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RNF34 Gene

protein-coding   GIFtS: 53
GCID: GC12P121837

Ring Finger Protein 34, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 34)
  Search for RNF34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 34, E3 Ubiquitin Protein Ligase1 2     RING Finger Protein RIFF2 3
RING Finger Protein 341 3     RFI2 5
Caspase Regulator CARP12 3     CARP12
Caspases-8 And -10-Associated RING Finger Protein 12 3     RIF2
FYVE-RING Finger Protein Momo2 3     RIFF2
Human RING Finger Homologous To Inhibitor Of Apoptosis Protein2 3     E3 Ubiquitin-Protein Ligase RNF342
CARP-12 3     EC 6.3.2.-3
hRFI2 3     EC 6.3.28

External Ids:    HGNC: 172971   Entrez Gene: 801962   Ensembl: ENSG000001706337   OMIM: 6082995   UniProtKB: Q969K33   

Export aliases for RNF34 gene to outside databases

Previous GC identifers: GC12P120717 GC12M121524 GC12P121621 GC12P120250 GC12P120251 GC12P120300 GC12P118847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF34 Gene:
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and
protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function
as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to
TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved
by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation.
Alternatively splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq,
Feb 2012)

GeneCards Summary for RNF34 Gene:
RNF34 (ring finger protein 34, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is RFFL.

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3
Function: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for
proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate
and phosphatidylinositol 3-phosphate

Gene Wiki entry for RNF34 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF34 gene promoter:
         Egr-3   GATA-3   HOXA3   RelA   GATA-2   GATA-1   S8   HOXA5   ARP-1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF34 promoter sequence
   Search Chromatin IP Primers for RNF34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

RNF34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF34 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P121837:  view genomic region     (about GC identifiers)

Start:
121,837,844 bp from pter      End:
121,868,389 bp from pter
Size:
30,546 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF34  
Size: 372 amino acids; 41641 Da
Subunit: Interacts with DNAJA3 (Potential). Interacts with CASP8 and CASP10
Caution: Was isolated as potential interaction partner of the mitochondrial protein DNAJA3, but the 2 proteins are
not in the same cellular compartments
Sequence caution: Sequence=BAH14169.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B7Z933 Q8NG47 Q9H6W8
Alternative splicing: 2 isoforms:  Q969K3-1   Q969K3-2   

Explore the universe of human proteins at neXtProt for RNF34: NX_Q969K3

Explore proteomics data for RNF34 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated (in vitro) (By similarity)1
  • Proteolytically cleaved by caspases upon induction of apoptosis by TNF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF34 (Q969K3) (see all 7)
     GCCEKWEL  TGPFRFTP  RMSECPICR  SSRSQTSSFFT 


    See RNF34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243787.1  NP_079402.2  NP_919247.1  

    ENSEMBL proteins: 
     ENSP00000355137   ENSP00000376258   ENSP00000452096   ENSP00000376257   ENSP00000452200  
     ENSP00000452321   ENSP00000451724  
    Reactome Protein details: Q969K3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q969K3

    ProtoNet protein and cluster: Q969K3

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003034 DNA-binding SAP


    UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3
    Similarity: Contains 1 FYVE-type zinc finger
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 SAP domains


    Find genes that share domains with RNF34           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF34_HUMAN, Q969K3
    Function: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for
    proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate
    and phosphatidylinositol 3-phosphate

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15069192
    GO:0005515protein binding IPI15069192
    GO:0008270zinc ion binding IEA--
    GO:1901981phosphatidylinositol phosphate binding IDA15069192
         
    Find genes that share ontologies with RNF34           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF34:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF34
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    miRNA
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    miRTarBase miRNAs that target RNF34:
    hsa-mir-30c-5p (MIRT047982), hsa-mir-93-5p (MIRT028023), hsa-mir-181a-5p (MIRT025100), hsa-mir-30b-5p (MIRT046149)

    Block miRNA regulation of human, mouse, rat RNF34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF34 (see all 16):
    hsa-miR-181c hsa-miR-449a hsa-miR-223 hsa-miR-129-3p hsa-miR-129* hsa-miR-181b hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidRNF34 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RNF34 (NM_025126)
    Sino Biological Human cDNA Clone for RNF34
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF34
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF34
    Addgene plasmids for RNF34 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF34


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF34_HUMAN, Q969K3: Nucleus speckle. Endomembrane system; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA15069192
    GO:0005886plasma membrane IDA15069192
    GO:0012505endomembrane system IEA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with RNF34           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF34 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with RNF34           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for RNF34
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF34: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF34

    Selected Interacting proteins for RNF34 (Q969K31, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJA3Q96EY13I2D: score=2 
    UBE2FQ969M73I2D: score=2 
    UBE2HP622563I2D: score=2 
    PPARGC1AQ9UBK23I2D: score=1 
    TP53P046373I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IDA15069192
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IDA15069192
    GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP15069192
    GO:2001271negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP15069192

    Find genes that share ontologies with RNF34           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RNF34



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF34 gene (3 alternative transcripts): 
    NM_001256858.1  NM_025126.3  NM_194271.2  

    Unigene Cluster for RNF34:

    Ring finger protein 34, E3 ubiquitin protein ligase
    Hs.292804  [show with all ESTs]
    Unigene Representative Sequence: NM_194271
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361234(uc001ual.1) ENST00000392465(uc001uak.1) ENST00000556562
    ENST00000553407(uc010szw.2) ENST00000554606 ENST00000392464 ENST00000555076
    ENST00000554868 ENST00000557402 ENST00000554484
    miRNA
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    Block miRNA regulation of human, mouse, rat RNF34 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF34 (see all 16):
    hsa-miR-181c hsa-miR-449a hsa-miR-223 hsa-miR-129-3p hsa-miR-129* hsa-miR-181b hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidRNF34 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RNF34 (NM_025126)
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF34
      QuantiFast Probe-based Assays in human, mouse, rat RNF34

