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RNF43 Gene

protein-coding   GIFtS: 52
GCID: GC17M056429

Ring Finger Protein 43

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 431 2 3
RNF1242 5
URCC2
E3 Ubiquitin-Protein Ligase RNF432
EC 6.3.2.-3

External Ids:    HGNC: 185051   Entrez Gene: 548942   Ensembl: ENSG000001083757   OMIM: 6124825   UniProtKB: Q68DV73   

Export aliases for RNF43 gene to outside databases

Previous GC identifers: GC17U990330 GC17M053787 GC17M051791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF43 Gene:
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in
colon cancer (Yagyu et al., 2004 (PubMed 15492824); Sugiura et al., 2008 (PubMed 18313049)).(supplied by OMIM,
Dec 2008)

GeneCards Summary for RNF43 Gene:
RNF43 (ring finger protein 43) is a protein-coding gene. Diseases associated with RNF43 include motion sickness, and lung adenocarcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and frizzled binding. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating
the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on
both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell
zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF43 gene promoter:
         c-Fos   AhR   AP-1   Arnt   FOXL1   PPAR-gamma1   SREBP-1a   FOXO4   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF43 promoter sequence
   Search Chromatin IP Primers for RNF43

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

RNF43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF43 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056429:  view genomic region     (about GC identifiers)

Start:
56,429,861 bp from pter      End:
56,494,956 bp from pter
Size:
65,096 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF43 precursor  
Size: 783 amino acids; 85722 Da
Subunit: Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Identified in a complex composed of RNF43,
LGR5 and RSPO1
Miscellaneous: Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for
cancer immunotherapy (PubMed:15623641)
Sequence caution: Sequence=BAH12871.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for RNF43:
4KNG (3D)    
Secondary accessions: A8K4R2 B7Z443 B7Z5D5 B7Z5J5 Q65ZA4 Q6AI04 Q9NXD0
Alternative splicing: 4 isoforms:  Q68DV7-1   Q68DV7-2   Q68DV7-3   Q68DV7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF43: NX_Q68DV7

Explore proteomics data for RNF43 at MOPED

Post-translational modifications: 

  • Autoubiquitinated1
  • Glycosylation2 at Asn62, Asn92

  • See RNF43 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060233.3  
    ENSEMBL proteins: 
     ENSP00000385328   ENSP00000462502   ENSP00000463069   ENSP00000462764   ENSP00000463716  
     ENSP00000462447   ENSP00000441969  
    Reactome Protein details: Q68DV7

    RNF43 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q68DV7

    ProtoNet protein and cluster: Q68DV7

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Similarity: Belongs to the ZNRF3 family
    Similarity: Contains 1 RING-type zinc finger


    RNF43 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF43_HUMAN, Q68DV7
    Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating
    the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on
    both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell
    zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0004871signal transducer activity ----
    GO:0005109frizzled binding IPI--
    GO:0005515protein binding IPI18313049
    GO:0008270zinc ion binding IEA--
         
    RNF43 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF43:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnf43):
     cellular  digestive/alimentary  endocrine/exocrine gland  tumorigenesis 

    RNF43 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF43
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    miRNA
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    miRTarBase miRNAs that target RNF43:
    hsa-mir-335-5p (MIRT019206)

    Block miRNA regulation of human, mouse, rat RNF43 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF43 (see all 38):
    hsa-miR-15a hsa-miR-29b-1* hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-181b hsa-miR-3173-3p hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidRNF43 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF43

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF43


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF43_HUMAN, Q68DV7: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted
    (PubMed:15492824)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus5
    plasma membrane5
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral component of plasma membrane IDA--

    RNF43 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways



    1 Reactome Pathway for RNF43
        regulation of FZD by ubiquitination


    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Pathway: Protein modification; protein ubiquitination


    RNF43 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF43: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for RNF43 (Q68DV71, 3 ENSP000003853284) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP8LQ9ULX61, 3, ENSP000003805574EBI-1647060,EBI-357530 I2D: score=2 STRING: ENSP00000380557
    UBE2D2P628371, 3, ENSP000003817174EBI-1647060,EBI-347677 I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610771, 3, ENSP000003497224EBI-1647060,EBI-348268 I2D: score=2 STRING: ENSP00000349722
    UBBP0CG471, 3, ENSP000003046974EBI-1647060,EBI-413034 I2D: score=1 STRING: ENSP00000304697
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0016055Wnt signaling pathway IEA--
    GO:0016567protein ubiquitination IDA--
    GO:0030178negative regulation of Wnt signaling pathway IMP--
    GO:0038018Wnt receptor catabolic process IDA--

    RNF43 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF43



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF43 gene: 
    NM_017763.4  

    Unigene Cluster for RNF43:

    Ring finger protein 43
    Hs.584916  [show with all ESTs]
    Unigene Representative Sequence: CR749257
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407977 ENST00000583753 ENST00000584437(uc002iwf.3 uc002iwh.4)
    ENST00000577716(uc002iwg.4) ENST00000577625 ENST00000581868(uc010dcw.3)
    ENST00000582293 ENST00000580014 ENST00000500597(uc010wnv.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF43 (see all 38):
    hsa-miR-15a hsa-miR-29b-1* hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-181b hsa-miR-3173-3p hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidRNF43 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat RNF43

