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Aliases for RNH1 Gene

Aliases for RNH1 Gene

  • Ribonuclease/Angiogenin Inhibitor 1 2 3 4 5
  • Placental Ribonuclease Inhibitor 3 4
  • Placental RNase Inhibitor 3 4
  • RAI 3 4
  • RNH 3 4
  • Ribonuclease/Angiogenin Inhibitor 2
  • Testicular Tissue Protein Li 164 3
  • Ribonuclease Inhibitor 3
  • PRI 4

External Ids for RNH1 Gene

Previous HGNC Symbols for RNH1 Gene

  • RNH

Previous GeneCards Identifiers for RNH1 Gene

  • GC11M000310

Summaries for RNH1 Gene

Entrez Gene Summary for RNH1 Gene

  • Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

GeneCards Summary for RNH1 Gene

RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. Diseases associated with RNH1 include Osteogenesis Imperfecta, Type V. GO annotations related to this gene include ribonuclease inhibitor activity.

UniProtKB/Swiss-Prot for RNH1 Gene

  • Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Wiki entry for RNH1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNH1 Gene

Genomics for RNH1 Gene

Regulatory Elements for RNH1 Gene

Enhancers for RNH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G000518 1.6 Ensembl ENCODE dbSUPER 18.4 -11.7 -11688 1.6 ARNT CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 FEZF1 YY1 SLC30A9 LRRC56 PHRF1 RNH1 SNORA52 ENSG00000255237 RIC8A TSPAN4 LOC105376507
GH11G000459 1.5 Ensembl ENCODE dbSUPER 17.7 +46.2 46239 3.3 ATF1 PKNOX1 CREB3L1 AGO1 SIN3A BRCA1 TCF12 CBX5 ELK1 GATA2 RNH1 PTDSS2 ENSG00000255237 GC11M000452
GH11G000501 1.4 ENCODE dbSUPER 18.8 +2.1 2070 6.5 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LRRC56 RNH1 PHRF1 PTDSS2 SNORA52 ENSG00000255237 RIC8A TSPAN4 DRD4 TMEM80
GH11G000534 1.3 ENCODE dbSUPER 16.6 -29.0 -28990 4.3 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A ZBTB7B ZNF143 ENSG00000255237 PHRF1 LRRC56 HRAS RNH1 SNORA52 TMEM80 DRD4 RIC8A ENSG00000255142
GH11G000443 1.7 Ensembl ENCODE dbSUPER 11.9 +59.6 59555 8.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC LRRC56 TSPAN4 SNORA52 PHRF1 PTDSS2 ENSG00000255237 ANO9 RNH1 ENSG00000255158 HRAS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNH1 on UCSC Golden Path with GeneCards custom track

Promoters for RNH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035641 400 2201 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for RNH1 Gene

Chromosome:
11
Start:
494,512 bp from pter
End:
507,300 bp from pter
Size:
12,789 bases
Orientation:
Minus strand

Genomic View for RNH1 Gene

Genes around RNH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNH1 Gene

Proteins for RNH1 Gene

  • Protein details for RNH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13489-RINI_HUMAN
    Recommended name:
    Ribonuclease inhibitor
    Protein Accession:
    P13489
    Secondary Accessions:
    • Q8IZK8
    • Q96FD7
    • Q9BQ80
    • Q9UDK6

    Protein attributes for RNH1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49973 Da
    Quaternary structure:
    • Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.

    Three dimensional structures from OCA and Proteopedia for RNH1 Gene

neXtProt entry for RNH1 Gene

Post-translational modifications for RNH1 Gene

  • At least 30 of the 32 cysteine residues are in the reduced form.
  • The N-terminus is blocked.
  • Ubiquitination at isoforms=89, Lys238, isoforms=321, and isoforms=454
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNH1 Gene

Domains & Families for RNH1 Gene

Suggested Antigen Peptide Sequences for RNH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13489

UniProtKB/Swiss-Prot:

RINI_HUMAN :
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
Domain:
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
genes like me logo Genes that share domains with RNH1: view

No data available for Gene Families for RNH1 Gene

Function for RNH1 Gene

Molecular function for RNH1 Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Ontology (GO) - Molecular Function for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2742853
GO:0008428 ribonuclease inhibitor activity IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view
genes like me logo Genes that share phenotypes with RNH1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RNH1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNH1 Gene

Localization for RNH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNH1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0032311 angiogenin-PRI complex IPI 3470787
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RNH1: view

Pathways & Interactions for RNH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process NAS 2081593
GO:0043086 negative regulation of catalytic activity IEA --
GO:0045765 regulation of angiogenesis IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view

No data available for Pathways by source and SIGNOR curated interactions for RNH1 Gene

Transcripts for RNH1 Gene

Unigene Clusters for RNH1 Gene

Ribonuclease/angiogenin inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RNH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - -
SP25: - - - - -
SP26: - - - - - - - -
SP27: - - - - -
SP28: - - -
SP29:
SP30: - -
SP31: - -
SP32: - -

ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16: - - - - -
SP17: - - - - -
SP18:
SP19: - - - - - - -
SP20: - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - -
SP30: - - - - - - -
SP31:
SP32: - -

ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - - - - - -
SP30:
SP31:
SP32:

