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RNF7 Gene

protein-coding   GIFtS: 60
GCID: GC03P141457

Ring Finger Protein 7

  See RNF7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 71 2 3     CKII Beta-Binding Protein 12 3
Regulator Of Cullins 21 2 3     Sensitive To Apoptosis1
ROC22 3 5     rbx22
SAG2 3 5     RING-Box Protein 22
Zinc RING Finger Protein SAG1 2     Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins
22
Sensitive To Apoptosis Gene Protein2 3     RBX23
CKBBP12 3     Rbx23

External Ids:    HGNC: 100701   Entrez Gene: 96162   Ensembl: ENSG000001141257   OMIM: 6038635   UniProtKB: Q9UBF63   

Export aliases for RNF7 gene to outside databases

Previous GC identifers: GC03P138366 GC03P142285 GC03P142738 GC03P142777 GC03P142939 GC03P138831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF7 Gene:
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of
SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery
important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of,
casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the
degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants
encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF7 Gene:
RNF7 (ring finger protein 7) is a protein-coding gene. Diseases associated with RNF7 include glomuvenous malformation. GO annotations related to this gene include NEDD8 ligase activity and copper ion binding. An important paralog of this gene is RBX1.

UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression,
signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination
enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via
its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents

Gene Wiki entry for RNF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF7 promoter sequence
   Search Chromatin IP Primers for RNF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22-q24   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q22-q24

RNF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P141457:  view genomic region     (about GC identifiers)

Start:
141,457,046 bp from pter      End:
141,466,402 bp from pter
Size:
9,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6 (See protein sequence)
Recommended Name: RING-box protein 2  
Size: 113 amino acids; 12683 Da
Subunit: Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts
(preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B.
Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2
1 PDB 3D structure from and Proteopedia for RNF7:
2ECL (3D)    
Secondary accessions: A8K1H9 A8MTB5 C9JYL3 D3DNF7 D3DNF8 Q9BXN8 Q9Y5M7
Alternative splicing: 4 isoforms:  Q9UBF6-1   Q9UBF6-2   Q9UBF6-3   Q9UBF6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF7: NX_Q9UBF6

Explore proteomics data for RNF7 at MOPED

Post-translational modifications: 

  • Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188299.1  NP_055060.1  NP_899060.1  

    ENSEMBL proteins: 
     ENSP00000273480   ENSP00000419084   ENSP00000376725   ENSP00000419339   ENSP00000419979  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR024766 Znf_RING_H2

    Graphical View of Domain Structure for InterPro Entry Q9UBF6

    ProtoNet protein and cluster: Q9UBF6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional
    third zinc ion
    Similarity: Belongs to the RING-box family
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBX2_HUMAN, Q9UBF6
    Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression,
    signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination
    enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via
    its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents
    Induction: By 1,10-phenanthroline

         Genatlas biochemistry entry for RNF7:
    RING finger protein 7,nucleocytoplasmic protein,sensitive to apoptosis gene,ubiquitously,predominantly expressed
    in muscle,heart and testis,protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal
    ions and reactive oxygen species,homolog to APC11,a subunit of the anaphase-promoting complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding TAS10082581
    GO:0005515protein binding IPI16325183
    GO:0008270zinc ion binding IEA--
    GO:0019788NEDD8 ligase activity IDA19250909
         
    Find genes that share ontologies with RNF7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF7:
     Wnt reporter downregulated 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rnf7):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  nervous system  normal 
     skeleton 

    Find genes that share phenotypes with RNF7           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF7

    miRNA
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    hsa-miR-30c hsa-let-7d hsa-miR-4263 hsa-miR-30d hsa-let-7c hsa-miR-340 hsa-miR-548a-3p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidRNF7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBX2_HUMAN, Q9UBF6: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10082581
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS10082581
    GO:0031466Cul5-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with RNF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF7 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    2Inactivation of APC/C via direct inhibition of the APC/C complex
    Common schema of ubiquitination0.33


