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Aliases for RNF7 Gene

Aliases for RNF7 Gene

  • Ring Finger Protein 7 2 3
  • Regulator Of Cullins 2 2 3 4
  • Sensitive To Apoptosis Gene Protein 3 4
  • Zinc RING Finger Protein SAG 2 3
  • CKII Beta-Binding Protein 1 3 4
  • RING Finger Protein 7 4 5
  • CKBBP1 3 4
  • ROC2 3 4
  • Rbx2 3 4
  • SAG 3 4
  • Sensitive To Apoptosis, Zinc RING Finger Protein SAG, Regulator Of Cullins 2 3
  • Sensitive To Apoptosis 2

External Ids for RNF7 Gene

Previous GeneCards Identifiers for RNF7 Gene

  • GC03P138366
  • GC03P142285
  • GC03P142738
  • GC03P142777
  • GC03P142939
  • GC03P141457
  • GC03P138831

Summaries for RNF7 Gene

Entrez Gene Summary for RNF7 Gene

  • The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF7 Gene

RNF7 (Ring Finger Protein 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. GO annotations related to this gene include copper ion binding and NEDD8 transferase activity. An important paralog of this gene is RBX1.

UniProtKB/Swiss-Prot for RNF7 Gene

  • Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.

Gene Wiki entry for RNF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF7 Gene

Genomics for RNF7 Gene

Regulatory Elements for RNF7 Gene

Promoters for RNF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF7 Gene

Chromosome:
3
Start:
141,738,204 bp from pter
End:
141,747,560 bp from pter
Size:
9,357 bases
Orientation:
Plus strand

Genomic View for RNF7 Gene

Genes around RNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF7 Gene

Proteins for RNF7 Gene

  • Protein details for RNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF6-RBX2_HUMAN
    Recommended name:
    RING-box protein 2
    Protein Accession:
    Q9UBF6
    Secondary Accessions:
    • A8K1H9
    • A8MTB5
    • C9JYL3
    • D3DNF7
    • D3DNF8
    • Q9BXN8
    • Q9Y5M7

    Protein attributes for RNF7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12683 Da
    Quaternary structure:
    • Probable part of SCF complexes, which consist of SKP1, CUL1, RNF7/RBX2 and a F-box protein. Interacts (preferentially) with CUL5. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2.

    Three dimensional structures from OCA and Proteopedia for RNF7 Gene

    Alternative splice isoforms for RNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF7 Gene

Proteomics data for RNF7 Gene at MOPED

Post-translational modifications for RNF7 Gene

  • Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF7 Gene

Antibody Products

No data available for DME Specific Peptides for RNF7 Gene

Domains & Families for RNF7 Gene

Gene Families for RNF7 Gene

Protein Domains for RNF7 Gene

Suggested Antigen Peptide Sequences for RNF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBF6

UniProtKB/Swiss-Prot:

RBX2_HUMAN :
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
  • Belongs to the RING-box family.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
Family:
  • Belongs to the RING-box family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF7: view

Function for RNF7 Gene

Molecular function for RNF7 Gene

GENATLAS Biochemistry:
RING finger protein 7,nucleocytoplasmic protein,sensitive to apoptosis gene,ubiquitously,predominantly expressed in muscle,heart and testis,protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species,homolog to APC11,a subunit of the anaphase-promoting complex
UniProtKB/Swiss-Prot Function:
Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
UniProtKB/Swiss-Prot Induction:
By 1,10-phenanthroline.

Gene Ontology (GO) - Molecular Function for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 10082581
GO:0005515 protein binding IPI 16325183
GO:0019788 NEDD8 transferase activity IDA 19250909
genes like me logo Genes that share ontologies with RNF7: view
genes like me logo Genes that share phenotypes with RNF7: view

Animal Models for RNF7 Gene

MGI Knock Outs for RNF7:
  • Rnf7 tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF7

miRNA for RNF7 Gene

miRTarBase miRNAs that target RNF7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF7 Gene

Localization for RNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF7 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF7 Gene COMPARTMENTS Subcellular localization image for RNF7 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10082581
GO:0005737 cytoplasm NAS 10082581
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
GO:0043224 nuclear SCF ubiquitin ligase complex IBA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with RNF7: view

Pathways & Interactions for RNF7 Gene

genes like me logo Genes that share pathways with RNF7: view

UniProtKB/Swiss-Prot Q9UBF6-RBX2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RNF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0051775 response to redox state TAS 10082581
genes like me logo Genes that share ontologies with RNF7: view

Drugs & Compounds for RNF7 Gene

(3) Drugs for RNF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for RNF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNF7: view

