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RNF5 Gene

protein-coding   GIFtS: 59
GCID: GC06P032146

Ring Finger Protein 5, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger Protein 5, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase RNF52
RING Finger Protein 51 3     EC 6.3.2.-3
Protein G162 3     G163
Ram1 Homolog2 3     HsRma13
RMA12 3     NG23
RING52 5     

External Ids:    HGNC: 100681   Entrez Gene: 60482   Ensembl: ENSG000002043087   OMIM: 6026775   UniProtKB: Q999423   
ORGUL members:         

Export aliases for RNF5 gene to outside databases

Previous GC identifers: GC06P032173 GC06P031916 GC06P032217 GC06P032254


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF5 Gene:
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein
interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting
paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal
adhesions. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF5 Gene:
RNF5 (ring finger protein 5, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with RNF5 include inclusion body myositis, and myositis. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is RNF185.

UniProtKB/Swiss-Prot: RNF5_HUMAN, Q99942
Function: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2
ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and
Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of
PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by
decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2
ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150'
leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and
regulates antiviral responses

Gene Wiki entry for RNF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNF5 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   ARP-1   E2F-2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF5 promoter sequence
   Search Chromatin IP Primers for RNF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.31

RNF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF5 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P032146:  view genomic region     (about GC identifiers)

Start:
32,146,131 bp from pter      End:
32,151,930 bp from pter
Size:
5,800 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167244 3,460,903-3,463,311      Chr6+,NT_167249 3,493,890-3,496,298      Chr6+,NT_167246 3,488,986-3,491,394     
Chr6+,NT_167247 3,525,991-3,528,397      Chr6+,NT_113891.2 3,616,843-3,619,251      Chr6+,NT_167248 3,407,182-3,409,590     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RNF5

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNF5_HUMAN, Q99942 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF5  
Size: 180 amino acids; 19881 Da
Subunit: Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JKAMP. Interacts with
TMEM173; the interaction of endogenous proteins is dependent on viral infection
Secondary accessions: A2BFI6 B2R4K3 Q0VDB7 Q9UMQ2

Explore the universe of human proteins at neXtProt for RNF5: NX_Q99942

Explore proteomics data for RNF5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys68, Lys75, Lys86, Lys93
  • Modification sites at PhosphoSitePlus

  • See RNF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008844.1  
    ENSEMBL proteins: 
     ENSP00000364235   ENSP00000407656  

    RNF5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RNF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q99942

    ProtoNet protein and cluster: Q99942

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF5_HUMAN, Q99942
    Similarity: Contains 1 RING-type zinc finger


    RNF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF5_HUMAN, Q99942
    Function: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2
    ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and
    Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of
    PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by
    decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2
    ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150'
    leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and
    regulates antiviral responses

         Genatlas biochemistry entry for RNF5:
    RING zinc-finger protein 5,widely expressed,homolog of a putative zinc finger gene from C elegans,same as D6S115E

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA19269966
    GO:0005515protein binding IPI12861019
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF5:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rnf5):
     muscle 

    RNF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnf5tm1Zron for RNF5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF5

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF5:
    hsa-mir-484 (MIRT042288)

    Block miRNA regulation of human, mouse, rat RNF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF5 (see all 21):
    hsa-let-7d hsa-miR-429 hsa-miR-1224-3p hsa-let-7c hsa-let-7g hsa-miR-483-3p hsa-miR-183* hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRNF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF5
    Predesigned siRNA for gene silencing in human, mouse, rat RNF5

    Gene Editing
    Products:
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RNF5 (NM_006913)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF5

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF5_HUMAN, Q99942: Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum
    membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic
    organelles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus3
    peroxisome2
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IEA--

    RNF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF5 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for RNF5
        Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR


    1 Kegg Pathway  (Kegg details for RNF5):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: RNF5_HUMAN, Q99942
    Pathway: Protein modification; protein ubiquitination


    RNF5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF5: 

              Unfolded Protein Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF5 (Q999421, 2, 3 ENSP000003642354) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABHD16AO958702, 3, ENSP000003792824MINT-62601 MINT-62699 MINT-62775 I2D: score=5 STRING: ENSP00000379282
    ENSG00000236063O958702, 3, ENSP000004069654MINT-62601 MINT-62699 MINT-62775 I2D: score=5 STRING: ENSP00000406965
    ENSG00000206403O958702, 3MINT-62601 MINT-62699 MINT-62775 I2D: score=5 
    ENSG00000224552O958702, 3MINT-62601 MINT-62699 MINT-62775 I2D: score=5 
    ENSG00000230475O958702, 3MINT-62601 MINT-62699 MINT-62775 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044257cellular protein catabolic process IMP19285439
    GO:0070534protein K63-linked ubiquitination IDA19269966
    GO:0070936protein K48-linked ubiquitination IDA19285439
    GO:0071712ER-associated misfolded protein catabolic process IMP19269966

    RNF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF5

    4 HMDB Compounds for RNF5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF5 gene: 
    NM_006913.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375094(uc003oaj.4) ENST00000487940 ENST00000427134
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF5 (see all 21):
    hsa-let-7d hsa-miR-429 hsa-miR-1224-3p hsa-let-7c hsa-let-7g hsa-miR-483-3p hsa-miR-183* hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidRNF5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF5
      QuantiFast Probe-based Assays in human, mouse, rat RNF5

