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Aliases for RNH1 Gene

Aliases for RNH1 Gene

  • Ribonuclease/Angiogenin Inhibitor 1 2 3 4
  • RNH 3 4 6
  • Placental Ribonuclease Inhibitor 3 4
  • Placental RNase Inhibitor 3 4
  • RAI 3 4
  • Ribonuclease/Angiogenin Inhibitor 2
  • Ribonuclease Inhibitor 3
  • PRI 4

External Ids for RNH1 Gene

Previous Symbols for RNH1 Gene

  • RNH

Summaries for RNH1 Gene

Entrez Gene Summary for RNH1 Gene

  • Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

GeneCards Summary for RNH1 Gene

RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include ribonuclease inhibitor activity.

UniProtKB/Swiss-Prot for RNH1 Gene

  • Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Wiki entry for RNH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNH1 Gene

Genomics for RNH1 Gene

Genomic Location for RNH1 Gene

Start:
494,512 bp from pter
End:
507,300 bp from pter
Size:
12,789 bases
Orientation:
Minus strand

Genomic View for RNH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNH1 Gene

Regulatory Elements for RNH1 Gene

Proteins for RNH1 Gene

  • Protein details for RNH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13489-RINI_HUMAN
    Recommended name:
    Ribonuclease inhibitor
    Protein Accession:
    P13489
    Secondary Accessions:
    • Q8IZK8
    • Q96FD7
    • Q9BQ80
    • Q9UDK6

    Protein attributes for RNH1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49973 Da
    Quaternary structure:
    • Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.

    Three dimensional structures from OCA and Proteopedia for RNH1 Gene

neXtProt entry for RNH1 Gene

Proteomics data for RNH1 Gene at MOPED

Post-translational modifications for RNH1 Gene

No data available for DME Specific Peptides for RNH1 Gene

Domains for RNH1 Gene

Protein Domains for RNH1 Gene

UniProtKB/Swiss-Prot:

RINI_HUMAN
Domain:
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.:
    • P13489
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.:
    • P13489
genes like me logo Genes that share domains with RNH1: view

No data available for Gene Families for RNH1 Gene

Function for RNH1 Gene

Molecular function for RNH1 Gene

UniProtKB/Swiss-Prot Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Ontology (GO) - Molecular Function for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10413501
GO:0008428 ribonuclease inhibitor activity IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view

miRNA for RNH1 Gene

miRTarBase miRNAs that target RNH1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNH1 Gene

Localization for RNH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNH1 Gene COMPARTMENTS Subcellular localization image for RNH1 gene
Compartment Confidence
cytosol 4
extracellular 4
chloroplast 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0032311 angiogenin-PRI complex IPI 3470787
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RNH1: view

Pathways for RNH1 Gene

SuperPathways for RNH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process NAS 2081593
GO:0043086 negative regulation of catalytic activity IDA 3470787
GO:0045765 regulation of angiogenesis IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view

No data available for Pathways by source for RNH1 Gene

Transcripts for RNH1 Gene

Unigene Clusters for RNH1 Gene

Ribonuclease/angiogenin inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - -
SP25: - - - - -
SP26: - - - - - - - -
SP27: - - - - -
SP28: - - -
SP29:
SP30: - -
SP31: - -
SP32: - -

ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16: - - - - -
SP17: - - - - -
SP18:
SP19: - - - - - - -
SP20: - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - -
SP30: - - - - - - -
SP31:
SP32: - -

ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - - - - - -
SP30:
SP31:
SP32:

Relevant External Links for RNH1 Gene

GeneLoc Exon Structure for
RNH1
ECgene alternative splicing isoforms for
RNH1

Expression for RNH1 Gene

mRNA expression in normal human tissues for RNH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNH1 Gene

