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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF7 Gene

protein-coding   GIFtS: 57
GCID: GC03P141457

ring finger protein 7
 Explore 5 diseases affiliated with
RNF7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF7    

Aliases
for RNF7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger Protein 71 2 3     Rbx23
ROC21 2 3 5     RING-Box Protein 22
SAG1 2 3 5     Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 22
CKBBP11 2 3     Zinc RING Finger Protein SAG2
Regulator Of Cullins 22 3     RBX23
Sensitive To Apoptosis Gene Protein2 3     Rbx23
CKII Beta-Binding Protein 12 3     

External Ids:    HGNC: 100701   Entrez Gene: 96162   Ensembl: ENSG000001141257   OMIM: 6038635   UniProtKB: Q9UBF63   
ORGUL members:         
NONCODE:n410539    

Export aliases for RNF7 gene to outside databases

Previous GC identifers: GC03P138366 GC03P142285 GC03P142738 GC03P142777 GC03P142939 GC03P138831


Summaries
for RNF7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNF7:
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of
SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for
cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II
(CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of
IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct
isoforms have been reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal
transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to
the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction
with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents

Gene Wiki entry for RNF7


Genomic Views
for RNF7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF7 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22-q24   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q22-q24

RNF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P141457:  view genomic region     (about GC identifiers)

Start:
 141,457,046 bp from pter      End:
 141,466,402 bp from pter
Size:
 9,357 bases      Orientation:
 plus strand

Proteins
for RNF7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6 (See protein sequence)
Recommended Name: RING-box protein 2  
Size: 113 amino acids; 12683 Da
Subunit: Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts
(preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts
with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for RNF7:
2ECL (3D)    
Secondary accessions: A8K1H9 A8MTB5 C9JYL3 D3DNF7 D3DNF8 Q9BXN8 Q9Y5M7
Alternative splicing: 4 isoforms:  Q9UBF6-1   Q9UBF6-2   Q9UBF6-3   Q9UBF6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF7: NX_Q9UBF6

Post-translational modifications:

  • Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UBF6

    • RNF7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188299.1  NP_055060.1  NP_899060.1  

    ENSEMBL proteins: 
     ENSP00000273480   ENSP00000419084   ENSP00000376725   ENSP00000419339   ENSP00000419979  

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    Uscn Proteins for RNF7

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10082581
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS10082581
    GO:0031466Cul5-RING ubiquitin ligase complex IDA--


    RNF7 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR024766 Znf_RING_H2

    Graphical View of Domain Structure for InterPro Entry Q9UBF6

    ProtoNet protein and cluster: Q9UBF6

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Domain: The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third
    zinc ion
    Similarity: Belongs to the RING-box family
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Function: Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal
    transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to
    the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction
    with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents
    Induction: By 1,10-phenanthroline

         Genatlas biochemistry entry for RNF7:
    RING finger protein 7,nucleocytoplasmic protein,sensitive to apoptosis gene,ubiquitously,predominantly expressed in
    muscle,heart and testis,protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and
    reactive oxygen species,homolog to APC11,a subunit of the anaphase-promoting complex

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    SwitchGear 3'UTR luciferase reporter plasmid: RNF7 3' UTR sequence
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding TAS10082581
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0019788NEDD8 ligase activity IDA19250909


    RNF7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RNF7:
     Wnt reporter downregulated 

    Animal Models:
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rnf7):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size 
     homeostasis/metabolism  integument  mortality/aging  skeleton 

    RNF7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RNF7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Ubiquitin mediated proteolysis0.36
    2APC-Cdc20 mediated degradation of Nek2A
    		Common schema of ubiquitination0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RNF7
        Common schema of ubiquitination



    1         Kegg Pathway  (Kegg details for RNF7):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Pathway: Protein modification; protein ubiquitination


