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Aliases for RNGTT Gene

Aliases for RNGTT Gene

  • RNA Guanylyltransferase And 5'-Phosphatase 2
  • RNA Guanylyltransferase And 5-Phosphatase 2 3 5
  • HCAP1 3 4
  • CAP1A 3 4
  • HCE 3 4
  • HCAP 3
  • HCE1 3

External Ids for RNGTT Gene

Previous GeneCards Identifiers for RNGTT Gene

  • GC06M089266
  • GC06M089315
  • GC06M089376
  • GC06M086535

Summaries for RNGTT Gene

GeneCards Summary for RNGTT Gene

RNGTT (RNA Guanylyltransferase And 5'-Phosphatase) is a Protein Coding gene. Diseases associated with RNGTT include hiv-1 and cecum adenocarcinoma. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include GTP binding and protein tyrosine phosphatase activity. An important paralog of this gene is DUSP11.

UniProtKB/Swiss-Prot for RNGTT Gene

  • Bifunctional mRNA-capping enzyme exhibiting RNA 5-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5-diphosphate terminus.

Gene Wiki entry for RNGTT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNGTT Gene

Genomics for RNGTT Gene

Regulatory Elements for RNGTT Gene

Promoters for RNGTT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNGTT on UCSC Golden Path with GeneCards custom track

Genomic Location for RNGTT Gene

Chromosome:
6
Start:
88,609,897 bp from pter
End:
88,963,721 bp from pter
Size:
353,825 bases
Orientation:
Minus strand

Genomic View for RNGTT Gene

Genes around RNGTT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNGTT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNGTT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNGTT Gene

Proteins for RNGTT Gene

  • Protein details for RNGTT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60942-MCE1_HUMAN
    Recommended name:
    mRNA-capping enzyme
    Protein Accession:
    O60942
    Secondary Accessions:
    • E1P513
    • E1P514
    • O43483
    • O60257
    • O60351
    • Q5TCW8
    • Q8WUM8

    Protein attributes for RNGTT Gene

    Size:
    597 amino acids
    Molecular mass:
    68557 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus); this enhances guanylyltransferase activity. Binds (via GTase domain) to the elongating phosphorylated form of RNA polymerase II; can form direct interactions with the phosphorylated POLR2A C-terminal domain and indirect interactions via bound RNA (By similarity). Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat.
    Miscellaneous:
    • Isoform 2 to isoform 4 lack mRNA 5-guanylyltransferase activity due to disruptions of the GTase domain.

    Three dimensional structures from OCA and Proteopedia for RNGTT Gene

    Alternative splice isoforms for RNGTT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNGTT Gene

Proteomics data for RNGTT Gene at MOPED

Post-translational modifications for RNGTT Gene

  • Ubiquitination at Lys 28 and Lys 171
  • Modification sites at PhosphoSitePlus

Other Protein References for RNGTT Gene

Antibody Products

No data available for DME Specific Peptides for RNGTT Gene

Domains & Families for RNGTT Gene

Gene Families for RNGTT Gene

Graphical View of Domain Structure for InterPro Entry

O60942

UniProtKB/Swiss-Prot:

MCE1_HUMAN :
  • In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
Family:
  • In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
  • In the C-terminal section; belongs to the eukaryotic GTase family.
genes like me logo Genes that share domains with RNGTT: view

Function for RNGTT Gene

Molecular function for RNGTT Gene

GENATLAS Biochemistry:
messenger RNA capping bifunctional enzyme
UniProtKB/Swiss-Prot CatalyticActivity:
A 5-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + (5)pp-Pur-mRNA = diphosphate + G(5)ppp-Pur-mRNA.
UniProtKB/Swiss-Prot Function:
Bifunctional mRNA-capping enzyme exhibiting RNA 5-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5-diphosphate terminus.

Gene Ontology (GO) - Molecular Function for RNGTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004484 mRNA guanylyltransferase activity IDA 9473487
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0050355 triphosphatase activity IDA 9473487
genes like me logo Genes that share ontologies with RNGTT: view
genes like me logo Genes that share phenotypes with RNGTT: view

Animal Model Products

miRNA for RNGTT Gene

miRTarBase miRNAs that target RNGTT

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNGTT Gene

Localization for RNGTT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNGTT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNGTT Gene COMPARTMENTS Subcellular localization image for RNGTT gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNGTT Gene

Pathways & Interactions for RNGTT Gene

genes like me logo Genes that share pathways with RNGTT: view

Pathways by source for RNGTT Gene

1 BioSystems pathway for RNGTT Gene
1 KEGG pathway for RNGTT Gene

Gene Ontology (GO) - Biological Process for RNGTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006397 mRNA processing IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0098507 polynucleotide 5 dephosphorylation TAS --
genes like me logo Genes that share ontologies with RNGTT: view

No data available for SIGNOR curated interactions for RNGTT Gene

Drugs & Compounds for RNGTT Gene

(10) Drugs for RNGTT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(12) Additional Compounds for RNGTT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
67-63-0
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with RNGTT: view

Transcripts for RNGTT Gene

Unigene Clusters for RNGTT Gene

RNA guanylyltransferase and 5-phosphatase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNGTT Gene

