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Aliases for RNF5 Gene

Aliases for RNF5 Gene

  • Ring Finger Protein 5 2 3
  • Ring Finger Protein 5, E3 Ubiquitin Protein Ligase 2 3 5
  • Ram1 Homolog 3 4
  • Protein G16 3 4
  • RMA1 3 4
  • RING Finger Protein 5 4
  • EC 6.3.2.- 4
  • HsRma1 4
  • RING5 3
  • NG2 4
  • G16 4

External Ids for RNF5 Gene

Previous GeneCards Identifiers for RNF5 Gene

  • GC06P032173
  • GC06P031916
  • GC06P032217
  • GC06P032254

Summaries for RNF5 Gene

Entrez Gene Summary for RNF5 Gene

  • The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF5 Gene

RNF5 (Ring Finger Protein 5) is a Protein Coding gene. Diseases associated with RNF5 include hereditary choroidal atrophy and partial central choroid dystrophy. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF185.

UniProtKB/Swiss-Prot for RNF5 Gene

  • Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Gene Wiki entry for RNF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF5 Gene

Genomics for RNF5 Gene

Regulatory Elements for RNF5 Gene

Enhancers for RNF5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF5 Gene

Chromosome:
6
Start:
32,178,354 bp from pter
End:
32,180,793 bp from pter
Size:
2,440 bases
Orientation:
Plus strand

Genomic View for RNF5 Gene

Genes around RNF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RNF5 Gene

  • Protein details for RNF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99942-RNF5_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF5
    Protein Accession:
    Q99942
    Secondary Accessions:
    • A2BFI6
    • B2R4K3
    • Q0VDB7
    • Q9UMQ2

    Protein attributes for RNF5 Gene

    Size:
    180 amino acids
    Molecular mass:
    19881 Da
    Quaternary structure:
    • Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JKAMP. Interacts with TMEM173; the interaction of endogenous proteins is dependent on viral infection.

neXtProt entry for RNF5 Gene

Proteomics data for RNF5 Gene at MOPED

Post-translational modifications for RNF5 Gene

  • Ubiquitination at Lys 68, Lys 75, Lys 86, and Lys 93
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF5 Gene

Domains & Families for RNF5 Gene

Gene Families for RNF5 Gene

Protein Domains for RNF5 Gene

Suggested Antigen Peptide Sequences for RNF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99942

UniProtKB/Swiss-Prot:

RNF5_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF5: view

Function for RNF5 Gene

Molecular function for RNF5 Gene

GENATLAS Biochemistry:
RING zinc-finger protein 5,widely expressed,homolog of a putative zinc finger gene from C elegans,same as D6S115E
UniProtKB/Swiss-Prot Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Enzyme Numbers (IUBMB) for RNF5 Gene

Gene Ontology (GO) - Molecular Function for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway TAS 24019521
genes like me logo Genes that share ontologies with RNF5: view
genes like me logo Genes that share phenotypes with RNF5: view

Animal Models for RNF5 Gene

MGI Knock Outs for RNF5:

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF5

miRNA for RNF5 Gene

miRTarBase miRNAs that target RNF5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF5 Gene

Localization for RNF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF5 Gene

Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF5 Gene COMPARTMENTS Subcellular localization image for RNF5 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 4
peroxisome 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF5: view

Pathways & Interactions for RNF5 Gene

genes like me logo Genes that share pathways with RNF5: view

Pathways by source for RNF5 Gene

UniProtKB/Swiss-Prot Q99942-RNF5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009617 response to bacterium IEA --
GO:0036503 ERAD pathway IMP 24019521
GO:0070534 protein K63-linked ubiquitination IDA 19269966
GO:2000785 regulation of autophagosome assembly IEA --
genes like me logo Genes that share ontologies with RNF5: view

No data available for SIGNOR curated interactions for RNF5 Gene

Drugs & Compounds for RNF5 Gene

(3) Drugs for RNF5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for RNF5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with RNF5: view

