RNF4 Gene
protein-coding GIFtS: 57
GCID: GC04P002463
|
|
ring finger protein 4
| |
Aliases
for RNF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 41 2 3 | | E3 Ubiquitin Ligase RNF42 | | SNURF1 2 3 | | E3 Ubiquitin-Protein Ligase RNF42 | | SLX51 2 | | EC 6.3.2.-3 | | Small Nuclear Ring Finger Protein2 3 | | Protein SNURF3 | | RES4-261 | | |
Export aliases for RNF4 gene to outside databasesPrevious GC identifers: GC04P002465 GC04P002337 GC04P002432 GC04P002438 GC04P002410 |
Summaries
for RNF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF4:
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein hasbeen shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediatedtranscription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce theenhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and ratcounterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome1.(provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequenttargeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and thetranscriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochoreCENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellularresponses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may alsobind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basaltranscription and steroid receptor-mediated transcriptional activation
Gene Wiki entry for RNF4
|
Genomic Views
for RNF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF4 gene promoter:
HEN1 PPAR-gamma1 NF-1 Nkx6-1 Pax-2 HNF-4alpha2 PPAR-gamma2 Pax-2a HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3RNF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P002463: view genomic region
(about GC identifiers)
Start:
|
2,463,947 bp from pter |
End:
|
2,627,047 bp from pter |
Size:
|
163,101 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF4 Size: 190 amino acids; 21319 Da
Subunit: Homodimer (via RING-type zinc finger domain). Interacts with GSC2 (By similarity). Interacts with AR/theandrogen receptor and TBP (By similarity). Interacts with TCF20 (By similarity). Interacts with PATZ1. Interacts withTRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML; SUMO1-dependent. Interactswith PML; SUMO2-dependent. Interacts with PARP1
Subcellular location: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm
2 PDB 3D structures from  and Proteopedia  for RNF4:2EA6 (3D)
2XEU (3D)
Secondary accessions: B2R6D6 D6RF58 Q49AR8Alternative splicing: 2 isoforms: P78317-1 P78317-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF4: NX_P78317
Post-translational modifications:
Sumoylated; conjugated by one or two SUMO1 moieties (By similarity)1
Autoubiquitinated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P78317
RNF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001171938.1 NP_001171939.1 NP_002929.1
ENSEMBL proteins: ENSP00000423186 ENSP00000425667 ENSP00000315212 ENSP00000423100 ENSP00000422728 ENSP00000422500 ENSP00000425724 ENSP00000422938 ENSP00000426615 ENSP00000424076 ENSP00000426503 ENSP00000422619 ENSP00000427212 ENSP00000446369 Reactome Protein details: P78317
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RNF4 for ontologies About GeneDecksing
RNF4 Antibody Products:
Assay Products for RNF4: |
Protein
Domains /
Families
for RNF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P78317ProtoNet protein and cluster: P78317 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317Domain: The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates (Bysimilarity)Similarity: Contains 1 RING-type zinc finger |
Function
for RNF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317Function: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequenttargeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and thetranscriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochoreCENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellularresponses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may alsobind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basaltranscription and steroid receptor-mediated transcriptional activation Genatlas biochemistry entry for RNF4:RING finger protein 4,abundantly expressed in fetal tissues,involved in the protein and DNA association in the nucleusof the cell
Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RNF4 (NM_001185009) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF4 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
RNF4 for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rnf4):
RNF4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RNF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Androgen receptor signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for RNF4
5 
Reactome Pathways for RNF4
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317Pathway: Protein modification; protein ubiquitination
RNF4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/74 Interacting proteins for RNF4 (P783172, 3 ENSP000003152124) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0016567 | protein ubiquitination |
-- | -- | | GO:0030521 | androgen receptor signaling pathway |
NAS | 15572661 | | GO:0043161 | proteasomal ubiquitin-dependent protein catabolic process |
IMP | -- |
RNF4 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RNF4 for compounds About GeneDecksing
