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Aliases for RNF38 Gene

Aliases for RNF38 Gene

  • Ring Finger Protein 38 2 3
  • RING Finger Protein 38 4 5
  • EC 6.3.2.- 4

External Ids for RNF38 Gene

Previous GeneCards Identifiers for RNF38 Gene

  • GC09M036648
  • GC09M036505
  • GC09M036326
  • GC09M036289

Summaries for RNF38 Gene

Entrez Gene Summary for RNF38 Gene

  • This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for RNF38 Gene

RNF38 (Ring Finger Protein 38) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF44.

UniProtKB/Swiss-Prot for RNF38 Gene

  • Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

Gene Wiki entry for RNF38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF38 Gene

Genomics for RNF38 Gene

Regulatory Elements for RNF38 Gene

Promoters for RNF38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF38 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF38 Gene

Chromosome:
9
Start:
36,336,396 bp from pter
End:
36,487,548 bp from pter
Size:
151,153 bases
Orientation:
Minus strand

Genomic View for RNF38 Gene

Genes around RNF38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF38 Gene

Proteins for RNF38 Gene

  • Protein details for RNF38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0F5-RNF38_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF38
    Protein Accession:
    Q9H0F5
    Secondary Accessions:
    • A6PVP9
    • B1AM81
    • B1AM82
    • B3KSG4
    • E7EVL3
    • Q7LB33
    • Q8N0Y0
    • Q9H748

    Protein attributes for RNF38 Gene

    Size:
    515 amino acids
    Molecular mass:
    57595 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF38 Gene

    Alternative splice isoforms for RNF38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF38 Gene

Proteomics data for RNF38 Gene at MOPED

Post-translational modifications for RNF38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RNF38 Gene

Domains & Families for RNF38 Gene

Gene Families for RNF38 Gene

Protein Domains for RNF38 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF38 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0F5

UniProtKB/Swiss-Prot:

RNF38_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF38: view

Function for RNF38 Gene

Molecular function for RNF38 Gene

UniProtKB/Swiss-Prot Function:
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

Enzyme Numbers (IUBMB) for RNF38 Gene

Gene Ontology (GO) - Molecular Function for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23973461
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF38: view
genes like me logo Genes that share phenotypes with RNF38: view

Animal Models for RNF38 Gene

MGI Knock Outs for RNF38:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF38 Gene

Localization for RNF38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF38 Gene COMPARTMENTS Subcellular localization image for RNF38 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with RNF38: view

Pathways & Interactions for RNF38 Gene

SuperPathways for RNF38 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H0F5-RNF38_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF38: view

No data available for Pathways by source and SIGNOR curated interactions for RNF38 Gene

Drugs & Compounds for RNF38 Gene

No Compound Related Data Available

Transcripts for RNF38 Gene

Unigene Clusters for RNF38 Gene

Ring finger protein 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF38 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14: - - -
SP15:

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for RNF38 Gene

GeneLoc Exon Structure for
RNF38
ECgene alternative splicing isoforms for
RNF38

Expression for RNF38 Gene

mRNA expression in normal human tissues for RNF38 Gene

Protein differential expression in normal tissues from HIPED for RNF38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF38 Gene



SOURCE GeneReport for Unigene cluster for RNF38 Gene Hs.333503

mRNA Expression by UniProt/SwissProt for RNF38 Gene

Q9H0F5-RNF38_HUMAN
Tissue specificity: Widely expressed with highest levels in testis.
genes like me logo Genes that share expression patterns with RNF38: view

Protein tissue co-expression partners for RNF38 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF38 Gene

Orthologs for RNF38 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF38 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF38 35
  • 95.68 (n)
  • 98.61 (a)
RNF38 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF38 35
  • 96.68 (n)
  • 99.22 (a)
RNF38 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf38 35
  • 93.65 (n)
  • 98.05 (a)
Rnf38 16
Rnf38 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF38 35
  • 99.81 (n)
  • 99.81 (a)
RNF38 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf38 35
  • 93.36 (n)
  • 97.45 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF38 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF38 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF38 35
  • 81.04 (n)
  • 88.02 (a)
RNF38 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF38 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf38 35
  • 81.03 (n)
  • 93.75 (a)
Str.10151 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24562 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-20n3.1 35
  • 70.92 (n)
  • 80.44 (a)
wufa94e11 35
RNF38 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mura 36
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5812 35
Species with no ortholog for RNF38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF38 Gene

ENSEMBL:
Gene Tree for RNF38 (if available)
TreeFam:
Gene Tree for RNF38 (if available)

Paralogs for RNF38 Gene

Paralogs for RNF38 Gene

(1) SIMAP similar genes for RNF38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF38: view

Variants for RNF38 Gene

Sequence variations from dbSNP and Humsavar for RNF38 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs183475137 - 36,357,897(+) TGGTG(C/T)CACTG reference, missense
rs1106275 -- 36,457,218(+) AAACA(C/T)GAAGG intron-variant
rs1106276 -- 36,457,224(+) GAAGG(C/T)ACTGA intron-variant
rs1125295 -- 36,485,344(-) cattt(A/G)cctaa intron-variant
rs1475529 -- 36,410,918(-) cctaa(A/G)ctgaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF38 Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv893052 CNV Loss 21882294
nsv893053 CNV Loss 21882294
esv2738421 CNV Deletion 23290073
esv2738422 CNV Deletion 23290073
esv2738423 CNV Deletion 23290073
nsv416514 CNV Loss 16902084
esv1684027 CNV Deletion 17803354
nsv824914 CNV Gain 20364138
nsv7420 OTHER Inversion 18451855
esv2453594 CNV Deletion 19546169
nsv824915 CNV Gain 20364138
nsv821197 CNV Deletion 20802225
esv27332 CNV Gain 19812545
nsv824916 CNV Loss 20364138
esv3856 CNV Deletion 18987735
nsv511432 CNV Loss 21212237
nsv512099 CNV Loss 21212237
esv2738424 CNV Deletion 23290073
nsv824917 CNV Gain+Loss 20364138
nsv499545 CNV Loss 21111241
esv33302 CNV Loss 17666407
nsv6529 CNV Insertion 18451855

Variation tolerance for RNF38 Gene

Residual Variation Intolerance Score: 6.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF38 Gene

HapMap Linkage Disequilibrium report
RNF38
Human Gene Mutation Database (HGMD)
RNF38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF38 Gene

Disorders for RNF38 Gene

Relevant External Links for RNF38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF38

No disorders were found for RNF38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF38 Gene

Publications for RNF38 Gene

  1. RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. (PMID: 23973461) Sheren J.E. … Kassenbrock C.K. (Biochem. Biophys. Res. Commun. 2013) 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  4. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. (PMID: 20308539) Lunardi A. … Collavin L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RNF38 Gene

Sources for RNF38 Gene

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