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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF44 Gene

protein-coding   GIFtS: 47
GCID: GC05M175886

Ring Finger Protein 44

  Search for RNF44
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 441 2
KIAA11003

External Ids:    HGNC: 191801   Entrez Gene: 228382   Ensembl: ENSG000001460837   UniProtKB: Q7L0R73   

Export aliases for RNF44 gene to outside databases

Previous GC identifers: GC00U991271 GC05M175889 GC05M175934 GC05M170877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF44 Gene:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct
proteins and known to be involved in protein-protein and protein-DNA interactions. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF44 Gene: 
RNF44 (ring finger protein 44) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF44 gene promoter:
         SRF   Spz1   AML1a   COMP1   SRF (504 AA)   Sox9   MIF-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF44 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF44

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF44


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

RNF44 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF44 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M175886:  view genomic region     (about GC identifiers)

Start:
175,953,698 bp from pter      End:
175,965,026 bp from pter
Size:
11,329 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNF44_HUMAN, Q7L0R7 (See protein sequence)
Recommended Name: RING finger protein 44  
Size: 432 amino acids; 47728 Da
Sequence caution: Sequence=BAA83052.2; Type=Erroneous initiation;
Secondary accessions: Q8ND05 Q9UPQ2

Explore the universe of human proteins at neXtProt for RNF44: NX_Q7L0R7

Explore proteomics data for RNF44 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L0R7

  • RNF44 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF44 Protein Expression
    REFSEQ proteins: NP_055716.1  
    ENSEMBL proteins: 
     ENSP00000274811   ENSP00000425253   ENSP00000427604   ENSP00000424699   ENSP00000440352  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q7L0R7

    ProtoNet protein and cluster: Q7L0R7

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF44_HUMAN, Q7L0R7
    Similarity: Contains 1 RING-type zinc finger


    RNF44 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF44 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidRNF44 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF44

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RNF44 (ENSP000002748114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF44

    Search CenterWatch for drugs/clinical trials and news about RNF44

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF44 gene: 
    NM_014901.4  

    Unigene Cluster for RNF44:

    Ring finger protein 44
    Hs.434888  [show with all ESTs]
    Unigene Representative Sequence: BC063297
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274811(uc003mek.1 uc011dfo.1 uc003mel.1) ENST00000506378
    ENST00000513029 ENST00000515051 ENST00000508478 ENST00000504160 ENST00000504434
    ENST00000509404 ENST00000537487
    miRNA
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    8/153 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF44 (see all 153):
    hsa-miR-579 hsa-miR-100* hsa-miR-3653 hsa-miR-637 hsa-miR-3622b-3p hsa-miR-92b hsa-miR-761 hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidRNF44 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF44
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF44
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                         Customized lentivirus expression plasmids for stable overexpression of RNF44 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF44
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF44

    Additional mRNA sequence: 

    AB029023.1 AK302385.1 BC039833.1 BC063297.1 

    12 DOTS entries:

    DT.316133  DT.95302330  DT.100789196  DT.100743872  DT.91852821  DT.100743871  DT.100836932  DT.100857470 
    DT.95104388  DT.86836090  DT.100789200  DT.95302360 

    24/209 AceView cDNA sequences (see all 209):

    CB995914 CB853367 AW304990 AI278726 BE464574 BM823925 AA332070 AI359016 
    BC039833 AA679991 CA441083 AI739655 AI246293 BM423564 AI919498 AI313471 
    CB988120 BM718433 CB215649 AA653171 BQ218158 BM683484 AB029023 AA314249 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RNF44 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                                                                                                  -                     
    SP2:                                                                                                                        
    SP3:              -                                                                                                         
    SP4:                                -                                                                                       
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for RNF44

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF44 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTCACAT
    RNF44 Expression
    About this image


    See RNF44 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF44

    SOURCE GeneReport for Unigene cluster: Hs.434888
        SABiosciences Expression via Pathway-Focused PCR Array including RNF44: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF44

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF44 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf441 , 5 ring finger protein 441, 5 89.33(n)1
    91.65(a)1
      13 (28.94 cM)5
    1052391  NM_001146025.11  NP_001139497.11 
     546794015 
    chicken
    (Gallus gallus)
    Aves LOC4162241 RING finger protein 44-like 80.89(n)
    81.35(a)
      416224  XM_003642073.1  XP_003642121.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF446
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343548.1(218989-244965)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480452262   -- 92.31(n)    48045226 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf441 ring finger protein 44 69.54(n)
    70.4(a)
      767686  NM_001076624.1  NP_001070092.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mura6
    murashka
    13(a)
    1 → many
    3R(5363876-5377528)


    ENSEMBL Gene Tree for RNF44 (if available)
    TreeFam Gene Tree for RNF44 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF44 gene
    RNF62  RNF382  RLIM2  
    1 SIMAP similar gene for RNF44 using alignment to 5 protein entries:     RNF44_HUMAN (see all proteins):
    RNF38

    RNF44 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/374 SNPs in RNF44 are shown (see all 374)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863748651,2
    C--175953260(+) CGGCAC/TGATCT 1 -- ds50010--------
    rs125135411,2
    C,H--175953359(+) cgcccA/Ggctaa 1 -- ds50010--------
    rs1431364891,2
    --175953435(+) GACCTC/TATGAT 1 -- ds50010--------
    rs131572761,2
    C,F,A--175953436(+) ACCTCG/ATGATC 1 -- ds50015Minor allele frequency- A:0.40NA WA CSA 10
    rs1903963901,2
    --175953678(+) CCAAAA/CAGACA 1 -- ds50010--------
    rs758138131,2
    C,F--175953702(+) GCAGCG/ATGGGC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1404054411,2
    C--175953707(+) GTGGGC/TGGTCG 1 -- ut310--------
    rs782824061,2
    C,F--175953713(+) GGTCGT/CTGGTA 1 -- ut311Minor allele frequency- C:0.08WA 118
    rs1829448911,2
    C--175953729(+) CATACA/GTTTAT 1 -- ut310--------
    rs1868685931,2
    --175953899(+) TAAATA/GCTACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF44 (175953698 - 175965026 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for RNF44:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731169CNV Deletion23290073
    esv2731171CNV Deletion23290073
    esv2731170CNV Deletion23290073
    nsv471056CNV Loss18288195
    dgv6375n71CNV Loss21882294
    nsv516244CNV Loss19592680
    nsv823350CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNF44 for disorders           About MalaCards

    RNF44 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF44
    Human Genome Epidemiology (HuGE) Navigator: RNF44 (1 document)

    Export disorders for RNF44 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF44 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF44)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PubMed id 22267201)1, 4 Stolk L....Lunetta K.L. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    10. [IMAGE: molecular integration of the analysis of the human genome and its expression] (PubMed id 7757816)1 Auffray C....Lamy B. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22838 HGNC: 19180 AceView: RNF44 Ensembl:ENSG00000146083 euGenes: HUgn22838
    ECgene: RNF44 H-InvDB: RNF44

    (According to HUGE)
    About This Section
    HUGE: KIAA1100

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF44 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF44 gene:
    Search GeneIP for patents involving RNF44

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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