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Aliases for RNF4 Gene

Aliases for RNF4 Gene

  • Ring Finger Protein 4 2 3
  • SNURF 3 4
  • Small Nuclear RING Finger Protein 3
  • Small Nuclear Ring Finger Protein 4
  • E3 Ubiquitin-Protein Ligase RNF4 3
  • E3 Ubiquitin Ligase RNF4 3
  • RING Finger Protein 4 4
  • Protein SNURF 4
  • EC 6.3.2.- 4
  • RES4-26 3
  • SLX5 3

External Ids for RNF4 Gene

Previous GeneCards Identifiers for RNF4 Gene

  • GC04P002465
  • GC04P002337
  • GC04P002432
  • GC04P002438
  • GC04P002463
  • GC04P002410

Summaries for RNF4 Gene

Entrez Gene Summary for RNF4 Gene

  • The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

GeneCards Summary for RNF4 Gene

RNF4 (Ring Finger Protein 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Coregulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF4 Gene

  • E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates Lys-6-, Lys-11-, Lys-48- and Lys-63-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Gene Wiki entry for RNF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF4 Gene

Genomics for RNF4 Gene

Regulatory Elements for RNF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF4 Gene

Start:
2,462,220 bp from pter
End:
2,625,320 bp from pter
Size:
163,101 bases
Orientation:
Plus strand

Genomic View for RNF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF4 Gene

Proteins for RNF4 Gene

  • Protein details for RNF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78317-RNF4_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF4
    Protein Accession:
    P78317
    Secondary Accessions:
    • B2R6D6
    • D6RF58
    • Q49AR8

    Protein attributes for RNF4 Gene

    Size:
    190 amino acids
    Molecular mass:
    21319 Da
    Quaternary structure:
    • Homodimer (via RING-type zinc finger domain). Interacts with GSC2 (By similarity). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with TCF20 (By similarity). Interacts with PATZ1. Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML; SUMO1-dependent. Interacts with PML; SUMO2-dependent. Interacts with PARP1. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6).

    Three dimensional structures from OCA and Proteopedia for RNF4 Gene

    Alternative splice isoforms for RNF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF4 Gene

Proteomics data for RNF4 Gene at MOPED

Post-translational modifications for RNF4 Gene

Antibody Products

No data available for DME Specific Peptides for RNF4 Gene

Domains for RNF4 Gene

Gene Families for RNF4 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF4 Gene

Suggested Antigen Peptide Sequences for RNF4 Gene

Graphical View of Domain Structure for InterPro Entry

P78317

UniProtKB/Swiss-Prot:

RNF4_HUMAN :
  • P78317
Domain:
  • The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF4: view

Function for RNF4 Gene

Molecular function for RNF4 Gene

GENATLAS Biochemistry:
RING finger protein 4,abundantly expressed in fetal tissues,involved in the protein and DNA association in the nucleus of the cell
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates Lys-6-, Lys-11-, Lys-48- and Lys-63-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Enzyme Numbers (IUBMB) for RNF4 Gene

Gene Ontology (GO) - Molecular Function for RNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9710597
GO:0003713 transcription coactivator activity NAS 15572661
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 12885770
genes like me logo Genes that share ontologies with RNF4: view

Phenotypes for RNF4 Gene

genes like me logo Genes that share phenotypes with RNF4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF4 Gene

Localization for RNF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF4 Gene

Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF4 Gene COMPARTMENTS Subcellular localization image for RNF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12885770
GO:0005737 cytoplasm IDA 12885770
GO:0016605 colocalizes_with PML body IDA 20943951
genes like me logo Genes that share ontologies with RNF4: view

Pathways for RNF4 Gene

genes like me logo Genes that share pathways with RNF4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P78317-RNF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 18408734
GO:0045893 positive regulation of transcription, DNA-templated ISS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12885770
genes like me logo Genes that share ontologies with RNF4: view

Compounds for RNF4 Gene

(4) Novoseek inferred chemical compound relationships for RNF4 Gene

Compound -log(P) Hits PubMed IDs
steroid 46.1 8
zinc 39.4 3
testosterone 37.7 5
estrogen 13.3 4
genes like me logo Genes that share compounds with RNF4: view

