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RNF41 Gene

protein-coding   GIFtS: 58
GCID: GC12M056598

Ring Finger Protein 41, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 41)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 41, E3 Ubiquitin Protein Ligase1 2     Fetal Liver Ring Finger2
RING Finger Protein 411 3     Neuregulin Receptor Degradation Protein-12
FLRF2 3     EC 6.3.2.-3
NRDP12 3     EC 6.3.28
E3 Ubiquitin-Protein Ligase NRDP12     

External Ids:    HGNC: 184011   Entrez Gene: 101932   Ensembl: ENSG000001818527   UniProtKB: Q9H4P43   

Export aliases for RNF41 gene to outside databases

Previous GC identifers: GC12M056315 GC12M054884 GC12M053637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF41 Gene:
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling
by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun 2011)

GeneCards Summary for RNF41 Gene:
RNF41 (ring finger protein 41, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and interleukin-3 receptor binding. An important paralog of this gene is RNF151.

UniProtKB/Swiss-Prot: RNF41_HUMAN, Q9H4P4
Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates
MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote
TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the
ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels
of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into
myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating
its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and
thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that
accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular
redox state

Gene Wiki entry for RNF41 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF41 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF41 promoter sequence
   Search Chromatin IP Primers for RNF41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.13

RNF41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF41 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M056598:  view genomic region     (about GC identifiers)

Start:
56,596,288 bp from pter      End:
56,615,753 bp from pter
Size:
19,466 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNF41_HUMAN, Q9H4P4 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase NRDP1  
Size: 317 amino acids; 35905 Da
Subunit: Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1 (By
similarity)
Sequence caution: Sequence=AAG01988.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for RNF41:
2FZP (3D)        2GWF (3D)    
Secondary accessions: A6NFW0 B2RBT8 O75598
Alternative splicing: 2 isoforms:  Q9H4P4-1   Q9H4P4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF41: NX_Q9H4P4

Explore proteomics data for RNF41 at MOPED

Post-translational modifications: 

  • Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized
    which induces apoptosis1
  • Ubiquitination2 at Lys174
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF41 (Q9H4P4) (see all 11)
     NPNLQNLEE  GCGLEMPKDE  CPICSGVLEEPV  DCEHNPKRPVTCE 


    See RNF41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001229755.1  NP_005776.1  NP_919339.1  NP_919340.1  

    ENSEMBL proteins: 
     ENSP00000342755   ENSP00000449575   ENSP00000377581   ENSP00000447303   ENSP00000450164  
     ENSP00000448187   ENSP00000446595   ENSP00000448330  
    Reactome Protein details: Q9H4P4

    RNF41 Human Recombinant Protein Products:

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    antibodies-online peptides for RNF41

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 8):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR015036 USP8_interacting
     IPR013010 Znf_SIAH

    Graphical View of Domain Structure for InterPro Entry Q9H4P4

    ProtoNet protein and cluster: Q9H4P4

    UniProtKB/Swiss-Prot: RNF41_HUMAN, Q9H4P4
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SIAH-type zinc finger


    Find genes that share domains with RNF41           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF41_HUMAN, Q9H4P4
    Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates
    MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote
    TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the
    ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels
    of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into
    myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating
    its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and
    thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that
    accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular
    redox state

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0005128erythropoietin receptor binding IEA--
    GO:0005135interleukin-3 receptor binding IEA--
    GO:0005515protein binding IPI11867753
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RNF41           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RNF41:
     Increased G1 DNA content  Increased cell death HMECs cel  Low eccentricity cells  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rnf41):
     reproductive system 

    Find genes that share phenotypes with RNF41           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF41

    miRNA
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    miRTarBase miRNAs that target RNF41:
    hsa-mir-7-5p (MIRT025964), hsa-mir-877-5p (MIRT037304), hsa-mir-130b-3p (MIRT020324), hsa-mir-19b-3p (MIRT031241), hsa-mir-708-5p (MIRT037744), hsa-mir-183-5p (MIRT025017), hsa-mir-320a (MIRT044633)