 Browse Tocris compounds for RNF4
4 Novoseek chemical compound relationships for RNF4 gene About this table
Search CenterWatch for drugs/clinical trials and news about RNF4
|
Transcripts
for RNF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF4 gene (3 alternative transcripts): NM_001185009.2 NM_001185010.2 NM_002938.4 Unigene Cluster for RNF4: Ring finger protein 4 Hs.740360 [show with all ESTs]Unigene Representative Sequence: AK12803818/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000503659 ENST00000504224 ENST00000314289(uc003gfb.3 uc010icj.3 uc003gfc.3)
ENST00000502316 ENST00000509388 ENST00000507247 ENST00000509258(uc010ici.2)
ENST00000511843 ENST00000504782 ENST00000513284 ENST00000507784 ENST00000513578
ENST00000511892 ENST00000511859 ENST00000513643 ENST00000503123 ENST00000509206
ENST00000506706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RNF4 (NM_001185009) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF4 |
Additional cDNA sequence: AB000468.1 AK128038.1 AK307372.1 AK309509.1 AK311314.1 AK312534.1 BC031935.1 U95140.1 24/25 DOTS entries (see all 25): DT.102824075 DT.418598 DT.99971300 DT.91670644 DT.91664071 DT.100793341 DT.40296901 DT.101984117 DT.95358974 DT.95358952 DT.121265842 DT.95118554 DT.100793343 DT.121265873 DT.91844988 DT.100793346 DT.86843942 DT.91849839 DT.95358946 DT.95358956 DT.121265806 DT.121265809 DT.92063829 DT.99994002 24/389 AceView cDNA sequences (see all 389): AU142773 BE275366 BE794591 CD655098 AU129999 BP354232 CD692446 BE697299 NM_002938 BP354272 CD656564 AA341612 BM785711 BG754096 AU130671 BM918597 AU129764 BU507746 BM479841 AA449395 BX462495 BM763930 D44752 BQ674461
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNF4 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF4
|
Expression
for RNF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATATCAGTC
About this image
See RNF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF4
SOURCE GeneReport for Unigene cluster: Hs.740360
UniProtKB/Swiss-Prot: RNF4_HUMAN, P78317Tissue specificity: Widely expressed at low levels in many tissues; highly expressed in testis
SABiosciences Expression via Pathway-Focused PCR Array including RNF4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF4 |
Orthologs
for RNF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF4 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for RNF4 (if available)
TreeFam Gene Tree for RNF4 (if available) |
Paralogs
for RNF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF4 gene
4 SIMAP similar genes for RNF4 using alignment to 11 protein entries: RNF4_HUMAN (see all proteins):PCGF3 RFWD2 RNF166 TRIM5
RNF4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RNF4
PGOHUM00000247103 PGOHUM00000245250
|
Genomic Variants
for RNF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RNF4
3 Indels: 68624 42809 34340 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF4 |
|
Disorders
/ Diseases
for RNF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF4 for disorders About GeneDecksing
OMIM gene information: 602850
OMIM disorders: --
7  diseases for RNF4: About MalaCardstesticular germ cell cancer testicular neoplasm germ cell cancer huntington's disease
breast cancer hypoxia leukemia
Human Genome Epidemiology (HuGE) Navigator: RNF4 (1 document)
Export disorders for RNF4 gene to outside databases
|
Publications
for RNF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF4 gene, integrated from 9 sources (see all 52):
(articles sorted by number of sources associating them with RNF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3. (PubMed id 9479498)1, 2, 3 Chiariotti L.... Bruni C.B. (1998)
- SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies. (PubMed id 15707587)1, 2, 9 Hakli M....Palvimo J.J. (2005)
- The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. (PubMed id 12885770)1, 2, 9 Kaiser F.J....Ludecke H.J. (2003)
- RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PubMed id 18408734)1, 2, 9 Tatham M.H....Hay R.T. (2008)
- Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies. (PubMed id 20943951)1, 2 Geoffroy M.C.... Hay R.T. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor. (PubMed id 10713105)1, 2 Fedele M....Chiatiotti L. (2000)
- The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3. (PubMed id 9734812)1, 2 Hadano S.... Ikeda J.-E. (1998)
- Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms. (PubMed id 10617653)1, 9 Poukka H....Palvimo J.J. (2000)
- Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein. (PubMed id 11696545)1, 9 Saville B....Safe S. (2002)
|
External Searches for RNF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF4 gene:
Search GeneIP for patents involving RNF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF4 | | | OriGene Protein Over-expression Lysate for RNF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF4 | | OriGene 3'-UTR Clone for RNF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF4 | | OriGene Custom Protein Services for RNF4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RNF4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RNF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF4 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF4 |
|
|
|
|
