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Aliases for RNF32 Gene

Aliases for RNF32 Gene

  • Ring Finger Protein 32 2 3 5
  • FKSG33 3
  • HSD15 3
  • LMBR2 3

External Ids for RNF32 Gene

Previous GeneCards Identifiers for RNF32 Gene

  • GC07P154663
  • GC07P155735
  • GC07P155850
  • GC07P155932
  • GC07P156126
  • GC07P156117
  • GC07P156433
  • GC07P150166

Summaries for RNF32 Gene

Entrez Gene Summary for RNF32 Gene

  • The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for RNF32 Gene

RNF32 (Ring Finger Protein 32) is a Protein Coding gene. Diseases associated with RNF32 include Triphalangeal Thumb and Neuropathy, Congenital Hypomyelinating.

UniProtKB/Swiss-Prot for RNF32 Gene

  • May play a role in sperm formation.

Gene Wiki entry for RNF32 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF32 Gene

Genomics for RNF32 Gene

Regulatory Elements for RNF32 Gene

Enhancers for RNF32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F156614 1.6 FANTOM5 Ensembl ENCODE 13.7 -24.3 -24296 4.0 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 MIER2 LINC01006 RNF32 NOM1 C7orf13 MNX1 GC07P156625 GC07M156563
GH07F156607 1.6 FANTOM5 Ensembl ENCODE 11.3 -30.3 -30295 5.6 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF766 KLF13 KDM4B SP5 LINC01006 RNF32 C7orf13 GC07P156625 GC07M156563
GH07F156523 0.6 FANTOM5 23.7 -116.7 -116661 0.1 L3MBTL2 ZBTB11 ELF1 ZBTB40 GABPA RNF32 LINC00244 PIR53126
GH07F156751 1.1 Ensembl ENCODE 10.1 +112.0 111972 2.4 CBX3 PKNOX1 ZFP64 SIN3A RAD21 GATA2 FOS EGR2 JUNB REST C7orf13 LINC01006 RNF32 NOM1 GC07M156670 GC07P156873
GH07F156842 1.1 Ensembl ENCODE 10 +202.4 202440 1.4 HDGF PKNOX1 ARNT GATA2 SMARCA5 MIER1 ZEB2 SMARCB1 SMARCA4 PBX2 NOM1 RNU4-31P LINC01006 RNF32 C7orf13 GC07P156873 GC07M156670
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF32 on UCSC Golden Path with GeneCards custom track

Promoters for RNF32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000315096 320 2399 ARNT CREB3L1 WRNIP1 SIN3A YY1 ZNF143 KLF13 SP3 REST ZNF592

Genomic Location for RNF32 Gene

156,640,281 bp from pter
156,677,893 bp from pter
37,613 bases
Plus strand

Genomic View for RNF32 Gene

Genes around RNF32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF32 Gene

Proteins for RNF32 Gene

  • Protein details for RNF32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 32
    Protein Accession:
    Secondary Accessions:
    • Q6FIB3
    • Q6X7T4
    • Q8N6V8
    • Q8TDG0
    • Q96BM5
    • Q9Y6U1

    Protein attributes for RNF32 Gene

    362 amino acids
    Molecular mass:
    41516 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF32 Gene


neXtProt entry for RNF32 Gene

Post-translational modifications for RNF32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF32 Gene

Domains & Families for RNF32 Gene

Gene Families for RNF32 Gene

Protein Domains for RNF32 Gene

Suggested Antigen Peptide Sequences for RNF32 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IQ domain.
  • Contains 2 RING-type zinc fingers.
  • Contains 1 IQ domain.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF32: view

Function for RNF32 Gene

Molecular function for RNF32 Gene

UniProtKB/Swiss-Prot Function:
May play a role in sperm formation.

Gene Ontology (GO) - Molecular Function for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21163940
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF32: view
genes like me logo Genes that share phenotypes with RNF32: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF32

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF32 Gene

Localization for RNF32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF32 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF32 gene
Compartment Confidence
endosome 4
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA --
GO:0016235 aggresome IDA 11890671
genes like me logo Genes that share ontologies with RNF32: view

Pathways & Interactions for RNF32 Gene

SuperPathways for RNF32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF32 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF32 Gene

Transcripts for RNF32 Gene

Unigene Clusters for RNF32 Gene

Ring finger protein 32:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for RNF32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF32 Gene

mRNA differential expression in normal tissues according to GTEx for RNF32 Gene

This gene is overexpressed in Testis (x14.1).

Protein differential expression in normal tissues from HIPED for RNF32 Gene

This gene is overexpressed in Stomach (39.9) and Fetal testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF32 Gene

Protein tissue co-expression partners for RNF32 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF32 Gene:


SOURCE GeneReport for Unigene cluster for RNF32 Gene:


mRNA Expression by UniProt/SwissProt for RNF32 Gene:

Tissue specificity: Highly expressed in testis, less abundant in ovary.
genes like me logo Genes that share expression patterns with RNF32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNF32 Gene

Orthologs for RNF32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF32 34 35
  • 99.17 (n)
(Canis familiaris)
Mammalia RNF32 34 35
  • 83.33 (n)
(Mus musculus)
Mammalia Rnf32 34 16 35
  • 79.83 (n)
(Bos Taurus)
Mammalia RNF32 34 35
  • 78.86 (n)
(Monodelphis domestica)
Mammalia RNF32 35
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia RNF32 35
  • 66 (a)
(Gallus gallus)
Aves RNF32 34 35
  • 65.33 (n)
(Anolis carolinensis)
Reptilia RNF32 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf32 34
  • 64.66 (n)
Str.13169 34
(Danio rerio)
Actinopterygii rnf32 34 35
  • 56.93 (n)
Dr.18813 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7850 34
Species where no ortholog for RNF32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF32 Gene

Gene Tree for RNF32 (if available)
Gene Tree for RNF32 (if available)

Paralogs for RNF32 Gene

No data available for Paralogs for RNF32 Gene

Variants for RNF32 Gene

Sequence variations from dbSNP and Humsavar for RNF32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1014831 -- 156,654,377(+) CTTCT(A/G)TCAGG intron-variant, downstream-variant-500B
rs10227910 -- 156,677,741(+) GCTAC(A/G)TATGT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10228019 -- 156,677,816(+) TCAAA(A/G)AATTT intron-variant, nc-transcript-variant, downstream-variant-500B
rs10235562 -- 156,644,300(+) ATTAA(A/C)TGAAA intron-variant
rs10236219 -- 156,653,624(+) TGACC(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF32 Gene

Variant ID Type Subtype PubMed ID
esv3615671 CNV loss 21293372
nsv1023469 CNV gain 25217958
nsv525099 CNV gain 19592680
nsv6020 CNV insertion 18451855
nsv609209 CNV gain 21841781
nsv831198 CNV loss 17160897

Variation tolerance for RNF32 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF32 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF32 Gene

Disorders for RNF32 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNF32 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
triphalangeal thumb
neuropathy, congenital hypomyelinating
  • neuropathy, congenital hypomyelinating, 1
- elite association - COSMIC cancer census association via MalaCards
Search RNF32 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RNF32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF32 Gene

Publications for RNF32 Gene

  1. A double RING-H2 domain in RNF32, a gene expressed during sperm formation. (PMID: 11890671) van Baren M.J. … Heutink P. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study. (PMID: 25228972) Wang X.W. … Fang D.C. (Gut Liver 2014) 3 64

Products for RNF32 Gene

Sources for RNF32 Gene

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