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Aliases for RNF43 Gene

Aliases for RNF43 Gene

  • Ring Finger Protein 43 2 3
  • RNF124 3 6
  • E3 Ubiquitin-Protein Ligase RNF43 3
  • RING Finger Protein 43 4
  • EC 6.3.2.- 4
  • URCC 3

External Ids for RNF43 Gene

Previous GeneCards Identifiers for RNF43 Gene

  • GC17U990330
  • GC17M053787
  • GC17M056429
  • GC17M051791

Summaries for RNF43 Gene

Entrez Gene Summary for RNF43 Gene

  • The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

GeneCards Summary for RNF43 Gene

RNF43 (Ring Finger Protein 43) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and frizzled binding. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF43 Gene

  • E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF43 Gene

Genomics for RNF43 Gene

Regulatory Elements for RNF43 Gene

Genomic Location for RNF43 Gene

Start:
58,352,500 bp from pter
End:
58,417,595 bp from pter
Size:
65,096 bases
Orientation:
Minus strand

Genomic View for RNF43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF43 Gene

Proteins for RNF43 Gene

  • Protein details for RNF43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DV7-RNF43_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF43
    Protein Accession:
    Q68DV7
    Secondary Accessions:
    • A8K4R2
    • B7Z443
    • B7Z5D5
    • B7Z5J5
    • Q65ZA4
    • Q6AI04
    • Q9NXD0

    Protein attributes for RNF43 Gene

    Size:
    783 amino acids
    Molecular mass:
    85722 Da
    Quaternary structure:
    • Interacts with AKAP8L, NONO and SFPQ. Interacts with FZD5. Identified in a complex composed of RNF43, LGR5 and RSPO1.
    Miscellaneous:
    • Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy.
    SequenceCaution:
    • Sequence=BAH12871.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF43 Gene

    Alternative splice isoforms for RNF43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF43 Gene

Proteomics data for RNF43 Gene at MOPED

Post-translational modifications for RNF43 Gene

Other Protein References for RNF43 Gene

No data available for DME Specific Peptides for RNF43 Gene

Domains for RNF43 Gene

Gene Families for RNF43 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF43 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF43 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q68DV7

UniProtKB/Swiss-Prot:

RNF43_HUMAN :
  • Q68DV7
Family:
  • Belongs to the ZNRF3 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF43: view

Function for RNF43 Gene

Molecular function for RNF43 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Enzyme Numbers (IUBMB) for RNF43 Gene

Gene Ontology (GO) - Molecular Function for RNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 22575959
GO:0004871 signal transducer activity --
GO:0005109 frizzled binding IPI 22895187
GO:0005515 protein binding IPI 18313049
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF43: view

Phenotypes for RNF43 Gene

genes like me logo Genes that share phenotypes with RNF43: view

miRNA for RNF43 Gene

miRTarBase miRNAs that target RNF43

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF43 Gene

Localization for RNF43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF43 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269 PubMed:15492824}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF43 Gene COMPARTMENTS Subcellular localization image for RNF43 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RNF43: view

Pathways for RNF43 Gene

SuperPathways for RNF43 Gene

No Data Available

UniProtKB/Swiss-Prot Q68DV7-RNF43_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0016055 Wnt signaling pathway IEA --
GO:0016567 protein ubiquitination IDA 22575959
GO:0030178 negative regulation of Wnt signaling pathway IMP 22575959
GO:0038018 Wnt receptor catabolic process IDA 22895187
genes like me logo Genes that share ontologies with RNF43: view

No data available for Pathways by source for RNF43 Gene

Transcripts for RNF43 Gene

Unigene Clusters for RNF43 Gene

Ring finger protein 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF43 Gene

No ASD Table

Relevant External Links for RNF43 Gene

GeneLoc Exon Structure for
RNF43
ECgene alternative splicing isoforms for
RNF43

Expression for RNF43 Gene

mRNA expression in normal human tissues for RNF43 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF43 Gene

This gene is overexpressed in Colon - Transverse (4.3).

SOURCE GeneReport for Unigene cluster for RNF43 Gene Hs.584916

mRNA Expression by UniProt/SwissProt for RNF43 Gene

Q68DV7-RNF43_HUMAN
Tissue specificity: Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
genes like me logo Genes that share expressions with RNF43: view

No data available for Protein expression for RNF43 Gene

Orthologs for RNF43 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF43 35
  • 99.36 (n)
  • 99.11 (a)
RNF43 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF43 35
  • 86.04 (n)
  • 86.21 (a)
RNF43 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF43 35
  • 89.12 (n)
  • 87.52 (a)
RNF43 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf43 35
  • 84.23 (n)
  • 82.44 (a)
Rnf43 16
Rnf43 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF43 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF43 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf43 35
  • 84.53 (n)
  • 83.46 (a)
chicken
(Gallus gallus)
Aves RNF43 35
  • 63.62 (n)
  • 59.77 (a)
RNF43 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF43 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y47D3B.11 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8714 36
  • 25 (a)
OneToMany
Species with no ortholog for RNF43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RNF43 Gene

ENSEMBL:
Gene Tree for RNF43 (if available)
TreeFam:
Gene Tree for RNF43 (if available)

Paralogs for RNF43 Gene

Selected SIMAP similar genes for RNF43 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF43: view

Variants for RNF43 Gene

Sequence variations from dbSNP and Humsavar for RNF43 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs720236 -- 58,408,459(+) GCACG(C/T)TAATA intron-variant
rs723991 -- 58,404,678(+) AAAAT(A/G)GTACT intron-variant
rs757484 -- 58,379,736(-) CTCTT(C/G)TTCTC intron-variant
rs917016 -- 58,376,795(-) CCACA(A/G)CCACA intron-variant
rs1047285 -- 58,376,405(-) TACTA(G/T)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF43 Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv908641 CNV Loss 21882294

Relevant External Links for RNF43 Gene

HapMap Linkage Disequilibrium report
RNF43
Human Gene Mutation Database (HGMD)
RNF43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF43 Gene

Disorders for RNF43 Gene

Relevant External Links for RNF43

Genetic Association Database (GAD)
RNF43
genes like me logo Genes that share disorders with RNF43: view

No data available for UniProtKB/Swiss-Prot for RNF43 Gene

Publications for RNF43 Gene

  1. A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. (PMID: 15492824) Yagyu R. … Nakamura Y. (Int. J. Oncol. 2004) 3 4 23
  2. Ring finger protein 43 as a new target for cancer immunotherapy. (PMID: 15623641) Uchida N. … Tahara H. (Clin. Cancer Res. 2004) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95. (PMID: 18313049) Sugiura T. … Miyamoto K. (Exp. Cell Res. 2008) 3 4

Products for RNF43 Gene

  • antibodies-online peptides for RNF43
  • antibodies-online antibodies for RNF43
  • antibodies-online kits for RNF43

Sources for RNF43 Gene

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