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Aliases for RNF7 Gene

Aliases for RNF7 Gene

  • Ring Finger Protein 7 2 3
  • Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2 2 3
  • Sensitive To Apoptosis Gene Protein 3 4
  • CKII Beta-Binding Protein 1 3 4
  • Regulator Of Cullins 2 3 4
  • RING Finger Protein 7 4 5
  • CKBBP1 3 4
  • ROC2 3 4
  • Rbx2 3 4
  • SAG 3 4
  • Zinc RING Finger Protein SAG 3
  • RING-Box Protein 2 3

External Ids for RNF7 Gene

Previous GeneCards Identifiers for RNF7 Gene

  • GC03P138366
  • GC03P142285
  • GC03P142738
  • GC03P142777
  • GC03P142939
  • GC03P141457
  • GC03P138831

Summaries for RNF7 Gene

Entrez Gene Summary for RNF7 Gene

  • The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF7 Gene

RNF7 (Ring Finger Protein 7) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include copper ion binding and NEDD8 transferase activity. An important paralog of this gene is RBX1.

UniProtKB/Swiss-Prot for RNF7 Gene

  • Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Gene Wiki entry for RNF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF7 Gene

Genomics for RNF7 Gene

Regulatory Elements for RNF7 Gene

Enhancers for RNF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F141845 0.4 Ensembl 17.1 +107.7 107697 0.2 CTCF ZBTB33 RNF7 ATP1B3 GRK7 GK5 LOC105374134 PIR31846
GH03F141707 1.2 Ensembl ENCODE 16.8 -28.6 -28596 4.9 HDAC1 PKNOX1 ZBTB40 YY1 RARA FOS EGR2 JUNB USF2 ZNF623 RNF7 GRK7 TPT1P3 LOC646730
GH03F141848 1 Ensembl 16.7 +111.3 111254 1.0 HDGF ARNT GATA2 KLF13 NCOA1 MBD2 MEF2D SMARCA4 MYNN NBN ATP1B3 RNF7 GRK7 GK5 LOC105374134 PIR31846
GH03F141828 0.8 Ensembl ENCODE 16.7 +91.8 91769 3.3 BCOR KLF1 MAX ZMYM3 FEZF1 RFX5 ZNF664 ZNF366 POLR2A RCOR1 GRK7 RNF7 ATP1B3 LOC105374134 PIR31846
GH03F141644 0.9 Ensembl ENCODE 12.3 -93.2 -93203 0.4 CTCF PKNOX1 ARID4B ZMYM3 RAD21 ADNP ZNF143 SMC3 THAP11 ZNF263 RNF7 GRK7 LOC646730 GC03P141615
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNF7 on UCSC Golden Path with GeneCards custom track

Promoters for RNF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001484315 896 3001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for RNF7 Gene

Chromosome:
3
Start:
141,738,204 bp from pter
End:
141,747,560 bp from pter
Size:
9,357 bases
Orientation:
Plus strand

Genomic View for RNF7 Gene

Genes around RNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF7 Gene

Proteins for RNF7 Gene

  • Protein details for RNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF6-RBX2_HUMAN
    Recommended name:
    RING-box protein 2
    Protein Accession:
    Q9UBF6
    Secondary Accessions:
    • A8K1H9
    • A8MTB5
    • C9JYL3
    • D3DNF7
    • D3DNF8
    • Q9BXN8
    • Q9Y5M7

    Protein attributes for RNF7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12683 Da
    Quaternary structure:
    • Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2.

    Three dimensional structures from OCA and Proteopedia for RNF7 Gene

    Alternative splice isoforms for RNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF7 Gene

Post-translational modifications for RNF7 Gene

  • Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF7 Gene

No data available for DME Specific Peptides for RNF7 Gene

Domains & Families for RNF7 Gene

Gene Families for RNF7 Gene

Protein Domains for RNF7 Gene

Suggested Antigen Peptide Sequences for RNF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBF6

UniProtKB/Swiss-Prot:

RBX2_HUMAN :
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
  • Belongs to the RING-box family.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
Family:
  • Belongs to the RING-box family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF7: view

Function for RNF7 Gene

Molecular function for RNF7 Gene

GENATLAS Biochemistry:
RING finger protein 7,nucleocytoplasmic protein,sensitive to apoptosis gene,ubiquitously,predominantly expressed in muscle,heart and testis,protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species,homolog to APC11,a subunit of the anaphase-promoting complex
UniProtKB/Swiss-Prot Function:
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
UniProtKB/Swiss-Prot Induction:
By 1,10-phenanthroline.

