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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF6 Gene

protein-coding   GIFtS: 56
GCID: GC13M026706

Ring Finger Protein (C3H2C3 Type) 6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein (C3H2C3 Type) 61 2
RING-H2 Protein RNF-61 2
E3 Ubiquitin-Protein Ligase RNF62
EC 6.3.2.-3
SPG23

External Ids:    HGNC: 100691   Entrez Gene: 60492   Ensembl: ENSG000001278707   OMIM: 6042425   UniProtKB: Q9Y2523   

Export aliases for RNF6 gene to outside databases

Previous GC identifers: GC13M024766 GC13M020766 GC13M025636 GC13M024584 GC13M024504 GC13M025604 GC13M007604


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF6 Gene:
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were
detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor
suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation
that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same
protein are observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF6 Gene: 
RNF6 (ring finger protein (C3H2C3 type) 6) is a protein-coding gene. Diseases associated with RNF6 include esophageal squamous cell carcinoma, and esophagitis, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and androgen receptor binding. An important paralog of this gene is RNF38.

UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent
targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the
LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby
modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF6 gene promoter:
         Nkx3-1   Nkx3-1 v2   TBP   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.2   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.2

RNF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF6 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M026706:  view genomic region     (about GC identifiers)

Start:
26,706,253 bp from pter      End:
26,796,791 bp from pter
Size:
90,539 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF6  
Size: 685 amino acids; 78091 Da
Subunit: Interacts with LIMK1 (By similarity). Interacts with AR
Subcellular location: Nucleus. Cytoplasm. Cell projection, axon (By similarity). Nucleus, PML body (By
similarity). Note=Localizes to the PML nuclear bodies in Sertoli cells (By similarity)
Developmental stage: Expressed in embryo and adult testis
Miscellaneous: Required for prostate tumor cell growth
Secondary accessions: Q5W0H0 Q9UF41

Explore the universe of human proteins at neXtProt for RNF6: NX_Q9Y252

Explore proteomics data for RNF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y252

  • RNF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_005968.1  NP_898864.1  NP_898865.1  

    ENSEMBL proteins: 
     ENSP00000342121   ENSP00000371000   ENSP00000370982   ENSP00000382665  
    Reactome Protein details: Q9Y252
    Human Recombinant Protein Products for RNF6: 
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    Cloud-Clone Corp. Proteins for RNF6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19345326
    GO:0005737cytoplasm IDA19345326
    GO:0016605PML body IEA--
    GO:0030424axon ISS--

    RNF6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y252

    ProtoNet protein and cluster: Q9Y252

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Similarity: Belongs to the RNF12 family
    Similarity: Contains 1 RING-type zinc finger


    RNF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF6_HUMAN, Q9Y252
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent
    targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the
    LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby
    modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator

         Genatlas biochemistry entry for RNF6:
    RING finger protein 6,not disrupted in the translocation t(4;13) associated with myeloproliferative disorders

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004842ubiquitin-protein ligase activity IMP19345326
    GO:0005515protein binding IPI19345326
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF6 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidRNF6 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNF6
        Androgen receptor signaling pathway

    4        Reactome Pathways for RNF6
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Pathway: Protein modification; protein ubiquitination


    RNF6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for RNF6 (Q9Y2521, 3 ENSP000003421214) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-2341483,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    RLN1P048083, ENSP000002238624I2D: score=1 STRING: ENSP00000223862
    RNF14Q9UBS83, ENSP000003249564I2D: score=1 STRING: ENSP00000324956
    BMFQ96LC93, ENSP000003466974I2D: score=1 STRING: ENSP00000346697
    KLK3P072883, ENSP000003141514I2D: score=1 STRING: ENSP00000314151
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IMP19345326
    GO:0006511ubiquitin-dependent protein catabolic process ISS--
    GO:0030517negative regulation of axon extension ISS--
    GO:0044314protein K27-linked ubiquitination IDA19345326
    GO:0045893positive regulation of transcription, DNA-dependent IMP19345326

    RNF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF6

    Search CenterWatch for drugs/clinical trials and news about RNF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF6 gene (4 alternative transcripts): 
    NM_005977.3  NM_183043.2  NM_183044.2  NM_183045.1  

    Unigene Cluster for RNF6:

    Ring finger protein (C3H2C3 type) 6
    Hs.136885  [show with all ESTs]
    Unigene Representative Sequence: NM_005977
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468480(uc001uqn.1) ENST00000346166(uc001uqp.3 uc010tdk.2)
    ENST00000381588(uc001uqq.3) ENST00000381570(uc001uqo.3) ENST00000498039
    ENST00000476347 ENST00000474280 ENST00000399762
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF293342.1 AJ010346.1 AJ010347.1 AK293272.1 AK312435.1 AL133621.1 AY009109.1 BC034688.2 
    CR749238.1 

