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RNGTT Gene

protein-coding   GIFtS: 66
GCID: GC06M089376

RNA Guanylyltransferase And 5'-Phosphatase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RNA Guanylyltransferase And 5'-Phosphatase1 2     HCE12 5
CAP1A2 3 5     hCAP2
HCAP12 3     MRNA-Capping Enzyme2
HCE2 3     

External Ids:    HGNC: 100731   Entrez Gene: 87322   Ensembl: ENSG000001118807   OMIM: 6035125   UniProtKB: O609423   

Export aliases for RNGTT gene to outside databases

Previous GC identifers: GC06M089266 GC06M089315 GC06M086535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNGTT Gene:
RNGTT (RNA guanylyltransferase and 5'-phosphatase) is a protein-coding gene. GO annotations related to this gene include protein tyrosine/serine/threonine phosphatase activity and GTP binding. An important paralog of this gene is DUSP11.

UniProtKB/Swiss-Prot: MCE1_HUMAN, O60942
Function: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and
mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by
removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by
transferring the gmp moiety of GTP to the 5'-diphosphate terminus

Gene Wiki entry for RNGTT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNGTT gene promoter:
         Nkx3-1   Nkx3-1 v4   MIF-1   AP-4   Nkx3-1 v1   Nkx3-1 v2   PPAR-gamma1   Hand1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNGTT promoter sequence
   Search Chromatin IP Primers for RNGTT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNGTT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q16

RNGTT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNGTT gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M089376:  view genomic region     (about GC identifiers)

Start:
89,319,985 bp from pter      End:
89,673,348 bp from pter
Size:
353,364 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MCE1_HUMAN, O60942 (See protein sequence)
Recommended Name: mRNA-capping enzyme  
Size: 597 amino acids; 68557 Da
Subunit: Interacts with POLR2A (via C-terminus); this enhances guanylyltransferase activity. Binds (via GTase
domain) to the elongating phosphorylated form of RNA polymerase II; can form direct interactions with the
phosphorylated POLR2A C-terminal domain and indirect interactions via bound RNA (By similarity). Interacts with
SUPT5H and RNMT. Interacts with HIV-1 Tat
Miscellaneous: Isoform 2 to isoform 4 lack mRNA 5'-guanylyltransferase activity due to disruptions of the GTase
domain
2 PDB 3D structures from and Proteopedia for RNGTT:
2C46 (3D)        3S24 (3D)    
Secondary accessions: E1P513 E1P514 O43483 O60257 O60351 Q5TCW8 Q8WUM8
Alternative splicing: 4 isoforms:  O60942-1   O60942-2   O60942-3   O60942-4   

Explore the universe of human proteins at neXtProt for RNGTT: NX_O60942

Explore proteomics data for RNGTT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys28, Lys171
  • Modification sites at PhosphoSitePlus

  • See RNGTT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273355.1  NP_001273357.1  NP_003791.3  

    ENSEMBL proteins: 
     ENSP00000358497   ENSP00000358487   ENSP00000265607   ENSP00000442609  
    Reactome Protein details: O60942

    RNGTT Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPA: Protein tyrosine phosphatases / Class I Cys-based PTPs : Atypical dual specificity phosphatases

    Selected InterPro protein domains (see all 7):
     IPR012340 NA-bd_OB-fold
     IPR000387 Tyr/Dual-sp_Pase
     IPR017074 mRNA_cap_enz_bifunc
     IPR001339 mRNA_cap_enzyme
     IPR016130 Tyr_Pase_AS

    Graphical View of Domain Structure for InterPro Entry O60942

    ProtoNet protein and cluster: O60942

    1 Blocks protein domain: IPB013846 mRNA capping enzyme

    UniProtKB/Swiss-Prot: MCE1_HUMAN, O60942
    Similarity: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase
    family
    Similarity: In the C-terminal section; belongs to the eukaryotic GTase family


    Find genes that share domains with RNGTT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MCE1_HUMAN, O60942
    Function: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and
    mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by
    removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by
    transferring the gmp moiety of GTP to the 5'-diphosphate terminus
    Catalytic activity: A 5'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate
    Catalytic activity: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA

         Genatlas biochemistry entry for RNGTT:
    messenger RNA capping bifunctional enzyme

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004484mRNA guanylyltransferase activity IDA9473487
    GO:0004651polynucleotide 5'-phosphatase activity IEA--
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
         
    Find genes that share ontologies with RNGTT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNGTT:
     Decreased focal adhesion (FA)  

         1 MGI phenotypic allele for Rngtt (no phenotypes)

    Find genes that share phenotypes with RNGTT           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNGTT
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    Selected qRT-PCR Assays for microRNAs that regulate RNGTT (see all 28):
    hsa-miR-323-3p hsa-miR-448 hsa-miR-361-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-128 hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidRNGTT 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MCE1_HUMAN, O60942: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9473487
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with RNGTT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNGTT About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Formation of RNA Pol II elongation complex
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    Transcription of the HIV genome0.71
    mRNA Capping0.93
    RNA Polymerase II Transcription0.60
    RNA Pol II CTD phosphorylation and interaction with CE0.93
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3mRNA Splicing - Major Pathway
    mRNA processing0.44
    4Gene Expression
    Gene Expression0.40
    5mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with RNGTT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNGTT
        mRNA processing

