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RNF6 Gene

protein-coding   GIFtS: 57
GCID: GC13M026706

Ring Finger Protein (C3H2C3 Type) 6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein (C3H2C3 Type) 61 2
RING-H2 Protein RNF-61 2
E3 Ubiquitin-Protein Ligase RNF62
EC 6.3.2.-3
SPG23

External Ids:    HGNC: 100691   Entrez Gene: 60492   Ensembl: ENSG000001278707   OMIM: 6042425   UniProtKB: Q9Y2523   

Export aliases for RNF6 gene to outside databases

Previous GC identifers: GC13M024766 GC13M020766 GC13M025636 GC13M024584 GC13M024504 GC13M025604 GC13M007604


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF6 Gene:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were
detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor
suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation
that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same
protein are observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF6 Gene:
RNF6 (ring finger protein (C3H2C3 type) 6) is a protein-coding gene. Diseases associated with RNF6 include esophageal cancer, somatic, and esophageal squamous cell carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and androgen receptor binding. An important paralog of this gene is RNF38.

UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent
targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the
LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby
modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF6 gene promoter:
         Nkx3-1   Nkx3-1 v2   TBP   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF6 promoter sequence
   Search Chromatin IP Primers for RNF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.2

RNF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M026706:  view genomic region     (about GC identifiers)

Start:
26,706,253 bp from pter      End:
26,796,791 bp from pter
Size:
90,539 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF6  
Size: 685 amino acids; 78091 Da
Subunit: Interacts with LIMK1 (By similarity). Interacts with AR
Developmental stage: Expressed in embryo and adult testis
Miscellaneous: Required for prostate tumor cell growth
Secondary accessions: Q5W0H0 Q9UF41

Explore the universe of human proteins at neXtProt for RNF6: NX_Q9Y252

Explore proteomics data for RNF6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys608
  • Modification sites at PhosphoSitePlus

  • See RNF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_005968.1  NP_898864.1  NP_898865.1  

    ENSEMBL proteins: 
     ENSP00000342121   ENSP00000371000   ENSP00000370982   ENSP00000382665  
    Reactome Protein details: Q9Y252

    RNF6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RNF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y252

    ProtoNet protein and cluster: Q9Y252

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Similarity: Belongs to the RNF12 family
    Similarity: Contains 1 RING-type zinc finger


    RNF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF6_HUMAN, Q9Y252
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent
    targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the
    LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby
    modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator

         Genatlas biochemistry entry for RNF6:
    RING finger protein 6,not disrupted in the translocation t(4;13) associated with myeloproliferative disorders

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IMP19345326
    GO:0005515protein binding IPI19345326
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF6
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF6

    miRNA
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    miRTarBase miRNAs that target RNF6:
    hsa-mir-215-5p (MIRT024905), hsa-mir-186-5p (MIRT021102), hsa-mir-192-5p (MIRT026154), hsa-mir-296-3p (MIRT038456), hsa-mir-26b-5p (MIRT029039)

    Block miRNA regulation of human, mouse, rat RNF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF6 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-219-5p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRNF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF6

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    GenScript: all cDNA clones in your preferred vector (see all 3): RNF6 (NM_005977)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF6_HUMAN, Q9Y252: Nucleus. Cytoplasm. Cell projection, axon (By similarity). Nucleus, PML body (By
    similarity). Note=Localizes to the PML nuclear bodies in Sertoli cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19345326
    GO:0005737cytoplasm IDA19345326
    GO:0016605PML body IEA--
    GO:0030424axon ISS--
    GO:0031965nuclear membrane IDA--

    RNF6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNF6
        Androgen receptor signaling pathway

    1 Reactome Pathway for RNF6
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Pathway: Protein modification; protein ubiquitination


    RNF6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF6: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RNF6 (Q9Y2521, 3 ENSP000003421214) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-2341483,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    RLN1P048083, ENSP000002238624I2D: score=1 STRING: ENSP00000223862
    RNF14Q9UBS83, ENSP000003249564I2D: score=1 STRING: ENSP00000324956
    BMFQ96LC93, ENSP000003466974I2D: score=1 STRING: ENSP00000346697
    KLK3P072883, ENSP000003141514I2D: score=1 STRING: ENSP00000314151
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IMP19345326
    GO:0006511ubiquitin-dependent protein catabolic process ISS--
    GO:0030517negative regulation of axon extension ISS--
    GO:0044314protein K27-linked ubiquitination IDA19345326
    GO:0045893positive regulation of transcription, DNA-templated IMP19345326

    RNF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF6 gene (4 alternative transcripts): 
    NM_005977.3  NM_183043.2  NM_183044.2  NM_183045.1  

    Unigene Cluster for RNF6:

    Ring finger protein (C3H2C3 type) 6
    Hs.136885  [show with all ESTs]
    Unigene Representative Sequence: NM_005977
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468480(uc001uqn.1) ENST00000346166(uc001uqp.3 uc010tdk.2)
    ENST00000381588(uc001uqq.3) ENST00000381570(uc001uqo.3) ENST00000498039
    ENST00000476347 ENST00000474280 ENST00000399762
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat RNF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF6 (see all 38):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-218-1* hsa-miR-219-5p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidRNF6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): RNF6 (NM_005977)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF6
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF6
      QuantiFast Probe-based Assays in human, mouse, rat RNF6

    Additional mRNA sequence: 

