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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNH1 Gene

protein-coding   GIFtS: 54
GCID: GC11M000485

Ribonuclease/Angiogenin Inhibitor 1

(Previous name: ribonuclease/angiogenin inhibitor)
(Previous symbol: RNH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease/Angiogenin Inhibitor 11 2 3     RAI2 3
RNH1 2 3 5     Ribonuclease/Angiogenin Inhibitor1
Placental Ribonuclease Inhibitor2 3     Ribonuclease Inhibitor2
Placental RNase Inhibitor2 3     PRI3

External Ids:    HGNC: 100741   Entrez Gene: 60502   Ensembl: ENSG000000231917   OMIM: 1733205   UniProtKB: P134893   

Export aliases for RNH1 gene to outside databases

Previous GC identifer: GC11M000310


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNH1 Gene:
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that
occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988
(PubMed 3219362)). In addition to control of intracellular RNases, the inhibitor may have a role in the
regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds
them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of
RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells
with ribonuclease may be reversible in vivo.(supplied by OMIM, Jul 2010)

GeneCards Summary for RNH1 Gene: 
RNH1 (ribonuclease/angiogenin inhibitor 1) is a protein-coding gene. Diseases associated with RNH1 include vaginal cancer, and vaginitis. GO annotations related to this gene include protein binding and ribonuclease inhibitor activity. An important paralog of this gene is NLRP1.

UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis

Gene Wiki entry for RNH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNH1 gene promoter:
         GR   AML1a   GATA-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RNH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNH1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000485:  view genomic region     (about GC identifiers)

Start:
494,512 bp from pter      End:
507,300 bp from pter
Size:
12,789 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RINI_HUMAN, P13489 (See protein sequence)
Recommended Name: Ribonuclease inhibitor  
Size: 461 amino acids; 49973 Da
Subunit: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2
Subcellular location: Cytoplasm
4 PDB 3D structures from and Proteopedia for RNH1:
1A4Y (3D)        1Z7X (3D)        2BEX (3D)        2Q4G (3D)    
Secondary accessions: Q8IZK8 Q96FD7 Q9BQ80 Q9UDK6

Explore the universe of human proteins at neXtProt for RNH1: NX_P13489

Explore proteomics data for RNH1 at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • UniProtKB: At least 30 of the 32 cysteine residues are in the reduced form
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13489

  • RNH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNH1 Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_002930.2  NP_976317.1  NP_976318.1  NP_976319.1  NP_976320.1  NP_976321.1  NP_976322.1  NP_976323.1  

    ENSEMBL proteins: 
     ENSP00000433999   ENSP00000380739   ENSP00000380729   ENSP00000436022   ENSP00000432170  
     ENSP00000435594   ENSP00000416589   ENSP00000346402   ENSP00000348515   ENSP00000431201  
     ENSP00000433033   ENSP00000435748   ENSP00000435057   ENSP00000434947   ENSP00000435798  
     ENSP00000434971   ENSP00000432781   ENSP00000380738  

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    Novus Biologicals RNH1 Lysates
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0032311angiogenin-PRI complex IPI3470787

    RNH1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003590 Leu-rich_rpt_RNase_inh_sub-typ

    Graphical View of Domain Structure for InterPro Entry P13489

    ProtoNet protein and cluster: P13489

    1 Blocks protein domain: IPB003590 Leucine-rich repeat

    UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
    Domain: The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large
    protein interaction surface on its interior side
    Similarity: Contains 15 LRR (leucine-rich) repeats


    RNH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RINI_HUMAN, P13489
    Function: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10413501
    GO:0008428ribonuclease inhibitor activity IDA3470787
         
    RNH1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/29 Interacting proteins for RNH1 (P134891, 2, 3 ENSP000003464024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANGP039501, 3, ENSP000003367624EBI-1237106,EBI-525291 I2D: score=4 STRING: ENSP00000336762
    RNASE1P079981, 3, ENSP000003441934EBI-1237106,EBI-2823523 I2D: score=3 STRING: ENSP00000344193
    PARP1P098742, 3, ENSP000003557594MINT-8086548 I2D: score=1 STRING: ENSP00000355759
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    RNASE2P101533, ENSP000003032764I2D: score=2 STRING: ENSP00000303276
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process NAS2081593
    GO:0045765regulation of angiogenesis IDA3470787

