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Aliases for RNF32 Gene

Aliases for RNF32 Gene

  • Ring Finger Protein 32 2 3
  • FKSG33 3
  • HSD15 3
  • LMBR2 3

External Ids for RNF32 Gene

Summaries for RNF32 Gene

Entrez Gene Summary for RNF32 Gene

  • The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for RNF32 Gene

RNF32 (Ring Finger Protein 32) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RNF32 Gene

  • May play a role in sperm formation.

Gene Wiki entry for RNF32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF32 Gene

Genomics for RNF32 Gene

Genomic Location for RNF32 Gene

Start:
156,640,281 bp from pter
End:
156,677,130 bp from pter
Size:
36,850 bases
Orientation:
Plus strand

Genomic View for RNF32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF32 Gene

Regulatory Elements for RNF32 Gene

Proteins for RNF32 Gene

  • Protein details for RNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A6-RNF32_HUMAN
    Recommended name:
    RING finger protein 32
    Protein Accession:
    Q9H0A6
    Secondary Accessions:
    • Q6FIB3
    • Q6X7T4
    • Q8N6V8
    • Q8TDG0
    • Q96BM5
    • Q9Y6U1

    Protein attributes for RNF32 Gene

    Size:
    362 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF32 Gene

Proteomics data for RNF32 Gene at MOPED

Post-translational modifications for RNF32 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNF32 Gene

Domains for RNF32 Gene

Gene Families for RNF32 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF32 Gene

UniProtKB/Swiss-Prot:

RNF32_HUMAN
Domain:
  • Contains 1 IQ domain.:
    • Q9H0A6
Similarity:
  • Contains 2 RING-type zinc fingers.:
    • Q9H0A6
genes like me logo Genes that share domains with RNF32: view

Function for RNF32 Gene

Molecular function for RNF32 Gene

UniProtKB/Swiss-Prot Function: May play a role in sperm formation.

Gene Ontology (GO) - Molecular Function for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF32: view
genes like me logo Genes that share phenotypes with RNF32: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF32 Gene

Localization for RNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF32 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF32 Gene COMPARTMENTS Subcellular localization image for RNF32 gene
Compartment Confidence
endosome 4
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0016235 aggresome IDA 11890671
genes like me logo Genes that share ontologies with RNF32: view

Pathways for RNF32 Gene

SuperPathways for RNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF32 Gene

None

No data available for Pathways by source for RNF32 Gene

Transcripts for RNF32 Gene

Unigene Clusters for RNF32 Gene

Ring finger protein 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for RNF32 Gene

GeneLoc Exon Structure for
RNF32
ECgene alternative splicing isoforms for
RNF32

Expression for RNF32 Gene

mRNA expression in normal human tissues for RNF32 Gene

mRNA differential expression in normal tissues according to GTEx for RNF32 Gene

This gene is overexpressed in Testis (14.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF32 Gene

SOURCE GeneReport for Unigene cluster for RNF32 Gene Hs.446194

mRNA Expression by UniProt/SwissProt for RNF32 Gene

Q9H0A6-RNF32_HUMAN
Tissue specificity: Highly expressed in testis, less abundant in ovary.
genes like me logo Genes that share expressions with RNF32: view

Orthologs for RNF32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF32 36
  • 99.17 (n)
  • 99.45 (a)
RNF32 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF32 36
  • 78.86 (n)
  • 79.14 (a)
RNF32 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF32 36
  • 83.33 (n)
  • 82.5 (a)
RNF32 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf32 36
  • 79.83 (n)
  • 78.18 (a)
Rnf32 16
Rnf32 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF32 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF32 37
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF32 36
  • 65.33 (n)
  • 60.57 (a)
RNF32 37
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF32 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf32 36
  • 64.66 (n)
  • 60.06 (a)
Str.13169 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7850 36
zebrafish
(Danio rerio)
Actinopterygii Dr.18813 36
rnf32 36
  • 56.93 (n)
  • 49.7 (a)
rnf32 37
  • 44 (a)
OneToOne
Species with no ortholog for RNF32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF32 Gene

ENSEMBL:
Gene Tree for RNF32 (if available)
TreeFam:
Gene Tree for RNF32 (if available)

Paralogs for RNF32 Gene

No data available for Paralogs for RNF32 Gene

Variants for RNF32 Gene

Sequence variations from dbSNP and Humsavar for RNF32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12007 -- 156,676,926(+) AAAAA(C/T)TGAGG utr-variant-3-prime
rs1014831 -- 156,654,377(+) CTTCT(A/G)TCAGG intron-variant
rs1024605 -- 156,673,002(-) ggctt(C/T)gcccc intron-variant
rs1045032 -- 156,665,707(+) CCCAC(C/T)CACCA intron-variant
rs2302145 -- 156,676,496(-) CTGCC(C/T)GCACC reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF32 Gene

Variant ID Type Subtype PubMed ID
nsv831198 CNV Loss 17160897
nsv6020 CNV Insertion 18451855
nsv525099 CNV Gain 19592680

Relevant External Links for RNF32 Gene

HapMap Linkage Disequilibrium report
RNF32
Human Gene Mutation Database (HGMD)
RNF32

Disorders for RNF32 Gene

(1) University of Copenhagen DISEASES for RNF32 Gene

genes like me logo Genes that share disorders with RNF32: view

No data available for UniProtKB/Swiss-Prot for RNF32 Gene

Publications for RNF32 Gene

  1. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. (PMID: 11890671) van Baren M.J. … Heutink P. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for RNF32 Gene

Sources for RNF32 Gene

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