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Aliases for RNF38 Gene

Aliases for RNF38 Gene

  • Ring Finger Protein 38 2 3
  • RING Finger Protein 38 4
  • EC 6.3.2.- 4

External Ids for RNF38 Gene

Summaries for RNF38 Gene

Entrez Gene Summary for RNF38 Gene

  • This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for RNF38 Gene

RNF38 (Ring Finger Protein 38) is a Protein Coding gene. An important paralog of this gene is RNF44.

UniProtKB/Swiss-Prot for RNF38 Gene

  • Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

Gene Wiki entry for RNF38 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF38 Gene

Genomics for RNF38 Gene

Genomic Location for RNF38 Gene

Start:
36,336,396 bp from pter
End:
36,487,571 bp from pter
Size:
151,176 bases
Orientation:
Minus strand

Genomic View for RNF38 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF38 Gene

Regulatory Elements for RNF38 Gene

Proteins for RNF38 Gene

  • Protein details for RNF38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0F5-RNF38_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF38
    Protein Accession:
    Q9H0F5
    Secondary Accessions:
    • A6PVP9
    • B1AM81
    • B1AM82
    • B3KSG4
    • E7EVL3
    • Q7LB33
    • Q8N0Y0
    • Q9H748

    Protein attributes for RNF38 Gene

    Size:
    515 amino acids
    Molecular mass:
    57595 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF38 Gene

    Alternative splice isoforms for RNF38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF38 Gene

Proteomics data for RNF38 Gene at MOPED

Post-translational modifications for RNF38 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys440

No data available for DME Specific Peptides for RNF38 Gene

Domains for RNF38 Gene

Gene Families for RNF38 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF38 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RNF38_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9H0F5
genes like me logo Genes that share domains with RNF38: view

Function for RNF38 Gene

Molecular function for RNF38 Gene

UniProtKB/Swiss-Prot Function: Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.

Enzyme Numbers (IUBMB) for RNF38 Gene

Gene Ontology (GO) - Molecular Function for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23973461
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF38: view

Phenotypes for RNF38 Gene

GenomeRNAi human phenotypes for RNF38:
genes like me logo Genes that share phenotypes with RNF38: view

miRNA for RNF38 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF38 Gene

Localization for RNF38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF38 Gene COMPARTMENTS Subcellular localization image for RNF38 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23973461
GO:0005654 nucleoplasm IDA --
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with RNF38: view

Pathways for RNF38 Gene

SuperPathways for RNF38 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H0F5-RNF38_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008584 male gonad development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF38: view

No data available for Pathways by source for RNF38 Gene

Transcripts for RNF38 Gene

Unigene Clusters for RNF38 Gene

Ring finger protein 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF38 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14: - - -
SP15:

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for RNF38 Gene

GeneLoc Exon Structure for
RNF38
ECgene alternative splicing isoforms for
RNF38

Expression for RNF38 Gene

mRNA expression in normal human tissues for RNF38 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF38 Gene

SOURCE GeneReport for Unigene cluster for RNF38 Gene Hs.333503

mRNA Expression by UniProt/SwissProt for RNF38 Gene

Q9H0F5-RNF38_HUMAN
Tissue specificity: Widely expressed with highest levels in testis.
genes like me logo Genes that share expressions with RNF38: view

Orthologs for RNF38 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF38 36
  • 99.81 (n)
  • 99.81 (a)
RNF38 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF38 36
  • 95.68 (n)
  • 98.61 (a)
RNF38 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF38 36
  • 96.68 (n)
  • 99.22 (a)
RNF38 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf38 36
  • 93.65 (n)
  • 98.05 (a)
Rnf38 16
Rnf38 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF38 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF38 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf38 36
  • 93.36 (n)
  • 97.45 (a)
chicken
(Gallus gallus)
Aves RNF38 36
  • 81.04 (n)
  • 88.02 (a)
RNF38 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF38 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24562 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf38 36
  • 81.03 (n)
  • 93.75 (a)
Str.10151 36
zebrafish
(Danio rerio)
Actinopterygii RNF38 37
  • 57 (a)
OneToOne
si:dkey-20n3.1 36
  • 70.92 (n)
  • 80.44 (a)
wufa94e11 36
fruit fly
(Drosophila melanogaster)
Insecta mura 37
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5812 36
Species with no ortholog for RNF38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF38 Gene

ENSEMBL:
Gene Tree for RNF38 (if available)
TreeFam:
Gene Tree for RNF38 (if available)

Paralogs for RNF38 Gene

Paralogs for RNF38 Gene

Selected SIMAP similar genes for RNF38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF38: view

Variants for RNF38 Gene

Sequence variations from dbSNP and Humsavar for RNF38 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs954182 -- 36,414,243(+) TTCAA(C/T)GTTAG intron-variant
rs954779 -- 36,419,532(+) CTGAG(A/G)GAATA intron-variant
rs965999 -- 36,398,344(+) aagga(A/G)gatca intron-variant
rs1106275 -- 36,457,218(+) AAACA(C/T)GAAGG intron-variant
rs1106276 -- 36,457,224(+) GAAGG(C/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF38 Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv893052 CNV Loss 21882294
nsv893053 CNV Loss 21882294
esv2738421 CNV Deletion 23290073
esv2738422 CNV Deletion 23290073
esv2738423 CNV Deletion 23290073
nsv416514 CNV Loss 16902084
esv1684027 CNV Deletion 17803354
nsv824914 CNV Gain 20364138
nsv7420 OTHER Inversion 18451855
esv2453594 CNV Deletion 19546169
nsv824915 CNV Gain 20364138
nsv821197 CNV Deletion 20802225
esv27332 CNV Gain 19812545
nsv824916 CNV Loss 20364138
esv3856 CNV Deletion 18987735
nsv511432 CNV Loss 21212237
nsv512099 CNV Loss 21212237
esv2738424 CNV Deletion 23290073
nsv824917 CNV Gain+Loss 20364138
nsv499545 CNV Loss 21111241
esv33302 CNV Loss 17666407
nsv6529 CNV Insertion 18451855

Relevant External Links for RNF38 Gene

HapMap Linkage Disequilibrium report
RNF38
Human Gene Mutation Database (HGMD)
RNF38

Disorders for RNF38 Gene

No disorders were found for RNF38 Gene.

No data available for UniProtKB/Swiss-Prot for RNF38 Gene

Publications for RNF38 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Cloning and characterization of a novel human gene RNF38 encoding a conserved putative protein with a RING finger domain. (PMID: 12074600) Eisenberg I. … Mitrani-Rosenbaum S. (Biochem. Biophys. Res. Commun. 2002) 3 4

Products for RNF38 Gene

Sources for RNF38 Gene

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