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Aliases for RNF31 Gene

Aliases for RNF31 Gene

  • Ring Finger Protein 31 2 3
  • HOIL-1-Interacting Protein 2 3 4
  • ZIBRA 3 4 6
  • Zinc In-Between-RING-Finger Ubiquitin-Associated Domain Protein 3 4
  • HOIP 3 4
  • E3 Ubiquitin-Protein Ligase RNF31 3
  • RING Finger Protein 31 4
  • EC 6.3.2.- 4

External Ids for RNF31 Gene

Summaries for RNF31 Gene

Entrez Gene Summary for RNF31 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF31 Gene

RNF31 (Ring Finger Protein 31) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin binding.

UniProtKB/Swiss-Prot for RNF31 Gene

  • E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (Met-1-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Gene Wiki entry for RNF31 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF31 Gene

Genomics for RNF31 Gene

Genomic Location for RNF31 Gene

Start:
24,146,683 bp from pter
End:
24,160,661 bp from pter
Size:
13,979 bases
Orientation:
Plus strand

Genomic View for RNF31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF31 Gene

Regulatory Elements for RNF31 Gene

Transcription factor binding sites by QIAGEN in the RNF31 gene promoter:

Proteins for RNF31 Gene

  • Protein details for RNF31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EP0-RNF31_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF31
    Protein Accession:
    Q96EP0
    Secondary Accessions:
    • A0A962
    • Q86VI2
    • Q8TEI0
    • Q96GB4
    • Q96NF1
    • Q9H5F1
    • Q9NWD2

    Protein attributes for RNF31 Gene

    Size:
    1072 amino acids
    Molecular mass:
    119652 Da
    Quaternary structure:
    • Interacts with MUSK (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Interacts with FAM105B/otulin; the interaction is direct.
    SequenceCaution:
    • Sequence=BAB15675.1; Type=Erroneous termination; Positions=1060; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAB15675.1; Type=Frameshift; Positions=1036; Evidence={ECO:0000305}; Sequence=BAB15675.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB70948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF31 Gene

    Alternative splice isoforms for RNF31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF31 Gene

Proteomics data for RNF31 Gene at MOPED

Post-translational modifications for RNF31 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys99, Lys330, Lys454, Lys458, Lys579, Lys640, and Lys848

No data available for DME Specific Peptides for RNF31 Gene

Domains for RNF31 Gene

Gene Families for RNF31 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

RNF31_HUMAN
Domain:
  • The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin:
    • Q96EP0
  • The UBA domain mediates association with RBCK1/HOIL1 via interaction with its UBL domain:
    • Q96EP0
  • RING 1 and IBR zinc-fingers catalyze the first step transfer of ubiquitin from the E2 onto RING 2, to transiently form a HECT-like covalent thioester intermediate.:
    • Q96EP0
  • The linear ubiquitin chain determining domain (LDD) mediates the final transfer of ubiquitin from RING 2 onto the N-terminus of a target ubiquitin.:
    • Q96EP0
  • Contains 1 UBA domain.:
    • Q96EP0
Similarity:
  • Contains 1 IBR-type zinc finger.:
    • Q96EP0
  • Contains 3 RanBP2-type zinc fingers.:
    • Q96EP0
  • Contains 2 RING-type zinc fingers.:
    • Q96EP0
genes like me logo Genes that share domains with RNF31: view

Function for RNF31 Gene

Molecular function for RNF31 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear (Met-1-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Enzyme Numbers (IUBMB) for RNF31 Gene

Gene Ontology (GO) - Molecular Function for RNF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 17006537
GO:0005515 protein binding IPI 17006537
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 23453807
genes like me logo Genes that share ontologies with RNF31: view

Phenotypes for RNF31 Gene

genes like me logo Genes that share phenotypes with RNF31: view

Animal Models for RNF31 Gene

MGI Knock Outs for RNF31:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RNF31 Gene