Transcripts for RNF4 Gene

Unigene Clusters for RNF4 Gene

Ring finger protein 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: -
SP3: - - - - - - -
SP4:
SP5:
SP6: -

Relevant External Links for RNF4 Gene

GeneLoc Exon Structure for
RNF4
ECgene alternative splicing isoforms for
RNF4

Expression for RNF4 Gene

mRNA expression in normal human tissues for RNF4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF4 Gene

SOURCE GeneReport for Unigene cluster for RNF4 Gene Hs.66394

mRNA Expression by UniProt/SwissProt for RNF4 Gene

P78317-RNF4_HUMAN
Tissue specificity: Widely expressed at low levels in many tissues; highly expressed in testis.
genes like me logo Genes that share expressions with RNF4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Expression partners for RNF4 Gene

Orthologs for RNF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF4 35
  • 84.41 (n)
  • 89.25 (a)
RNF4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF4 35
  • 89.12 (n)
  • 93.68 (a)
RNF4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf4 35
  • 88.95 (n)
  • 91.44 (a)
Rnf4 16
Rnf4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF4 35
  • 99.47 (n)
  • 99.47 (a)
RNF4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf4 35
  • 88.59 (n)
  • 93.05 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF4 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF4 35
  • 70.37 (n)
  • 70.9 (a)
RNF4 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF4 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf4 35
  • 61.72 (n)
  • 59.34 (a)
Str.2024 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5794 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17303 35
im:7142942 35
  • 53.33 (n)
  • 47.22 (a)
RNF4 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8525 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5143 36
  • 23 (a)
OneToOne
Species with no ortholog for RNF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF4 Gene

ENSEMBL:
Gene Tree for RNF4 (if available)
TreeFam:
Gene Tree for RNF4 (if available)

Paralogs for RNF4 Gene

Pseudogenes.org Pseudogenes for RNF4 Gene

genes like me logo Genes that share paralogs with RNF4: view

No data available for Paralogs for RNF4 Gene

Variants for RNF4 Gene

Sequence variations from dbSNP and Humsavar for RNF4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs704347 -- 2,468,886(-) CAAGG(C/T)TTTTC upstream-variant-2KB
rs704348 -- 2,469,410(-) GACGG(C/T)AGTGC upstream-variant-2KB, intron-variant
rs704349 -- 2,470,075(-) GGAAC(C/T)GACAA intron-variant
rs704350 -- 2,471,525(-) aactt(C/G)actta intron-variant
rs704351 -- 2,483,660(+) ttagc(C/T)gggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF4 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv878423 CNV Loss 21882294
nsv878433 CNV Loss 21882294
nsv518472 CNV Loss 19592680
dgv5424n71 CNV Loss 21882294
dgv5425n71 CNV Loss 21882294
nsv878442 CNV Loss 21882294
esv2823 CNV Deletion 18987735
esv25411 CNV Loss 19812545
esv2726853 CNV Deletion 23290073
nsv290753 CNV Loss 16902084

Relevant External Links for RNF4 Gene

HapMap Linkage Disequilibrium report
RNF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF4 Gene

Disorders for RNF4 Gene

Relevant External Links for RNF4

Genetic Association Database (GAD)
RNF4
Human Genome Epidemiology (HuGE) Navigator
RNF4

No disorders were found for RNF4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF4 Gene

Publications for RNF4 Gene

  1. The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor. (PMID: 12885770) Kaiser F.J. … Luedecke H.J. (J. Biol. Chem. 2003) 3 4 23
  2. Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3. (PMID: 9479498) Chiariotti L. … Bruni C.B. (Genomics 1998) 2 3 4
  3. SUMO-1 promotes association of SNURF (RNF4) with PML nuclear bodies. (PMID: 15707587) Haekli M. … Palvimo J.J. (Exp. Cell Res. 2005) 3 4 23
  4. RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. (PMID: 18408734) Tatham M.H. … Hay R.T. (Nat. Cell Biol. 2008) 3 4 23
  5. Oestrogen receptors and small nuclear ring finger protein 4 (RNF4) in malignant ovarian germ cell tumours. (PMID: 19524139) Salonen J. … Heikinheimo O. (Mol. Cell. Endocrinol. 2009) 3 23

Products for RNF4 Gene

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