    Additional mRNA sequence: 

    AB081837.1 AK000322.1 AK291027.1 AK296769.1 AK298789.1 AK299024.1 AK309297.1 BC109028.2 
    CR627423.1 CR749257.1 

    8 DOTS entries:

    DT.212026  DT.100692797  DT.95163093  DT.100748282  DT.438801  DT.92023227  DT.95365396  DT.75162075 

    Selected AceView cDNA sequences (see all 568):

    F37330 BM713751 AI360079 AU105960 CB128448 CA444131 AA669239 CF529800 
    BM753215 AA310551 CF529241 AW161536 AI302657 AU105959 AU099670 CR613341 
    AI368395 AI858181 BU581099 AI564898 CB124628 BQ434346 AI366007 BU735646 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTATTTATA
    RNF43 Expression
    About this image


    RNF43 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Collecting Duct System
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RNF43 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF43 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584916

    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Tissue specificity: Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and
    lung adenocarcinomas. Overexpressed in colorectal cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF43: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF43

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF43 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf431 , 5 ring finger protein 431, 5 84.23(n)1
    82.44(a)1
      11 (52.17 cM)5
    2077421  NM_172448.31  NP_766036.21 
     876627225 
    chicken
    (Gallus gallus)
    Aves RNF431 ring finger protein 43 63.62(n)
    59.77(a)
      100857874  XM_003642379.2  XP_003642427.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF436
    ring finger protein 43
    37(a)
    1 ↔ 1
    GL344014.1(8445-13799)
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3B.116
    Protein Y47D3B.11 (Y47D3B.11) mRNA, complete cds
    21(a)
    1 → many
    III(11456877-11462882) WBGene00012944


    ENSEMBL Gene Tree for RNF43 (if available)
    TreeFam Gene Tree for RNF43 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF43 gene
    ZNRF32  RNF1482  RNF1492  RNF1332  RNF1502  RNF1302  RNF1672  RNF1282  
    RNF2152  ZNRF42  RNF132  
    1 SIMAP similar gene for RNF43 using alignment to 2 protein entries:     RNF43_HUMAN (see all proteins):
    RNF215

    RNF43 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF43 (see all 1028)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1863620961,2
    --56431719(+) TCAGGA/GACCCC 1 -- ut310--------
    rs1389035671,2
    C--56431873(+) GATAAA/GGTGTC 1 -- ut310--------
    rs1164798711,2
    C,F--56431879(+) GTGTCA/GTGCGT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1493944821,2
    C--56432039(+) ACACAC/TGCCAC 1 -- ut310--------
    rs1158030581,2
    C,F--56432088(+) GCACTG/ACAGAT 1 -- ut312Minor allele frequency- A:0.02WA NA 238
    rs1130132851,2
    C--56432131(+) GGAAAC/TGGCAC 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1439570221,2
    --56432201(+) GAATGA/GTGTTT 1 -- ut310--------
    rs1913195151,2
    --56432219(+) TCCTTC/TCCTTT 1 -- ut310--------
    rs1115947161,2
    C,F--56432234(+) GGAGCC/AGGACT 1 -- ut311Minor allele frequency- A:0.50CSA 4
    rs1403527041,2
    C--56432264(+) AACACA/TTCTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF43 (56429861 - 56494956 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF43:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908641CNV Loss21882294
    nsv517229CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612482    OMIM disorders: --

    12 diseases for RNF43:    
    About MalaCards
    motion sickness    lung adenocarcinoma    tonsillitis    pancreatic cancer
    hepatocellular carcinoma    colorectal cancer    pancreatitis    adenocarcinoma
    thyroiditis    cerebritis    prostatitis    endotheliitis


    RNF43 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF43

    Export disorders for RNF43 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF43 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with RNF43)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. (PubMed id 15492824)1, 2, 9 Yagyu R....Nakamura Y. (Int. J. Oncol. 2004)
    2. Ring finger protein 43 as a new target for cancer immunotherapy. (PubMed id 15623641)1, 2, 9 Uchida N.... Tahara H. (Clin. Cancer Res. 2004)
    3. The structural basis of R-spondin recognition by LGR5 and RNF43. (PubMed id 23756651)1, 2 Chen P.H....He X. (amp 2013)
    4. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. (PubMed id 22895187)1, 2 Koo B.K....Clevers H. (Nature 2012)
    5. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (PLoS ONE 2010)
    6. A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95. (PubMed id 18313049)1, 2 Sugiura T.... Miyamoto K. (Exp. Cell Res. 2008)
    7. Proteomic identification of a PSF/p54nrb heterodimer as RNF43 oncoprotein-interacting proteins. (PubMed id 18655028)1, 2 Miyamoto K.... Sugiura T. (Proteomics 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Reversing effect of ring finger protein 43 inhibition on malignant phenotypes of human hepatocellular carcinoma. (PubMed id 23136185)1 Xing C....Zhou L. (Mol. Cancer Ther. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54894 HGNC: 18505 AceView: SUPT4H1andFLJ20315 Ensembl:ENSG00000108375 euGenes: HUgn54894
    ECgene: RNF43 H-InvDB: RNF43

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF43 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF43 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF43 gene:
    Search GeneIP for patents involving RNF43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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