No ASD Table

Relevant External Links for RNGTT Gene

GeneLoc Exon Structure for
RNGTT
ECgene alternative splicing isoforms for
RNGTT

Expression for RNGTT Gene

mRNA expression in normal human tissues for RNGTT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNGTT Gene

This gene is overexpressed in Urine (39.7), Peripheral blood mononuclear cells (7.5), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNGTT Gene



SOURCE GeneReport for Unigene cluster for RNGTT Gene Hs.567378

mRNA Expression by UniProt/SwissProt for RNGTT Gene

O60942-MCE1_HUMAN
Tissue specificity: Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
genes like me logo Genes that share expression patterns with RNGTT: view

Protein tissue co-expression partners for RNGTT Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNGTT Gene

Orthologs for RNGTT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNGTT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNGTT 36
  • 100 (a)
OneToOne
RNGTT 35
  • 99.94 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia RNGTT 36
  • 98 (a)
OneToOne
RNGTT 35
  • 93.93 (n)
  • 98.15 (a)
dog
(Canis familiaris)
Mammalia RNGTT 35
  • 94.92 (n)
  • 98.32 (a)
RNGTT 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rngtt 36
  • 95 (a)
OneToOne
Rngtt 16
Rngtt 35
  • 91.62 (n)
  • 95.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RNGTT 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rngtt 35
  • 91.28 (n)
  • 95.38 (a)
chicken
(Gallus gallus)
Aves RNGTT 36
  • 88 (a)
OneToOne
RNGTT 35
  • 82.17 (n)
  • 88.89 (a)
lizard
(Anolis carolinensis)
Reptilia RNGTT 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.612 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rngtt 35
  • 76.7 (n)
  • 82.22 (a)
Str.20130 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6807 35
zebrafish
(Danio rerio)
Actinopterygii rngtt 35
  • 70.18 (n)
  • 79.24 (a)
rngtt 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005142 35
  • 52.59 (n)
  • 52.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRNA-cap 36
  • 44 (a)
OneToOne
mRNA-capping-enzyme 37
  • 54 (a)
mRNA-cap 35
  • 54.58 (n)
  • 51.58 (a)
worm
(Caenorhabditis elegans)
Secernentea cel-1 37
  • 41 (a)
cel-1 36
  • 37 (a)
OneToOne
cel-1 35
  • 49.97 (n)
  • 42.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09100 35
  • 47.97 (n)
  • 37.63 (a)
rice
(Oryza sativa)
Liliopsida Os12g0193200 35
  • 47.6 (n)
  • 36.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5117 36
  • 54 (a)
OneToOne
Species with no ortholog for RNGTT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNGTT Gene

ENSEMBL:
Gene Tree for RNGTT (if available)
TreeFam:
Gene Tree for RNGTT (if available)

Paralogs for RNGTT Gene

Paralogs for RNGTT Gene

(1) SIMAP similar genes for RNGTT Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RNGTT Gene

genes like me logo Genes that share paralogs with RNGTT: view

Variants for RNGTT Gene

Sequence variations from dbSNP and Humsavar for RNGTT Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17856595 - 88,612,732(+) AAGGG(C/T)GTGGT nc-transcript-variant, reference, missense
rs767429 -- 88,636,014(-) CTGAA(A/C/G)AAATA intron-variant
rs964209 -- 88,626,213(+) AGATA(C/T)GCAGA intron-variant
rs1128990 -- 88,928,998(-) AATCC(A/G)CCTGA nc-transcript-variant, reference, synonymous-codon
rs1128992 -- 88,678,408(-) TCCTC(A/C)GAATG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNGTT Gene

Variant ID Type Subtype PubMed ID
nsv5390 CNV Loss 18451855
esv270881 CNV Insertion 20981092
esv2000290 CNV Deletion 18987734
esv2732400 CNV Deletion 23290073
esv2661539 CNV Deletion 23128226
nsv528054 CNV Loss 19592680
esv2663981 CNV Deletion 23128226
esv2732401 CNV Deletion 23290073
esv2732402 CNV Deletion 23290073
esv2576850 CNV Deletion 19546169
esv2667862 CNV Deletion 23128226
esv22257 CNV Loss 19812545
esv2732403 CNV Deletion 23290073
esv2458928 CNV Deletion 19546169
esv2660011 CNV Deletion 23128226
esv270730 CNV Insertion 20981092
esv2732404 CNV Deletion 23290073

Variation tolerance for RNGTT Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNGTT Gene

HapMap Linkage Disequilibrium report
RNGTT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNGTT Gene

Disorders for RNGTT Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNGTT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
cecum adenocarcinoma
  • adenocarcinoma of cecum
- elite association - COSMIC cancer census association via MalaCards
Search RNGTT in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNGTT

Genetic Association Database (GAD)
RNGTT
Human Genome Epidemiology (HuGE) Navigator
RNGTT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNGTT
genes like me logo Genes that share disorders with RNGTT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNGTT Gene

Publications for RNGTT Gene

  1. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. (PMID: 9512541) Yamada-Okabe T. … Yamada-Okabe H. (Nucleic Acids Res. 1998) 2 3 4 23 67
  2. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PMID: 9828141) Pillutla R.C. … Shatkin A.J. (Genomics 1998) 2 3 23
  3. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. (PMID: 9473487) Tsukamoto T. … Mizumoto K. (Biochem. Biophys. Res. Commun. 1998) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RNGTT Gene

Sources for RNGTT Gene

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