    Selected AceView cDNA sequences (see all 345):

    AI198446 BM474579 BQ071257 BC020290 AI143856 AW794712 BI759232 BU736213 
    CA309229 BU624820 CR609098 BQ437174 BQ673980 CA423500 CA310882 BQ225172 
    CD107128 CR593664 BM975114 BX427279 BU178881 BU849202 AI633636 AA335952 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTTTCCG
    RNF5 Expression
    About this image

    RNF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF5 Protein Expression

    UniProtKB/Swiss-Prot: RNF5_HUMAN, Q99942
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF5: 
              Unfolded Protein Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RNF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf51 , 5 ring finger protein 51, 5 91.67(n)1
    97.56(a)1
      17 (18.18 cM)5
    541971  NM_019403.31  NP_062276.11 
     346010915 
    lizard
    (Anolis carolinensis)
    Reptilia RNF56
    ring finger protein 5, E3 ubiquitin protein ligase...
    64(a)
    1 ↔ 1
    2(198588669-198608415)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153972 Xenopus laevis transcribed sequence with weak similarity to protein refNP_008844.1 (H.sapiens) ring finger protein 5 [Homo sapiens] less 80.78(n)    AW641687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.130102 Transcribed sequence with weak similarity to protein refNP_008844.1 (H.sapiens) ring finger protein 5 [Homo sapiens] less 77.38(n)    BI881878.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89743   -- 60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea rnf-53 Zinc finger, C3HC4 type (RING finger) 48(a)   III(4236213-4238174)   --


    ENSEMBL Gene Tree for RNF5 (if available)
    TreeFam Gene Tree for RNF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for RNF5 gene
    RNF1852  
    2 SIMAP similar genes for RNF5 using alignment to 2 protein entries:     RNF5_HUMAN (see all proteins):
    RNF185    TRIM39

    RNF5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF5
    PGOHUM00000263131 PGOHUM00000249301


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    9 SNPs for RNF5    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1408702011,2
    C--32147928(+) CCCATC/GAGGGA 1 -- int10--------
    rs10620701,2
    C,F,A--32148031(+) CACCCA/GGCCTC 2 P syn1 ese314Minor allele frequency- G:0.17NA MN WA EA EU 6570
    rs1471759551,2
    C,F--32148071(+) TCGCCA/GTCTTC 2 I V mis11Minor allele frequency- G:0.00NA 4542
    rs3736465581,2
    ----32147982(+) TGCTTC/TCACAG 1 -- int10--------
    rs1415190841,2
    ----32148067(+) TTTCTC/TGCCAT 2 L syn11Minor allele frequency- T:0.00NA 4542
    rs2007587751,2
    ----32148172(+) CCTTCC/TGTACT 1 -- ut311Minor allele frequency- T:0.00EU 569
    rs2003154421,2
    ----32148068(+) TTCTCA/GCCATC 2 T A mis10--------
    rs3751906671,2
    ----32147992(+) GCTTTC/TCTCTC 1 -- int10--------
    rs3703767871,2
    ----32148120(+) TTCCTA/GCCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF5 (32146131 - 32151930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RNF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24778CNV Loss19812545
    nsv884707CNV Loss21882294
    nsv884706CNV Loss21882294
    nsv830629CNV Loss17160897
    dgv1929e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602677    OMIM disorders: --

    10 diseases for RNF5:    
    About MalaCards
    inclusion body myositis    myositis    myopathy    cystic fibrosis
    type 1 diabetes    systemic lupus erythematosus    lupus erythematosus    schizophrenia
    endotheliitis    breast cancer


    RNF5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF5
    Human Genome Epidemiology (HuGE) Navigator: RNF5 (4 documents)

    Export disorders for RNF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF5 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with RNF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. (PubMed id 9533025)1, 2, 3 Kyushiki H.... Horie M. (Cytogenet. Cell Genet. 1997)
    2. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PubMed id 12861019)1, 2, 9 Didier C....Ronai Z. (Mol. Cell. Biol. 2003)
    3. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (PubMed id 19285439)1, 2 Zhong B.... Shu H.B. (Immunity 2009)
    4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    5. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. (PubMed id 19143821)1, 4 McKinnon E....James I. (amp 2009)
    6. Regulation of endoplasmic reticulum-associated degradation by RNF5- dependent ubiquitination of JNK-associated membrane protein (JAMP). (PubMed id 19269966)1, 2 Tcherpakov M....Ronai Z.A. (J. Biol. Chem. 2009)
    7. Recognition and ubiquitination of Salmonella type III effector SopA by a ubiquitin E3 ligase, HsRMA1. (PubMed id 16176924)1, 2 Zhang Y.... Zhou D. (J. Biol. Chem. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6048 HGNC: 10068 AceView: RNF5 Ensembl:ENSG00000204308 euGenes: HUgn6048
    ECgene: RNF5 Kegg: 6048 H-InvDB: RNF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF5 gene:
    Search GeneIP for patents involving RNF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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