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RNF31 Gene

protein-coding   GIFtS: 54
GCID: GC14P024616

Ring Finger Protein 31

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 311 2 3     HOIP2 3
HOIL-1-Interacting Protein1 2 3     E3 Ubiquitin-Protein Ligase RNF312
ZIBRA2 3 5     EC 6.3.2.-3
Zinc In-Between-RING-Finger Ubiquitin-Associated Domain Protein2 3     

External Ids:    HGNC: 160311   Entrez Gene: 550722   Ensembl: ENSG000000920987   OMIM: 6124875   UniProtKB: Q96EP03   

Export aliases for RNF31 gene to outside databases

Previous GC identifers: GC14P022606 GC14P023687 GC14P023688 GC14P004731


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF31 Gene:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct
proteins and known to be involved in protein-DNA and protein-protein interactions. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF31 Gene:
RNF31 (ring finger protein 31) is a protein-coding gene. Diseases associated with RNF31 include x-linked hyper igm syndrome, and dengue hemorrhagic fever. GO annotations related to this gene include ubiquitin binding and ubiquitin-protein ligase activity. An important paralog of this gene is ENSG00000259529.

UniProtKB/Swiss-Prot: RNF31_HUMAN, Q96EP0
Function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked)
polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical
NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with
TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1
signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to
conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the
complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during
angiogenesis. Binds polyubiquitin of different linkage types

Gene Wiki entry for RNF31 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF31 gene promoter:
         TBP   AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF31 promoter sequence
   Search Chromatin IP Primers for RNF31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

RNF31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF31 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024616:  view genomic region     (about GC identifiers)

Start:
24,615,892 bp from pter      End:
24,629,870 bp from pter
Size:
13,979 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNF31_HUMAN, Q96EP0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF31  
Size: 1072 amino acids; 119652 Da
Subunit: Interacts with MUSK (By similarity). Component of the LUBAC complex (linear ubiquitin chain assembly
complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a
heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a
stimulation-dependent manner. Interacts with FAM105B/otulin; the interaction is direct
Sequence caution: Sequence=BAB15675.1; Type=Erroneous termination; Positions=1060; Note=Translated as Glu;
Sequence=BAB15675.1; Type=Frameshift; Positions=1036; Sequence=BAB15675.1; Type=Miscellaneous discrepancy;
Note=Intron retention; Sequence=BAB70948.1; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for RNF31:
2CT7 (3D)        4DBG (3D)        4JUY (3D)        4LJO (3D)        4LJP (3D)        4LJQ (3D)    
Secondary accessions: A0A962 Q86VI2 Q8TEI0 Q96GB4 Q96NF1 Q9H5F1 Q9NWD2
Alternative splicing: 3 isoforms:  Q96EP0-1   Q96EP0-2   Q96EP0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF31: NX_Q96EP0

Explore proteomics data for RNF31 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys99, Lys330, Lys454, Lys458, Lys579, Lys640, Lys848
  • Modification sites at PhosphoSitePlus

  • See RNF31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060469.4  
    ENSEMBL proteins: 
     ENSP00000454032   ENSP00000453471   ENSP00000454048   ENSP00000453423   ENSP00000453948  
     ENSP00000453574   ENSP00000315112   ENSP00000453645   ENSP00000453595   ENSP00000453601  
     ENSP00000452972   ENSP00000453501   ENSP00000454140   ENSP00000453672   ENSP00000452820  
     ENSP00000372134  

    RNF31 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RNF31

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    Cloud-Clone Corp. CLIAs for RNF31


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 8):
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR026254 RNF31
     IPR001876 Znf_RanBP2

    Graphical View of Domain Structure for InterPro Entry Q96EP0

    ProtoNet protein and cluster: Q96EP0

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB001876 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: RNF31_HUMAN, Q96EP0
    Domain: The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin
    Domain: The UBA domain mediates association with RBCK1/HOIL1 via interaction with its UBL domain
    Domain: RING 1 and IBR zinc-fingers catalyze the first step transfer of ubiquitin from the E2 onto RING 2, to
    transiently form a HECT-like covalent thioester intermediate (PubMed:22863777)
    Domain: The linear ubiquitin chain determining domain (LDD) mediates the final transfer of ubiquitin from RING 2
    onto the N-terminus of a target ubiquitin (PubMed:22863777)
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 3 RanBP2-type zinc fingers
    Similarity: Contains 2 RING-type zinc fingers
    Similarity: Contains 1 UBA domain


