Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF6 Gene

Aliases for RNF6 Gene

  • Ring Finger Protein (C3H2C3 Type) 6 2 3
  • RING-H2 Protein RNF-6 2
  • EC 6.3.2.- 4
  • SPG2 4

External Ids for RNF6 Gene

Previous GeneCards Identifiers for RNF6 Gene

  • GC13M024766
  • GC13M020766
  • GC13M025636
  • GC13M024584
  • GC13M024504
  • GC13M025604
  • GC13M026706
  • GC13M007604

Summaries for RNF6 Gene

Entrez Gene Summary for RNF6 Gene

  • The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF6 Gene

RNF6 (Ring Finger Protein (C3H2C3 Type) 6) is a Protein Coding gene. Diseases associated with RNF6 include esophageal cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Androgen receptor signaling pathway. GO annotations related to this gene include ubiquitin-protein transferase activity and androgen receptor binding. An important paralog of this gene is RNF38.

UniProtKB/Swiss-Prot for RNF6 Gene

  • E3 ubiquitin-protein ligase mediating Lys-48-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates Lys-6 and Lys-27-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF6 Gene

Genomics for RNF6 Gene

Regulatory Elements for RNF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF6 Gene

Start:
26,132,115 bp from pter
End:
26,222,549 bp from pter
Size:
90,435 bases
Orientation:
Minus strand

Genomic View for RNF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF6 Gene

Proteins for RNF6 Gene

  • Protein details for RNF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y252-RNF6_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF6
    Protein Accession:
    Q9Y252
    Secondary Accessions:
    • B4DDP0
    • Q5W0H0
    • Q9BZP5
    • Q9UF41

    Protein attributes for RNF6 Gene

    Size:
    685 amino acids
    Molecular mass:
    78091 Da
    Quaternary structure:
    • Interacts with LIMK1 (By similarity). Interacts with AR.
    Miscellaneous:
    • Required for prostate tumor cell growth

    Alternative splice isoforms for RNF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF6 Gene

Proteomics data for RNF6 Gene at MOPED

Post-translational modifications for RNF6 Gene

  • Ubiquitination at Lys608
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF6 Gene

Domains for RNF6 Gene

Gene Families for RNF6 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF6 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y252

UniProtKB/Swiss-Prot:

RNF6_HUMAN :
  • Q9Y252
Family:
  • Belongs to the RNF12 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF6: view

Function for RNF6 Gene

Molecular function for RNF6 Gene

GENATLAS Biochemistry: RING finger protein 6,not disrupted in the translocation t(4;13) associated with myeloproliferative disorders
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase mediating Lys-48-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates Lys-6 and Lys-27-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.

Enzyme Numbers (IUBMB) for RNF6 Gene

Gene Ontology (GO) - Molecular Function for RNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IMP 19345326
GO:0005515 protein binding IPI 19345326
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF6

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF6 Gene

Localization for RNF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF6 Gene

Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF6 Gene COMPARTMENTS Subcellular localization image for RNF6 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19345326
GO:0005737 cytoplasm IDA 19345326
GO:0016605 PML body IEA --
GO:0030424 axon ISS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with RNF6: view

Pathways for RNF6 Gene

genes like me logo Genes that share pathways with RNF6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q9Y252-RNF6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IMP 19345326
GO:0006511 ubiquitin-dependent protein catabolic process ISS --
GO:0030517 negative regulation of axon extension ISS --
GO:0044314 protein K27-linked ubiquitination IDA 19345326
GO:0045893 positive regulation of transcription, DNA-templated IMP 19345326
genes like me logo Genes that share ontologies with RNF6: view

Transcripts for RNF6 Gene

Unigene Clusters for RNF6 Gene

Ring finger protein (C3H2C3 type) 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: - -
SP8: - - - - - -
SP9: - - - - - - - -
SP10: - - -
SP11: -

Relevant External Links for RNF6 Gene

GeneLoc Exon Structure for
RNF6
ECgene alternative splicing isoforms for
RNF6

Expression for RNF6 Gene

mRNA expression in normal human tissues for RNF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF6 Gene

SOURCE GeneReport for Unigene cluster for RNF6 Gene Hs.136885

mRNA Expression by UniProt/SwissProt for RNF6 Gene

Q9Y252-RNF6_HUMAN
Tissue specificity: Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
genes like me logo Genes that share expressions with RNF6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF6 Gene

Orthologs for RNF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF6 35
  • 99.66 (n)
  • 99.85 (a)
RNF6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF6 35
  • 74.5 (n)
  • 76.2 (a)
RNF6 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF6 35
  • 91.64 (n)
  • 89.15 (a)
RNF6 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf6 35
  • 78.9 (n)
  • 74.59 (a)
Rnf6 16
Rnf6 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF6 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF6 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf6 35
  • 76.93 (n)
  • 73.72 (a)
chicken
(Gallus gallus)
Aves RNF6 35
  • 66.17 (n)
  • 60.9 (a)
RNF6 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF6 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rnf6 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mura 36
  • 10 (a)
OneToMany
Species with no ortholog for RNF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF6 Gene

ENSEMBL:
Gene Tree for RNF6 (if available)
TreeFam:
Gene Tree for RNF6 (if available)

Paralogs for RNF6 Gene

Paralogs for RNF6 Gene

Selected SIMAP similar genes for RNF6 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RNF6 Gene

genes like me logo Genes that share paralogs with RNF6: view

Variants for RNF6 Gene

Sequence variations from dbSNP and Humsavar for RNF6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1830 -- 26,212,948(+) TTAAA(A/G)CTAAA utr-variant-3-prime, intron-variant
rs167288 -- 26,165,645(+) ctgta(C/T)gtgaa intron-variant
rs167289 -- 26,166,947(+) ATCAC(C/T)tgtaa intron-variant
rs167290 -- 26,146,085(-) ggaca(C/T)tatct intron-variant
rs167291 -- 26,145,301(-) attcc(C/G)atcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF6 Gene

Variant ID Type Subtype PubMed ID
esv2469087 CNV Deletion 19546169

Relevant External Links for RNF6 Gene

HapMap Linkage Disequilibrium report
RNF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF6 Gene

Disorders for RNF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RNF6 Gene including...

Search for RNF6 Gene in MalaCards »

(1) OMIM Diseases for RNF6 Gene (604242)

UniProtKB/Swiss-Prot

RNF6_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:12154016}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with RNF6: view

Publications for RNF6 Gene

  1. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. (PMID: 10331950) Macdonald D.H.C. … Cross N.C.P. (Genomics 1999) 2 3 4
  2. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. (PMID: 12154016) Lo H.S. … Lee M.P. (Cancer Res. 2002) 3 4
  3. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. (PMID: 11971979) Lopez P. … Rassoulzadegan M. (Mol. Cell. Biol. 2002) 3 23
  4. Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development. (PMID: 18368307) Zhu L. … Ma J. (Sci. China, Ser. C, Life Sci. 2008) 3 4
  5. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. (PMID: 19345326) Xu K. … Qiu Y. (Cancer Cell 2009) 3 4

Products for RNF6 Gene

Sources for RNF6 Gene

Back to Top

Content