    AF293342.1 AJ010346.1 AJ010347.1 AK293272.1 AK312435.1 AL133621.1 AY009109.1 BC034688.2 
    CR749238.1 

    15 DOTS entries:

    DT.100881831  DT.97811899  DT.40268885  DT.70104738  DT.100686779  DT.40112763  DT.100039569  DT.101957242 
    DT.91755701  DT.95103728  DT.100737187  DT.100887173  DT.40288606  DT.95349297  DT.100887176 

    Selected AceView cDNA sequences (see all 169):

    BI711099 NM_183044 BM983939 BX445111 BU633523 BF431803 AL549975 BQ614081 
    AW298548 AA731338 NM_183043 BM857600 AI638247 AA807189 BI463376 BU430342 
    BM969214 CB114703 AW627474 AI973253 AA423848 AA259109 AW631071 AA282443 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF6 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
    SP1:                    -     -     -     -     -     -     -     -                             -                       -     -     -     -     -         
    SP2:                    -     -     -     -     -     -     -     -                             -                                                         
    SP3:                                            -     -     -     -                             -                                                         
    SP4:                                            -     -     -     -                             -                                                         
    SP5:                                                              -                             -                                                         


    ECgene alternative splicing isoforms for RNF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCTCAAA
    RNF6 Expression
    About this image

    RNF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.136885

    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Tissue specificity: Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to
    PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RNF6
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF6
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    QuantiTect SYBR Green Assays in human, mouse, rat RNF6
    QuantiFast Probe-based Assays in human, mouse, rat RNF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf61 , 5 ring finger protein (C3H2C3 type) 61, 5 78.9(n)1
    74.59(a)1
      5 (85.18 cM)5
    741321  NM_001256086.11  NP_001243015.11 
     1462091925 
    chicken
    (Gallus gallus)
    Aves RNF61 ring finger protein (C3H2C3 type) 6 66.17(n)
    60.9(a)
      418935  XM_004938784.1  XP_004938841.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF66
    ring finger protein (C3H2C3 type) 6
    52(a)
    1 ↔ 1
    GL343306.1(680348-691313)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf66
    ring finger protein (C3H2C3 type) 6
    45(a)
    1 ↔ 1
    24(22109790-22119685) ENSDARG00000077955
    fruit fly
    (Drosophila melanogaster)
    Insecta mura6
    murashka
    10(a)
    1 → many
    3R(5363876-5377528)


    ENSEMBL Gene Tree for RNF6 (if available)
    TreeFam Gene Tree for RNF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF6 gene
    RNF382  RLIM2  RNF442  
    2 SIMAP similar genes for RNF6 using alignment to 3 protein entries:     RNF6_HUMAN (see all proteins):
    DKFZp686P0776    RLIM

    RNF6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF6
    PGOHUM00000248571 PGOHUM00000239086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF6 (see all 291)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs795610431,2
    C--7615362(+) TATAT-/AAAACCC 3 -- us2k10--------
    rs731583011,2
    C--7615363(+) ATATAA/TAACCC 3 -- us2k10--------
    rs1865660541,2
    --7740977(+) CCTTTC/TACTCC 3 -- ds50010--------
    rs1910268451,2
    --7740980(+) TTTACG/TCCATG 3 -- ds50010--------
    rs1830522091,2
    --7741039(+) GAACAC/TAGTCA 3 -- ds50010--------
    rs1468855351,2
    --7741043(+) ATAGTC/TACCAG 3 -- ds50010--------
    rs1772931,2
    C,F,O,A,H--7741212(-) CTGAAA/TATCAA 3 -- ds500115Minor allele frequency- T:0.19NS EA NA WA CSA 656
    rs1159806561,2
    C,F--7741327(+) AGTGGA/GGGGTG 3 -- ds50011Minor allele frequency- G:0.06WA 118
    rs18301,2
    C,F,O,A--7741552(+) TTAAAA/GCTAAA 3 -- ut319Minor allele frequency- G:0.37MN NA WA EA 738
    rs1865849831,2
    --7741612(+) GTTTGC/TACTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF6 (26706253 - 26796791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2469087CNV Deletion19546169

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF6
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604242   
    OMIM disorders: 133239  
    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease may
    be caused by mutations affecting the gene represented in this entry

  • 13 diseases for RNF6:    About MalaCards
    esophageal cancer, somatic    esophageal squamous cell carcinoma    esophagitis    squamous cell carcinoma
    myeloproliferative disorder    esophageal cancer    hepatocellular carcinoma    multiple myeloma
    hiv-1    myeloma    adenocarcinoma    hepatitis
    prostatitis


    RNF6 for disorders           About GeneDecksing


    Export disorders for RNF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with RNF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. (PubMed id 10331950)1, 2, 3 Macdonald D.H.C....Cross N.C.P. (Genomics 1999)
    2. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. (PubMed id 19345326)1, 2 Xu K.... Qiu Y. (Cancer Cell 2009)
    3. Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development. (PubMed id 18368307)1, 2 Zhu L.... Ma J. (Sci. China, Ser. C, Life Sci. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. (PubMed id 12154016)1, 2 Lo H.S....Lee M.P. (Cancer Res. 2002)
    6. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. (PubMed id 11971979)1, 9 Lopez P....Rassoulzadegan M. (Mol. Cell. Biol. 2002)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    9. In vitro nuclear interactome of the HIV-1 Tat protein. (PubMed id 19454010)1 Gautier V.W....Hall W.W. (Retrovirology 2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6049 HGNC: 10069 AceView: RNF6 Ensembl:ENSG00000127870 euGenes: HUgn6049
    ECgene: RNF6 H-InvDB: RNF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF6 gene:
    Search GeneIP for patents involving RNF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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