RNF44 Gene
protein-coding GIFtS: 47
GCID: GC05M175886
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ring finger protein 44
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Aliases
for RNF44 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 441 2 | | KIAA11001 3 |
Export aliases for RNF44 gene to outside databasesPrevious GC identifers: GC00U991271 GC05M175889 GC05M175934 GC05M170877 |
Summaries
for RNF44 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF44:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteinsand known to be involved in protein-protein and protein-DNA interactions. (provided by RefSeq, Jul 2008)
|
Genomic Views
for RNF44 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF44 gene promoter:
SRF Spz1 AML1a COMP1 SRF (504 AA) Sox9 MIF-1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF44
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF44 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.3RNF44 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M175886: view genomic region
(about GC identifiers)
Start:
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175,953,698 bp from pter |
End:
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175,965,026 bp from pter |
Size:
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11,329 bases |
Orientation:
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minus strand |
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Proteins
for RNF44 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNF44_HUMAN, Q7L0R7 (See
protein sequence)Recommended Name: RING finger protein 44 Size: 432 amino acids; 47728 Da
Sequence caution: Sequence=BAA83052.2; Type=Erroneous initiation;
Secondary accessions: Q8ND05 Q9UPQ2Explore the universe of human proteins at neXtProt for RNF44: NX_Q7L0R7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L0R7
RNF44 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055716.1
ENSEMBL proteins: ENSP00000274811 ENSP00000425253 ENSP00000427604 ENSP00000424699 ENSP00000440352
Human Recombinant Protein Products:
RNF44 Antibody Products:
Assay Products for RNF44: |
Protein
Domains /
Families
for RNF44 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF44 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L0R7ProtoNet protein and cluster: Q7L0R7 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RNF44_HUMAN, Q7L0R7Similarity: Contains 1 RING-type zinc finger |
Function
for RNF44 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF44 (NM_014901) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF44 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF44 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF44 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF44 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF44 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF44
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RNF44 (ENSP000002748114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RNF44 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF44
Search CenterWatch for drugs/clinical trials and news about RNF44
|
Transcripts
for RNF44 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF44 gene: NM_014901.4 Unigene Cluster for RNF44: Ring finger protein 44 Hs.434888 [show with all ESTs]Unigene Representative Sequence: BC0632979 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000274811(uc003mek.1 uc011dfo.1 uc003mel.1) ENST00000506378
ENST00000513029 ENST00000515051 ENST00000508478 ENST00000504160 ENST00000504434
ENST00000509404 ENST00000537487
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF44 (NM_014901) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF44 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF44 |
Additional cDNA sequence: AB029023.1 AK302385.1 BC039833.1 BC063297.1 12 DOTS entries: DT.316133 DT.95302330 DT.100789196 DT.100743872 DT.91852821 DT.100743871 DT.100836932 DT.100857470 DT.95104388 DT.86836090 DT.100789200 DT.95302360 24/209 AceView cDNA sequences (see all 209): AA279046 CD359784 AA314249 AI358360 AI313471 BM683484 AA679991 AI690867 CB853367 AI278726 BM823925 BC039833 BU149983 BF439046 AA730224 NM_014901 CA441083 AI246293 BM672494 BI258258 AA653171 AI245682 AA807635 BQ181768
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RNF44 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF44
|
Expression
for RNF44 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF44 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATTCACAT
About this image
See RNF44 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF44
SOURCE GeneReport for Unigene cluster: Hs.434888
SABiosciences Expression via Pathway-Focused PCR Array including RNF44:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF44
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF44 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF44 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF44 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF44 |
Orthologs
for RNF44 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF44 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for RNF44 (if available)
TreeFam Gene Tree for RNF44 (if available) |
Paralogs
for RNF44 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF44 gene
- RNF62 RNF112 RNF1652 RNF382 RLIM2 RNF1112
1 SIMAP similar gene for RNF44 using alignment to 5 protein entries: RNF44_HUMAN (see all proteins):RNF38
RNF44 for paralogs About GeneDecksing
|
Genomic Variants
for RNF44 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF44 (175953698 - 175965026 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RNF44
5 CNVs: 51635 30223 30222 51633 51634 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF44 |
|
Disorders
/ Diseases
for RNF44 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RNF44 for disorders About MalaCards
RNF44 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RNF44 (1 document)
Export disorders for RNF44 gene to outside databases
|
Publications
for RNF44 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF44 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF44) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1 Stolk L....Lunetta K.L. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- [IMAGE: molecular integration of the analysis of the human genome and its expression] (PubMed id 7757816)1 Auffray C....Lamy B. (1995)
|
External Searches for RNF44 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF44 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF44 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RNF44 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF44 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF44 gene:
Search GeneIP for patents involving RNF44
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF44 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF44 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF44 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF44 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF44 | | OriGene 3'-UTR Clone for RNF44 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF44 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF44 | | OriGene Custom Protein Services for RNF44 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF44 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF44 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF44 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF44 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF44 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF44 |
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| | | | Search Tocris compounds for RNF44 |
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 | | | RNF44 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF44 |
|  |  |  | | | | ThermoFisher Antibodies for RNF44 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF44 |
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