    Additional mRNA sequence: 

    AB084914.1 AF306709.1 AK025439.1 AK225285.1 AK304366.1 AY098934.1 BC007826.2 BC059954.1 
    BT007283.1 CR457342.1 

    24 DOTS entries:

    DT.100655270  DT.416565  DT.100655267  DT.101983209  DT.95241592  DT.100655265  DT.40107011  DT.91705125 
    DT.100655268  DT.100779773  DT.121128747  DT.95206635  DT.434339  DT.95167649  DT.100699341  DT.121128704 
    DT.40268240  DT.95203625  DT.95291882  DT.121128658  DT.121128663  DT.75150484  DT.95249316  DT.99938684 

    Selected AceView cDNA sequences (see all 259):

    CA416663 Z38175 CB850708 BM127217 CA866963 CA418549 CR601814 CA777047 
    AI805963 T30351 BI772644 AL557811 BM671135 AI269404 CB120192 BE855389 
    AK024957 AI291755 R88580 CB132688 BI771113 CK906125 BU181539 AI244125 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF34 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:                          -     -     -           -                       -                                 
    SP2:                          -     -     -     -     -     -     -           -                                 
    SP3:                                -     -           -                       -                                 
    SP4:                                      -           -                                                         
    SP5:                          -     -                 -                                                         


    ECgene alternative splicing isoforms for RNF34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCATTTTTG
    RNF34 Expression
    About this image

    RNF34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF34 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.292804

    UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3
    Tissue specificity: Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen,
    thymus, prostate, testis, ovary, colon and leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF34: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RNF34
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    QuantiFast Probe-based Assays in human, mouse, rat RNF34
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF34 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf341 , 5 ring finger protein 341, 5 86.83(n)1
    88.98(a)1
      5 (62.62 cM)5
    807511  NM_030564.11  NP_085041.11 
     1228501885 
    chicken
    (Gallus gallus)
    Aves RNF341 ring finger protein 34, E3 ubiquitin protein ligase 75.51(n)
    79.3(a)
      416843  NM_001006188.1  NP_001006188.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    80(a)
    62(a)
    1 ↔ many
    1 ↔ many
    GL343550.1(38769-40432)
    AAWZ02039581(21-3665)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA973381.12   -- 79.86(n)    CA973381.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf34a1 ring finger protein 34a 61.74(n)
    65.62(a)
      334203  NM_001030068.1  NP_001025239.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG170193 apoptosis inhibitor 50(a)     --


    ENSEMBL Gene Tree for RNF34 (if available)
    TreeFam Gene Tree for RNF34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF34 gene
    RFFL2  
    1 SIMAP similar gene for RNF34 using alignment to 6 protein entries:     RNF34_HUMAN (see all proteins):
    RFFL

    Find genes that share paralogs with RNF34           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNF34
    PGOHUM00000241421


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF34 (see all 589)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs108498751,2
    C,F,A,H--121835979(+) AGACCA/GTCCTG 3 -- us2k17Minor allele frequency- G:0.00NS EA NA 420
    rs1918300831,2
    --121835992(+) TAACAC/TGGTGA 3 -- us2k10--------
    rs107447611,2
    C,F,H--121836026(+) AAAAAT/CTAGCC 3 -- us2k15Minor allele frequency- C:0.27NA CSA 11
    rs1831998311,2
    --121836036(+) CGGGCA/GCGGTG 3 -- us2k10--------
    rs598346471,2
    C--121836047(+) GCGGGC/GGCCTG 3 -- us2k10--------
    rs1883115041,2
    --121836093(+) TGGCGC/TGAACC 3 -- us2k10--------
    rs108498761,2
    C,F,H--121836105(+) aggagG/Acggag 3 -- us2k16Minor allele frequency- A:0.23NA CSA 13
    rs1916306271,2
    --121836160(+) ACAGAA/GCGAGA 3 -- us2k10--------
    rs1838808931,2
    --121836162(+) AGAGCA/GAGACT 3 -- us2k10--------
    rs118303071,2
    C,F,A,H--121836187(+) AAAAAT/ATTTTT 3 -- us2k1 trp31Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for RNF34 (121837844 - 121868389 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RNF34: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF34
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF34

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608299    OMIM disorders: --


    Find genes that share disorders with RNF34           About GenesLikeMe


    Export disorders for RNF34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF34 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RNF34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. (PubMed id 12118383)1, 2, 3 Sasaki S....Croce C.M. (Oncogene 2002)
    2. Overexpression of hRFI (human RING finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. (PubMed id 15897238)1, 2 Konishi T.... Nagawa H. (Mol. Cancer Ther. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. (PubMed id 15069192)1, 2 McDonald E.R. III and El-Deiry W.S. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1I+ and modulates brown fat cell metabolism. (PubMed id 22064484)1 Wei P....Wang Y.X. (Mol. Cell. Biol. 2012)
    8. Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. (PubMed id 21308745)1 Lin M.L....Chen S.S. (J. Cell. Biochem. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. (PubMed id 21903591)1 Puliyappadamba V.T....Rishi A.K. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80196 HGNC: 17297 AceView: RNF34 Ensembl:ENSG00000170633 euGenes: HUgn80196
    ECgene: RNF34 H-InvDB: RNF34

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF34 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF34 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF34 gene:
    Search GeneIP for patents involving RNF34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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