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Aliases for RNF32 Gene

Aliases for RNF32 Gene

  • Ring Finger Protein 32 2 3
  • FKSG33 3
  • HSD15 3
  • LMBR2 3

External Ids for RNF32 Gene

Previous GeneCards Identifiers for RNF32 Gene

  • GC07P154663
  • GC07P155735
  • GC07P155850
  • GC07P155932
  • GC07P156126
  • GC07P156117
  • GC07P156433
  • GC07P150166

Summaries for RNF32 Gene

Entrez Gene Summary for RNF32 Gene

  • The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RNF32 Gene

RNF32 (Ring Finger Protein 32) is a Protein Coding gene. Diseases associated with RNF32 include triphalangeal thumb.

UniProtKB/Swiss-Prot for RNF32 Gene

  • May play a role in sperm formation.

Gene Wiki entry for RNF32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF32 Gene

Genomics for RNF32 Gene

Regulatory Elements for RNF32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF32 Gene

156,640,281 bp from pter
156,677,893 bp from pter
37,613 bases
Plus strand

Genomic View for RNF32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF32 Gene

Proteins for RNF32 Gene

  • Protein details for RNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 32
    Protein Accession:
    Secondary Accessions:
    • Q6FIB3
    • Q6X7T4
    • Q8N6V8
    • Q8TDG0
    • Q96BM5
    • Q9Y6U1

    Protein attributes for RNF32 Gene

    362 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF32 Gene


neXtProt entry for RNF32 Gene

Proteomics data for RNF32 Gene at MOPED

Post-translational modifications for RNF32 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for RNF32 Gene

Domains & Families for RNF32 Gene

Gene Families for RNF32 Gene

Protein Domains for RNF32 Gene

Suggested Antigen Peptide Sequences for RNF32 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Contains 2 RING-type zinc fingers.
  • Contains 1 IQ domain.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF32: view

Function for RNF32 Gene

Molecular function for RNF32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm formation.

Gene Ontology (GO) - Molecular Function for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF32: view
genes like me logo Genes that share phenotypes with RNF32: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF32

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF32 Gene

Localization for RNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF32 Gene


Subcellular locations from

Jensen Localization Image for RNF32 Gene COMPARTMENTS Subcellular localization image for RNF32 gene
Compartment Confidence
endosome 4

Gene Ontology (GO) - Cellular Components for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0016235 aggresome IDA 11890671
genes like me logo Genes that share ontologies with RNF32: view

Pathways & Interactions for RNF32 Gene

SuperPathways for RNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF32 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF32 Gene

Drugs & Compounds for RNF32 Gene

No Compound Related Data Available

Transcripts for RNF32 Gene

Unigene Clusters for RNF32 Gene

Ring finger protein 32:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for RNF32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF32 Gene

mRNA expression in normal human tissues for RNF32 Gene

mRNA differential expression in normal tissues according to GTEx for RNF32 Gene

This gene is overexpressed in Testis (x14.1).

Protein differential expression in normal tissues from HIPED for RNF32 Gene

This gene is overexpressed in Stomach (39.9) and Fetal testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF32 Gene

SOURCE GeneReport for Unigene cluster for RNF32 Gene Hs.446194

mRNA Expression by UniProt/SwissProt for RNF32 Gene

Tissue specificity: Highly expressed in testis, less abundant in ovary.
genes like me logo Genes that share expression patterns with RNF32: view

Protein tissue co-expression partners for RNF32 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNF32 Gene

Orthologs for RNF32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF32 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF32 35
  • 78.86 (n)
  • 79.14 (a)
RNF32 36
  • 78 (a)
(Canis familiaris)
Mammalia RNF32 35
  • 83.33 (n)
  • 82.5 (a)
RNF32 36
  • 80 (a)
(Mus musculus)
Mammalia Rnf32 35
  • 79.83 (n)
  • 78.18 (a)
Rnf32 16
Rnf32 36
  • 77 (a)
(Pan troglodytes)
Mammalia RNF32 35
  • 99.17 (n)
  • 99.45 (a)
RNF32 36
  • 99 (a)
(Monodelphis domestica)
Mammalia RNF32 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia RNF32 36
  • 66 (a)
(Gallus gallus)
Aves RNF32 35
  • 65.33 (n)
  • 60.57 (a)
RNF32 36
  • 57 (a)
(Anolis carolinensis)
Reptilia RNF32 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf32 35
  • 64.66 (n)
  • 60.06 (a)
Str.13169 35
(Danio rerio)
Actinopterygii Dr.18813 35
rnf32 35
  • 56.93 (n)
  • 49.7 (a)
rnf32 36
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7850 35
Species with no ortholog for RNF32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF32 Gene

Gene Tree for RNF32 (if available)
Gene Tree for RNF32 (if available)

Paralogs for RNF32 Gene

No data available for Paralogs for RNF32 Gene

Variants for RNF32 Gene

Sequence variations from dbSNP and Humsavar for RNF32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1014831 -- 156,654,377(+) CTTCT(A/G)TCAGG intron-variant
rs1045032 -- 156,665,707(+) CCCAC(C/T)CACCA intron-variant
rs2302150 -- 156,662,169(-) TCTAC(C/T)CATAC intron-variant
rs4716437 -- 156,649,341(+) GTAAG(C/T)TGATC intron-variant
rs4716438 -- 156,649,509(+) tttac(C/T)tactt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF32 Gene

Variant ID Type Subtype PubMed ID
nsv831198 CNV Loss 17160897
nsv6020 CNV Insertion 18451855
nsv525099 CNV Gain 19592680

Variation tolerance for RNF32 Gene

Residual Variation Intolerance Score: 79.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF32 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF32 Gene

Disorders for RNF32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF32 Gene - From: GeneCards

Disorder Aliases PubMed IDs
triphalangeal thumb
- elite association
Search RNF32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RNF32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF32 Gene

Publications for RNF32 Gene

  1. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. (PMID: 11890671) van Baren M.J. … Heutink P. (Biochem. Biophys. Res. Commun. 2002) 2 67
  2. RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study. (PMID: 25228972) Wang X.W. … Fang D.C. (Gut Liver 2014) 67
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 67
  4. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 67
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67

Products for RNF32 Gene

Sources for RNF32 Gene

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