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Aliases for RNF39 Gene

Aliases for RNF39 Gene

  • Ring Finger Protein 39 2 3
  • HZFW 3 4 6
  • Protein HZFw 3 4
  • LIRF 3 6
  • HZF 3 6
  • LTP (Long-Term Potentiation) Induced RING Finger Protein 3

External Ids for RNF39 Gene

Previous GeneCards Identifiers for RNF39 Gene

  • GC06M029808
  • GC06M030144
  • GC06M030146
  • GC06M030038
  • GC06M029837

Summaries for RNF39 Gene

Entrez Gene Summary for RNF39 Gene

  • This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF39 Gene

RNF39 (Ring Finger Protein 39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RNF39 Gene

  • May play a role in prolonged long term-potentiation (LTP) maintenance.

Gene Wiki entry for RNF39 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF39 Gene

Genomics for RNF39 Gene

Regulatory Elements for RNF39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF39 Gene

30,070,266 bp from pter
30,075,887 bp from pter
5,622 bases
Minus strand

Genomic View for RNF39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for RNF39 Gene

  • Protein details for RNF39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 39
    Protein Accession:
    Secondary Accessions:
    • A2BEK3
    • A6NCD6
    • B0S858
    • Q5SPM8
    • Q5SPM9
    • Q5SPN0
    • Q5SRJ9
    • Q5SRK1
    • Q5SS29
    • Q9H2S3
    • Q9H2S4

    Protein attributes for RNF39 Gene

    420 amino acids
    Molecular mass:
    45525 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF39 Gene


neXtProt entry for RNF39 Gene

Proteomics data for RNF39 Gene at MOPED

Post-translational modifications for RNF39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF39 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNF39 Gene

Domains for RNF39 Gene

Gene Families for RNF39 Gene

Suggested Antigen Peptide Sequences for RNF39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF39: view

Function for RNF39 Gene

Molecular function for RNF39 Gene

UniProtKB/Swiss-Prot Function:
May play a role in prolonged long term-potentiation (LTP) maintenance.

Gene Ontology (GO) - Molecular Function for RNF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF39: view

Phenotypes for RNF39 Gene

GenomeRNAi human phenotypes for RNF39:
genes like me logo Genes that share phenotypes with RNF39: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF39 Gene

Localization for RNF39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF39 Gene


Subcellular locations from

Jensen Localization Image for RNF39 Gene COMPARTMENTS Subcellular localization image for RNF39 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RNF39: view

Pathways for RNF39 Gene

SuperPathways for RNF39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with RNF39: view

No data available for Pathways by source for RNF39 Gene

Transcripts for RNF39 Gene

mRNA/cDNA for RNF39 Gene

Unigene Clusters for RNF39 Gene

Ring finger protein 39:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF39

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF39 Gene

No ASD Table

Relevant External Links for RNF39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF39 Gene

mRNA expression in normal human tissues for RNF39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF39 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.7), Skin - Sun Exposed (Lower leg) (10.9), Esophagus - Mucosa (5.7), Minor Salivary Gland (5.2), and Vagina (4.1).

Protein differential expression in normal tissues for RNF39 Gene

This gene is overexpressed in Frontal cortex (34.7) and Cervix (20.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF39 Gene

SOURCE GeneReport for Unigene cluster for RNF39 Gene Hs.121178

mRNA Expression by UniProt/SwissProt for RNF39 Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with RNF39: view

Expression partners for RNF39 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for RNF39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF39 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF39 35
  • 87.33 (n)
  • 85.43 (a)
(Canis familiaris)
Mammalia RNF39 35
  • 85.19 (n)
  • 86.61 (a)
RNF39 36
  • 85 (a)
(Mus musculus)
Mammalia Rnf39 35
  • 82.48 (n)
  • 83.24 (a)
Rnf39 16
Rnf39 36
  • 83 (a)
(Pan troglodytes)
Mammalia RNF39 35
  • 99.44 (n)
  • 99.29 (a)
RNF39 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnf39 35
  • 81.63 (n)
  • 81.82 (a)
(Ornithorhynchus anatinus)
Mammalia RNF39 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
-- 36
  • 21 (a)
-- 36
  • 34 (a)
Species with no ortholog for RNF39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF39 Gene

Gene Tree for RNF39 (if available)
Gene Tree for RNF39 (if available)

Paralogs for RNF39 Gene

(2) SIMAP similar genes for RNF39 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF39: view

No data available for Paralogs for RNF39 Gene

Variants for RNF39 Gene

Sequence variations from dbSNP and Humsavar for RNF39 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1057539 - 30,071,572(-) GCTTC(A/G)ATCAG missense, reference
rs1150735 -- 30,077,422(-) caggc(C/T)gatca upstream-variant-2KB
rs1150736 -- 30,075,178(-) GGGAG(A/G)TTCCC intron-variant
rs1150737 -- 30,074,752(-) GGCGA(C/G)GGCAG intron-variant
rs1245369 -- 30,073,931(-) TGTGT(C/T)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF39 Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV Deletion 23290073
nsv884049 CNV Loss 21882294

Relevant External Links for RNF39 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF39 Gene

Disorders for RNF39 Gene

Relevant External Links for RNF39

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RNF39 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF39 Gene

Publications for RNF39 Gene

  1. Transcriptional analysis of the 69-kb sequence centromeric to HLA-J: a dense and complex structure of five genes. (PMID: 11130983) Coriton O. … Mosser J. (Mamm. Genome 2000) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection. (PMID: 19050382) van Manen D. … Schuitemaker H. (AIDS 2009) 3 48
  4. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S. … Zagury J.F. (J. Infect. Dis. 2009) 3 48
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for RNF39 Gene

Sources for RNF39 Gene

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