    RNF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for RNF7 (Q9UBF61, 2, 3 ENSP000002734804) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB12Q8WXK42, 3, ENSP000003551954MINT-77975 I2D: score=2 STRING: ENSP00000355195
    ASB7Q9H6722, 3, ENSP000003283274MINT-77978 I2D: score=2 STRING: ENSP00000328327
    ASB2Q96Q272, 3, ENSP000003206754MINT-75030 MINT-77969 I2D: score=2 STRING: ENSP00000320675
    ASB1Q9Y5762, 3, ENSP000002646074MINT-77973 I2D: score=2 STRING: ENSP00000264607
    ASB6Q9NWX52, 3, ENSP000002774584MINT-77971 I2D: score=2 STRING: ENSP00000277458
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress TAS10082581
    GO:0016567protein ubiquitination IEA--
    GO:0043066negative regulation of apoptotic process TAS10082581
    GO:0045116protein neddylation IDA19250909
    GO:0051775response to redox state TAS10082581


    RNF7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNF7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RNF7
    6 Novoseek chemical compound relationships for RNF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 58 3 12565832 (1), 11999705 (1)
    dithiothreitol 40.7 8 10443936 (3), 11999705 (2)
    zinc 40.2 4 12565832 (1), 10443936 (1), 11005251 (1), 11999705 (1)
    etoposide 30.2 1 17217622 (1)
    h2o2 13.9 5 11999705 (4), 10443936 (1)
    oxygen 0 2 12565832 (1), 11999705 (1)

    Search CenterWatch for drugs/clinical trials and news about RNF7 / RBX2 

    Transcripts
    for RNF7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF7 gene (4 alternative transcripts): 
    NM_001201370.1  NM_014245.4  NM_183237.2  NM_183063.1  

    Unigene Cluster for RNF7:

    Ring finger protein 7
    Hs.134623  [show with all ESTs]
    Unigene Representative Sequence: NR_037702
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273480(uc021xet.1 uc003eue.3 uc003euc.3 uc003eud.3 uc021xeu.1)
    ENST00000498828 ENST00000480908 ENST00000393000 ENST00000477012 ENST00000477393
    ENST00000486377

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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF7 (see all 28):
    hsa-miR-30c hsa-let-7d hsa-miR-4263 hsa-miR-30d hsa-let-7c hsa-miR-340 hsa-miR-548a-3p hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmid: RNF7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF092878.1 AF142060.1 AF164679.1 AK289894.1 AK311982.1 BC005966.1 BC008627.1 BT007348.1 
    NR_037702.1 NR_037703.1 

    9 DOTS entries:

    DT.95127593  DT.100732697  DT.75140271  DT.431478  DT.100031275  DT.120861889  DT.91754009  DT.95127582 
    DT.120850661 

    24/249 AceView cDNA sequences (see all 249):

    AF312226 BU731067 BC008627 W02650 BF432705 BM873390 AA521294 AI521985 
    AI984384 BU734881 BM767171 CR590381 NM_014245 BU730720 BG054821 AI000294 
    BE711656 AA627733 BG742338 BF446298 AI302054 N92941 BM979431 AI341449 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF7    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                                                        
    SP2:                          -                                             
    SP3:                                -                                       
    SP4:                          -     -                                       
    SP5:                                -     -                                 


    ECgene alternative splicing isoforms for RNF7

    Expression
    for RNF7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTATGGTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RNF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF7

    SOURCE GeneReport for Unigene cluster: Hs.134623

    UniProtKB/Swiss-Prot: RBX2_HUMAN, Q9UBF6
    Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain,
    placenta and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF7: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Orthologs
    for RNF7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RNF7 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnf71 , 5 ring finger protein 71, 5 93.81(n)1
    96.46(a)1    		   9 (50.63 cM)5
    198231  NM_011279.21  NP_035409.11 
     964709415 
    chicken
    (Gallus gallus)    		 Aves RNF71 ring finger protein 7 86.14(n)
    92.92(a)    		   424781  NM_001031307.1  NP_001026478.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF76
    		 --
    		 91(a)
    		 1 ↔ 1
    		 3(22196443-22200571)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.210832 Xenopus laevis transcribed sequence with strong similarity more 86.25(n)    BU901115.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufj63f042 Transcribed sequence with strong similarity to protein more 83.33(n)    57092737 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Roc21 CG8998-PA 69.81(n)
    74.53(a)    		   36246  NM_136847.2  NP_610691.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea R10A10.23
    rbx-21    		 zinc finger protein3
    Protein RBX-21    		 58(a)3
    59.43(n)1
    61.32(a)1    		   I(6428459-6429968)3
    1723441  NM_059448.31  NP_491849.11 