    RNF31 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF31_HUMAN, Q96EP0
    Function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked)
    polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation.
    LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical
    NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with
    TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1
    signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to
    conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the
    complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during
    angiogenesis. Binds polyubiquitin of different linkage types

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA17006537
    GO:0005515protein binding IPI17006537
    GO:0008270zinc ion binding IEA--
    GO:0043130ubiquitin binding IDA--
         
    RNF31 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF31:
     Increased cell number in S and 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnf31):
     hematopoietic system  immune system  mortality/aging 

    RNF31 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnf31tm1.2Kiwa for RNF31

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF31
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF31
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF31

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    hsa-miR-1287 hsa-miR-544b hsa-miR-378* hsa-miR-3907
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF31_HUMAN, Q96EP0: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0009898cytoplasmic side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--
    GO:0071797LUBAC complex IDA17006537

    RNF31 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF31: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF31

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF31 (Q96EP01, 2, 3 ENSP000003151124) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBCK1Q9BYM81, 2, 3, ENSP000003486324EBI-948111,EBI-2340624 MINT-8410460 MINT-8410293 MINT-3377861 MINT-8380224 MINT-8380275 MINT-3377799 MINT-8294986 MINT-8380394 MINT-3377829 MINT-8380340 MINT-3377775 MINT-8380248 MINT-8380301 MINT-8380321 MINT-8402491 MINT-8410335 MINT-8380361 MINT-8380200 MINT-8379171 MINT-8410542 MINT-8380117 MINT-8410390 MINT-8380160 MINT-8380141 MINT-8380181 MINT-3377753 I2D: score=4 STRING: ENSP00000348632
    ENSG00000204490P013752, 3MINT-8410390 I2D: score=1 
    ENSG00000206439P013752, 3MINT-8410390 I2D: score=1 
    ENSG00000223952P013752, 3MINT-8410390 I2D: score=1 
    ENSG00000228849P013752, 3MINT-8410390 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA12629548
    GO:0023035CD40 signaling pathway ISS--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IDA19136968
    GO:0050852T cell receptor signaling pathway IDA--
    GO:0051092positive regulation of NF-kappaB transcription factor activity IDA19136968

    RNF31 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF31



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF31 gene: 
    NM_017999.4  

    Unigene Cluster for RNF31:

    Ring finger protein 31
    Hs.375217  [show with all ESTs]
    Unigene Representative Sequence: NM_017999
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000560875 ENST00000559308 ENST00000558634 ENST00000557878 ENST00000559533
    ENST00000557991 ENST00000559438 ENST00000560071 ENST00000559275(uc001wml.1)
    ENST00000324103(uc001wmm.1 uc001wmn.1 uc010alg.1) ENST00000559882
    ENST00000559260 ENST00000491351 ENST00000560342 ENST00000558907 ENST00000560787
    ENST00000559583 ENST00000559071
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      QuantiFast Probe-based Assays in human, mouse, rat RNF31

    Additional mRNA sequence: 

    AB265810.1 AK000973.1 AK055542.1 AK122711.1 AK225832.1 AK291247.1 AY256461.1 BC009821.2 
    BC012077.1 BC017376.2 

    21 DOTS entries:

    DT.87013010  DT.87016890  DT.312276  DT.100651230  DT.120772567  DT.212225  DT.97818991  DT.97790739 
    DT.100784299  DT.452108  DT.95306414  DT.100784297  DT.100784302  DT.100665760  DT.100784295  DT.120772530 
    DT.120772572  DT.120772613  DT.86836532  DT.95323921  DT.87012582 

    Selected AceView cDNA sequences (see all 410):

    BM769792 CR603020 BM906740 CB216083 CA308170 BU633631 AA974114 BM807974 
    BM831096 AY256461 BX644892 CA446496 BQ722748 BM826910 BF525953 BX378006 
    BM905847 BM553042 BG058600 BM667985 BM811285 BX099826 BU784065 BF530066 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF31 (see all 22)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:                                                  -                 -                                         -                                   -     -   
    SP2:                                                                    -                                         -                                   -     -   
    SP3:                                                  -                 -                                         -     -                             -     -   
    SP4:                                                                                                                                                  -     -   
    SP5:                                                                                                                                                  -     -   

