RNF40 Gene
protein-coding GIFtS: 59
GCID: GC16P030773
|
|
ring finger protein 40, E3 ubiquitin protein ligase(Previous name: ring finger protein 40 )
| |
Aliases
for RNF40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 40, E3 Ubiquitin Protein Ligase1 2 | | BRE1-B2 3 | | BRE1B1 2 3 | | 95 KDa Retinoblastoma Protein Binding Protein2 | | RBP951 2 3 | | BRE1 E3 Ubiquitin Ligase Homolog B2 | | STARING1 2 | | E3 Ubiquitin-Protein Ligase BRE1B2 | | KIAA06611 3 | | Rb-Associated Protein2 | | RING Finger Protein 401 3 | | EC 6.3.2.-3 | | 95 KDa Retinoblastoma-Associated Protein2 3 | | EC 6.3.28 |
Export aliases for RNF40 gene to outside databasesPrevious GC identifers: GC16P030056 GC16P031262 GC16P030770 GC16P030809 GC16P030681 GC16P028337 |
Summaries
for RNF40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF40:
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of therat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate theubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter releasemachinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for thisgene. (provided by RefSeq, May 2011)
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120'of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is alsoprerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays acentral role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex incooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.Required for transcriptional activation of Hox genes
Gene Wiki entry for RNF40
|
Genomic Views
for RNF40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF40 gene promoter:
ATF-2 Lmo2 Nkx2-5 Cdc5 c-Ets-1 Pax-3 PPAR-gamma1 Ik-2 PPAR-gamma2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2-p11.1 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2-p11.1RNF40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P030773: view genomic region
(about GC identifiers)
Start:
|
30,773,066 bp from pter |
End:
|
30,787,628 bp from pter |
Size:
|
14,563 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase BRE1B Size: 1001 amino acids; 113650 Da
Subunit: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1Aand 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1 and WAC
Subcellular location: Nucleus
Sequence caution: Sequence=BAA31636.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAE45869.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q6AHZ6 Q6N005 Q7L3T6 Q8N615 Q96T18 Q9BSV9 Q9HC82Alternative splicing: 3 isoforms: O75150-1 O75150-3 O75150-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF40: NX_O75150
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75150
4/18 DME Specific Peptides for RNF40 (O75150) (see all 18)
RNF40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001193962.1 NP_001193963.1 NP_055586.1
ENSEMBL proteins: ENSP00000455678 ENSP00000325677 ENSP00000457697 ENSP00000456538 ENSP00000455180 ENSP00000350563 ENSP00000460142 ENSP00000384942
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
RNF40 for ontologies About GeneDecksing
RNF40 Antibody Products:
Assay Products for RNF40: |
Protein
Domains /
Families
for RNF40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF40 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75150ProtoNet protein and cluster: O75150 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150Similarity: Belongs to the BRE1 familySimilarity: Contains 1 RING-type zinc finger |
Function
for RNF40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120'of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is alsoprerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays acentral role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex incooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory.Required for transcriptional activation of Hox genesEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF40 (NM_014771) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF40 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
RNF40 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RNF40:
|
Pathways & Interactions
for RNF40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein Stability | | | 2 | DNA Damage | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Cell Signaling Technology (CST) Pathways for RNF40
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150Pathway: Protein modification; protein ubiquitination
RNF40 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF40
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/56 Interacting proteins for RNF40 (O751501, 2, 3 ENSP000003256774) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TRIM51 | Q9BSJ12, 3 | MINT-66497 I2D:
score=5 | | RNF20 | Q5VTR21, 2, 3, ENSP000003737724 | EBI-744408,EBI-2372238 MINT-8387176 I2D:
score=2 STRING: ENSP00000373772 | | RB1 | P064001, 3, ENSP000002671634 | EBI-744408,EBI-491274 I2D:
score=2 STRING: ENSP00000267163 | | ZNF451 | Q9Y4E52, 3, ENSP000003597404 | MINT-68396 I2D:
score=5 STRING: ENSP00000359740 | | NCBP1 | Q091613, ENSP000003642894 | I2D:
score=4 STRING: ENSP00000364289 |
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RNF40 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF40
Search CenterWatch for drugs/clinical trials and news about RNF40 / BRE1B
|
Transcripts
for RNF40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF40 gene (3 alternative transcripts): NM_001207033.1 NM_001207034.1 NM_014771.3 Unigene Cluster for RNF40: Ring finger protein 40, E3 ubiquitin protein ligase Hs.65238 [show with all ESTs]Unigene Representative Sequence: NM_01477112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000563909 ENST00000324685(uc010caa.3 uc002dzq.3 uc010cab.3 uc010vfa.2 uc002dzr.3 uc010vfb.2)
ENST00000566811 ENST00000565995 ENST00000563683 ENST00000357890 ENST00000565931