    3 Reactome Pathways for RNGTT
        mRNA Capping
    RNA Pol II CTD phosphorylation and interaction with CE
    RNA Pol II CTD phosphorylation and interaction with CE


    1 Kegg Pathway  (Kegg details for RNGTT):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNGTT
    Interactions:

        Search GeneGlobe Interaction Network for RNGTT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNGTT (O609423 ENSP000003584974) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    RNMTO431483, ENSP000002621734I2D: score=3 STRING: ENSP00000262173
    STAG1ENSP000003726894STRING: ENSP00000372689
    WAPALENSP000002987674STRING: ENSP00000298767
    STAG2ENSP000002180894STRING: ENSP00000218089
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:00063707-methylguanosine mRNA capping TAS--
    GO:0006396RNA processing IDA--
    GO:0006397mRNA processing ----
    GO:0006470protein dephosphorylation ----

    Find genes that share ontologies with RNGTT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNGTT (MCE1)

    5 HMDB Compounds for RNGTT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for RNGTT gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxyribose-1-phosphate 78.2 2 16375757 (1), 15123637 (1)
    pyrimidine nucleoside 70.5 3 15123637 (1), 16675660 (1)
    thymidine 61 29 10736423 (3), 15123637 (3), 14717594 (2), 16675660 (2) (see all 15)
    pyrimidine 59.1 6 15123637 (2), 10736423 (1), 16375757 (1), 17065049 (1)
    fudr 58.2 3 9923556 (1), 9524089 (1)
    thymine 56.5 1 11761459 (1)
    deoxyuridine 54.6 1 11761459 (1)
    nucleoside 45.2 4 15123637 (2), 16375757 (1), 16942029 (1)
    uridine 44.5 4 10736423 (1), 15319798 (1), 18600781 (1)
    inosine 38.1 1 17065049 (1)



    Find genes that share compounds with RNGTT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNGTT gene (3 alternative transcripts): 
    NM_001286426.1  NM_001286428.1  NM_003800.4  

    Unigene Cluster for RNGTT:

    RNA guanylyltransferase and 5'-phosphatase
    Hs.567378  [show with all ESTs]
    Unigene Representative Sequence: BX537450
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369485(uc003pmr.2) ENST00000369475(uc003pmt.2) ENST00000265607(uc003pms.2 uc011dzu.1)
    ENST00000538899
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    Additional mRNA sequence: 

    AB009022.1 AB009023.1 AB009024.1 AB012142.1 AB012143.1 AF025654.1 AK295719.1 AK299777.1 
    AK312407.1 BC019954.1 BX537450.1 

    8 DOTS entries:

    DT.442983  DT.100673440  DT.100791817  DT.95092016  DT.101970741  DT.92072258  DT.95091976  DT.97842533 

    Selected AceView cDNA sequences (see all 146):

    AA504267 AA761444 BX537450 AW236415 CA311368 BU192697 Z41631 AA359634 
    BE889187 AB009024 BM455087 AW172881 AI380437 F02697 AI050945 BU191852 
    AA975661 AA243443 AA811241 AA399971 AA461478 CD107638 AA258038 AA719370 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNGTT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAGCTTT
    RNGTT Expression
    About this image


    RNGTT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
    RNGTT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNGTT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567378

    UniProtKB/Swiss-Prot: MCE1_HUMAN, O60942
    Tissue specificity: Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid,
    lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNGTT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNGTT gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rngtt1 , 5 RNA guanylyltransferase and 5'-phosphatase1, 5 91.62(n)1
    95.56(a)1
      4 (14.78 cM)5
    240181  NM_011884.21  NP_036014.11 
     333103115 
    chicken
    (Gallus gallus)
    Aves RNGTT1 RNA guanylyltransferase and 5'-phosphatase 82.17(n)
    88.89(a)
      421819  XM_419843.4  XP_419843.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNGTT6
    RNA guanylyltransferase and 5'-phosphatase
    81(a)
    1 ↔ 1
    1(175280811-175512437)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6122 Xenopus laevis mRNA capping enzyme (xCAP1a) mRNA, complete more 78.6(n)    AF218793.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rngtt1 RNA guanylyltransferase and 5'-phosphatase 70.18(n)
    79.24(a)
      405803  NM_212867.1  NP_998032.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRNA-capping-enzyme3
    mRNA-cap1
    mRNA capping protein
    tyrosine/serine/threonine more3
    mRNA-capping-enzyme1
    54(a)3
    54.58(n)1
    51.58(a)1
      12E63
    323791  NM_132724.21  NP_572952.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cel-11 , 3 mRNA capping enzyme3
    cel-11
    41(a)3
    49.97(n)1
    42.18(a)1
      I(9673365-9675826)3
    1728141  NM_001025808.41  NP_001020979.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G091001 AT3G09100 47.97(n)
    37.63(a)
      820064  NM_202534.1  NP_974263.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01932001 Os12g0193200 47.6(n)
    36.53(a)
      4351709  NM_001072877.1  NP_001066345.1 


