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Aliases for RNGTT Gene

Aliases for RNGTT Gene

  • RNA Guanylyltransferase And 5'-Phosphatase 2
  • CAP1A 3 4 6
  • RNA Guanylyltransferase And 5-Phosphatase 2 3
  • HCAP1 3 4
  • HCE1 3 6
  • HCE 3 4
  • MRNA-Capping Enzyme 3
  • HCAP 3

External Ids for RNGTT Gene

Summaries for RNGTT Gene

GeneCards Summary for RNGTT Gene

RNGTT (RNA Guanylyltransferase And 5'-Phosphatase) is a Protein Coding gene. Among its related pathways are Disease and Gene Expression. GO annotations related to this gene include GTP binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP11.

UniProtKB/Swiss-Prot for RNGTT Gene

  • Bifunctional mRNA-capping enzyme exhibiting RNA 5-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5-diphosphate terminus.

Gene Wiki entry for RNGTT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNGTT Gene

Genomics for RNGTT Gene

Genomic Location for RNGTT Gene

88,609,897 bp from pter
88,963,721 bp from pter
353,825 bases
Minus strand

Genomic View for RNGTT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNGTT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNGTT Gene

Regulatory Elements for RNGTT Gene

Proteins for RNGTT Gene

  • Protein details for RNGTT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    mRNA-capping enzyme
    Protein Accession:
    Secondary Accessions:
    • E1P513
    • E1P514
    • O43483
    • O60257
    • O60351
    • Q5TCW8
    • Q8WUM8

    Protein attributes for RNGTT Gene

    597 amino acids
    Molecular mass:
    68557 Da
    Quaternary structure:
    • Interacts with POLR2A (via C-terminus); this enhances guanylyltransferase activity. Binds (via GTase domain) to the elongating phosphorylated form of RNA polymerase II; can form direct interactions with the phosphorylated POLR2A C-terminal domain and indirect interactions via bound RNA (By similarity). Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat.
    • Isoform 2 to isoform 4 lack mRNA 5-guanylyltransferase activity due to disruptions of the GTase domain

    Three dimensional structures from OCA and Proteopedia for RNGTT Gene

    Alternative splice isoforms for RNGTT Gene


neXtProt entry for RNGTT Gene

Proteomics data for RNGTT Gene at MOPED

Post-translational modifications for RNGTT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28 and Lys171

Other Protein References for RNGTT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RNGTT Gene

Domains for RNGTT Gene

Gene Families for RNGTT Gene

  • DUSPA :Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases


  • In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.:
    • O60942
  • In the C-terminal section; belongs to the eukaryotic GTase family.:
    • O60942
genes like me logo Genes that share domains with RNGTT: view

Function for RNGTT Gene

Molecular function for RNGTT Gene

GENATLAS Biochemistry: messenger RNA capping bifunctional enzyme
UniProtKB/Swiss-Prot CatalyticActivity: A 5-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate
UniProtKB/Swiss-Prot CatalyticActivity: GTP + (5)pp-Pur-mRNA = diphosphate + G(5)ppp-Pur-mRNA
UniProtKB/Swiss-Prot Function: Bifunctional mRNA-capping enzyme exhibiting RNA 5-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5-diphosphate terminus.

Gene Ontology (GO) - Molecular Function for RNGTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004484 mRNA guanylyltransferase activity IDA 9473487
GO:0004651 polynucleotide 5-phosphatase activity TAS --
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005525 GTP binding IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
genes like me logo Genes that share ontologies with RNGTT: view

Phenotypes for RNGTT Gene

GenomeRNAi human phenotypes for RNGTT:
genes like me logo Genes that share phenotypes with RNGTT: view

miRNA for RNGTT Gene

miRTarBase miRNAs that target RNGTT

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNGTT Gene

Localization for RNGTT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNGTT Gene

Subcellular locations from

Jensen Localization Image for RNGTT Gene COMPARTMENTS Subcellular localization image for RNGTT gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNGTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9473487
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RNGTT: view

Pathways for RNGTT Gene

genes like me logo Genes that share pathways with RNGTT: view

Pathways by source for RNGTT Gene

1 BioSystems pathway for RNGTT Gene
1 KEGG pathway for RNGTT Gene

Gene Ontology (GO) - Biological Process for RNGTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006370 7-methylguanosine mRNA capping TAS --
GO:0006396 RNA processing IDA 21636784
GO:0006397 mRNA processing --
GO:0006470 protein dephosphorylation --
genes like me logo Genes that share ontologies with RNGTT: view

Compounds for RNGTT Gene

(5) HMDB Compounds for RNGTT Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
  • NFB Orthophosphate
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
  • Dihydrogen oxide

(16) Novoseek inferred chemical compound relationships for RNGTT Gene

Compound -log(P) Hits PubMed IDs
deoxyribose-1-phosphate 78.2 2
pyrimidine nucleoside 70.5 2
thymidine 61 23
pyrimidine 59.1 5
fudr 58.2 2
genes like me logo Genes that share compounds with RNGTT: view

Transcripts for RNGTT Gene

Unigene Clusters for RNGTT Gene

RNA guanylyltransferase and 5-phosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNGTT Gene