    ExUns: 16 ^ 17 ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 32 ^ 33a · 33b · 33c ^ 34a · 34b ^ 35 ^ 36a · 36b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for RNF31

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGCTCCC
    RNF31 Expression
    About this image

    RNF31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.375217

    UniProtKB/Swiss-Prot: RNF31_HUMAN, Q96EP0
    Tissue specificity: Expressed in both normal and transformed breast epithelial cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF31: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF31 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf311 , 5 ring finger protein 311, 5 86.34(n)1
    86.96(a)1
      14 (28.19 cM)5
    2687491  NM_194346.21  NP_919327.21 
     555917085 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    46(a)
    1 → many
    JH375631.1(21-4759)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    1 → many
    AAWZ02038155(161-12654)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.297312 Xenopus laevis transcribed sequence with weak similarity more 73.16(n)    CF289644.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003341031 E3 ubiquitin-protein ligase RNF31-like 61.61(n)
    59.44(a)
      100334103  XM_002660827.3  XP_002660873.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113216
    --
    8(a)
    1 → many
    2L(6759829-6772609)


    ENSEMBL Gene Tree for RNF31 (if available)
    TreeFam Gene Tree for RNF31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF31 gene
    ENSG000002595292  

    RNF31 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF31 (see all 356)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs595365891,2
    C--24617947(+) AAGGAA/GACAGG 1 -- int12Minor allele frequency- G:0.07WA 120
    rs1164623571,2
    C,F--24617972(+) GTGTCC/GCTAAA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1413415831,2
    C--24617977(+) CCTAAA/CCCCTT 1 -- int10--------
    rs1502486771,2
    C--24618058(+) CTCCTG/AGCCCC 2 /S /G mis11Minor allele frequency- A:0.00EU 1323
    rs1123097391,2
    C,F--24618242(+) ATCTCC/TGCTCA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs116211701,2
    H--24618243(+) tctccA/Gctcac 1 -- int10--------
    rs283732971,2
    C--24618250(+) TCACCA/GCAACC 1 -- int10--------
    rs1489554271,2
    C--24618322(+) CATGCC/GCCACC 1 -- int10--------
    rs1118539461,2
    C,F--24618328(+) CCACCG/ACGCTC 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1382938631,2
    C--24618334(+) CGCTCA/GGCTAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF31 (24615892 - 24629870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF31:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901498CNV Loss21882294
    nsv7249OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF31
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612487    OMIM disorders: --

    10 diseases for RNF31:    
    About MalaCards
    x-linked hyper igm syndrome    dengue hemorrhagic fever    adrenocortical carcinoma    hemorrhagic fever
    hepatitis c virus    ataxia    alzheimer's disease    hepatitis c
    breast cancer    hepatitis


    RNF31 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF31
    Human Genome Epidemiology (HuGE) Navigator: RNF31 (1 document)

    Export disorders for RNF31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF31 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with RNF31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells. (PubMed id 15093743)1, 2, 9 Thompson H.G.R.... Brody J.P. (Exp. Cell Res. 2004)
    2. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. (PubMed id 23708998)1, 2 Rivkin E.... Cordes S.P. (Nature 2013)
    3. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. (PubMed id 22430200)1, 2 Yagi H.... Kato K. (EMBO Rep. 2012)
    4. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. (PubMed id 22863777)1, 2 Smit J.J.... Sixma T.K. (EMBO J. 2012)
    5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    6. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. (PubMed id 19136968)1, 2 Tokunaga F.... Iwai K. (Nat. Cell Biol. 2009)
    7. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. (PubMed id 20005846)1, 2 Haas T.L.... Walczak H. (Mol. Cell 2009)
    8. A ubiquitin ligase complex assembles linear polyubiquitin chains. (PubMed id 17006537)1, 2 Kirisako T.... Iwai K. (EMBO J. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55072 HGNC: 16031 AceView: ISGF3GandRNF31 Ensembl:ENSG00000092098 euGenes: HUgn55072
    ECgene: RNF31 H-InvDB: RNF31

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF31 gene:
    Search GeneIP for patents involving RNF31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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