    Find genes that share SuperPaths with RNF7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RNF7
        Visual Cycle in Retinal Rods



    1 Kegg Pathway  (Kegg details for RNF7):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF7: 

              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF7 (Q9UBF61, 2, 3 ENSP000002734804) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB12Q8WXK42, 3, ENSP000003551954MINT-77975 I2D: score=2 STRING: ENSP00000355195
    ASB7Q9H6722, 3, ENSP000003283274MINT-77978 I2D: score=2 STRING: ENSP00000328327
    CSNK2BP678703, ENSP000003650254I2D: score=2 STRING: ENSP00000365025
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000206406P678703I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress TAS10082581
    GO:0016567protein ubiquitination IEA--
    GO:0043066negative regulation of apoptotic process TAS10082581
    GO:0045116protein neddylation IDA19250909
    GO:0051775response to redox state TAS10082581

    Find genes that share ontologies with RNF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF7 (RBX2)

    6 Novoseek inferred chemical compound relationships for RNF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 58 3 12565832 (1), 11999705 (1)
    dithiothreitol 40.7 8 10443936 (3), 11999705 (2)
    zinc 40.2 4 12565832 (1), 10443936 (1), 11005251 (1), 11999705 (1)
    etoposide 30.2 1 17217622 (1)
    h2o2 13.9 5 11999705 (4), 10443936 (1)
    oxygen 0 2 12565832 (1), 11999705 (1)



    Find genes that share compounds with RNF7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF7 gene (4 alternative transcripts): 
    NM_001201370.1  NM_014245.4  NM_183237.2  NM_183063.1  

    Unigene Cluster for RNF7:

    Ring finger protein 7
    Hs.134623  [show with all ESTs]
    Unigene Representative Sequence: NR_037702
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273480(uc021xet.1 uc003eue.3 uc003euc.3 uc003eud.3 uc021xeu.1)
    ENST00000498828 ENST00000480908 ENST00000393000 ENST00000477012 ENST00000477393
    ENST00000486377
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    Additional mRNA sequence: 

    AF092878.1 AF142060.1 AF164679.1 AK289894.1 AK311982.1 BC005966.1 BC008627.1 BT007348.1 
    NR_037702.1 NR_037703.1 

    9 DOTS entries:

    DT.95127593  DT.100732697  DT.75140271  DT.431478  DT.100031275  DT.120861889  DT.91754009  DT.95127582 
    DT.120850661 

    Selected AceView cDNA sequences (see all 249):

    AI015717 AW963641 AA504853 NM_014245 BG769106 BU730720 BM792427 BE882793 
    AA521294 BM806910 AI302054 BG054821 AW628047 BQ632301 AW295328 NM_183063 
    BC008627 BM767171 BQ083848 AA938668 BM873390 BQ876591 AF312226 NM_183237 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF7    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                                                        
    SP2:                          -                                             
    SP3:                                -                                       
    SP4:                          -     -                                       
    SP5:                                -     -                                 


    ECgene alternative splicing isoforms for RNF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATGGTTG
    RNF7 Expression
    About this image


    RNF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Brain (Nervous System)
             Lateral Ventricle
    RNF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134623

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in
    brain, placenta and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF7: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNF7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf71 , 5 ring finger protein 71, 5 93.81(n)1
    96.46(a)1
      9 (50.63 cM)5
    198231  NM_011279.21  NP_035409.11 
     964709415 
    chicken
    (Gallus gallus)
    Aves RNF71 ring finger protein 7 80.83(n)
    86.73(a)
      424781  NM_001031307.1  NP_001026478.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF76
    ring finger protein 7
    89(a)
    1 ↔ 1
    3(22193920-22200619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.210832 Xenopus laevis transcribed sequence with strong similarity more 86.25(n)    BU901115.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj63f042 Transcribed sequence with strong similarity to protein more 83.33(n)    57092737 
    fruit fly
    (Drosophila melanogaster)
    Insecta Roc21 Roc2 75.86(n)
    86.21(a)
      36246  NM_001169648.1  NP_001163119.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R10A10.23
    rbx-21
    zinc finger protein3
    rbx-21
    58(a)3
    65.89(n)1
    69.77(a)1
      I(6428459-6429968)3
    1723441  NM_059448.41  NP_491849.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRT16
    RING finger containing subunit of Skp1-Cullin-F-bo...
    37(a)
    1 → many
    XV(70325-70690) YOL133W