No ASD Table

Relevant External Links for RNGTT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNGTT Gene

mRNA expression in normal human tissues for RNGTT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNGTT Gene

SOURCE GeneReport for Unigene cluster for RNGTT Gene Hs.567378

mRNA Expression by UniProt/SwissProt for RNGTT Gene

Tissue specificity: Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle
genes like me logo Genes that share expressions with RNGTT: view

Orthologs for RNGTT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNGTT Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNGTT 36
  • 99.94 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia RNGTT 36
  • 93.93 (n)
  • 98.15 (a)
  • 98 (a)
(Canis familiaris)
Mammalia RNGTT 36
  • 94.92 (n)
  • 98.32 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rngtt 36
  • 91.62 (n)
  • 95.56 (a)
Rngtt 16
Rngtt 37
  • 95 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
-- 37
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia RNGTT 37
  • 94 (a)
(Rattus norvegicus)
Mammalia Rngtt 36
  • 91.28 (n)
  • 95.38 (a)
(Gallus gallus)
Aves RNGTT 36
  • 82.17 (n)
  • 88.89 (a)
  • 88 (a)
(Anolis carolinensis)
Reptilia RNGTT 37
  • 81 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.612 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rngtt 36
  • 76.7 (n)
  • 82.22 (a)
Str.20130 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6807 36
(Danio rerio)
Actinopterygii rngtt 36
  • 70.18 (n)
  • 79.24 (a)
rngtt 37
  • 77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005142 36
  • 52.59 (n)
  • 52.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRNA-cap 36
  • 54.58 (n)
  • 51.58 (a)
mRNA-cap 37
  • 44 (a)
mRNA-capping-enzyme 38
  • 54 (a)
(Caenorhabditis elegans)
Secernentea cel-1 36
  • 49.97 (n)
  • 42.18 (a)
cel-1 37
  • 37 (a)
cel-1 38
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEG1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09100 36
  • 47.97 (n)
  • 37.63 (a)
(Oryza sativa)
Liliopsida Os12g0193200 36
  • 47.6 (n)
  • 36.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5117 37
  • 54 (a)
Species with no ortholog for RNGTT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNGTT Gene

Gene Tree for RNGTT (if available)
Gene Tree for RNGTT (if available)

Paralogs for RNGTT Gene

Paralogs for RNGTT Gene

Selected SIMAP similar genes for RNGTT Gene using alignment to 3 proteins: Pseudogenes for RNGTT Gene

genes like me logo Genes that share paralogs with RNGTT: view

Variants for RNGTT Gene

Sequence variations from dbSNP and Humsavar for RNGTT Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs264572 -- 88,715,997(-) tttgc(C/T)gtgca intron-variant
rs264573 -- 88,675,036(+) gaggt(A/T)gcagt intron-variant
rs767429 -- 88,636,014(-) CTGAA(A/G)AAATA intron-variant
rs911596 -- 88,640,830(+) ATTTA(C/T)GTTGT intron-variant
rs927368 -- 88,630,190(+) AAACT(A/G)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNGTT Gene

Variant ID Type Subtype PubMed ID
nsv5390 CNV Loss 18451855
esv270881 CNV Insertion 20981092
esv2000290 CNV Deletion 18987734
esv2732400 CNV Deletion 23290073
esv2661539 CNV Deletion 23128226
nsv528054 CNV Loss 19592680
esv2663981 CNV Deletion 23128226
esv2732401 CNV Deletion 23290073
esv2732402 CNV Deletion 23290073
esv2576850 CNV Deletion 19546169
esv2667862 CNV Deletion 23128226
esv22257 CNV Loss 19812545
esv2732403 CNV Deletion 23290073
esv2458928 CNV Deletion 19546169
esv2660011 CNV Deletion 23128226
esv270730 CNV Insertion 20981092
esv2732404 CNV Deletion 23290073

Relevant External Links for RNGTT Gene

HapMap Linkage Disequilibrium report

Disorders for RNGTT Gene

(2) University of Copenhagen DISEASES for RNGTT Gene

(6) Novoseek inferred disease relationships for RNGTT Gene

Disease -log(P) Hits PubMed IDs
meningeal carcinomatosis 50.6 4
brain tumors 21.3 5
rheumatoid arthritis 19.4 4
metastasis 0 2
tumors 0 8

Relevant External Links for RNGTT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNGTT: view

No data available for UniProtKB/Swiss-Prot for RNGTT Gene

Publications for RNGTT Gene

  1. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. (PMID: 9512541) Yamada-Okabe T. … Yamada-Okabe H. (Nucleic Acids Res. 1998) 2 3 4 23
  2. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PMID: 9828141) Pillutla R.C. … Shatkin A.J. (Genomics 1998) 2 3 23
  3. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. (PMID: 9473487) Tsukamoto T. … Mizumoto K. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  4. Structure of the guanylyltransferase domain of human mRNA capping enzyme. (PMID: 21636784) Chu C. … Shatkin A.J. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4
  5. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. (PMID: 9371772) Yue Z. … Shatkin A.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4

Products for RNGTT Gene

  • Addgene plasmids for RNGTT

Sources for RNGTT Gene

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