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Aliases for RNFT1 Gene

Aliases for RNFT1 Gene

  • Ring Finger Protein, Transmembrane 1 2 3
  • RING Finger And Transmembrane Domain-Containing Protein 1 3
  • Protein PTD016 4
  • PTD016 3

External Ids for RNFT1 Gene

Previous GeneCards Identifiers for RNFT1 Gene

  • GC17M055387
  • GC17M058029
  • GC17M053402

Summaries for RNFT1 Gene

GeneCards Summary for RNFT1 Gene

RNFT1 (Ring Finger Protein, Transmembrane 1) is a Protein Coding gene. An important paralog of this gene is RNFT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNFT1 Gene

Genomics for RNFT1 Gene

Genomic Location for RNFT1 Gene

Start:
59,952,240 bp from pter
End:
59,964,761 bp from pter
Size:
12,522 bases
Orientation:
Minus strand

Genomic View for RNFT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNFT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNFT1 Gene

Proteins for RNFT1 Gene

  • Protein details for RNFT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M7Z0-RNFT1_HUMAN
    Recommended name:
    RING finger and transmembrane domain-containing protein 1
    Protein Accession:
    Q5M7Z0
    Secondary Accessions:
    • Q8N7D0
    • Q96IZ9
    • Q9Y686

    Protein attributes for RNFT1 Gene

    Size:
    435 amino acids
    Molecular mass:
    49710 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD43009.1; Type=Frameshift; Positions=150, 167; Evidence={ECO:0000305}; Sequence=BAC05364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNFT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNFT1 Gene

Proteomics data for RNFT1 Gene at MOPED

Post-translational modifications for RNFT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNFT1 Gene

No data available for DME Specific Peptides for RNFT1 Gene

Domains for RNFT1 Gene

Gene Families for RNFT1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNFT1 Gene

Suggested Antigen Peptide Sequences for RNFT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5M7Z0

UniProtKB/Swiss-Prot:

RNFT1_HUMAN :
  • Q5M7Z0
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNFT1: view

Function for RNFT1 Gene

Gene Ontology (GO) - Molecular Function for RNFT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNFT1: view

miRNA for RNFT1 Gene

miRTarBase miRNAs that target RNFT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNFT1 Gene

Localization for RNFT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNFT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNFT1 Gene COMPARTMENTS Subcellular localization image for RNFT1 gene
Compartment Confidence
peroxisome 2
plasma membrane 2
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNFT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNFT1: view

Pathways for RNFT1 Gene

SuperPathways for RNFT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNFT1 Gene

None

No data available for Pathways by source for RNFT1 Gene

Transcripts for RNFT1 Gene

Unigene Clusters for RNFT1 Gene

Ring finger protein, transmembrane 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNFT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6: - - -

Relevant External Links for RNFT1 Gene

GeneLoc Exon Structure for
RNFT1
ECgene alternative splicing isoforms for
RNFT1

Expression for RNFT1 Gene

mRNA expression in normal human tissues for RNFT1 Gene

mRNA differential expression in normal tissues according to GTEx for RNFT1 Gene

This gene is overexpressed in Testis (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNFT1 Gene

SOURCE GeneReport for Unigene cluster for RNFT1 Gene Hs.531701

mRNA Expression by UniProt/SwissProt for RNFT1 Gene

Q5M7Z0-RNFT1_HUMAN
Tissue specificity: Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney. Not detected in brain, ovary, and uterus. Down-regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS).
genes like me logo Genes that share expressions with RNFT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNFT1 Gene

Orthologs for RNFT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNFT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNFT1 35
  • 99.77 (n)
  • 99.54 (a)
RNFT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNFT1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNFT1 35
  • 91.94 (n)
  • 89.17 (a)
RNFT1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnft1 35
  • 87.26 (n)
  • 86.08 (a)
Rnft1 16
Rnft1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNFT1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNFT1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnft1 35
  • 86.4 (n)
  • 84.63 (a)
chicken
(Gallus gallus)
Aves RNFT1 35
  • 72.5 (n)
  • 70.23 (a)
RNFT1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNFT1 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34003 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnft1 35
  • 67.01 (n)
  • 60 (a)
Str.9619 35
zebrafish
(Danio rerio)
Actinopterygii rnft1 35
  • 58.86 (n)
  • 54.22 (a)
rnft1 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13605 36
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC13.1 36
  • 17 (a)
OneToMany
Species with no ortholog for RNFT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNFT1 Gene

ENSEMBL:
Gene Tree for RNFT1 (if available)
TreeFam:
Gene Tree for RNFT1 (if available)

Paralogs for RNFT1 Gene

Paralogs for RNFT1 Gene

Selected SIMAP similar genes for RNFT1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RNFT1 Gene

genes like me logo Genes that share paralogs with RNFT1: view

Variants for RNFT1 Gene

Sequence variations from dbSNP and Humsavar for RNFT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs11368 -- 59,954,051(+) TGACA(A/G)ATGAG synonymous-codon, reference
rs180511 -- 59,955,087(-) ATGAC(C/T)GTGAC intron-variant
rs180512 -- 59,954,470(-) ATACA(G/T)GGCTA intron-variant
rs180514 -- 59,953,288(-) ccagt(C/T)ggggg intron-variant
rs767811 -- 59,962,691(-) TTAAT(G/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNFT1 Gene

Variant ID Type Subtype PubMed ID
nsv471702 CNV Gain 15918152
nsv833502 CNV Gain 17160897
dgv996e1 CNV Complex 17122850
nsv428348 CNV Gain 18775914
nsv471544 CNV Duplication 19718026
nsv9577 CNV Gain 18304495

Relevant External Links for RNFT1 Gene

HapMap Linkage Disequilibrium report
RNFT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNFT1 Gene

Disorders for RNFT1 Gene

(1) University of Copenhagen DISEASES for RNFT1 Gene

Relevant External Links for RNFT1

Genetic Association Database (GAD)
RNFT1
Human Genome Epidemiology (HuGE) Navigator
RNFT1
genes like me logo Genes that share disorders with RNFT1: view

No data available for UniProtKB/Swiss-Prot for RNFT1 Gene

Publications for RNFT1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RNFT1 Gene

Sources for RNFT1 Gene

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