    RNH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNH1 (RINI)

    Search CenterWatch for drugs/clinical trials and news about RNH1 / RINI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNH1 gene (8 alternative transcripts): 
    NM_002939.3  NM_203383.1  NM_203384.1  NM_203385.1  NM_203386.2  NM_203387.2  NM_203388.2  NM_203389.2  

    Unigene Cluster for RNH1:

    Ribonuclease/angiogenin inhibitor 1
    Hs.530687  [show with all ESTs]
    Unigene Representative Sequence: AB209196
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000534797(uc001lpk.1) ENST00000397615(uc001lpl.1 uc001lpn.1)
    ENST00000397604(uc001lps.2) ENST00000525522 ENST00000525701 ENST00000529768
    ENST00000533410(uc001lpr.2) ENST00000438658 ENST00000354420(uc001lpp.2)
    ENST00000356187(uc001lpq.2) ENST00000524464 ENST00000529115 ENST00000527485
    ENST00000529368 ENST00000529306 ENST00000524780 ENST00000531149 ENST00000531223

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RNH1:
    hsa-miR-142-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidRNH1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209196.1 AK095144.1 AK308340.1 AK310173.1 AK311379.1 AY071904.2 BC000677.2 BC003506.1 
    BC011186.1 BC011500.1 BC014629.2 BC024037.1 BC047730.1 M22414.1 M36717.1 X13973.1 

    24/41 DOTS entries (see all 41):

    DT.100888996  DT.91767822  DT.100889006  DT.91767841  DT.91805855  DT.102835588  DT.91767837  DT.95113324 
    DT.91767833  DT.100691026  DT.91815635  DT.95113378  DT.100888990  DT.100889007  DT.75192219  DT.95113384 
    DT.100888987  DT.95113383  DT.95191671  DT.91767834  DT.95313613  DT.95361649  DT.100888993  DT.95113386 

    24/859 AceView cDNA sequences (see all 859):

    BQ639116 BM765105 BM551838 BX335203 CB529136 CR608218 BU501161 BQ072376 
    BM704205 BG766093 BU859804 BC011186 BM773175 BU617098 BQ641262 CR595919 
    BM757217 BG924391 BM694417 NM_002939 BQ645871 NM_203389 BQ440119 CR613915 

    GeneLoc Exon Structure

    5/32 Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 (see all 32)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
    SP1:                                                              -     -     -                             -     -                                   -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -     -   
    SP4:                                                              -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP5:                                                                                                        -     -     -     -                       -     -   

    ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:                                                        -     -     -     -     -                                                                           
    SP2:                                                        -     -     -     -     -                                                                           
    SP3:                                                        -     -     -     -     -                                                                           
    SP4:                                                        -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for RNH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCACCCT
    RNH1 Expression
    About this image


    See RNH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNH1

    SOURCE GeneReport for Unigene cluster: Hs.530687
        SABiosciences Expression via Pathway-Focused PCR Array including RNH1: 
              Angiogenic Growth Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNH1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnh11 , 5 ribonuclease/angiogenin inhibitor 11, 5 78.97(n)1
    73.85(a)1
      7 (86.44 cM)5
    1077021  NM_001172101.11  NP_001165572.11 
     1411603285 
    chicken
    (Gallus gallus)
    Aves RNH11 ribonuclease/angiogenin inhibitor 1 59.62(n)
    50(a)
      423111  NM_001006473.1  NP_001006473.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNH16
    --
    --
    46(a)
    17(a)
    1 ↔ 1
    possible ortholog
    1(74960580-74984196)
    1(77089333-77108440)
    zebrafish
    (Danio rerio)
    Actinopterygii RNH1 (2 of 8)6
    RNH1 (1 of 8)6
    (see all 8)
    ribonuclease/angiogenin inhibitor 1
    (see all 8)
    40(a)
    31(a)
    (see all 8)
    1 ↔ many
    1 ↔ many
    (see all 8)
    4(50236434-50236904)
    5(54209583-54213044)