    Block miRNA regulation of human, mouse, rat RNF41 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF41 (see all 103):
    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-149 hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidRNF41 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF41

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RNF41           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF41 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Signaling by FGFR
    Signaling by ERBB20.89
    Downregulation of ERBB2-ERBB3 signaling0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4Translation Insulin regulation of translation
    ErbB2/ErbB3 signaling events0.31
    5Endocytosis
    Endocytosis


    Find genes that share SuperPaths with RNF41           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNF41
        ErbB2/ErbB3 signaling events


    2 Reactome Pathways for RNF41
        Antigen processing: Ubiquitination & Proteasome degradation
    Downregulation of ERBB2:ERBB3 signaling


    1 Kegg Pathway  (Kegg details for RNF41):
        Endocytosis

    UniProtKB/Swiss-Prot: RNF41_HUMAN, Q9H4P4
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF41: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF41

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF41 (Q9H4P43 ENSP000003427554) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3AP842433, ENSP000003557784I2D: score=1 STRING: ENSP00000355778
    MARK4Q96L343, ENSP000003008434I2D: score=2 STRING: ENSP00000300843
    TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    H3F3BP842433I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA14765125
    GO:0008285negative regulation of cell proliferation IDA17145873
    GO:0016567protein ubiquitination ----
    GO:0030336negative regulation of cell migration IMP17145873
    GO:0043408regulation of MAPK cascade IDA17145873

    Find genes that share ontologies with RNF41           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF41

    1 Novoseek inferred chemical compound relationship for RNF41 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 45 1 15314180 (1)



    Find genes that share compounds with RNF41           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF41 gene (4 alternative transcripts): 
    NM_001242826.1  NM_005785.3  NM_194358.2  NM_194359.2  

    Unigene Cluster for RNF41:

    Ring finger protein 41
    Hs.524502  [show with all ESTs]
    Unigene Representative Sequence: NR_040053
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345093(uc021qyz.1 uc001ske.2 uc001skf.2 uc001skg.2 uc010sqh.2 uc010sqg.2)
    ENST00000547967 ENST00000394013 ENST00000552656 ENST00000548120 ENST00000551711
    ENST00000552244 ENST00000549038 ENST00000549119 ENST00000548225 ENST00000550379

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    hsa-miR-607 hsa-miR-15a hsa-miR-1224-3p hsa-miR-1260b hsa-miR-149 hsa-miR-3622b-3p hsa-miR-3116 hsa-miR-29a*
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    Additional mRNA sequence: 

    AF077599.1 AK300752.1 AK314811.1 AL080105.1 AY007109.1 BC011626.1 BC024284.1 BC032637.1 
    BC036267.1 BC095418.1 NR_040053.1 

    10 DOTS entries:

    DT.452620  DT.101984473  DT.100813560  DT.121206392  DT.437067  DT.97802216  DT.40133052  DT.97843303 
    DT.100813549  DT.121206394 

    Selected AceView cDNA sequences (see all 317):

    CD513755 BE741105 CN484896 BE251903 AI568020 AI198332 BP369779 D55820 
    BM930341 BU675667 AF077599 BM682139 AI693169 AA721471 BP370158 CR623486 
    AA155950 BM702640 BX376497 BM458263 AA485443 CN484905 NM_194358 CR602750 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF41 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -                                                     -                                             
    SP2:                          -                                                     -                             -               
    SP3:                          -                       -     -     -                 -                             -               
    SP4:                                                  -     -     -                 -                                             
    SP5:              -     -     -                       -     -     -                 -                                             


    ECgene alternative splicing isoforms for RNF41

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF41 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF41 Expression
    About this image


    RNF41 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
    RNF41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF41 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524502

    UniProtKB/Swiss-Prot: RNF41_HUMAN, Q9H4P4
    Tissue specificity: Detected in ovary, testis and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF41: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF41