Relevant External Links for RNH1 Gene

GeneLoc Exon Structure for
RNH1
ECgene alternative splicing isoforms for
RNH1

Expression for RNH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNH1 Gene

Protein differential expression in normal tissues from HIPED for RNH1 Gene

This gene is overexpressed in Bone marrow stromal cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNH1 Gene



Protein tissue co-expression partners for RNH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNH1 Gene:

RNH1

SOURCE GeneReport for Unigene cluster for RNH1 Gene:

Hs.530687

Evidence on tissue expression from TISSUES for RNH1 Gene

  • Nervous system(4.9)
  • Intestine(4.5)
  • Liver(4.5)
  • Skin(4.2)
  • Lung(3)
  • Blood(2.8)
  • Eye(2.7)
  • Heart(2.5)
  • Pancreas(2.3)
  • Gall bladder(2.1)
  • Kidney(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNH1 Gene

Orthologs for RNH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNH1 34 35
  • 99.28 (n)
cow
(Bos Taurus)
Mammalia RNH1 35 34
  • 81.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnh1 34 16 35
  • 78.97 (n)
rat
(Rattus norvegicus)
Mammalia Rnh1 34
  • 78.68 (n)
dog
(Canis familiaris)
Mammalia RNH1 34 35
  • 78.1 (n)
oppossum
(Monodelphis domestica)
Mammalia RNH1 35
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNH1 35
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNH1 34 35
  • 59.62 (n)
lizard
(Anolis carolinensis)
Reptilia RNH1 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RNH1 (23 of 23) 35
  • 40 (a)
OneToMany
RNH1 (21 of 23) 35
  • 37 (a)
OneToMany
RNH1 (22 of 23) 35
  • 37 (a)
OneToMany
RNH1 (7 of 23) 35
  • 35 (a)
OneToMany
RNH1 (13 of 23) 35
  • 30 (a)
OneToMany
RNH1 (10 of 23) 35
  • 25 (a)
OneToMany
RNH1 (5 of 23) 35
  • 15 (a)
OneToMany
RNH1 (20 of 23) 35
  • 14 (a)
OneToMany
RNH1 (18 of 23) 35
  • 12 (a)
OneToMany
RNH1 (15 of 23) 35
  • 11 (a)
OneToMany
RNH1 (9 of 23) 35
  • 11 (a)
OneToMany
RNH1 (1 of 23) 35
  • 10 (a)
OneToMany
RNH1 (11 of 23) 35
  • 10 (a)
OneToMany
RNH1 (14 of 23) 35
  • 10 (a)
OneToMany
RNH1 (16 of 23) 35
  • 10 (a)
OneToMany
RNH1 (17 of 23) 35
  • 10 (a)
OneToMany
RNH1 (19 of 23) 35
  • 10 (a)
OneToMany
RNH1 (2 of 23) 35
  • 10 (a)
OneToMany
RNH1 (3 of 23) 35
  • 10 (a)
OneToMany
RNH1 (4 of 23) 35
  • 10 (a)
OneToMany
RNH1 (6 of 23) 35
  • 10 (a)
OneToMany
RNH1 (8 of 23) 35
  • 9 (a)
OneToMany
RNH1 (12 of 23) 35
  • 8 (a)
OneToMany
Species where no ortholog for RNH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNH1 Gene

ENSEMBL:
Gene Tree for RNH1 (if available)
TreeFam:
Gene Tree for RNH1 (if available)

Paralogs for RNH1 Gene

genes like me logo Genes that share paralogs with RNH1: view

No data available for Paralogs for RNH1 Gene

Variants for RNH1 Gene

Sequence variations from dbSNP and Humsavar for RNH1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000327523 -- 497,091(+) ACTCT(A/C)GCCCA intron-variant
rs1000439430 -- 508,631(+) GCATG(C/G)TGGTG upstream-variant-2KB
rs1000472844 -- 499,740(+) CCTCA(C/T)GGCTC intron-variant
rs1000529147 -- 496,742(+) CAGAA(A/C)AGGGG intron-variant
rs1000628005 -- 501,539(+) CACCA(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNH1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2759794 CNV loss 17122850
nsv1053964 CNV gain 25217958
nsv1070920 CNV deletion 25765185
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv951268 CNV deletion 24416366
nsv951269 CNV deletion 24416366

Variation tolerance for RNH1 Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 74.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNH1 Gene

Disorders for RNH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNH1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type v
  • osteogenesis imperfecta type 5
- elite association - COSMIC cancer census association via MalaCards
Search RNH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNH1

Genetic Association Database (GAD)
RNH1
Human Genome Epidemiology (HuGE) Navigator
RNH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNH1
genes like me logo Genes that share disorders with RNH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNH1 Gene

Publications for RNH1 Gene

  1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson R.J. … Raines R.T. (J. Mol. Biol. 2007) 3 4 22 64
  2. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PMID: 15755456) Iyer S. … Acharya K.R. (J. Mol. Biol. 2005) 3 4 64
  3. Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. (PMID: 15936590) Vogel U. … B.A. (Cancer Detect. Prev. 2005) 3 46 64
  4. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PMID: 15592448) Fu P. … Zhao B. (Cancer Gene Ther. 2005) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RNH1 Gene

Sources for RNH1 Gene

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