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RNH1 Gene

protein-coding   GIFtS: 56
GCID: GC11M000485

Ribonuclease/Angiogenin Inhibitor 1

(Previous name: ribonuclease/angiogenin inhibitor)
(Previous symbol: RNH)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease/Angiogenin Inhibitor 11 2 3     RAI2 3
RNH1 2 3 5     Ribonuclease/Angiogenin Inhibitor1
Placental Ribonuclease Inhibitor2 3     Ribonuclease Inhibitor2
Placental RNase Inhibitor2 3     PRI3

External Ids:    HGNC: 100741   Entrez Gene: 60502   Ensembl: ENSG000000231917   OMIM: 1733205   UniProtKB: P134893   

Export aliases for RNH1 gene to outside databases

Previous GC identifer: GC11M000310


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNH1 Gene:
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that
occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988
(PubMed 3219362)). In addition to control of intracellular RNases, the inhibitor may have a role in the
regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds
them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of
RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells
with ribonuclease may be reversible in vivo.(supplied by OMIM, Jul 2010)

GeneCards Summary for RNH1 Gene:
RNH1 (ribonuclease/angiogenin inhibitor 1) is a protein-coding gene. GO annotations related to this gene include ribonuclease inhibitor activity.

UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis

Gene Wiki entry for RNH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  NT_187586.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNH1 gene promoter:
         GR   AML1a   GATA-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNH1 promoter sequence
   Search Chromatin IP Primers for RNH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RNH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNH1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000485:  view genomic region     (about GC identifiers)

Start:
494,512 bp from pter      End:
507,300 bp from pter
Size:
12,789 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RINI_HUMAN, P13489 (See protein sequence)
Recommended Name: Ribonuclease inhibitor  
Size: 461 amino acids; 49973 Da
Subunit: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2
4 PDB 3D structures from and Proteopedia for RNH1:
1A4Y (3D)        1Z7X (3D)        2BEX (3D)        2Q4G (3D)    
Secondary accessions: Q8IZK8 Q96FD7 Q9BQ80 Q9UDK6

Explore the universe of human proteins at neXtProt for RNH1: NX_P13489

Explore proteomics data for RNH1 at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • At least 30 of the 32 cysteine residues are in the reduced form1
  • Ubiquitination2 at Lys89, Lys238, Lys321, Lys452, Lys454
  • Modification sites at PhosphoSitePlus

  • See RNH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_002930.2  NP_976317.1  NP_976318.1  NP_976319.1  NP_976320.1  NP_976321.1  NP_976322.1  NP_976323.1  

    ENSEMBL proteins: 
     ENSP00000433999   ENSP00000380739   ENSP00000380729   ENSP00000436022   ENSP00000432170  
     ENSP00000435594   ENSP00000416589   ENSP00000346402   ENSP00000348515   ENSP00000431201  
     ENSP00000433033   ENSP00000435748   ENSP00000435057   ENSP00000434947   ENSP00000435798  
     ENSP00000434971   ENSP00000432781   ENSP00000380738  

    RNH1 Human Recombinant Protein Products:

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    Novus Biologicals RNH1 Proteins
    Novus Biologicals RNH1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RNH1 

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    LSBio Antibodies in human, mouse, rat for RNH1

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for RNH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003590 Leu-rich_rpt_RNase_inh_sub-typ

    Graphical View of Domain Structure for InterPro Entry P13489

    ProtoNet protein and cluster: P13489

    1 Blocks protein domain: IPB003590 Leucine-rich repeat

    UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
    Domain: The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large
    protein interaction surface on its interior side
    Similarity: Contains 15 LRR (leucine-rich) repeats


    Find genes that share domains with RNH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RINI_HUMAN, P13489
    Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10413501
    GO:0008428ribonuclease inhibitor activity IDA3470787
         
    Find genes that share ontologies with RNH1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNH1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNH1

    miRNA
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    miRTarBase miRNAs that target RNH1:
    hsa-mir-92a-3p (MIRT049793), hsa-mir-125b-5p (MIRT045994)