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF41 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf411 , 5 ring finger protein 411, 5 92.22(n)1
    99.68(a)1
      10 (76.55 cM)5
    675881  NM_001164237.11  NP_001157709.11 
     1284116165 
    chicken
    (Gallus gallus)
    Aves RNF411 ring finger protein 41 83.81(n)
    97.15(a)
      426468  XM_424113.4  XP_424113.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF416
    ring finger protein 41
    97(a)
    1 ↔ 1
    2(93723309-93751259)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31572 Xenopus laevis transcribed sequence with moderate similarity more 80.51(n)    CA793141.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.116672 Danio rerio mRNA similar to hypothetical SBBI03 protein more 77.57(n)    BC045329.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta elgi1 early girl 60.85(n)
    57.46(a)
      39735  NM_001274975.1  NP_001261904.1 


    ENSEMBL Gene Tree for RNF41 (if available)
    TreeFam Gene Tree for RNF41 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF41 gene
    RNF1512  
    2 SIMAP similar genes for RNF41 using alignment to 6 protein entries:     RNF41_HUMAN (see all proteins):
    PDZRN4    RNF151

    Find genes that share paralogs with RNF41           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF41 (see all 416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124258551,2
    C,H--56595910(+) cctatC/Ttaaaa 5 -- ds50010--------
    rs47592191,2
    C,H--56595991(-) TACTAT/GTAAAA 5 -- ds50018Minor allele frequency- G:0.09NA WA CSA 249
    rs1810489441,2
    --56596336(+) AAAAGC/GAGGCA 5 -- ut31 nc-transcript-variant0--------
    rs1860575731,2
    --56596440(+) TTATCA/GTCCTT 5 -- ut31 nc-transcript-variant0--------
    rs1906332461,2
    --56596566(+) CTCATG/TTTCAC 5 -- ut31 nc-transcript-variant0--------
    rs1444190681,2
    --56596823(+) AGAAGC/TGCAGA 5 -- ut31 nc-transcript-variant0--------
    rs1995433191,2
    C--56596845(+) AATGCC/TTNNNN 5 -- ut31 nc-transcript-variant0--------
    rs1484057511,2
    --56596911(+) ATGATA/GAATGC 5 -- ut31 nc-transcript-variant0--------
    rs1999605571,2
    --56596966(+) TTCTT-/TTCTTCTT 5 -- cds1 nc-transcript-variant0--------
    rs574352921,2
    C--56596970(+) TTTTC-/TTTTCTT 5 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for RNF41 (56596288 - 56615753 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF41:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv720CNV Insertion18451855
    nsv482992CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF41
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF41

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF41           About GenesLikeMe

    1 Novoseek inferred disease relationship for RNF41 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 17145873 (2), 11867753 (1)

    Genetic Association Database (GAD): RNF41
    Human Genome Epidemiology (HuGE) Navigator: RNF41 (1 document)

    Export disorders for RNF41 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF41 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with RNF41)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PubMed id 15314180)1, 2, 9 Wu X.... Carraway K.L. III (Mol. Cell. Biol. 2004)
    2. Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population. (PubMed id 19800834)1, 4 Mo X....Xia K. (amp 2010)
    3. Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress. (PubMed id 18541373)1, 2 Yu F. and Zhou J. (Neurosci. Lett. 2008)
    4. Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. (PubMed id 17210635)1, 2 Cao Z.... Carraway K.L. III (Mol. Cell. Biol. 2007)
    5. Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). (PubMed id 17035239)1, 2 Avvakumov G.V.... Dhe-Paganon S. (J. Biol. Chem. 2006)
    6. RING finger ubiquitin-protein isopeptide ligase Nrdp1/FLRF regulates parkin stability and activity. (PubMed id 15632191)1, 2 Zhong L.... Zhou J. (J. Biol. Chem. 2005)
    7. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PubMed id 14765125)1, 2 Qiu X.B.... Goldberg A.L. (EMBO J. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. (PubMed id 12411582)1, 2 Qiu X.-B. and Goldberg A.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. (PubMed id 17384230)1, 9 Bouyain S. and Leahy D.J. (Protein Sci. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10193 HGNC: 18401 AceView: RNF41 Ensembl:ENSG00000181852 euGenes: HUgn10193
    ECgene: RNF41 Kegg: 10193 H-InvDB: RNF41

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF41 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF41 gene:
    Search GeneIP for patents involving RNF41

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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