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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF43 Gene

protein-coding   GIFtS: 49
GCID: GC17M056429

ring finger protein 43
 Explore 10 diseases affiliated with
RNF43 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF43    

Aliases
for RNF43 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 431 2 3     FLJ203151
URCC1 2     E3 Ubiquitin-Protein Ligase RNF432
RNF1242 5     EC 6.3.2.-3
DKFZp781H03921     

External Ids:    HGNC: 185051   Entrez Gene: 548942   Ensembl: ENSG000001083757   OMIM: 6124825   UniProtKB: Q68DV73   

Export aliases for RNF43 gene to outside databases

Previous GC identifers: GC17U990330 GC17M053787 GC17M051791


Summaries
for RNF43 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNF43:
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon
cancer (Yagyu et al., 2004 (PubMed 15492824); Sugiura et al., 2008 (PubMed 18313049)).(supplied by OMIM, Dec 2008)

UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the
ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both
canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by
inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone




Genomic Views
for RNF43 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF43 gene promoter:
         c-Fos   AhR   AP-1   Arnt   FOXL1   PPAR-gamma1   SREBP-1a   FOXO4   c-Jun   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF43 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF43

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF43


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

RNF43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF43 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056429:  view genomic region     (about GC identifiers)

Start:
 56,429,861 bp from pter      End:
 56,494,956 bp from pter
Size:
 65,096 bases      Orientation:
 minus strand

Proteins
for RNF43 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF43 precursor  
Size: 783 amino acids; 85722 Da
Subunit: Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted (PubMed:15492824)
Miscellaneous: Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer
immunotherapy (PubMed:15623641)
Sequence caution: Sequence=BAH12871.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K4R2 B7Z443 B7Z5D5 B7Z5J5 Q65ZA4 Q6AI04 Q9NXD0
Alternative splicing: 4 isoforms:  Q68DV7-1   Q68DV7-2   Q68DV7-3   Q68DV7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF43: NX_Q68DV7

Post-translational modifications:

  • Autoubiquitinated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68DV7

    • RNF43 Protein expression data from MOPED and PaxDb:    About this image 
    RNF43 Protein Expression
    REFSEQ proteins: NP_060233.3  
    ENSEMBL proteins: 
     ENSP00000385328   ENSP00000462502   ENSP00000463069   ENSP00000462764   ENSP00000463716  
     ENSP00000462447   ENSP00000441969  

    Human Recombinant Protein Products for RNF43: 
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    Uscn Proteins for RNF43

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral to plasma membrane IDA--

    RNF43 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF43 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF43 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q68DV7

    ProtoNet protein and cluster: Q68DV7

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Similarity: Belongs to the ZNRF3 family
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF43 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF43_HUMAN, Q68DV7
    Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the
    ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both
    canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by
    inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005109frizzled binding IPI--
    GO:0005515protein binding IPI19690564
    GO:0008270zinc ion binding IEA--
         
    RNF43 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF43:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnf43):
     cellular  digestive/alimentary  endocrine/exocrine gland  tumorigenesis 

    RNF43 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF43 

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF43 (see all 38):
    hsa-miR-15a hsa-miR-29b-1* hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-181b hsa-miR-3173-3p hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmid: RNF43 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF43 (see all 7)
    OriGene shRNA RFP: RNF43
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    Gene Editing
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for RNF43 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF43

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/16 Interacting proteins for RNF43 (Q68DV71, 3 ENSP000003853284) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP8LQ9ULX61, 3, ENSP000003805574EBI-1647060,EBI-357530 I2D: score=2 STRING: ENSP00000380557
    UBE2D2P628371, 3, ENSP000003817174EBI-1647060,EBI-347677 I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610771, 3, ENSP000003497224EBI-1647060,EBI-2809412 I2D: score=2 STRING: ENSP00000349722
    UBBP0CG471, 3, ENSP000003046974EBI-1647060,EBI-413034 I2D: score=1 STRING: ENSP00000304697
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0016567protein ubiquitination IDA--
    GO:0030178negative regulation of Wnt receptor signaling pathway IMP--
    GO:0038018Wnt receptor catabolic process IDA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA--

    RNF43 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNF43 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF43
    Search CenterWatch for drugs/clinical trials and news about RNF43 

    Transcripts
    for RNF43 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF43 gene: 
    NM_017763.4  

    Unigene Cluster for RNF43:

    Ring finger protein 43
    Hs.584916  [show with all ESTs]
    Unigene Representative Sequence: CR749257
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407977 ENST00000583753 ENST00000584437(uc002iwf.3 uc002iwh.4)
    ENST00000577716(uc002iwg.4) ENST00000577625 ENST00000581868(uc010dcw.3)
    ENST00000582293 ENST00000580014 ENST00000500597(uc010wnv.2)

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF43 (see all 38):
    hsa-miR-15a hsa-miR-29b-1* hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-181b hsa-miR-3173-3p hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmid: RNF43 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB081837.1 AK000322.1 AK291027.1 AK296769.1 AK298789.1 AK299024.1 AK309297.1 BC109028.2 
    CR627423.1 CR749257.1 

    8 DOTS entries:

    DT.212026  DT.100692797  DT.95163093  DT.100748282  DT.438801  DT.92023227  DT.95365396  DT.75162075 

    24/568 AceView cDNA sequences (see all 568):