    Block miRNA regulation of human, mouse, rat RNH1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNH1:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidRNH1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 8): RNH1 (NM_002939)
    Sino Biological Human cDNA Clone for RNH1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNH1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RINI_HUMAN, P13489: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular4
    chloroplast1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0032311angiogenin-PRI complex IPI3470787
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with RNH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNH1: 
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for RNH1 (P134891, 2, 3 ENSP000003464024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANGP039501, 3, ENSP000003367624EBI-1237106,EBI-525291 I2D: score=4 STRING: ENSP00000336762
    RNASE1P079981, 3, ENSP000003441934EBI-1237106,EBI-2823523 I2D: score=3 STRING: ENSP00000344193
    PARP1P098742, 3, ENSP000003557594MINT-8086548 I2D: score=1 STRING: ENSP00000355759
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    RNASE2P101533, ENSP000003032764I2D: score=2 STRING: ENSP00000303276
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process NAS2081593
    GO:0043086negative regulation of catalytic activity IDA3470787
    GO:0045765regulation of angiogenesis IDA3470787

    Find genes that share ontologies with RNH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNH1 (RINI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNH1 gene (8 alternative transcripts): 
    NM_002939.3  NM_203383.1  NM_203384.1  NM_203385.1  NM_203386.2  NM_203387.2  NM_203388.2  NM_203389.2  

    Unigene Cluster for RNH1:

    Ribonuclease/angiogenin inhibitor 1
    Hs.530687  [show with all ESTs]
    Unigene Representative Sequence: AB209196
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000534797(uc001lpk.1) ENST00000397615(uc001lpl.1 uc001lpn.1)
    ENST00000397604(uc001lps.2) ENST00000525522 ENST00000525701 ENST00000529768
    ENST00000533410(uc001lpr.2) ENST00000438658 ENST00000354420(uc001lpp.2)
    ENST00000356187(uc001lpq.2) ENST00000524464 ENST00000529115 ENST00000527485
    ENST00000529368 ENST00000529306 ENST00000524780 ENST00000531149 ENST00000531223

    miRNA
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    Block miRNA regulation of human, mouse, rat RNH1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNH1:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidRNH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNH1
    Predesigned siRNA for gene silencing in human, mouse, rat RNH1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): RNH1 (NM_002939)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNH1
    Primer
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    OriGene qPCR primer pairs and template standards for RNH1
    OriGene qSTAR qPCR primer pairs in human, mouse for RNH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNH1
      QuantiTect SYBR Green Assays in human, mouse, rat RNH1
      QuantiFast Probe-based Assays in human, mouse, rat RNH1

    Additional mRNA sequence: 

    AB209196.1 AK095144.1 AK308340.1 AK310173.1 AK311379.1 AY071904.2 BC000677.2 BC003506.1 
    BC011186.1 BC011500.1 BC014629.2 BC024037.1 BC047730.1 M22414.1 M36717.1 X13973.1 

    Selected DOTS entries (see all 41):

    DT.100888996  DT.91767822  DT.100889006  DT.91767841  DT.91805855  DT.102835588  DT.91767837  DT.95113324 
    DT.91767833  DT.100691026  DT.91815635  DT.95113378  DT.100888990  DT.100889007  DT.75192219  DT.95113384 
    DT.100888987  DT.95113383  DT.95191671  DT.91767834  DT.95313613  DT.95361649  DT.100888993  DT.95113386 

    Selected AceView cDNA sequences (see all 859):

    BQ063742 BU170583 CB528974 BQ639116 BM551838 BM458722 CN481428 AI128016 
    BU528634 BG740488 CR592774 BE276887 CR596248 BM756944 CR608218 BC047730 
    CA423030 BM765105 BI522476 BM757208 BQ771954 BQ772973 AW069030 BM704788 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 (see all 32)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
    SP1:                                                              -     -     -                             -     -                                   -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -     -   
    SP4:                                                              -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP5:                                                                                                        -     -     -     -                       -     -   

    ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:                                                        -     -     -     -     -                                                                           
    SP2:                                                        -     -     -     -     -                                                                           
    SP3:                                                        -     -     -     -     -                                                                           
    SP4:                                                        -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for RNH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCACCCT
    RNH1 Expression
    About this image


    RNH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebellum
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    RNH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530687
        Pathway & Disease-focused RT2 Profiler PCR Array including RNH1: 
              Angiogenic Growth Factors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RNH1
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    QuantiTect SYBR Green Assays in human, mouse, rat RNH1
    QuantiFast Probe-based Assays in human, mouse, rat RNH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNH1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnh11 , 5 ribonuclease/angiogenin inhibitor 11, 5 78.97(n)1
    73.85(a)1
      7 (86.44 cM)5
    1077021  NM_001172101.11  NP_001165572.11 
     1411603285 
    chicken
    (Gallus gallus)
    Aves RNH11 ribonuclease/angiogenin inhibitor 1 59.62(n)
    50(a)
      423111  NM_001006473.1  NP_001006473.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNH16
    ribonuclease/angiogenin inhibitor 1
    46(a)
    1 ↔ 1
    1(74960580-74984196)
    zebrafish
    (Danio rerio)
    Actinopterygii RNH1 (8 of 23)6
    RNH1 (12 of 23)6
    (see all 23)
    ribonuclease/angiogenin inhibitor 1
    (see all 23)
    9(a)
    8(a)
    (see all 23)
    many → 1
    many → 1
    (see all 23)
    4(52584333-52612469) ENSDARG00000088142
    16(183117-191500) ENSDARG00000088689