Transcripts for RNF7 Gene

Unigene Clusters for RNF7 Gene

Ring finger protein 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1:
SP2: -
SP3: -
SP4: - -
SP5: - -

Relevant External Links for RNF7 Gene

GeneLoc Exon Structure for
RNF7
ECgene alternative splicing isoforms for
RNF7

Expression for RNF7 Gene

mRNA expression in normal human tissues for RNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF7 Gene

This gene is overexpressed in Liver (26.1), Gallbladder (7.9), and Breast (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF7 Gene



SOURCE GeneReport for Unigene cluster for RNF7 Gene Hs.134623

mRNA Expression by UniProt/SwissProt for RNF7 Gene

Q9UBF6-RBX2_HUMAN
Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
genes like me logo Genes that share expression patterns with RNF7: view

Protein tissue co-expression partners for RNF7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNF7 Gene

Orthologs for RNF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF7 35
  • 100 (n)
  • 100 (a)
RNF7 36
  • 100 (a)
OneToMany
RNF7 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNF7 36
  • 97 (a)
OneToOne
LOC515595 35
  • 95.87 (n)
  • 97.35 (a)
dog
(Canis familiaris)
Mammalia RNF7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf7 16
Gm7075 36
  • 95 (a)
OneToMany
Rnf7 36
  • 96 (a)
OneToMany
Rnf7 35
  • 93.81 (n)
  • 96.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RNF7 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf7 35
  • 94.4 (n)
  • 96.46 (a)
chicken
(Gallus gallus)
Aves RNF7 36
  • 90 (a)
OneToOne
RNF7 35
  • 80.83 (n)
  • 86.73 (a)
lizard
(Anolis carolinensis)
Reptilia RNF7 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21083 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf7 35
  • 86.27 (n)
  • 100 (a)
Str.1308 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13795 35
zebrafish
(Danio rerio)
Actinopterygii rnf7 36
  • 92 (a)
OneToOne
rnf7 35
  • 79.35 (n)
  • 92.04 (a)
wufj63f04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005562 35
  • 79.31 (n)
  • 88.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Roc2 36
  • 67 (a)
OneToOne
Roc2 35
  • 75.86 (n)
  • 86.21 (a)
worm
(Caenorhabditis elegans)
Secernentea rbx-2 35
  • 65.89 (n)
  • 69.77 (a)
rbx-2 36
  • 55 (a)
OneToOne
R10A10.2 37
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRT1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.612 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToOne
Species with no ortholog for RNF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF7 Gene

ENSEMBL:
Gene Tree for RNF7 (if available)
TreeFam:
Gene Tree for RNF7 (if available)

Paralogs for RNF7 Gene

Paralogs for RNF7 Gene

(2) SIMAP similar genes for RNF7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF7 Gene

genes like me logo Genes that share paralogs with RNF7: view

Variants for RNF7 Gene

Sequence variations from dbSNP and Humsavar for RNF7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1829258 -- 141,736,683(+) TGAAG(A/G)CCTCC upstream-variant-2KB
rs1879284 -- 141,739,888(-) TGGTC(A/G)GCTTT intron-variant
rs1879285 -- 141,739,881(-) CTTTT(C/T)ATTTT intron-variant
rs1879286 -- 141,739,808(-) TCAAG(C/T)GATCC intron-variant
rs3052146 -- 141,737,628(+) GTATG(-/AA/AATA)TATAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF7 Gene

Variant ID Type Subtype PubMed ID
nsv877552 CNV Gain 21882294

Variation tolerance for RNF7 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF7 Gene

HapMap Linkage Disequilibrium report
RNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF7 Gene

Disorders for RNF7 Gene

Relevant External Links for RNF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF7

No disorders were found for RNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF7 Gene

Publications for RNF7 Gene

  1. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. (PMID: 10230407) Ohta T. … Xiong Y. (Mol. Cell 1999) 2 3 4 23 67
  2. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. (PMID: 20103673) Jia L. … Sun Y. (Clin. Cancer Res. 2010) 3 23
  3. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. (PMID: 17828303) Tan M. … Sun Y. (Oncogene 2008) 3 23
  4. CK2 phosphorylation of SAG at Thr10 regulates SAG stability, but not its E3 ligase activity. (PMID: 16874460) He H. … Sun Y. (Mol. Cell. Biochem. 2007) 3 23
  5. SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. (PMID: 17217622) Tan M. … Sun Y. (Neoplasia 2006) 3 23

Products for RNF7 Gene

Sources for RNF7 Gene

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