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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF5P1 Gene

pseudogene GIFtS: 24
GCID: GC08M038457

ring finger protein 5, E3 ubiquitin protein ligase pseudogene...

(Previous name: ring finger protein 5 pseudogene 1 )

Explore 2 diseases affiliated with
RNF5P1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 5, E3 Ubiquitin Protein Ligase Pseudogene 1¹ ²
Ring Finger Protein 5 Pseudogene 1¹

External Ids:	HGNC: 31053¹	Entrez Gene: 286140²	Ensembl: ENSG00000253570⁷

Export aliases for RNF5P1 gene to outside databases

Previous GC identifers: GC00U921549 GC08M038577 GC08M036992

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for RNF5P1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF5P1 gene promoter:
E2F-4 E2F-3a E2F-5 Pax-2 Pax-2a E2F-2 Nkx2-5 E2F E2F-1 c-Myb
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF5P1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p11.23

RNF5P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF5P1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M038457: view genomic region (about GC identifiers)

Start:	38,457,691 bp from pter	End:	38,458,775 bp from pter
Size:	1,085 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
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UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
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Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF5P1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

Unigene Cluster for RNF5P1:

Ring finger protein 5, E3 ubiquitin protein ligase pseudogene 1

Hs.512071 [show with all ESTs]

Unigene Representative Sequence: BF797142

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000524091(uc003xly.3)

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Additional cDNA sequence: NR_003129.1

6 DOTS entries:

DT.102845462 DT.448281 DT.100757936 DT.91722873 DT.121474131 DT.95278806

24/27 AceView cDNA sequences (see all 27):

CR610330 CR602529 CR594045 W73464 BM673200 BM668982 AA326251 T84842

CD623430 BM794433 BF992502 AA954998 AL559071 AA923132 BU727404 AA205944

BM693108 BM930574 CA438215 AI708032 BE186044 AI744770 BE926964 H87107

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF5P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RNF5P1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

SOURCE GeneReport for Unigene cluster: Hs.512071

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for RNF5P1 (if available)
TreeFam Gene Tree for RNF5P1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11775919^1,2	C,F,H,	--	38457203(+)	`ctcatC/Gatgcc`	1	--	ds500¹		5		NS EA NA	414
rs147540918^1,2		--	38457204(+)	`TCATCA/TTGCCT`	1	--	ds500¹		0	--	--	--	--
rs327932^1,2	C,H,	--	38457237(+)	`ATTTTA/GTTATT`	1	--	ds500¹		11		NA WA CSA EA	372
rs189493085^1,2		--	38457369(+)	`GTAGTC/TGGAAT`	1	--	ds500¹		0	--	--	--	--
rs7834231^1,2	C,A,	--	38457458(+)	`CTCGAG/ACTCCT`	1	--	ds500¹		5		NA CSA	9
rs6474430^1,2	C,A,	--	38457520(+)	`GGTGAT/GCCACC`	1	--	ds500¹		9		NA WA CSA EA	253
rs142801226^1,2		--	38457563(+)	`AGACCC/TTGCCC`	1	--	ds500¹		0	--	--	--	--
rs151026288^1,2		--	38457655(+)	`TCTAAC/TTGAGT`	1	--	ds500¹		0	--	--	--	--
rs77506692^1,2	C	--	38457666(+)	`TGTTTG/TAGCCC`	1	--	ds500¹		0	--	--	--	--
rs139686432^1,2		--	38457749(+)	`AAGGAA/GGTAGT`	1	--	nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for RNF5P1 (38457691 - 38458775 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RNF5P1
3 CNVs: 3602 4589 64475
1 Indel: 40850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF5P1 for disorders About GeneDecksing

2 diseases for RNF5P1: About MalaCards

pancreatic cancer pancreatitis

Export disorders for RNF5P1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF5P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF5P1)

Utopia: connect your pdf to the dynamic
world of online information

Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)¹ Low S.K....Sakamoto H. (2010)
Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. (PubMed id 16176924)¹ Zhang Y.... Zhou D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)¹ Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)¹ Mungall A.J.... Beck S. (2003)
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)¹ Xie T.... Hood L. (2003)
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PubMed id 12861019)¹ Didier C....Ronai Z. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. (PubMed id 11329381)¹ Matsuda N.... Nakano A. (2001)
Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. (PubMed id 9533025)¹ Kyushiki H.... Horie M. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 286140	HGNC: 31053	AceView: LOC286140	Ensembl:ENSG00000253570	euGenes: HUgn286140
ECgene: RNF5P1	H-InvDB: RNF5P1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNF5P1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF5P1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNF5P1 gene:
Search GeneIP for patents involving RNF5P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ring finger protein 5, E3 ubiquitin protein ligase pseudogene...

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RNF5P1 Gene

ring finger protein 5, E3 ubiquitin protein ligase pseudogene...

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Orthologs
for RNF5P1 gene

Paralogs
for RNF5P1 gene

Genomic Variants
for RNF5P1 gene

Disorders / Diseases
for RNF5P1 gene

Publications
for RNF5P1 gene

Intellectual Property
for RNF5P1 gene

Products
for RNF5P1 gene