    ENSEMBL Gene Tree for RNH1 (if available)
    TreeFam Gene Tree for RNH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNH1 gene
    12 SIMAP similar genes for RNH1 using alignment to 10 protein entries:     RINI_HUMAN (see all proteins):
    NLRP12    NLRP1    NLRP3    NLRP11    NLRP7    NLRP4
    NLRP14    NLRP9    CIAS1    NLRP5    PP1579    NLRP2

    Find genes that share paralogs with RNH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNH1 (see all 521)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124182401,2
    C,F,A,H--494138(+) ggccgC/Ggctgg 8 -- int12Minor allele frequency- G:0.25NA 4
    rs124191571,2
    C,F,A,H--494141(+) cgcgcC/Tgggcc 8 -- int11Minor allele frequency- T:0.50NA 2
    rs124171971,2
    C,F,A,H--494149(+) gccgcG/Actggg 8 -- int11Minor allele frequency- A:0.50NA 2
    rs1482068591,2
    --494293(+) CTGCAC/GGGGCA 8 -- int10--------
    rs1411544741,2
    --494346(+) CTGTGC/TTCCCC 8 -- int10--------
    rs1507058181,2
    C--494463(+) GTGTCA/GTCTCC 8 -- int10--------
    rs124192091,2
    C,F,H--494510(+) GAGCCT/CCTCCT 8 -- spd15Minor allele frequency- C:0.13NA 130
    rs1116640141,2
    C--494514(+) CTCTCC/G/TTGCCA 16 -- ut311CSA 1
    rs1394307761,2
    --494521(+) GCCAAA/GAAAGT 8 -- ut310--------
    rs1836091201,2
    C--494637(+) GTGGGA/CCCCAG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for RNH1 (494512 - 507300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNH1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    dgv920n71CNV Loss21882294
    dgv932n71CNV Loss21882294
    nsv527327CNV Loss19592680
    dgv931n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv921n71CNV Loss21882294
    dgv933n71CNV Loss21882294
    dgv930n71CNV Loss21882294
    dgv918n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNH1
    DNA2.0 Custom Variant and Variant Library Synthesis for RNH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 173320    OMIM disorders: --


    Find genes that share disorders with RNH1           About GenesLikeMe

    2 Novoseek inferred disease relationships for RNH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 15592448 (1), 1544320 (1), 17032310 (1)
    cancer 0 1 11801605 (1)

    Genetic Association Database (GAD): RNH1
    Human Genome Epidemiology (HuGE) Navigator: RNH1 (2 documents)

    Export disorders for RNH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNH1 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with RNH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 2, 9 Johnson R.J....Raines R.T. (J. Mol. Biol. 2007)
    2. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PubMed id 15755456)1, 2 Iyer S.... Acharya K.R. (J. Mol. Biol. 2005)
    3. Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. (PubMed id 15936590)1, 4 Vogel U.... B.A. (Cancer Detect. Prev. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A. (PubMed id 10413501)1, 2 Chen C.Z. and Shapiro R. (Biochemistry 1999)
    6. Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977)1, 2 Papageorgiou A.C.... Acharya K.R. (EMBO J. 1997)
    7. Purification and characterization of human brain ribonuclease inhibitor. (PubMed id 8037455)1, 2 Nadano D.... Kishi K. (Arch. Biochem. Biophys. 1994)
    8. Primary structure of human placental ribonuclease inhibitor. (PubMed id 3219362)1, 2 Lee F.S.... Vallee B.L. (Biochemistry 1988)
    9. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. (PubMed id 3243277)1, 2 Schneider R....Schweiger M. (EMBO J. 1988)
    10. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PubMed id 15592448)1, 9 Fu P....Zhao B. (Cancer Gene Ther. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6050 HGNC: 10074 AceView: RNH Ensembl:ENSG00000023191 euGenes: HUgn6050
    ECgene: RNH1 H-InvDB: RNH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNH1 gene:
    Search GeneIP for patents involving RNH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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