    ENSEMBL Gene Tree for RNF7 (if available)
    TreeFam Gene Tree for RNF7 (if available) 

    Paralogs
    for RNF7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF7 gene
    RBX12  
    2 SIMAP similar genes for RNF7 using alignment to 2 protein entries:     RBX2_HUMAN (see all proteins):
    RBX1    ANAPC11

    RNF7 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF7
    PGOHUM00000237364 PGOHUM00000237633


    Genomic Variants
    for RNF7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in RNF7 are shown (see all 176)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1437091721,2
    		C,unknown141465067(+) GCCCAA/CCTCAG 5 -- ut31 nc-transcript-variant0--------
    rs599986481,2
    		C,--141455090(+) AAAACT/CGTACT 5 -- us2k14Minor allele frequency- C:0.06NA WA EA 360
    rs758546491,2
    		C,--141455268(+) ACTTTC/AAAACT 5 -- us2k14Minor allele frequency- A:0.04NA WA EA 360
    rs1474658591,2
    		C,--141455331(+) TAGAT-/AACCTA 5 -- us2k10--------
    rs1478948291,2
    		C,--141455392(+) AACAC-/ATGTTTT 5 -- us2k10--------
    rs1501333311,2
    		--141455418(+) ATGGGA/TGTCTG 5 -- us2k10--------
    rs18292581,2
    		C,F,A,--141455525(+) TGAAGA/GCCTCC 5 -- us2k19Minor allele frequency- G:0.38NA WA CSA EA 368
    rs8689341,2
    		C,F,A,H,--141455781(-) ATATAC/TAGAAA 5 -- us2k1 tfbs317Minor allele frequency- T:0.35NS EA NA WA CSA 911
    rs1825777631,2
    		--141455866(+) ATGGGA/GAGAGG 5 -- us2k10--------
    rs1152673881,2
    		F,--141456002(+) GTGATG/TGTGGG 5 -- us2k11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for RNF7 (141457046 - 141466402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNF7: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RNF7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF7 for disorders           About GeneDecksing

    OMIM gene information: 603863    OMIM disorders: --

    5 diseases for RNF7:    About MalaCards
    colon carcinoma    immunodeficiency    carcinoma    malaria
    leukemia

    2 Novoseek disease relationships for RNF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neoplastic transformation 47.9 6 11255265 (2), 17440073 (1)
    cancer 0 6 20103673 (3), 11255265 (1)


    Export disorders for RNF7 gene to outside databases

    Publications
    for RNF7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF7 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with RNF7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PubMed id 10230407)1, 2, 3, 9 Ohta T.... Xiong Y. (1999)
    2. SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. (PubMed id 10082581)1, 2, 3 Duan H.... Sun Y. (1999)
    3. Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. (PubMed id 10512750)1, 2, 9 Son M.-Y....Bae Y.-S. (1999)
    4. SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. (PubMed id 11506706)1, 2, 9 Swaroop M.... Sun Y. (2001)
    5. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2 Huang D.T....Schulman B.A. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. (PubMed id 12748192)1, 2 Kim Y.-S.... Bae Y.-S. (2003)
    8. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. (PubMed id 10851089)1, 2 Swaroop M....Sun Y. (2000)
    9. CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity. (PubMed id 16874460)1, 9 He H....Sun Y. (2007)
    10. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. (PubMed id 20103673)1, 9 Jia L....Sun Y. (2010)

    External Searches for RNF7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNF7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9616 HGNC: 10070 AceView: RNF7 Ensembl:ENSG00000114125 euGenes: HUgn9616
    ECgene: RNF7 Kegg: 9616 H-InvDB: RNF7

    Other Databases showing RNF7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RNF7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF7 gene:
    Search GeneIP for patents involving RNF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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