Transcripts for RNF5 Gene

mRNA/cDNA for RNF5 Gene

Unigene Clusters for RNF5 Gene

Ring finger protein 5, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF5 Gene

No ASD Table

Relevant External Links for RNF5 Gene

GeneLoc Exon Structure for
RNF5
ECgene alternative splicing isoforms for
RNF5

Expression for RNF5 Gene

mRNA expression in normal human tissues for RNF5 Gene

Protein differential expression in normal tissues from HIPED for RNF5 Gene

This gene is overexpressed in Breast (20.4), Adrenal (14.5), Bone (8.9), and Frontal cortex (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF5 Gene



SOURCE GeneReport for Unigene cluster for RNF5 Gene Hs.731774

mRNA Expression by UniProt/SwissProt for RNF5 Gene

Q99942-RNF5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNF5: view

Protein tissue co-expression partners for RNF5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF5 Gene

Orthologs for RNF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF5 35
  • 94.81 (n)
  • 98.33 (a)
RNF5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF5 35
  • 95.19 (n)
  • 98.33 (a)
RNF5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf5 35
  • 91.67 (n)
  • 97.56 (a)
Rnf5 16
Rnf5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF5 35
  • 99.63 (n)
  • 100 (a)
RNF5 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf5 35
  • 90.45 (n)
  • 97.56 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF5 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF5 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf5 35
  • 73.71 (n)
  • 80.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15397 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13010 35
LOC100537822 35
  • 68.21 (n)
  • 75.5 (a)
RNF5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8974 37
  • 60 (a)
CG32581 36
  • 33 (a)
ManyToMany
CG32847 36
  • 38 (a)
ManyToMany
CG8974 36
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rnf-5 37
  • 48 (a)
rnf-5 36
  • 34 (a)
OneToMany
Species with no ortholog for RNF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF5 Gene

ENSEMBL:
Gene Tree for RNF5 (if available)
TreeFam:
Gene Tree for RNF5 (if available)

Paralogs for RNF5 Gene

Paralogs for RNF5 Gene

(2) SIMAP similar genes for RNF5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF5 Gene

genes like me logo Genes that share paralogs with RNF5: view

Variants for RNF5 Gene

Sequence variations from dbSNP and Humsavar for RNF5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs200758775 -- 32,180,395(+) CCTTC(C/T)GTACT utr-variant-3-prime
rs554526845 -- 32,180,391(+) TGACC(C/T)TTCCG utr-variant-3-prime
rs751795168 -- 32,180,408(+) TGGAC(C/T)CCCTT utr-variant-3-prime
rs772797058 -- 32,180,396(+) CTTCC(A/G)TACTC utr-variant-3-prime
rs755232242 -- 32,180,429(+) TTTCT(A/G)TTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF5 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884706 CNV Loss 21882294
nsv884707 CNV Loss 21882294
esv24778 CNV Loss 19812545

Variation tolerance for RNF5 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF5 Gene

HapMap Linkage Disequilibrium report
RNF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF5 Gene

Disorders for RNF5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary choroidal atrophy
  • hereditary choroidal dystrophy
partial central choroid dystrophy
  • choroidal dystrophy, central areolar
- elite association - COSMIC cancer census association via MalaCards
Search RNF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF5

Genetic Association Database (GAD)
RNF5
Human Genome Epidemiology (HuGE) Navigator
RNF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF5
genes like me logo Genes that share disorders with RNF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF5 Gene

Publications for RNF5 Gene

  1. Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. (PMID: 9533025) Kyushiki H. … Horie M. (Cytogenet. Cell Genet. 1997) 2 3 4 67
  2. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PMID: 12861019) Didier C. … Ronai Z. (Mol. Cell. Biol. 2003) 3 23
  3. Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. (PMID: 25759021) Jeon Y.J. … Ronai Z.A. (Cancer Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RNF5 Gene

Sources for RNF5 Gene

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