    ENSEMBL Gene Tree for RNH1 (if available)
    TreeFam Gene Tree for RNH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNH1 gene
    NLRP12  CARD82  
    12 SIMAP similar genes for RNH1 using alignment to 10 protein entries:     RINI_HUMAN (see all proteins):
    NLRP12    NLRP1    NLRP11    NLRP7    NLRP4    NLRP14
    NLRP9    CIAS1    NLRP3    NLRP5    PP1579    NLRP2

    RNH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/521 SNPs in RNH1 are shown (see all 521)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124182401,2
    C,F,A,H--494138(+) ggccgC/Ggctgg 8 -- int12Minor allele frequency- G:0.25NA 4
    rs124191571,2
    C,F,A,H--494141(+) cgcgcC/Tgggcc 8 -- int11Minor allele frequency- T:0.50NA 2
    rs124171971,2
    C,F,A,H--494149(+) gccgcG/Actggg 8 -- int11Minor allele frequency- A:0.50NA 2
    rs1482068591,2
    --494293(+) CTGCAC/GGGGCA 8 -- int10--------
    rs1411544741,2
    --494346(+) CTGTGC/TTCCCC 8 -- int10--------
    rs1507058181,2
    C--494463(+) GTGTCA/GTCTCC 8 -- int10--------
    rs124192091,2
    C,F,H--494510(+) GAGCCT/CCTCCT 8 -- spd15Minor allele frequency- C:0.13NA 130
    rs1116640141,2
    C--494514(+) CTCTCC/G/TTGCCA 16 -- ut311CSA 1
    rs1394307761,2
    --494521(+) GCCAAA/GAAAGT 8 -- ut310--------
    rs1836091201,2
    C--494637(+) GTGGGA/CCCCAG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for RNH1 (494512 - 507300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for RNH1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    dgv920n71CNV Loss21882294
    dgv932n71CNV Loss21882294
    nsv527327CNV Loss19592680
    dgv931n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv921n71CNV Loss21882294
    dgv933n71CNV Loss21882294
    dgv930n71CNV Loss21882294
    dgv918n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173320    OMIM disorders: --

    7 diseases for RNH1:    About MalaCards
    vaginal cancer    vaginitis    malignant mesothelioma    basal cell carcinoma
    endometriosis    schizophrenia    pancreatitis


    RNH1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RNH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 15592448 (1), 1544320 (1), 17032310 (1)
    cancer 0 1 11801605 (1)

    Genetic Association Database (GAD): RNH1
    Human Genome Epidemiology (HuGE) Navigator: RNH1 (2 documents)

    Export disorders for RNH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNH1 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with RNH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 2, 9 Johnson R.J....Raines R.T. (2007)
    2. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PubMed id 15755456)1, 2 Iyer S....Acharya K.R. (2005)
    3. Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. (PubMed id 15936590)1, 4 Vogel U....Nexo B.A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Superadditive and subadditive effects of 'hot spot' mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A. (PubMed id 10413501)1, 2 Chen C.Z. and Shapiro R. (1999)
    6. Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977)1, 2 Papageorgiou A.C.... Acharya K.R. (1997)
    7. Purification and characterization of human brain ribonuclease inhibitor. (PubMed id 8037455)1, 2 Nadano D.... Kishi K. (1994)
    8. Primary structure of human placental ribonuclease inhibitor. (PubMed id 3219362)1, 2 Lee F.S.... Vallee B.L. (1988)
    9. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. (PubMed id 3243277)1, 2 Schneider R....Schweiger M. (1988)
    10. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PubMed id 15592448)1, 9 Fu P....Zhao B. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6050 HGNC: 10074 AceView: RNH Ensembl:ENSG00000023191 euGenes: HUgn6050
    ECgene: RNH1 H-InvDB: RNH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNH1 gene:
    Search GeneIP for patents involving RNH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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