    AK129758 AA580390 AA297042 BG026473 AW161536 CF529911 CR613341 BM753215 
    AI815625 BU581321 BI760487 AA338733 AI056205 CR616121 AU105957 BM697767 
    CR605018 BM766053 CB127121 CF530045 AI274814 AI359974 AI250344 AA831464 

    GeneLoc Exon Structure


    Expression
    for RNF43 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF43 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTATTTATA
    RNF43 Expression
    About this image

    RNF43 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RNF43 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF43

    SOURCE GeneReport for Unigene cluster: Hs.584916

    UniProtKB/Swiss-Prot: RNF43_HUMAN, Q68DV7
    Tissue specificity: Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung
    adenocarcinomas. Overexpressed in colorectal cancer cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including RNF43: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RNF43 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF43 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RNF431 ring finger protein 43 67.84(n)
    64.61(a)    		   100857874  XM_003642379.1  XP_003642427.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF436
    		 --
    		 27(a)
    		 1 ↔ 1
    		 GL344014.1(8445-13406)
    worm
    (Caenorhabditis elegans)    		 Secernentea Y47D3B.116
    		 Protein Y47D3B.11
    		 16(a)
    		 1 → many
    		 III(11456777-11462782)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 zinc finger, C3HC4 type domain containing protein
    		 35(a)
    		 1 → many
    		 12(26391264-26391518)


    ENSEMBL Gene Tree for RNF43 (if available)
    TreeFam Gene Tree for RNF43 (if available) 

    Paralogs
    for RNF43 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF43 gene
    ZNRF32  RNF1482  RNF1492  RNF1332  RNF1502  RNF1302  RNF1672  RNF2152  
    RNF1282  ZNRF42  RNF132  
    1 SIMAP similar gene for RNF43 using alignment to 2 protein entries:     RNF43_HUMAN (see all proteins):
    RNF215

    RNF43 for paralogs           About GeneDecksing



    Genomic Variants
    for RNF43 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/858 NCBI SNPs in RNF43 are shown (see all 858)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1863620961,2
    		--56431719(+) TCAGGA/GACCCC 1 -- ut310--------
    rs1389035671,2
    		--56431873(+) GATAAA/GGTGTC 1 -- ut310--------
    rs1164798711,2
    		F--56431879(+) GTGTCA/GTGCGT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1493944821,2
    		--56432039(+) ACACAC/TGCCAC 1 -- ut310--------
    rs1158030581,2
    		C,F--56432088(+) GCACTG/ACAGAT 1 -- ut312Minor allele frequency- A:0.02WA NA 238
    rs1439570221,2
    		--56432201(+) GAATGA/GTGTTT 1 -- ut310--------
    rs1913195151,2
    		--56432219(+) TCCTTC/TCCTTT 1 -- ut310--------
    rs1115947161,2
    		F--56432234(+) GGAGCC/AGGACT 1 -- ut311Minor allele frequency- A:0.50CSA 4
    rs1403527041,2
    		C--56432264(+) AACACA/TTCTGG 1 -- ut310--------
    rs354455161,2
    		C--56432318(-) TGTGTG/CAACAG 2 /Q /E mis11Minor allele frequency- C:0.01NA 76

    HapMap Linkage Disequilibrium report for RNF43 (56429861 - 56494956 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RNF43
         2 CNVs: 4410 49893

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    Disorders / Diseases
    for RNF43 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF43 for disorders           About GeneDecksing

    OMIM gene information: 612482    OMIM disorders: --

    10 diseases for RNF43:    About MalaCards
    colon cancer    motion sickness    sigmoid colon cancer    lung adenocarcinoma
    hepatocellular carcinoma    pancreatic cancer    colorectal cancer    adenocarcinoma
    pancreatitis    carcinoma


    Export disorders for RNF43 gene to outside databases

    Publications
    for RNF43 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF43 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with RNF43)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. (PubMed id 15492824)1, 2, 9 Yagyu R....Nakamura Y. (2004)
    2. Ring finger protein 43 as a new target for cancer immunotherapy. (PubMed id 15623641)1, 2, 9 Uchida N.... Tahara H. (2004)
    3. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. (PubMed id 22895187)1, 2 Koo B.K....Clevers H. (2012)
    4. A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95. (PubMed id 18313049)1, 2 Sugiura T.... Miyamoto K. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PubMed id 22575959)2 Hao H.X....Cong F. (2012)
    8. RNF43 interacts with NEDL1 and regulates p53-mediated transcription. (PubMed id 21108931)1 Shinada K....Hatakeyama S. (2011)
    9. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1 Low S.K....Sakamoto H. (2010)
    10. The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. (PubMed id 19336002)1 Zhou W....Zhang L. (2009)

    External Searches for RNF43 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing RNF43 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54894 HGNC: 18505 AceView: SUPT4H1andFLJ20315 Ensembl:ENSG00000108375 euGenes: HUgn54894
    ECgene: RNF43 H-InvDB: RNF43

    Other Databases showing RNF43 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF43 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF43 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF43 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RNF43 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF43 gene:
    Search GeneIP for patents involving RNF43

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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