Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF7 Gene

Aliases for RNF7 Gene

  • Ring Finger Protein 7 2 3
  • Regulator Of Cullins 2 2 3 4
  • Sensitive To Apoptosis Gene Protein 3 4
  • Zinc RING Finger Protein SAG 2 3
  • CKII Beta-Binding Protein 1 3 4
  • CKBBP1 3 4
  • ROC2 3 4
  • Rbx2 3 4
  • SAG 3 4
  • Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2 3
  • Sensitive To Apoptosis Gene) 6
  • Sensitive To Apoptosis 2
  • RING Finger Protein 7 4
  • RING-Box Protein 2 3

External Ids for RNF7 Gene

Previous GeneCards Identifiers for RNF7 Gene

  • GC03P138366
  • GC03P142285
  • GC03P142738
  • GC03P142777
  • GC03P142939
  • GC03P141457
  • GC03P138831

Summaries for RNF7 Gene

Entrez Gene Summary for RNF7 Gene

  • The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF7 Gene

RNF7 (Ring Finger Protein 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include copper ion binding and NEDD8 transferase activity. An important paralog of this gene is RBX1.

UniProtKB/Swiss-Prot for RNF7 Gene

  • Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Gene Wiki entry for RNF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF7 Gene

Genomics for RNF7 Gene

Regulatory Elements for RNF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF7 Gene

Start:
141,738,204 bp from pter
End:
141,747,560 bp from pter
Size:
9,357 bases
Orientation:
Plus strand

Genomic View for RNF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF7 Gene

Proteins for RNF7 Gene

  • Protein details for RNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF6-RBX2_HUMAN
    Recommended name:
    RING-box protein 2
    Protein Accession:
    Q9UBF6
    Secondary Accessions:
    • A8K1H9
    • A8MTB5
    • C9JYL3
    • D3DNF7
    • D3DNF8
    • Q9BXN8
    • Q9Y5M7

    Protein attributes for RNF7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12683 Da
    Quaternary structure:
    • Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2.

    Three dimensional structures from OCA and Proteopedia for RNF7 Gene

    Alternative splice isoforms for RNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF7 Gene

Proteomics data for RNF7 Gene at MOPED

Post-translational modifications for RNF7 Gene

  • Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF7 Gene

No data available for DME Specific Peptides for RNF7 Gene

Domains for RNF7 Gene

Gene Families for RNF7 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF7 Gene

Suggested Antigen Peptide Sequences for RNF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBF6

UniProtKB/Swiss-Prot:

RBX2_HUMAN :
  • Q9UBF6
Domain:
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion
Family:
  • Belongs to the RING-box family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF7: view

Function for RNF7 Gene

Molecular function for RNF7 Gene

GENATLAS Biochemistry: RING finger protein 7,nucleocytoplasmic protein,sensitive to apoptosis gene,ubiquitously,predominantly expressed in muscle,heart and testis,protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species,homolog to APC11,a subunit of the anaphase-promoting complex
UniProtKB/Swiss-Prot Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
UniProtKB/Swiss-Prot Induction: By 1,10-phenanthroline.

Gene Ontology (GO) - Molecular Function for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 10082581
GO:0005515 protein binding IPI 16325183
GO:0008270 zinc ion binding IEA --
GO:0019788 NEDD8 transferase activity IDA 19250909
GO:0097602 cullin family protein binding IDA 10230407
genes like me logo Genes that share ontologies with RNF7: view
genes like me logo Genes that share phenotypes with RNF7: view

Animal Model Products

CRISPR Products

miRNA for RNF7 Gene

miRTarBase miRNAs that target RNF7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF7 Gene

Localization for RNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF7 Gene COMPARTMENTS Subcellular localization image for RNF7 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10082581
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 10082581
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 22405651
genes like me logo Genes that share ontologies with RNF7: view

Pathways for RNF7 Gene

genes like me logo Genes that share pathways with RNF7: view

Pathways by source for RNF7 Gene

1 Qiagen pathway for RNF7 Gene
2 Cell Signaling Technology pathways for RNF7 Gene
1 BioSystems pathway for RNF7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UBF6-RBX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress --
GO:0016567 protein ubiquitination IEA --
GO:0043066 negative regulation of apoptotic process --
GO:0045116 protein neddylation IDA 19250909
GO:0051775 response to redox state TAS 10082581
genes like me logo Genes that share ontologies with RNF7: view