Localization for RNF31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF31 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF31 Gene COMPARTMENTS Subcellular localization image for RNF31 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0009898 cytoplasmic side of plasma membrane ISS 20614026
GO:0035631 CD40 receptor complex ISS --
GO:0071797 LUBAC complex IDA 17006537
genes like me logo Genes that share ontologies with RNF31: view

Pathways for RNF31 Gene

SuperPathways for RNF31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 12629548
GO:0016567 protein ubiquitination --
GO:0023035 CD40 signaling pathway ISS --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 19136968
GO:0050852 T cell receptor signaling pathway IDA 20005846
genes like me logo Genes that share ontologies with RNF31: view

No data available for Pathways by source for RNF31 Gene

Transcripts for RNF31 Gene

Unigene Clusters for RNF31 Gene

Ring finger protein 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: - -
SP21:
SP22:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20:
SP21:
SP22:

ExUns: 32 ^ 33a · 33b · 33c ^ 34a · 34b ^ 35 ^ 36a · 36b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for RNF31 Gene

GeneLoc Exon Structure for
RNF31
ECgene alternative splicing isoforms for
RNF31

Expression for RNF31 Gene

mRNA expression in normal human tissues for RNF31 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF31 Gene

SOURCE GeneReport for Unigene cluster for RNF31 Gene Hs.375217

mRNA Expression by UniProt/SwissProt for RNF31 Gene

Q96EP0-RNF31_HUMAN
Tissue specificity: Expressed in both normal and transformed breast epithelial cell lines.
genes like me logo Genes that share expressions with RNF31: view

Orthologs for RNF31 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF31 36
  • 99.38 (n)
  • 99.53 (a)
RNF31 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 93 (a)
OneToMany
RNF31 36
  • 91.04 (n)
  • 93 (a)
mouse
(Mus musculus)
Mammalia Rnf31 36
  • 86.34 (n)
  • 86.96 (a)
Rnf31 16
Rnf31 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnf31 36
  • 86.32 (n)
  • 87.38 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.29731 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf31 36
  • 57.15 (n)
  • 55.81 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01085085.1 37
  • 59 (a)
ManyToMany
CU693487.1 37
  • 36 (a)
ManyToMany
LOC100334103 36
  • 61.61 (n)
  • 59.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11321 37
  • 8 (a)
OneToMany
Species with no ortholog for RNF31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF31 Gene

ENSEMBL:
Gene Tree for RNF31 (if available)
TreeFam:
Gene Tree for RNF31 (if available)

Paralogs for RNF31 Gene

No data available for Paralogs for RNF31 Gene

Variants for RNF31 Gene

Sequence variations from dbSNP and Humsavar for RNF31 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs743272 -- 24,149,650(-) GCAGG(C/T)AGTCC intron-variant
rs2031101 -- 24,158,987(-) ggcgc(A/C/G)atctc intron-variant
rs2295979 -- 24,155,532(-) TAGCT(C/G)CCCTG intron-variant
rs4982862 -- 24,155,822(+) GACTA(C/G)TCAGA intron-variant
rs4982863 -- 24,158,774(+) gctca(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF31 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294
nsv7249 OTHER Inversion 18451855

Relevant External Links for RNF31 Gene

HapMap Linkage Disequilibrium report
RNF31

Disorders for RNF31 Gene

Relevant External Links for RNF31

Genetic Association Database (GAD)
RNF31
Human Genome Epidemiology (HuGE) Navigator
RNF31
genes like me logo Genes that share disorders with RNF31: view

No data available for UniProtKB/Swiss-Prot for RNF31 Gene

Publications for RNF31 Gene

  1. Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells. (PMID: 15093743) Thompson H.G.R. … Brody J.P. (Exp. Cell Res. 2004) 3 4 23
  2. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PMID: 10422847) van der Reijden B.A. … Jansen J.H. (Protein Sci. 1999) 2 3
  3. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H. … Ohara O. (DNA Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF31 Gene

Sources for RNF31 Gene

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