Gene Ontology (GO) - Molecular Function for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 10082581
GO:0005515 protein binding IPI 16325183
GO:0008270 zinc ion binding IEA,TAS --
GO:0019788 NEDD8 transferase activity IDA 19250909
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF7: view
genes like me logo Genes that share phenotypes with RNF7: view

Animal Models for RNF7 Gene

MGI Knock Outs for RNF7:
  • Rnf7 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF7

miRNA for RNF7 Gene

miRTarBase miRNAs that target RNF7

Clone Products

  • Addgene plasmids for RNF7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF7 Gene

Localization for RNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF7 Gene COMPARTMENTS Subcellular localization image for RNF7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS,TAS 10082581
GO:0005654 nucleoplasm IDA --
GO:0005680 anaphase-promoting complex IEA --
GO:0005737 cytoplasm NAS,TAS 10082581
GO:0031462 Cul2-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with RNF7: view

Pathways & Interactions for RNF7 Gene

genes like me logo Genes that share pathways with RNF7: view

UniProtKB/Swiss-Prot Q9UBF6-RBX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RNF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0045116 protein neddylation IDA 19250909
GO:0051775 response to redox state TAS 10082581
genes like me logo Genes that share ontologies with RNF7: view

Drugs & Compounds for RNF7 Gene

(4) Drugs for RNF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for RNF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNF7: view

Transcripts for RNF7 Gene

Unigene Clusters for RNF7 Gene

Ring finger protein 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for RNF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1:
SP2: -
SP3: -
SP4: - -
SP5: - -

Relevant External Links for RNF7 Gene

GeneLoc Exon Structure for
RNF7
ECgene alternative splicing isoforms for
RNF7

Expression for RNF7 Gene

mRNA expression in normal human tissues for RNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF7 Gene

This gene is overexpressed in Liver (26.1), Gallbladder (7.9), and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF7 Gene



Protein tissue co-expression partners for RNF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF7 Gene:

RNF7

SOURCE GeneReport for Unigene cluster for RNF7 Gene:

Hs.134623

mRNA Expression by UniProt/SwissProt for RNF7 Gene:

Q9UBF6-RBX2_HUMAN
Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
genes like me logo Genes that share expression patterns with RNF7: view

Primer Products

No data available for mRNA differential expression in normal tissues for RNF7 Gene

Orthologs for RNF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF7 34 35 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia RNF7 35
  • 97 (a)
OneToOne
LOC515595 34
  • 95.87 (n)
dog
(Canis familiaris)
Mammalia RNF7 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm7075 35
  • 95 (a)
OneToMany
Rnf7 34 16 35
  • 93.81 (n)
rat
(Rattus norvegicus)
Mammalia Rnf7 34
  • 94.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF7 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF7 34 35
  • 80.83 (n)
lizard
(Anolis carolinensis)
Reptilia RNF7 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf7 34
  • 86.27 (n)
Str.1308 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21083 34
zebrafish
(Danio rerio)
Actinopterygii rnf7 34 35
  • 79.35 (n)
wufj63f04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13795 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005562 34
  • 79.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Roc2 34 35
  • 75.86 (n)
worm
(Caenorhabditis elegans)
Secernentea rbx-2 34 35
  • 65.89 (n)
R10A10.2 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 76 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.612 34
Species where no ortholog for RNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF7 Gene

ENSEMBL:
Gene Tree for RNF7 (if available)
TreeFam:
Gene Tree for RNF7 (if available)

Paralogs for RNF7 Gene

Paralogs for RNF7 Gene

(2) SIMAP similar genes for RNF7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF7 Gene

genes like me logo Genes that share paralogs with RNF7: view

Variants for RNF7 Gene

Sequence variations from dbSNP and Humsavar for RNF7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1065369 -- 141,738,934(-) GCCTT(C/T)ACCCT intron-variant
rs10660073 -- 141,743,026(+) TGGAA(-/GAG)GAGTG intron-variant
rs111262302 -- 141,742,156(+) CAAAA(A/G)GCCCC intron-variant
rs111369760 -- 141,742,105(+) AGCCT(A/G)GTACC intron-variant
rs111558867 -- 141,738,572(+) CCTCG(A/G)GGTTG intron-variant

Variation tolerance for RNF7 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF7 Gene

Disorders for RNF7 Gene

Relevant External Links for RNF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF7

No disorders were found for RNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF7 Gene

Publications for RNF7 Gene

  1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 2 3 4 22 64
  2. SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. (PMID: 11506706) Swaroop M. … Sun Y. (DNA Cell Biol. 2001) 3 4 22 64
  3. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. (PMID: 10082581) Duan H. … Sun Y. (Mol. Cell. Biol. 1999) 2 3 4 64
  4. Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. (PMID: 10512750) Son M.-Y. … Bae Y.-S. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  5. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. (PMID: 20103673) Jia L. … Sun Y. (Clin. Cancer Res. 2010) 3 22 64

Products for RNF7 Gene

Sources for RNF7 Gene

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