    15 DOTS entries:

    DT.100881831  DT.97811899  DT.40268885  DT.70104738  DT.100686779  DT.40112763  DT.100039569  DT.101957242 
    DT.91755701  DT.95103728  DT.100737187  DT.100887173  DT.40288606  DT.95349297  DT.100887176 

    24/169 AceView cDNA sequences (see all 169):

    BU633523 AL549975 BM983939 BF431803 AI376065 AI242096 AA282443 AA809886 
    BM971408 AA280614 AA807189 AA831404 AI973253 AW298548 BU430342 BM969214 
    AA731338 AI934319 CB114703 BI463376 AI829542 CR604595 AW631071 CB128742 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RNF6 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8
    SP1:                    -     -     -     -     -     -     -     -                             -                       -     -     -     -     -         
    SP2:                    -     -     -     -     -     -     -     -                             -                                                         
    SP3:                                            -     -     -     -                             -                                                         
    SP4:                                            -     -     -     -                             -                                                         
    SP5:                                                              -                             -                                                         


    ECgene alternative splicing isoforms for RNF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCTCAAA
    RNF6 Expression
    About this image


    See RNF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF6

    SOURCE GeneReport for Unigene cluster: Hs.136885

    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
    Tissue specificity: Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to
    PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF6: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF6 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf61 , 5 ring finger protein (C3H2C3 type) 61, 5 79.3(n)1
    75.34(a)1
      5 (85.18 cM)5
    741321  NM_001256086.11  NP_001243015.11 
     1462091925 
    chicken
    (Gallus gallus)
    Aves RNF61 ring finger protein (C3H2C3 type) 6 65.82(n)
    60.84(a)
      418935  XM_417129.3  XP_417129.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF66
    ring finger protein (C3H2C3 type) 6
    52(a)
    1 ↔ 1
    GL343306.1(680348-691313)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf61 ring finger protein (C3H2C3 type) 6 50.67(n)
    51.4(a)
      100359398  XM_003201305.1  XP_003201353.1 


    ENSEMBL Gene Tree for RNF6 (if available)
    TreeFam Gene Tree for RNF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF6 gene
    RNF382  RNF442  RLIM2  
    2 SIMAP similar genes for RNF6 using alignment to 3 protein entries:     RNF6_HUMAN (see all proteins):
    DKFZp686P0776    RLIM

    RNF6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF6
    PGOHUM00000248571 PGOHUM00000239086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/291 SNPs in RNF6 are shown (see all 291)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0634934
    ----see VAR_0634932 G D mis40--------
    VAR_0634924
    ----see VAR_0634922 A T mis40--------
    VAR_0634904
    ----see VAR_0634902 R K mis40--------
    rs795610431,2
    C--7615362(+) TATAT-/AAAACCC 3 -- us2k10--------
    rs731583011,2
    C--7615363(+) ATATAA/TAACCC 3 -- us2k10--------
    rs1865660541,2
    --7740977(+) CCTTTC/TACTCC 3 -- ds50010--------
    rs1910268451,2
    --7740980(+) TTTACG/TCCATG 3 -- ds50010--------
    rs1830522091,2
    --7741039(+) GAACAC/TAGTCA 3 -- ds50010--------
    rs1468855351,2
    --7741043(+) ATAGTC/TACCAG 3 -- ds50010--------
    rs1772931,2
    C,F,O,A,H--7741212(-) CTGAAA/TATCAA 3 -- ds500115Minor allele frequency- T:0.19NS EA NA WA CSA 656

    HapMap Linkage Disequilibrium report for RNF6 (26706253 - 26796791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2469087CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604242   
    OMIM disorders: 133239  
    UniProtKB/Swiss-Prot: RNF6_HUMAN, Q9Y252
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=The disease may
    be caused by mutations affecting the gene represented in this entry

  • 9 diseases for RNF6:    About MalaCards
    esophageal squamous cell carcinoma    esophagitis    squamous cell carcinoma    esophageal cancer
    gastric cancer    hepatocellular carcinoma    adenocarcinoma    hepatitis
    prostatitis


    RNF6 for disorders           About GeneDecksing


    Export disorders for RNF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF6 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with RNF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12. (PubMed id 10331950)1, 2, 3 Macdonald D.H.C....Cross N.C.P. (1999)
    2. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. (PubMed id 19345326)1, 2 Xu K.... Qiu Y. (2009)
    3. Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development. (PubMed id 18368307)1, 2 Zhu L....Ma J. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. (PubMed id 12154016)1, 2 Lo H.S....Lee M.P. (2002)
    6. Gene control in germinal differentiation: RNF6, a transcription regulatory protein in the mouse sertoli cell. (PubMed id 11971979)1, 9 Lopez P....Rassoulzadegan M. (2002)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    9. In vitro nuclear interactome of the HIV-1 Tat protein . (PubMed id 19454010)1 Gautier V.W....Hall W.W. (2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6049 HGNC: 10069 AceView: RNF6 Ensembl:ENSG00000127870 euGenes: HUgn6049
    ECgene: RNF6 H-InvDB: RNF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF6 gene:
    Search GeneIP for patents involving RNF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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