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Aliases for RNF41 Gene

Aliases for RNF41 Gene

  • Ring Finger Protein 41 2 3
  • Ring Finger Protein 41, E3 Ubiquitin Protein Ligase 2 3 5
  • NRDP1 3 4
  • FLRF 3 4
  • Neuregulin Receptor Degradation Protein-1 3
  • Fetal Liver Ring Finger 3
  • RING Finger Protein 41 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • SBBI03 3

External Ids for RNF41 Gene

Previous GeneCards Identifiers for RNF41 Gene

  • GC12M056315
  • GC12M054884
  • GC12M056598
  • GC12M053637

Summaries for RNF41 Gene

Entrez Gene Summary for RNF41 Gene

  • This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

GeneCards Summary for RNF41 Gene

RNF41 (Ring Finger Protein 41) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity and acid-amino acid ligase activity. An important paralog of this gene is RNF151.

UniProtKB/Swiss-Prot for RNF41 Gene

  • Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Gene Wiki entry for RNF41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF41 Gene

Genomics for RNF41 Gene

Regulatory Elements for RNF41 Gene

Enhancers for RNF41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF41 on UCSC Golden Path with GeneCards custom track

Promoters for RNF41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF41 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RNF41 gene promoter:

Genomic Location for RNF41 Gene

Chromosome:
12
Start:
56,202,175 bp from pter
End:
56,221,982 bp from pter
Size:
19,808 bases
Orientation:
Minus strand

Genomic View for RNF41 Gene

Genes around RNF41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF41 Gene

Proteins for RNF41 Gene

  • Protein details for RNF41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4P4-RNF41_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase NRDP1
    Protein Accession:
    Q9H4P4
    Secondary Accessions:
    • A6NFW0
    • B2RBT8
    • O75598

    Protein attributes for RNF41 Gene

    Size:
    317 amino acids
    Molecular mass:
    35905 Da
    Quaternary structure:
    • Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with CLEC16A (By similarity).
    SequenceCaution:
    • Sequence=AAG01988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF41 Gene

    Alternative splice isoforms for RNF41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF41 Gene

Proteomics data for RNF41 Gene at MOPED

Post-translational modifications for RNF41 Gene

  • Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
  • Ubiquitination at Lys 174
  • Modification sites at PhosphoSitePlus

Domains & Families for RNF41 Gene

Gene Families for RNF41 Gene

Suggested Antigen Peptide Sequences for RNF41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4P4

UniProtKB/Swiss-Prot:

RNF41_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 SIAH-type zinc finger.
genes like me logo Genes that share domains with RNF41: view

Function for RNF41 Gene

Molecular function for RNF41 Gene

UniProtKB/Swiss-Prot Function:
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Enzyme Numbers (IUBMB) for RNF41 Gene

Gene Ontology (GO) - Molecular Function for RNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005135 interleukin-3 receptor binding IEA --
GO:0016881 acid-amino acid ligase activity IEA --
genes like me logo Genes that share ontologies with RNF41: view
genes like me logo Genes that share phenotypes with RNF41: view

Animal Model Products

miRNA for RNF41 Gene

miRTarBase miRNAs that target RNF41

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF41 Gene

Localization for RNF41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF41 Gene COMPARTMENTS Subcellular localization image for RNF41 gene
Compartment Confidence
cytosol 5
nucleus 4
lysosome 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF41 Gene

Pathways & Interactions for RNF41 Gene

genes like me logo Genes that share pathways with RNF41: view

UniProtKB/Swiss-Prot Q9H4P4-RNF41_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0010498 proteasomal protein catabolic process IDA 18541373
GO:0030336 negative regulation of cell migration IMP 17145873
GO:0045619 regulation of lymphocyte differentiation IEA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF41: view

No data available for SIGNOR curated interactions for RNF41 Gene

Drugs & Compounds for RNF41 Gene

(1) Drugs for RNF41 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNF41: view

Transcripts for RNF41 Gene

Unigene Clusters for RNF41 Gene

Ring finger protein 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF41 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - - -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for RNF41 Gene

GeneLoc Exon Structure for
RNF41
ECgene alternative splicing isoforms for
RNF41

Expression for RNF41 Gene

mRNA expression in normal human tissues for RNF41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF41 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (54.7), Fetal testis (6.1), and Fetal gut (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF41 Gene



SOURCE GeneReport for Unigene cluster for RNF41 Gene Hs.524502

mRNA Expression by UniProt/SwissProt for RNF41 Gene

Q9H4P4-RNF41_HUMAN
Tissue specificity: Detected in ovary, testis and prostate.
genes like me logo Genes that share expression patterns with RNF41: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RNF41 Gene

Orthologs for RNF41 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF41 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF41 35
  • 92.64 (n)
  • 99.68 (a)
RNF41 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF41 35
  • 95.16 (n)
  • 100 (a)
RNF41 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf41 35
  • 92.22 (n)
  • 99.68 (a)
Rnf41 16
Rnf41 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF41 35
  • 99.89 (n)
  • 100 (a)
RNF41 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf41 35
  • 91.47 (n)
  • 99.66 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF41 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF41 35
  • 83.81 (n)
  • 97.15 (a)
RNF41 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF41 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf41 35
  • 81.91 (n)
  • 95.27 (a)
Str.4381 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3157 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11667 35
rnf41 35
  • 78.13 (n)
  • 90.54 (a)
rnf41 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.721 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001882 35
  • 61.06 (n)
  • 58.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta elgi 35
  • 60.85 (n)
  • 57.46 (a)
elgi 36
  • 57 (a)
OneToOne
Species with no ortholog for RNF41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF41 Gene

ENSEMBL:
Gene Tree for RNF41 (if available)
TreeFam:
Gene Tree for RNF41 (if available)

Paralogs for RNF41 Gene

Paralogs for RNF41 Gene

(2) SIMAP similar genes for RNF41 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNF41: view

Variants for RNF41 Gene

Sequence variations from dbSNP and Humsavar for RNF41 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2056730 -- 56,211,535(+) AAATG(C/T)CCAGA intron-variant
rs7301339 -- 56,204,890(+) GAGCC(C/T)TTCTA nc-transcript-variant, utr-variant-3-prime
rs10876879 -- 56,216,101(+) TAGGC(A/G)ACAGA intron-variant
rs703822 -- 56,206,744(-) ATCTC(A/G)ACTCC nc-transcript-variant, reference, synonymous-codon
rs703823 -- 56,207,453(-) TTATG(C/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF41 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789
nsv720 CNV Insertion 18451855

Variation tolerance for RNF41 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF41 Gene

Disorders for RNF41 Gene

Relevant External Links for RNF41

Genetic Association Database (GAD)
RNF41
Human Genome Epidemiology (HuGE) Navigator
RNF41
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF41

No disorders were found for RNF41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF41 Gene

Publications for RNF41 Gene

  1. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PMID: 15314180) Wu X. … Carraway K.L. III (Mol. Cell. Biol. 2004) 3 4 23 67
  2. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. (PMID: 17384230) Bouyain S. … Leahy D.J. (Protein Sci. 2007) 3 23
  3. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. (PMID: 17145873) Yen L. … Carraway K.L. (Cancer Res. 2006) 3 23
  4. An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. (PMID: 11867753) Diamonti A.J. … Carraway K.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation. (PMID: 25330950) Jiang Y. … Niu J. (Tumour Biol. 2015) 3

Products for RNF41 Gene

Sources for RNF41 Gene

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