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Aliases for RNFT2 Gene

Aliases for RNFT2 Gene

  • Ring Finger Protein, Transmembrane 2 2 3
  • Transmembrane Protein 118 2 3 4
  • TMEM118 3 4
  • RING Finger And Transmembrane Domain-Containing Protein 2 3

External Ids for RNFT2 Gene

Previous HGNC Symbols for RNFT2 Gene

  • TMEM118

Previous GeneCards Identifiers for RNFT2 Gene

  • GC12P115660
  • GC12P117176
  • GC12P114185

Summaries for RNFT2 Gene

GeneCards Summary for RNFT2 Gene

RNFT2 (Ring Finger Protein, Transmembrane 2) is a Protein Coding gene. An important paralog of this gene is RNFT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNFT2 Gene

Genomics for RNFT2 Gene

Regulatory Elements for RNFT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNFT2 Gene

116,738,178 bp from pter
116,853,631 bp from pter
115,454 bases
Plus strand

Genomic View for RNFT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNFT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNFT2 Gene

Proteins for RNFT2 Gene

  • Protein details for RNFT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger and transmembrane domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • E9PAM7
    • Q96SU5

    Protein attributes for RNFT2 Gene

    444 amino acids
    Molecular mass:
    48965 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11878.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNFT2 Gene


neXtProt entry for RNFT2 Gene

Proteomics data for RNFT2 Gene at MOPED

Post-translational modifications for RNFT2 Gene

  • Ubiquitination at Lys360
  • Modification sites at PhosphoSitePlus

Other Protein References for RNFT2 Gene

No data available for DME Specific Peptides for RNFT2 Gene

Domains for RNFT2 Gene

Gene Families for RNFT2 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNFT2 Gene

Suggested Antigen Peptide Sequences for RNFT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96EX2
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNFT2: view

Function for RNFT2 Gene

Gene Ontology (GO) - Molecular Function for RNFT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0009055 electron carrier activity --
GO:0046872 metal ion binding --
GO:0051536 iron-sulfur cluster binding --
genes like me logo Genes that share ontologies with RNFT2: view

Animal Model Products

miRNA for RNFT2 Gene

miRTarBase miRNAs that target RNFT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNFT2 Gene

Localization for RNFT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNFT2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNFT2 Gene COMPARTMENTS Subcellular localization image for RNFT2 gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RNFT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNFT2: view

Pathways for RNFT2 Gene

SuperPathways for RNFT2 Gene

No Data Available

Interacting Proteins for RNFT2 Gene

Gene Ontology (GO) - Biological Process for RNFT2 Gene


No data available for Pathways by source for RNFT2 Gene

Transcripts for RNFT2 Gene

Unigene Clusters for RNFT2 Gene

Ring finger protein, transmembrane 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNFT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNFT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP4: - -

Relevant External Links for RNFT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNFT2 Gene

mRNA expression in normal human tissues for RNFT2 Gene

mRNA differential expression in normal tissues according to GTEx for RNFT2 Gene

This gene is overexpressed in Brain - Cortex (4.7) and Brain - Frontal Cortex (BA9) (4.2).

Protein differential expression in normal tissues for RNFT2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNFT2 Gene

SOURCE GeneReport for Unigene cluster for RNFT2 Gene Hs.437195

genes like me logo Genes that share expressions with RNFT2: view

Expression partners for RNFT2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNFT2 Gene

Orthologs for RNFT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNFT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNFT2 35
  • 91.22 (n)
  • 94.82 (a)
RNFT2 36
  • 95 (a)
(Mus musculus)
Mammalia Rnft2 35
  • 87.54 (n)
  • 92.12 (a)
Rnft2 16
Rnft2 36
  • 92 (a)
(Pan troglodytes)
Mammalia RNFT2 35
  • 99.32 (n)
  • 99.77 (a)
RNFT2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnft2 35
  • 87.24 (n)
  • 91.67 (a)
(Canis familiaris)
Mammalia RNFT2 36
  • 90 (a)
(Monodelphis domestica)
Mammalia RNFT2 36
  • 73 (a)
(Gallus gallus)
Aves RNFT2 35
  • 79.02 (n)
  • 84.21 (a)
RNFT2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia RNFT2 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnft2 35
  • 66.82 (n)
  • 70.05 (a)
(Danio rerio)
Actinopterygii rnft2 35
  • 67.91 (n)
  • 67.6 (a)
rnft2 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004640 35
  • 42.61 (n)
  • 36.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13605 36
  • 13 (a)
(Caenorhabditis elegans)
Secernentea ZC13.1 35
  • 41.76 (n)
  • 26.69 (a)
ZC13.1 36
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G01960 35
  • 44.01 (n)
  • 31.7 (a)
(Oryza sativa)
Liliopsida Os01g0168400 35
  • 44.25 (n)
  • 31.36 (a)
Species with no ortholog for RNFT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNFT2 Gene

Gene Tree for RNFT2 (if available)
Gene Tree for RNFT2 (if available)

Paralogs for RNFT2 Gene

Paralogs for RNFT2 Gene

Selected SIMAP similar genes for RNFT2 Gene using alignment to 5 proteins: Pseudogenes for RNFT2 Gene

genes like me logo Genes that share paralogs with RNFT2: view

Variants for RNFT2 Gene

Sequence variations from dbSNP and Humsavar for RNFT2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs884273 -- 116,784,335(-) CCCAA(A/G)AGCTG intron-variant
rs903771 -- 116,853,786(-) GCACT(G/T)CTGTA downstream-variant-500B
rs903772 -- 116,852,796(-) GCTAC(A/G)GGGAG utr-variant-3-prime
rs903773 -- 116,852,350(-) GGGGC(A/G)AATGT utr-variant-3-prime, intron-variant, downstream-variant-500B
rs903774 -- 116,852,291(-) GACAG(C/G)GAGGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNFT2 Gene

Variant ID Type Subtype PubMed ID
nsv832523 CNV Gain+Loss 17160897
nsv53492 CNV Loss 16902084
esv2672682 CNV Deletion 23128226
esv2658721 CNV Deletion 23128226
esv1515587 CNV Deletion 17803354
nsv898 CNV Insertion 18451855
esv2660236 CNV Deletion 23128226

Relevant External Links for RNFT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNFT2 Gene

Disorders for RNFT2 Gene

No disorders were found for RNFT2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNFT2 Gene

Publications for RNFT2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for RNFT2 Gene

Sources for RNFT2 Gene

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