    ENSEMBL Gene Tree for RNF7 (if available)
    TreeFam Gene Tree for RNF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF7 gene
    RBX12  
    2 SIMAP similar genes for RNF7 using alignment to 2 protein entries:     RBX2_HUMAN (see all proteins):
    RBX1    ANAPC11

    Find genes that share paralogs with RNF7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RNF7
    PGOHUM00000237364 PGOHUM00000237633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RNF7 (see all 222)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437091721,2
    Cuntested1141465067(+) GCCCAA/CCTCAG 5 -- ut31 nc-transcript-variant0--------
    rs599986481,2
    C--141455090(+) AAAACT/CGTACT 5 -- us2k14Minor allele frequency- C:0.06NA WA EA 360
    rs758546491,2
    C--141455268(+) ACTTTC/AAAACT 5 -- us2k14Minor allele frequency- A:0.04NA WA EA 360
    rs1474658591,2
    C--141455332(+) TAGAT-/AACCTA 5 -- us2k10--------
    rs1478948291,2
    C--141455392(+) AACAC-/ATGTTTT 5 -- us2k10--------
    rs1501333311,2
    --141455418(+) ATGGGA/TGTCTG 5 -- us2k10--------
    rs18292581,2
    C,F,A--141455525(+) TGAAGA/GCCTCC 5 -- us2k19Minor allele frequency- G:0.38NA WA CSA EA 368
    rs8689341,2
    C,F,A,H--141455781(-) ATATAC/TAGAAA 5 -- us2k1 tfbs317Minor allele frequency- T:0.35NS EA NA WA CSA 911
    rs1825777631,2
    --141455866(+) ATGGGA/GAGAGG 5 -- us2k10--------
    rs1152673881,2
    F--141456002(+) GTGATG/TGTGGG 5 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for RNF7 (141457046 - 141466402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877552CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF7
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603863    OMIM disorders: --

    1 disease for RNF7:    
    About MalaCards
    glomuvenous malformation


    Find genes that share disorders with RNF7           About GenesLikeMe

    2 Novoseek inferred disease relationships for RNF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neoplastic transformation 47.9 6 11255265 (2), 17440073 (1)
    cancer 0 6 20103673 (3), 11255265 (1)


    Export disorders for RNF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF7 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with RNF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 2, 3, 9 Ohta T.... Xiong Y. (Mol. Cell 1999)
    2. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. (PubMed id 10082581)1, 2, 3 Duan H.... Sun Y. (Mol. Cell. Biol. 1999)
    3. Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. (PubMed id 10512750)1, 2, 9 Son M.-Y....Bae Y.-S. (Biochem. Biophys. Res. Commun. 1999)
    4. SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. (PubMed id 11506706)1, 2, 9 Swaroop M.... Sun Y. (DNA Cell Biol. 2001)
    5. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2 Huang D.T....Schulman B.A. (Mol. Cell 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. (PubMed id 12748192)1, 2 Kim Y.-S.... Bae Y.-S. (J. Biol. Chem. 2003)
    8. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PubMed id 10851089)1, 2 Swaroop M....Sun Y. (Oncogene 2000)
    9. CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity. (PubMed id 16874460)1, 9 He H....Sun Y. (Mol. Cell. Biochem. 2007)
    10. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. (PubMed id 20103673)1, 9 Jia L....Sun Y. (Clin. Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9616 HGNC: 10070 AceView: RNF7 Ensembl:ENSG00000114125 euGenes: HUgn9616
    ECgene: RNF7 Kegg: 9616 H-InvDB: RNF7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNF7 gene:
    Search GeneIP for patents involving RNF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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