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Aliases for RNF34 Gene

Aliases for RNF34 Gene

  • Ring Finger Protein 34, E3 Ubiquitin Protein Ligase 2 3
  • Human RING Finger Homologous To Inhibitor Of Apoptosis Protein 3 4
  • Caspases-8 And -10-Associated RING Finger Protein 1 3 4
  • RING Finger Protein RIFF 3 4
  • Caspase Regulator CARP1 3 4
  • CARP-1 3 4
  • HRFI 3 4
  • RFI 3 6
  • E3 Ubiquitin-Protein Ligase RNF34 3
  • FYVE-RING Finger Protein MOMO 3
  • FYVE-RING Finger Protein Momo 4
  • Ring Finger Protein 34 2
  • RING Finger Protein 34 4
  • EC 6.3.2.- 4
  • EC 6.3.2 64
  • CARP1 3
  • RIFF 3
  • RIF 3

External Ids for RNF34 Gene

Summaries for RNF34 Gene

Entrez Gene Summary for RNF34 Gene

  • The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

GeneCards Summary for RNF34 Gene

RNF34 (Ring Finger Protein 34, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RFFL.

UniProtKB/Swiss-Prot for RNF34 Gene

  • E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate Lys-48-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through Lys-48-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Gene Wiki entry for RNF34 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF34 Gene

Genomics for RNF34 Gene

Genomic Location for RNF34 Gene

Start:
121,400,041 bp from pter
End:
121,430,623 bp from pter
Size:
30,583 bases
Orientation:
Plus strand

Genomic View for RNF34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF34 Gene

Regulatory Elements for RNF34 Gene

Proteins for RNF34 Gene

  • Protein details for RNF34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969K3-RNF34_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF34
    Protein Accession:
    Q969K3
    Secondary Accessions:
    • B7Z933
    • Q8NG47
    • Q9H6W8

    Protein attributes for RNF34 Gene

    Size:
    372 amino acids
    Molecular mass:
    41641 Da
    Quaternary structure:
    • Interacts with CASP8 and CASP10. Interacts (via RING-type zinc finger) with PPARGC1A. Interacts with NOD1. Interacts with p53/TP53; involved in p53/TP53 ubiquitination. Interacts (via RING-type zinc finger) with MDM2; the interaction stabilizes MDM2.
    SequenceCaution:
    • Sequence=BAH14169.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF34 Gene

Proteomics data for RNF34 Gene at MOPED

Post-translational modifications for RNF34 Gene

Other Protein References for RNF34 Gene

Domains for RNF34 Gene

Gene Families for RNF34 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF34 Gene

UniProtKB/Swiss-Prot:

RNF34_HUMAN
Domain:
  • The RING-type zinc finger is required for the ubiquitination of target proteins.:
    • Q969K3
  • The FYVE-type zinc finger domain is required for localization and may confer affinity for cellular compartments enriched in phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate phospholipids.:
    • Q969K3
  • Contains 2 SAP domains.:
    • Q969K3
Similarity:
  • Contains 1 FYVE-type zinc finger.:
    • Q969K3
  • Contains 1 RING-type zinc finger.:
    • Q969K3
genes like me logo Genes that share domains with RNF34: view

Function for RNF34 Gene

Molecular function for RNF34 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate Lys-48-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through Lys-48-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Enzyme Numbers (IUBMB) for RNF34 Gene

Gene Ontology (GO) - Molecular Function for RNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 17121812
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 15069192
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF34: view
genes like me logo Genes that share phenotypes with RNF34: view

miRNA for RNF34 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF34 Gene

Localization for RNF34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF34 Gene

Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Nucleus. Nucleus speckle. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF34 Gene COMPARTMENTS Subcellular localization image for RNF34 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22064484
GO:0005737 cytoplasm IDA 15069192
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA 15069192
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with RNF34: view

Pathways for RNF34 Gene

genes like me logo Genes that share pathways with RNF34: view

UniProtKB/Swiss-Prot Q969K3-RNF34_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IMP 22064484
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway IMP 25012219
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP 22064484
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 22064484
GO:0070417 cellular response to cold IEA --
genes like me logo Genes that share ontologies with RNF34: view

Transcripts for RNF34 Gene

Unigene Clusters for RNF34 Gene

Ring finger protein 34, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF34 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - - - - - - - -

Relevant External Links for RNF34 Gene

GeneLoc Exon Structure for
RNF34
ECgene alternative splicing isoforms for
RNF34

Expression for RNF34 Gene

mRNA expression in normal human tissues for RNF34 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF34 Gene

SOURCE GeneReport for Unigene cluster for RNF34 Gene Hs.292804

mRNA Expression by UniProt/SwissProt for RNF34 Gene

Q969K3-RNF34_HUMAN
Tissue specificity: Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
genes like me logo Genes that share expressions with RNF34: view

Orthologs for RNF34 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF34 36
  • 99.73 (n)
  • 99.46 (a)
RNF34 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF34 36
  • 89.07 (n)
  • 92.74 (a)
RNF34 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF34 36
  • 89.61 (n)
  • 90.05 (a)
RNF34 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf34 36
  • 86.83 (n)
  • 88.98 (a)
Rnf34 16
Rnf34 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF34 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF34 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf34 36
  • 86.2 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves RNF34 36
  • 75.51 (n)
  • 79.3 (a)
RNF34 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf34 36
  • 67.62 (n)
  • 74.64 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf34a 36
  • 61.74 (n)
  • 65.62 (a)
rnf34a 37
  • 63 (a)
OneToMany
rnf34b 37
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17019 37
  • 17 (a)
OneToMany
CG17019 38
  • 50 (a)
Species with no ortholog for RNF34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF34 Gene

ENSEMBL:
Gene Tree for RNF34 (if available)
TreeFam:
Gene Tree for RNF34 (if available)

Paralogs for RNF34 Gene

Paralogs for RNF34 Gene

Selected SIMAP similar genes for RNF34 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RNF34 Gene

genes like me logo Genes that share paralogs with RNF34: view

Variants for RNF34 Gene

Sequence variations from dbSNP and Humsavar for RNF34 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8462 -- 121,424,268(-) AAACA(A/G)TGTAA utr-variant-3-prime
rs750008 -- 121,419,701(+) CTAAA(C/G)TGTTC intron-variant
rs889970 -- 121,418,414(-) CCTCA(C/T)TGGGA intron-variant
rs1110337 -- 121,420,730(+) TGGTA(A/G)AGAAA missense, reference
rs1177625 -- 121,408,270(-) agaga(C/G/T)ggggt intron-variant

Relevant External Links for RNF34 Gene

HapMap Linkage Disequilibrium report
RNF34

No data available for Structural Variations from Database of Genomic Variants (DGV) for RNF34 Gene

Disorders for RNF34 Gene

No disorders were found for RNF34 Gene.

No data available for UniProtKB/Swiss-Prot for RNF34 Gene

Publications for RNF34 Gene

  1. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. (PMID: 12118383) Sasaki S. … Croce C.M. (Oncogene 2002) 2 3 4
  2. Overexpression of hRFI (human RING finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. (PMID: 15897238) Konishi T. … Nagawa H. (Mol. Cancer Ther. 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. (PMID: 15069192) McDonald E.R. III … El-Deiry W.S. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF34 Gene

  • Addgene plasmids for RNF34

Sources for RNF34 Gene

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