SOURCE GeneReport for Unigene cluster for RNH1 Gene Hs.530687

genes like me logo Genes that share expressions with RNH1: view

Orthologs for RNH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNH1 36
  • 99.28 (n)
  • 98.92 (a)
RNH1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNH1 36
  • 81.57 (n)
  • 74.67 (a)
RNH1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNH1 36
  • 78.1 (n)
  • 70.98 (a)
RNH1 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnh1 36
  • 78.97 (n)
  • 73.85 (a)
Rnh1 16
Rnh1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNH1 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNH1 37
  • 27 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnh1 36
  • 78.68 (n)
  • 75.38 (a)
chicken
(Gallus gallus)
Aves RNH1 36
  • 59.62 (n)
  • 50 (a)
RNH1 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNH1 37
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RNH1 (1 of 23) 37
  • 10 (a)
OneToMany
RNH1 (10 of 23) 37
  • 25 (a)
OneToMany
RNH1 (11 of 23) 37
  • 10 (a)
OneToMany
RNH1 (12 of 23) 37
  • 8 (a)
OneToMany
RNH1 (13 of 23) 37
  • 30 (a)
OneToMany
RNH1 (14 of 23) 37
  • 10 (a)
OneToMany
RNH1 (15 of 23) 37
  • 11 (a)
OneToMany
RNH1 (16 of 23) 37
  • 10 (a)
OneToMany
RNH1 (17 of 23) 37
  • 10 (a)
OneToMany
RNH1 (18 of 23) 37
  • 12 (a)
OneToMany
RNH1 (19 of 23) 37
  • 10 (a)
OneToMany
RNH1 (2 of 23) 37
  • 10 (a)
OneToMany
RNH1 (20 of 23) 37
  • 14 (a)
OneToMany
RNH1 (21 of 23) 37
  • 37 (a)
OneToMany
RNH1 (22 of 23) 37
  • 37 (a)
OneToMany
RNH1 (23 of 23) 37
  • 40 (a)
OneToMany
RNH1 (3 of 23) 37
  • 10 (a)
OneToMany
RNH1 (4 of 23) 37
  • 10 (a)
OneToMany
RNH1 (5 of 23) 37
  • 15 (a)
OneToMany
RNH1 (6 of 23) 37
  • 10 (a)
OneToMany
RNH1 (7 of 23) 37
  • 35 (a)
OneToMany
RNH1 (8 of 23) 37
  • 9 (a)
OneToMany
RNH1 (9 of 23) 37
  • 11 (a)
OneToMany
Species with no ortholog for RNH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNH1 Gene

ENSEMBL:
Gene Tree for RNH1 (if available)
TreeFam:
Gene Tree for RNH1 (if available)

Paralogs for RNH1 Gene

genes like me logo Genes that share paralogs with RNH1: view

No data available for Paralogs for RNH1 Gene

Variants for RNH1 Gene

Sequence variations from dbSNP and Humsavar for RNH1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7983 -- 494,942(-) GACGC(C/G)GGCAT reference, synonymous-codon
rs10540 -- 494,662(-) CTGGA(C/T)GACCG utr-variant-3-prime
rs17584 -- 499,059(-) GTGCT(A/G)TGCCA synonymous-codon, reference
rs17585 - 499,120(-) CAAGC(C/T)GGACT reference, missense
rs176939 -- 496,073(-) TTTTT(C/G)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNH1 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv932n71 CNV Loss 21882294
dgv933n71 CNV Loss 21882294

Relevant External Links for RNH1 Gene

HapMap Linkage Disequilibrium report
RNH1

Disorders for RNH1 Gene

(2) Novoseek inferred disease relationships for RNH1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3
cancer 0 1

Relevant External Links for RNH1

Genetic Association Database (GAD)
RNH1
Human Genome Epidemiology (HuGE) Navigator
RNH1
genes like me logo Genes that share disorders with RNH1: view

No data available for UniProtKB/Swiss-Prot for RNH1 Gene

Publications for RNH1 Gene

  1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson R.J. … Raines R.T. (J. Mol. Biol. 2007) 3 4 23
  2. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PMID: 15592448) Fu P. … Zhao B. (Cancer Gene Ther. 2005) 3 23
  3. Primary structure of human placental ribonuclease inhibitor. (PMID: 3219362) Lee F.S. … Vallee B.L. (Biochemistry 1988) 3 4
  4. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. (PMID: 3243277) Schneider R. … Schweiger M. (EMBO J. 1988) 3 4
  5. Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PMID: 9311977) Papageorgiou A.C. … Acharya K.R. (EMBO J. 1997) 3 4

Products for RNH1 Gene

Sources for RNH1 Gene

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