Compounds for RNF7 Gene

(6) Novoseek inferred chemical compound relationships for RNF7 Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 58 2
dithiothreitol 40.7 5
zinc 40.2 4
etoposide 30.2 1
h2o2 13.9 5
genes like me logo Genes that share compounds with RNF7: view

Transcripts for RNF7 Gene

Unigene Clusters for RNF7 Gene

Ring finger protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1:
SP2: -
SP3: -
SP4: - -
SP5: - -

Relevant External Links for RNF7 Gene

GeneLoc Exon Structure for
RNF7
ECgene alternative splicing isoforms for
RNF7

Expression for RNF7 Gene

mRNA expression in normal human tissues for RNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF7 Gene

SOURCE GeneReport for Unigene cluster for RNF7 Gene Hs.134623

mRNA Expression by UniProt/SwissProt for RNF7 Gene

Q9UBF6-RBX2_HUMAN
Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
genes like me logo Genes that share expressions with RNF7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNF7 Gene

Orthologs for RNF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF7 35
  • 100 (n)
  • 100 (a)
RNF7 36
  • 100 (a)
OneToMany
RNF7 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LOC515595 35
  • 95.87 (n)
  • 97.35 (a)
RNF7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm7075 36
  • 95 (a)
OneToMany
Rnf7 35
  • 93.81 (n)
  • 96.46 (a)
Rnf7 16
Rnf7 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RNF7 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf7 35
  • 94.4 (n)
  • 96.46 (a)
chicken
(Gallus gallus)
Aves RNF7 35
  • 80.83 (n)
  • 86.73 (a)
RNF7 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF7 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21083 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf7 35
  • 86.27 (n)
  • 100 (a)
Str.1308 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13795 35
zebrafish
(Danio rerio)
Actinopterygii rnf7 35
  • 79.35 (n)
  • 92.04 (a)
rnf7 36
  • 92 (a)
OneToOne
wufj63f04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005562 35
  • 79.31 (n)
  • 88.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Roc2 35
  • 75.86 (n)
  • 86.21 (a)
Roc2 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rbx-2 35
  • 65.89 (n)
  • 69.77 (a)
rbx-2 36
  • 55 (a)
OneToOne
R10A10.2 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.612 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToOne
Species with no ortholog for RNF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF7 Gene

ENSEMBL:
Gene Tree for RNF7 (if available)
TreeFam:
Gene Tree for RNF7 (if available)

Paralogs for RNF7 Gene

Paralogs for RNF7 Gene

Selected SIMAP similar genes for RNF7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF7 Gene

genes like me logo Genes that share paralogs with RNF7: view

Variants for RNF7 Gene

Sequence variations from dbSNP and Humsavar for RNF7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs868934 -- 141,736,939(-) ATATA(C/T)AGAAA upstream-variant-2KB
rs1065369 -- 141,738,934(-) GCCTT(C/T)ACCCT intron-variant
rs1829258 -- 141,736,683(+) TGAAG(A/G)CCTCC upstream-variant-2KB
rs1879284 -- 141,739,888(-) TGGTC(A/G)GCTTT intron-variant
rs1879285 -- 141,739,881(-) CTTTT(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF7 Gene

Variant ID Type Subtype PubMed ID
nsv877552 CNV Gain 21882294

Relevant External Links for RNF7 Gene

HapMap Linkage Disequilibrium report
RNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF7 Gene

Disorders for RNF7 Gene

(2) Novoseek inferred disease relationships for RNF7 Gene

Disease -log(P) Hits PubMed IDs
neoplastic transformation 47.9 3
cancer 0 4
genes like me logo Genes that share disorders with RNF7: view

No data available for UniProtKB/Swiss-Prot for RNF7 Gene

Publications for RNF7 Gene

  1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 2 3 4 23
  2. Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. (PMID: 10512750) Son M.-Y. … Bae Y.-S. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. (PMID: 11506706) Swaroop M. … Sun Y. (DNA Cell Biol. 2001) 3 4 23
  4. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. (PMID: 10082581) Duan H. … Sun Y. (Mol. Cell. Biol. 1999) 2 3 4
  5. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. (PMID: 17828303) Tan M. … Sun Y. (Oncogene 2008) 3 23

Products for RNF7 Gene

  • Addgene plasmids for RNF7

Sources for RNF7 Gene

Back to Top

Content