proteins for RNH1 Gene

  • Protein details for RNH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13489-RINI_HUMAN
    Recommended name:
    Ribonuclease inhibitor
    Protein Accession:
    P13489
    Secondary Accessions:
    • Q8IZK8
    • Q96FD7
    • Q9BQ80
    • Q9UDK6

    Protein attributes for RNH1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49973 Da
    Quaternary structure:
    • Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.

    Three dimensional structures from OCA and Proteopedia for RNH1 Gene

neXtProt entry for RNH1 Gene

Proteomics data for RNH1 Gene at MOPED

Post-translational modifications for RNH1 Gene

No data available for DME Specific Peptides for RNH1 Gene

Domains & Families for RNH1 Gene

Suggested Antigen Peptide Sequences for RNH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13489

UniProtKB/Swiss-Prot:

RINI_HUMAN :
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RNH1: view

No data available for Gene Families for RNH1 Gene

Function for RNH1 Gene

Molecular function for RNH1 Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
genes like me logo Genes that share phenotypes with RNH1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNH1 Gene

Localization for RNH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNH1 Gene COMPARTMENTS Subcellular localization image for RNH1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RNH1: view

Pathways & Interactions for RNH1 Gene

SuperPathways for RNH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process NAS 2081593
GO:0043086 negative regulation of catalytic activity IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view

No data available for Pathways by source and SIGNOR curated interactions for RNH1 Gene

Drugs & Compounds for RNH1 Gene

No Compound Related Data Available

Transcripts for RNH1 Gene

Unigene Clusters for RNH1 Gene

Ribonuclease/angiogenin inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - -
SP25: - - - - -
SP26: - - - - - - - -
SP27: - - - - -
SP28: - - -
SP29:
SP30: - -
SP31: - -
SP32: - -

ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16: - - - - -
SP17: - - - - -
SP18:
SP19: - - - - - - -
SP20: - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - -
SP30: - - - - - - -
SP31:
SP32: - -

ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - - - - - -
SP30:
SP31:
SP32:

Relevant External Links for RNH1 Gene

GeneLoc Exon Structure for
RNH1
ECgene alternative splicing isoforms for
RNH1

Expression for RNH1 Gene

mRNA expression in normal human tissues for RNH1 Gene

Protein differential expression in normal tissues from HIPED for RNH1 Gene

This gene is overexpressed in Bone marrow stromal cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNH1 Gene



SOURCE GeneReport for Unigene cluster for RNH1 Gene Hs.530687

genes like me logo Genes that share expression patterns with RNH1: view

Protein tissue co-expression partners for RNH1 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNH1 Gene

Orthologs for RNH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNH1 35
  • 81.57 (n)
  • 74.67 (a)
RNH1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNH1 35
  • 78.1 (n)
  • 70.98 (a)
RNH1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnh1 35
  • 78.97 (n)
  • 73.85 (a)
Rnh1 16
Rnh1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNH1 35
  • 99.28 (n)
  • 98.92 (a)
RNH1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnh1 35
  • 78.68 (n)
  • 75.38 (a)
oppossum
(Monodelphis domestica)
Mammalia RNH1 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNH1 36
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNH1 35
  • 59.62 (n)
  • 50 (a)
RNH1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNH1 36
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RNH1 (1 of 23) 36
  • 10 (a)
OneToMany
RNH1 (10 of 23) 36
  • 25 (a)
OneToMany
RNH1 (11 of 23) 36
  • 10 (a)
OneToMany
RNH1 (12 of 23) 36
  • 8 (a)
OneToMany
RNH1 (13 of 23) 36
  • 30 (a)
OneToMany
RNH1 (14 of 23) 36
  • 10 (a)
OneToMany
RNH1 (15 of 23) 36
  • 11 (a)
OneToMany
RNH1 (16 of 23) 36
  • 10 (a)
OneToMany
RNH1 (17 of 23) 36
  • 10 (a)
OneToMany
RNH1 (18 of 23) 36
  • 12 (a)
OneToMany
RNH1 (19 of 23) 36
  • 10 (a)
OneToMany
RNH1 (2 of 23) 36
  • 10 (a)
OneToMany
RNH1 (20 of 23) 36
  • 14 (a)
OneToMany
RNH1 (21 of 23) 36
  • 37 (a)
OneToMany
RNH1 (22 of 23) 36
  • 37 (a)
OneToMany
RNH1 (23 of 23) 36
  • 40 (a)
OneToMany
RNH1 (3 of 23) 36
  • 10 (a)
OneToMany
RNH1 (4 of 23) 36
  • 10 (a)
OneToMany
RNH1 (5 of 23) 36
  • 15 (a)
OneToMany
RNH1 (6 of 23) 36
  • 10 (a)
OneToMany
RNH1 (7 of 23) 36
  • 35 (a)
OneToMany
RNH1 (8 of 23) 36
  • 9 (a)
OneToMany
RNH1 (9 of 23) 36
  • 11 (a)
OneToMany
Species with no ortholog for RNH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNH1 Gene

ENSEMBL:
Gene Tree for RNH1 (if available)
TreeFam:
Gene Tree for RNH1 (if available)

Paralogs for RNH1 Gene

genes like me logo Genes that share paralogs with RNH1: view

No data available for Paralogs for RNH1 Gene

Variants for RNH1 Gene

Sequence variations from dbSNP and Humsavar for RNH1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17585 - 499,120(-) CAAGC(C/T)GGACT reference, missense
rs1049350 -- 504,867(-) TCAAC(C/G)TGTTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1049499 -- 494,545(-) TGGAC(A/C)CTTTA utr-variant-3-prime
rs2269394 -- 502,722(+) GGCCA(C/T)AGTGT intron-variant
rs7121057 -- 497,784(-) AGCAT(A/G)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNH1 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv932n71 CNV Loss 21882294
dgv933n71 CNV Loss 21882294

Variation tolerance for RNH1 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 74.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNH1 Gene

Disorders for RNH1 Gene

Relevant External Links for RNH1

Genetic Association Database (GAD)
RNH1
Human Genome Epidemiology (HuGE) Navigator
RNH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNH1

No disorders were found for RNH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNH1 Gene

Publications for RNH1 Gene

  1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson R.J. … Raines R.T. (J. Mol. Biol. 2007) 3 4 23 67
  2. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PMID: 15592448) Fu P. … Zhao B. (Cancer Gene Ther. 2005) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. (PMID: 26124079) Nishiyama M. … Nakayama K.I. (Stem Cells 2015) 3

Products for RNH1 Gene

Sources for RNH1 Gene

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