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Aliases for RNF5 Gene

Aliases for RNF5 Gene

  • Ring Finger Protein 5, E3 Ubiquitin Protein Ligase 2 3
  • Ram1 Homolog 3 4
  • Protein G16 3 4
  • RING5 3 6
  • RMA1 3 4
  • E3 Ubiquitin-Protein Ligase RNF5 3
  • Ring Finger Protein 5 2
  • RING Finger Protein 5 4
  • EC 6.3.2.- 4
  • HsRma1 4
  • G16 4
  • NG2 4

External Ids for RNF5 Gene

Previous GeneCards Identifiers for RNF5 Gene

  • GC06P032173
  • GC06P031916
  • GC06P032217
  • GC06P032254

Summaries for RNF5 Gene

Entrez Gene Summary for RNF5 Gene

  • The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF5 Gene

RNF5 (Ring Finger Protein 5, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of degradation of deltaF508 CFTR in CF. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF185.

UniProtKB/Swiss-Prot for RNF5 Gene

  • Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Gene Wiki entry for RNF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF5 Gene

Genomics for RNF5 Gene

Regulatory Elements for RNF5 Gene

Genomic Location for RNF5 Gene

Start:
32,178,354 bp from pter
End:
32,180,793 bp from pter
Size:
2,440 bases
Orientation:
Plus strand

Genomic View for RNF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RNF5 Gene

  • Protein details for RNF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99942-RNF5_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF5
    Protein Accession:
    Q99942
    Secondary Accessions:
    • A2BFI6
    • B2R4K3
    • Q0VDB7
    • Q9UMQ2

    Protein attributes for RNF5 Gene

    Size:
    180 amino acids
    Molecular mass:
    19881 Da
    Quaternary structure:
    • Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JKAMP. Interacts with TMEM173; the interaction of endogenous proteins is dependent on viral infection.

neXtProt entry for RNF5 Gene

Proteomics data for RNF5 Gene at MOPED

Post-translational modifications for RNF5 Gene

  • Ubiquitination at Lys68, Lys75, Lys86, and Lys93
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF5 Gene

Domains for RNF5 Gene

Gene Families for RNF5 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF5 Gene

Suggested Antigen Peptide Sequences for RNF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99942

UniProtKB/Swiss-Prot:

RNF5_HUMAN :
  • Q99942
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF5: view

Function for RNF5 Gene

Molecular function for RNF5 Gene

GENATLAS Biochemistry: RING zinc-finger protein 5,widely expressed,homolog of a putative zinc finger gene from C elegans,same as D6S115E
UniProtKB/Swiss-Prot Function: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Enzyme Numbers (IUBMB) for RNF5 Gene

Gene Ontology (GO) - Molecular Function for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19269966
GO:0005515 protein binding IPI 12861019
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF5: view

Phenotypes for RNF5 Gene

MGI mutant phenotypes for RNF5:
inferred from 1 alleles
GenomeRNAi human phenotypes for RNF5:
genes like me logo Genes that share phenotypes with RNF5: view

Animal Models for RNF5 Gene

MGI Knock Outs for RNF5:

Animal Model Products

CRISPR Products

miRNA for RNF5 Gene

miRTarBase miRNAs that target RNF5

No data available for Transcription Factor Targeting and HOMER Transcription for RNF5 Gene

Localization for RNF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF5 Gene

Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF5 Gene COMPARTMENTS Subcellular localization image for RNF5 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 3
peroxisome 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF5: view

Pathways for RNF5 Gene

genes like me logo Genes that share pathways with RNF5: view

Pathways by source for RNF5 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q99942-RNF5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009617 response to bacterium IEA --
GO:0010507 negative regulation of autophagy IEA --
GO:0016567 protein ubiquitination --
GO:0031648 protein destabilization IEA --
GO:0044257 cellular protein catabolic process IMP 19285439
genes like me logo Genes that share ontologies with RNF5: view

Compounds for RNF5 Gene

(4) HMDB Compounds for RNF5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with RNF5: view

Transcripts for RNF5 Gene

mRNA/cDNA for RNF5 Gene

(345) Selected AceView cDNA sequences:
(15) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF5 Gene

Ring finger protein 5, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF5 Gene

No ASD Table

Relevant External Links for RNF5 Gene

GeneLoc Exon Structure for
RNF5
ECgene alternative splicing isoforms for
RNF5

Expression for RNF5 Gene

mRNA expression in normal human tissues for RNF5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF5 Gene

SOURCE GeneReport for Unigene cluster for RNF5 Gene Hs.731774

mRNA Expression by UniProt/SwissProt for RNF5 Gene

Q99942-RNF5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RNF5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF5 Gene

Orthologs for RNF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF5 35
  • 99.63 (n)
  • 100 (a)
RNF5 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF5 35
  • 94.81 (n)
  • 98.33 (a)
RNF5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF5 35
  • 95.19 (n)
  • 98.33 (a)
RNF5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf5 35
  • 91.67 (n)
  • 97.56 (a)
Rnf5 16
Rnf5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF5 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf5 35
  • 90.45 (n)
  • 97.56 (a)
lizard
(Anolis carolinensis)
Reptilia RNF5 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15397 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf5 35
  • 73.71 (n)
  • 80.49 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13010 35
LOC100537822 35
  • 68.21 (n)
  • 75.5 (a)
RNF5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG32581 36
  • 33 (a)
ManyToMany
CG32847 36
  • 38 (a)
ManyToMany
CG8974 36
  • 33 (a)
ManyToMany
CG8974 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea rnf-5 36
  • 34 (a)
OneToMany
rnf-5 37
  • 48 (a)
Species with no ortholog for RNF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF5 Gene

ENSEMBL:
Gene Tree for RNF5 (if available)
TreeFam:
Gene Tree for RNF5 (if available)

Paralogs for RNF5 Gene

Paralogs for RNF5 Gene

Selected SIMAP similar genes for RNF5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF5 Gene

genes like me logo Genes that share paralogs with RNF5: view

Variants for RNF5 Gene

Sequence variations from dbSNP and Humsavar for RNF5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs200758775 -- 32,180,395(+) CCTTC(C/T)GTACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF5 Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884706 CNV Loss 21882294
nsv884707 CNV Loss 21882294
esv24778 CNV Loss 19812545

Relevant External Links for RNF5 Gene

HapMap Linkage Disequilibrium report
RNF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF5 Gene

Disorders for RNF5 Gene

Relevant External Links for RNF5

Genetic Association Database (GAD)
RNF5
Human Genome Epidemiology (HuGE) Navigator
RNF5
genes like me logo Genes that share disorders with RNF5: view

No data available for UniProtKB/Swiss-Prot for RNF5 Gene

Publications for RNF5 Gene

  1. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. (PMID: 12861019) Didier C. … Ronai Z. (Mol. Cell. Biol. 2003) 3 4 23
  2. Cloning, expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis elegans. (PMID: 9533025) Kyushiki H. … Horie M. (Cytogenet. Cell Genet. 1997) 2 3 4
  3. Rma1, a novel type of RING finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. (PMID: 11329381) Matsuda N. … Nakano A. (J. Cell Sci. 2001) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T. … Hood L. (Genome Res. 2003) 3 4

Products for RNF5 Gene

Sources for RNF5 Gene

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