    ENSEMBL Gene Tree for RNGTT (if available)
    TreeFam Gene Tree for RNGTT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNGTT gene
    DUSP112  
    1 SIMAP similar gene for RNGTT using alignment to 3 protein entries:     MCE1_HUMAN (see all proteins):
    DKFZp686J2031

    Find genes that share paralogs with RNGTT           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNGTT
    PGOHUM00000239158


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNGTT (see all 6621)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3735869051,2
    C--86752075(+) gtgtg-/TATA  
            
    tatat
    1 -- int10--------
    rs1422540761,2
    --89319521(+) GCAGAA/GTTCAA 1 -- ds50010--------
    rs561060651,2
    C,F--89319597(+) AAAATT/CTGGTA 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1391069081,2
    C--89319613(+) CGACT-/TCATCATT 1 -- ds50010--------
    rs1920521531,2
    --89319913(+) TGGCTG/TACAGC 1 -- ds50010--------
    rs595865971,2
    C,F--89319927(+) AGGATG/ATGATG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1461798521,2
    --89319953(+) ACACAA/GGAGTA 1 -- ds50010--------
    rs1894144961,2
    --89319982(+) AGATAA/CACTTA 1 -- ds50010--------
    rs1390634271,2
    C--89320100(+) ACGCAA/GTAGAG 1 -- ut310--------
    rs1810507241,2
    --89320332(+) TCAGGA/GGCTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNGTT (89319985 - 89569985 bp, first 250kb of RNGTT)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNGTT (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732403CNV Deletion23290073
    esv2732401CNV Deletion23290073
    esv2732404CNV Deletion23290073
    esv2663981CNV Deletion23128226
    esv2660011CNV Deletion23128226
    esv2667862CNV Deletion23128226
    esv2000290CNV Deletion18987734
    esv2732402CNV Deletion23290073
    esv2576850CNV Deletion19546169
    esv2458928CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNGTT
    DNA2.0 Custom Variant and Variant Library Synthesis for RNGTT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603512    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for RNGTT:
    Vaccinia     Cecum carcinoma

    Find genes that share disorders with RNGTT           About GenesLikeMe

    6 Novoseek inferred disease relationships for RNGTT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    meningeal carcinomatosis 50.6 4 9923556 (3), 9757455 (1)
    brain tumors 21.3 6 9923556 (3), 9757455 (1), 9524089 (1)
    rheumatoid arthritis 19.4 4 1347295 (1), 15290729 (1), 8597247 (1), 7496133 (1)
    metastasis 0 2 16375757 (1), 16675660 (1)
    tumors 0 10 11761459 (2), 15661051 (2), 9923556 (1), 10736423 (1) (see all 6)
    cancer 0 1 15123637 (1)

    Genetic Association Database (GAD): RNGTT
    Human Genome Epidemiology (HuGE) Navigator: RNGTT (1 document)

    Export disorders for RNGTT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNGTT gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with RNGTT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. (PubMed id 9512541)1, 2, 3, 9 Yamada-Okabe T.... Yamada-Okabe H. (Nucleic Acids Res. 1998)
    2. Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. (PubMed id 9473487)1, 2, 9 Tsukamoto T.... Mizumoto K. (Biochem. Biophys. Res. Commun. 1998)
    3. Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively. (PubMed id 9828141)1, 3, 9 Pillutla R.C....Shatkin A.J. (Genomics 1998)
    4. Structure of the guanylyltransferase domain of human mRNA capping enzyme. (PubMed id 21636784)1, 2 Chu C....Shatkin A.J. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. HIV-1 Tat protein interacts with mammalian capping enzyme and stimulates capping of TAR RNA. (PubMed id 11278368)1, 2 Chiu Y.-L.... Rana T.M. (J. Biol. Chem. 2001)
    7. Transcription elongation factor hSPT5 stimulates mRNA capping. (PubMed id 10421630)1, 2 Wen Y. and Shatkin A.J. (Genes Dev. 1999)
    8. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PubMed id 9705270)1, 2 Pillutla R.C.... Shatkin A.J. (J. Biol. Chem. 1998)
    9. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II. (PubMed id 9371772)1, 2 Yue Z.... Shatkin A.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    10. The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme. (PubMed id 23349942)1 Picard-Jean F....Bisaillon M. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8732 HGNC: 10073 AceView: RNGTT Ensembl:ENSG00000111880 euGenes: HUgn8732
    ECgene: RNGTT Kegg: 8732 H-InvDB: RNGTT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNGTT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNGTT gene:
    Search GeneIP for patents involving RNGTT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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