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Aliases for RNF32 Gene

Aliases for RNF32 Gene

  • Ring Finger Protein 32 2 3 5
  • FKSG33 3
  • HSD15 3
  • LMBR2 3

External Ids for RNF32 Gene

Previous GeneCards Identifiers for RNF32 Gene

  • GC07P154663
  • GC07P155735
  • GC07P155850
  • GC07P155932
  • GC07P156126
  • GC07P156117
  • GC07P156433
  • GC07P150166

Summaries for RNF32 Gene

Entrez Gene Summary for RNF32 Gene

  • The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RNF32 Gene

RNF32 (Ring Finger Protein 32) is a Protein Coding gene. Diseases associated with RNF32 include Triphalangeal Thumb.

UniProtKB/Swiss-Prot for RNF32 Gene

  • May play a role in sperm formation.

Gene Wiki entry for RNF32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF32 Gene

Genomics for RNF32 Gene

Regulatory Elements for RNF32 Gene

Enhancers for RNF32 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF32 on UCSC Golden Path with GeneCards custom track

Promoters for RNF32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF32 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF32 Gene

Chromosome:
7
Start:
156,640,281 bp from pter
End:
156,677,893 bp from pter
Size:
37,613 bases
Orientation:
Plus strand

Genomic View for RNF32 Gene

Genes around RNF32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF32 Gene

Proteins for RNF32 Gene

  • Protein details for RNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A6-RNF32_HUMAN
    Recommended name:
    RING finger protein 32
    Protein Accession:
    Q9H0A6
    Secondary Accessions:
    • Q6FIB3
    • Q6X7T4
    • Q8N6V8
    • Q8TDG0
    • Q96BM5
    • Q9Y6U1

    Protein attributes for RNF32 Gene

    Size:
    362 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF32 Gene

Proteomics data for RNF32 Gene at MOPED

Post-translational modifications for RNF32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF32 Gene

Domains & Families for RNF32 Gene

Gene Families for RNF32 Gene

Protein Domains for RNF32 Gene

Suggested Antigen Peptide Sequences for RNF32 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0A6

UniProtKB/Swiss-Prot:

RNF32_HUMAN :
  • Contains 1 IQ domain.
  • Contains 2 RING-type zinc fingers.
Domain:
  • Contains 1 IQ domain.
Similarity:
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF32: view

Function for RNF32 Gene

Molecular function for RNF32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm formation.

Gene Ontology (GO) - Molecular Function for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
genes like me logo Genes that share ontologies with RNF32: view
genes like me logo Genes that share phenotypes with RNF32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF32

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF32 Gene

Localization for RNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF32 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF32 Gene COMPARTMENTS Subcellular localization image for RNF32 gene
Compartment Confidence
endosome 4
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNF32 Gene

Pathways & Interactions for RNF32 Gene

SuperPathways for RNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF32 Gene

Drugs & Compounds for RNF32 Gene

No Compound Related Data Available

Transcripts for RNF32 Gene

Unigene Clusters for RNF32 Gene

Ring finger protein 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for RNF32 Gene

GeneLoc Exon Structure for
RNF32
ECgene alternative splicing isoforms for
RNF32

Expression for RNF32 Gene

mRNA expression in normal human tissues for RNF32 Gene

mRNA differential expression in normal tissues according to GTEx for RNF32 Gene

This gene is overexpressed in Testis (x14.1).

Protein differential expression in normal tissues from HIPED for RNF32 Gene

This gene is overexpressed in Stomach (39.9) and Fetal testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF32 Gene



SOURCE GeneReport for Unigene cluster for RNF32 Gene Hs.446194

mRNA Expression by UniProt/SwissProt for RNF32 Gene

Q9H0A6-RNF32_HUMAN
Tissue specificity: Highly expressed in testis, less abundant in ovary.
genes like me logo Genes that share expression patterns with RNF32: view

Protein tissue co-expression partners for RNF32 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNF32 Gene

Orthologs for RNF32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF32 35
  • 78.86 (n)
  • 79.14 (a)
RNF32 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF32 35
  • 83.33 (n)
  • 82.5 (a)
RNF32 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf32 35
  • 79.83 (n)
  • 78.18 (a)
Rnf32 16
Rnf32 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF32 35
  • 99.17 (n)
  • 99.45 (a)
RNF32 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF32 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF32 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF32 35
  • 65.33 (n)
  • 60.57 (a)
RNF32 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF32 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf32 35
  • 64.66 (n)
  • 60.06 (a)
Str.13169 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18813 35
rnf32 35
  • 56.93 (n)
  • 49.7 (a)
rnf32 36
  • 44 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7850 35
Species with no ortholog for RNF32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF32 Gene

ENSEMBL:
Gene Tree for RNF32 (if available)
TreeFam:
Gene Tree for RNF32 (if available)

Paralogs for RNF32 Gene

No data available for Paralogs for RNF32 Gene

Variants for RNF32 Gene

Sequence variations from dbSNP and Humsavar for RNF32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_026982 -
VAR_026983 -
VAR_026984 -
rs1014831 -- 156,654,377(+) CTTCT(A/G)TCAGG intron-variant
rs6948790 -- 156,647,132(+) aaggc(A/G)tgagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF32 Gene

Variant ID Type Subtype PubMed ID
nsv831198 CNV Loss 17160897
nsv6020 CNV Insertion 18451855
nsv525099 CNV Gain 19592680

Variation tolerance for RNF32 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF32 Gene

Human Gene Mutation Database (HGMD)
RNF32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF32 Gene

Disorders for RNF32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF32 Gene - From: GeneCards

Disorder Aliases PubMed IDs
triphalangeal thumb
- elite association - COSMIC cancer census association via MalaCards
Search RNF32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF32
genes like me logo Genes that share disorders with RNF32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF32 Gene

Publications for RNF32 Gene

  1. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. (PMID: 11890671) van Baren M.J. … Heutink P. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study. (PMID: 25228972) Wang X.W. … Fang D.C. (Gut Liver 2014) 3
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  4. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 3
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3

Products for RNF32 Gene

Sources for RNF32 Gene

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