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Aliases for RNF44 Gene

Aliases for RNF44 Gene

  • Ring Finger Protein 44 2 3
  • KIAA1100 4

External Ids for RNF44 Gene

Previous GeneCards Identifiers for RNF44 Gene

  • GC00U991271
  • GC05M175889
  • GC05M175934
  • GC05M175886
  • GC05M170877

Summaries for RNF44 Gene

Entrez Gene Summary for RNF44 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF44 Gene

RNF44 (Ring Finger Protein 44) is a Protein Coding gene. An important paralog of this gene is RNF38.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF44 Gene

Genomics for RNF44 Gene

Regulatory Elements for RNF44 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF44 Gene

Start:
176,526,697 bp from pter
End:
176,538,025 bp from pter
Size:
11,329 bases
Orientation:
Minus strand

Genomic View for RNF44 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF44 Gene

Proteins for RNF44 Gene

  • Protein details for RNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0R7-RNF44_HUMAN
    Recommended name:
    RING finger protein 44
    Protein Accession:
    Q7L0R7
    Secondary Accessions:
    • B4DYE0
    • Q8ND05
    • Q9UPQ2

    Protein attributes for RNF44 Gene

    Size:
    432 amino acids
    Molecular mass:
    47728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83052.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF44 Gene

Proteomics data for RNF44 Gene at MOPED

Post-translational modifications for RNF44 Gene

  • Ubiquitination at Lys357
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF44 Gene

No data available for DME Specific Peptides for RNF44 Gene

Domains for RNF44 Gene

Gene Families for RNF44 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF44 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF44 Gene

Graphical View of Domain Structure for InterPro Entry

Q7L0R7

UniProtKB/Swiss-Prot:

RNF44_HUMAN :
  • Q7L0R7
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF44: view

Function for RNF44 Gene

Gene Ontology (GO) - Molecular Function for RNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF44: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF44

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF44 Gene

Localization for RNF44 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF44 Gene COMPARTMENTS Subcellular localization image for RNF44 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF44 Gene

Pathways for RNF44 Gene

SuperPathways for RNF44 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RNF44 Gene

None

No data available for Pathways by source for RNF44 Gene

Transcripts for RNF44 Gene

Unigene Clusters for RNF44 Gene

Ring finger protein 44:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF44

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNF44

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -

Relevant External Links for RNF44 Gene

GeneLoc Exon Structure for
RNF44
ECgene alternative splicing isoforms for
RNF44

Expression for RNF44 Gene

mRNA expression in normal human tissues for RNF44 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF44 Gene

SOURCE GeneReport for Unigene cluster for RNF44 Gene Hs.434888

genes like me logo Genes that share expressions with RNF44: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF44 Gene

Orthologs for RNF44 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF44 35
  • 99.84 (n)
  • 100 (a)
RNF44 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF44 35
  • 91.28 (n)
  • 93.29 (a)
RNF44 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF44 35
  • 92.65 (n)
  • 96.29 (a)
RNF44 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf44 35
  • 89.33 (n)
  • 91.65 (a)
Rnf44 16
Rnf44 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF44 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf44 35
  • 89.52 (n)
  • 94.29 (a)
chicken
(Gallus gallus)
Aves RNF44 35
  • 79.81 (n)
  • 79.81 (a)
RNF44 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF44 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf44 35
  • 72.51 (n)
  • 75.83 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf44 35
  • 69.39 (n)
  • 69.7 (a)
rnf44 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mura 36
  • 13 (a)
OneToMany
Species with no ortholog for RNF44:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF44 Gene

ENSEMBL:
Gene Tree for RNF44 (if available)
TreeFam:
Gene Tree for RNF44 (if available)

Paralogs for RNF44 Gene

Paralogs for RNF44 Gene

Selected SIMAP similar genes for RNF44 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF44: view

Variants for RNF44 Gene

Sequence variations from dbSNP and Humsavar for RNF44 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs876224 -- 176,532,918(-) TGAGC(G/T)GTCCT intron-variant
rs876225 -- 176,532,763(-) tcttt(C/T)ttttt intron-variant
rs890834 -- 176,528,813(+) CGGGC(A/C/G)GGCAG utr-variant-3-prime
rs890835 -- 176,529,270(+) GGAGC(A/C/T)GACCT intron-variant
rs890836 -- 176,537,482(+) GGGCC(A/G)CCATC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF44 Gene

Variant ID Type Subtype PubMed ID
nsv516244 CNV Loss 19592680
nsv471056 CNV Loss 18288195
dgv6375n71 CNV Loss 21882294
esv2731169 CNV Deletion 23290073
esv2731170 CNV Deletion 23290073
esv2731171 CNV Deletion 23290073
nsv823350 CNV Gain 20364138

Relevant External Links for RNF44 Gene

HapMap Linkage Disequilibrium report
RNF44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF44 Gene

Disorders for RNF44 Gene

Relevant External Links for RNF44

Genetic Association Database (GAD)
RNF44
Human Genome Epidemiology (HuGE) Navigator
RNF44
genes like me logo Genes that share disorders with RNF44: view

No data available for UniProtKB/Swiss-Prot for RNF44 Gene

Publications for RNF44 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for RNF44 Gene

Sources for RNF44 Gene

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