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Aliases for RNF41 Gene

Aliases for RNF41 Gene

  • Ring Finger Protein 41, E3 Ubiquitin Protein Ligase 2 3
  • NRDP1 3 4
  • FLRF 3 4
  • Neuregulin Receptor Degradation Protein-1 3
  • E3 Ubiquitin-Protein Ligase NRDP1 3
  • Fetal Liver Ring Finger 3
  • Ring Finger Protein 41 2
  • RING Finger Protein 41 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • SBBI03 3

External Ids for RNF41 Gene

Previous GeneCards Identifiers for RNF41 Gene

  • GC12M056315
  • GC12M054884
  • GC12M056598
  • GC12M053637

Summaries for RNF41 Gene

Entrez Gene Summary for RNF41 Gene

  • This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

GeneCards Summary for RNF41 Gene

RNF41 (Ring Finger Protein 41, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include ubiquitin-protein transferase activity and interleukin-3 receptor binding. An important paralog of this gene is RNF151.

UniProtKB/Swiss-Prot for RNF41 Gene

  • Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Gene Wiki entry for RNF41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF41 Gene

Genomics for RNF41 Gene

Regulatory Elements for RNF41 Gene

Transcription factor binding sites by QIAGEN in the RNF41 gene promoter:

Genomic Location for RNF41 Gene

Start:
56,202,175 bp from pter
End:
56,221,970 bp from pter
Size:
19,796 bases
Orientation:
Minus strand

Genomic View for RNF41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF41 Gene

Proteins for RNF41 Gene

  • Protein details for RNF41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4P4-RNF41_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NRDP1
    Protein Accession:
    Q9H4P4
    Secondary Accessions:
    • A6NFW0
    • B2RBT8
    • O75598

    Protein attributes for RNF41 Gene

    Size:
    317 amino acids
    Molecular mass:
    35905 Da
    Quaternary structure:
    • Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with CLEC16A (By similarity).
    SequenceCaution:
    • Sequence=AAG01988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF41 Gene

    Alternative splice isoforms for RNF41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF41 Gene

Proteomics data for RNF41 Gene at MOPED

Post-translational modifications for RNF41 Gene

  • Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
  • Ubiquitination at Lys174
  • Modification sites at PhosphoSitePlus

Domains for RNF41 Gene

Gene Families for RNF41 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for RNF41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4P4

UniProtKB/Swiss-Prot:

RNF41_HUMAN :
  • Q9H4P4
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 SIAH-type zinc finger.
genes like me logo Genes that share domains with RNF41: view

Function for RNF41 Gene

Molecular function for RNF41 Gene

UniProtKB/Swiss-Prot Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Enzyme Numbers (IUBMB) for RNF41 Gene

Gene Ontology (GO) - Molecular Function for RNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005128 erythropoietin receptor binding IEA --
GO:0005135 interleukin-3 receptor binding IEA --
GO:0005515 protein binding IPI 11867753
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF41: view

Phenotypes for RNF41 Gene

genes like me logo Genes that share phenotypes with RNF41: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF41 Gene

Localization for RNF41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF41 Gene COMPARTMENTS Subcellular localization image for RNF41 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for RNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RNF41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF41 Gene

Pathways for RNF41 Gene

genes like me logo Genes that share pathways with RNF41: view

UniProtKB/Swiss-Prot Q9H4P4-RNF41_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 14765125
GO:0006914 autophagy IEA --
GO:0008285 negative regulation of cell proliferation IDA 17145873
GO:0010468 regulation of gene expression --
GO:0010498 proteasomal protein catabolic process IDA 18541373
genes like me logo Genes that share ontologies with RNF41: view

Compounds for RNF41 Gene

(1) Novoseek inferred chemical compound relationships for RNF41 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 45 1
genes like me logo Genes that share compounds with RNF41: view

Transcripts for RNF41 Gene

Unigene Clusters for RNF41 Gene

Ring finger protein 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF41 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for RNF41 Gene

GeneLoc Exon Structure for
RNF41
ECgene alternative splicing isoforms for
RNF41

Expression for RNF41 Gene

mRNA expression in normal human tissues for RNF41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF41 Gene

SOURCE GeneReport for Unigene cluster for RNF41 Gene Hs.524502

mRNA Expression by UniProt/SwissProt for RNF41 Gene

Q9H4P4-RNF41_HUMAN
Tissue specificity: Detected in ovary, testis and prostate.
genes like me logo Genes that share expressions with RNF41: view

No data available for mRNA differential expression in normal tissues for RNF41 Gene

Orthologs for RNF41 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF41 35
  • 99.89 (n)
  • 100 (a)
RNF41 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF41 35
  • 92.64 (n)
  • 99.68 (a)
RNF41 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF41 35
  • 95.16 (n)
  • 100 (a)
RNF41 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf41 35
  • 92.22 (n)
  • 99.68 (a)
Rnf41 16
Rnf41 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF41 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf41 35
  • 91.47 (n)
  • 99.66 (a)
chicken
(Gallus gallus)
Aves RNF41 35
  • 83.81 (n)
  • 97.15 (a)
RNF41 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF41 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3157 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf41 35
  • 81.91 (n)
  • 95.27 (a)
Str.4381 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.721 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11667 35
rnf41 35
  • 78.13 (n)
  • 90.54 (a)
rnf41 36
  • 91 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001882 35
  • 61.06 (n)
  • 58.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta elgi 35
  • 60.85 (n)
  • 57.46 (a)
elgi 36
  • 57 (a)
OneToOne
Species with no ortholog for RNF41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF41 Gene

ENSEMBL:
Gene Tree for RNF41 (if available)
TreeFam:
Gene Tree for RNF41 (if available)

Paralogs for RNF41 Gene

Paralogs for RNF41 Gene

Selected SIMAP similar genes for RNF41 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNF41: view

Variants for RNF41 Gene

Sequence variations from dbSNP and Humsavar for RNF41 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs703822 -- 56,206,744(-) ATCTC(A/G)ACTCC synonymous-codon, reference, nc-transcript-variant
rs703823 -- 56,207,453(-) TTATG(C/T)GTTTG intron-variant
rs773654 -- 56,204,260(-) TGTGT(A/G)CTTCC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs773655 -- 56,203,799(-) gaacc(C/T)gggag utr-variant-3-prime, nc-transcript-variant
rs773656 -- 56,203,736(-) agagc(A/G)aggct utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF41 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789
nsv720 CNV Insertion 18451855

Relevant External Links for RNF41 Gene

HapMap Linkage Disequilibrium report
RNF41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF41 Gene

Disorders for RNF41 Gene

(1) Novoseek inferred disease relationships for RNF41 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for RNF41

Genetic Association Database (GAD)
RNF41
Human Genome Epidemiology (HuGE) Navigator
RNF41
genes like me logo Genes that share disorders with RNF41: view

No data available for UniProtKB/Swiss-Prot for RNF41 Gene

Publications for RNF41 Gene

  1. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PMID: 15314180) Wu X. … Carraway K.L. III (Mol. Cell. Biol. 2004) 3 4 23
  2. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. (PMID: 17145873) Yen L. … Carraway K.L. (Cancer Res. 2006) 3 23
  3. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. (PMID: 17384230) Bouyain S. … Leahy D.J. (Protein Sci. 2007) 3 23
  4. Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. (PMID: 12411582) Qiu X.-B. … Goldberg A.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  5. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. (PMID: 14765125) Qiu X.B. … Goldberg A.L. (EMBO J. 2004) 3 4

Products for RNF41 Gene

  • Addgene plasmids for RNF41

Sources for RNF41 Gene

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