ENST00000493683 ENST00000566703 ENST00000564260 ENST00000567365 ENST00000402121(uc010vfc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF40 (NM_014771) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF40 |
Additional cDNA sequence: AB014561.1 AK027406.1 AK291666.1 AK297531.1 BC004527.2 BC006133.1 BC011769.2 BC018647.2 BC030802.1 BC113827.1 CR627431.1 24/34 DOTS entries (see all 34): DT.97794528 DT.86853373 DT.100887020 DT.100887027 DT.102845511 DT.101985549 DT.97855945 DT.100887043 DT.445993 DT.120714173 DT.99933784 DT.120714140 DT.100060379 DT.95266484 DT.99933835 DT.100887040 DT.102838763 DT.120714007 DT.91802974 DT.100765701 DT.100772308 DT.100832268 DT.101985550 DT.120714034 24/415 AceView cDNA sequences (see all 415): AI868427 BC011769 BI711116 BQ933846 BU931202 BM854816 CA448720 AI348164 Z43896 BG055903 F03139 BQ062152 BQ687874 AW247186 AA292101 CD626122 BI042624 BM013880 CK820415 BQ933392 BU158070 BQ688446 CA419010 BQ010157
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RNF40 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF40
|
Expression
for RNF40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCATCGGC
About this image
See RNF40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF40
SOURCE GeneReport for Unigene cluster: Hs.65238
UniProtKB/Swiss-Prot: BRE1B_HUMAN, O75150Tissue specificity: Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is onlyweakly expressed in lung, skeletal muscle and small intestine
SABiosciences Expression via Pathway-Focused PCR Arrays including RNF40: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat | | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF40 |
Orthologs
for RNF40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF40 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RNF406 |
-- |
74(a) |
1 ↔ 1 |
GL343516.1(66228-79872) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3985362 |
similar to ring finger protein 40 |
75.77(n) |
|
BC042342.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufk48a062 |
Transcribed sequence with moderate similarity to protein more |
81.28(n) |
|
CF996002.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG105423
Bre11 |
Bre11 |
47(a)3
57.28(n)1
48.99(a)1 |
|
64E83
386521 NM_139732.21 NP_647989.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
R05D3.43 |
-- |
30(a) |
|
III(8430362-8433823) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HUB21 |
E3 ubiquitin-protein ligase BRE1-like 2 |
39.93(n)
25.31(a) |
|
841968 NM_001198304.1 NP_001185233.1 |
rice
(Oryza sativa) |
Liliopsida |
Os10g05656001 |
hypothetical protein |
39.81(n)
25.49(a) |
|
4349420 NM_001071953.1 NP_001065421.1 |
ENSEMBL Gene Tree for RNF40 (if available)
TreeFam Gene Tree for RNF40 (if available) |
Paralogs
for RNF40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF40 gene
- RNF202
1 SIMAP similar gene for RNF40 using alignment to 7 protein entries: BRE1B_HUMAN (see all proteins):RNF20
RNF40 for paralogs About GeneDecksing
|
Genomic Variants
for RNF40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF40 (30773066 - 30787628 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNF40
2 CNVs: 30780 2209 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF40 |
|
Disorders
/ Diseases
for RNF40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF40 for disorders About GeneDecksing
OMIM gene information: 607700
OMIM disorders: --
5  diseases for RNF40: About MalaCardsretinoblastoma hermaphroditism prostate cancer prostatitis
neuronitis
Export disorders for RNF40 gene to outside databases
|
Publications
for RNF40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF40 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with RNF40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RBP95, a novel leucine zipper protein, binds to the retinoblastoma protein. (PubMed id 10944455)1, 2, 3 Wen H. and Ao S. (2000)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2, 9 Zhu B.... Reinberg D. (2005)
- WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. (PubMed id 21329877)1, 2 Zhang F. and Yu X. (2011)
- RAD6-Mediated transcription-coupled H2B ubiquitylatio n directly stimulates H3K4 methylation in human cells. (PubMed id 19410543)1, 2 Kim J....Roeder R.G. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation. (PubMed id 12121982)1, 3 Chin L.S....Li L. (2002)
- The tumor suppressor CDC73 interacts with the ring fin ger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B m onoubiquitination. (PubMed id 22021426)1 Hahn M.A....Marsh D.J. (2012)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
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External Searches for RNF40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RNF40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RNF40 gene
(According to HUGE)
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Specialized Databases showing RNF40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for RNF40 gene:
Search GeneIP for patents involving RNF40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RNF40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF40 | | | OriGene Protein Over-expression Lysate for RNF40 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF40 | | OriGene 3'-UTR Clone for RNF40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF40 | | OriGene Custom Protein Services for RNF40 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF40 |
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| | Antibodies & Assays for RNF40 |
| | | | Search Tocris compounds for RNF40 |
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 | | | RNF40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF40 |
|  |  |  | | | | ThermoFisher Antibodies for RNF40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF40 |
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