RNF26 Gene
protein-coding GIFtS: 46
GCID: GC11P119205
|
|
ring finger protein 26
| |
Aliases
for RNF26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 261 2 | | MGC26421 | | Ring Finger Protein With Leucine Zipper2 |
Export aliases for RNF26 gene to outside databasesPrevious GC identifers: GC11P121204 GC11P120717 GC11P119239 GC11P118743 GC11P118742 GC11P118710 GC11P115145 |
Summaries
for RNF26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF26:
The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved inprotein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer celllines derived from different types of cancer. (provided by RefSeq, Jul 2008)
|
Genomic Views
for RNF26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF26 gene promoter:
Max1 Elk-1 NF-kappaB CREB AREB6 Max deltaCREB NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF26
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF26 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23RNF26 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P119205: view genomic region
(about GC identifiers)
Start:
|
119,205,237 bp from pter |
End:
|
119,208,023 bp from pter |
Size:
|
2,787 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78 (See
protein sequence)Recommended Name: RING finger protein 26 Size: 433 amino acids; 47737 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q542Y8Explore the universe of human proteins at neXtProt for RNF26: NX_Q9BY78
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BY78
RNF26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114404.1
ENSEMBL proteins: ENSP00000312439
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
RNF26 for ontologies About GeneDecksing
RNF26 Antibody Products:
Assay Products for RNF26: |
Protein
Domains /
Families
for RNF26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF26 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BY78ProtoNet protein and cluster: Q9BY78 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78Similarity: Contains 1 RING-type zinc finger |
Function
for RNF26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF26 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF26 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RNF26 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for RNF26:
|
Pathways & Interactions
for RNF26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF26
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for RNF26 (Q9BY783 ENSP000003124394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
RNF26 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF26
Search CenterWatch for drugs/clinical trials and news about RNF26
|
Transcripts
for RNF26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF26 gene: NM_032015.4 Unigene Clusters for RNF26: Ring finger protein 26 Hs.524084 [show with all ESTs], Hs.727631 [show with all ESTs]Unigene Representative Sequences: BX648447, NM_0320151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000311413(uc001pwh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF26 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF26 (NM_032015) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF26 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF26 |
Additional cDNA sequence: AB055622.1 AK075379.1 AK122642.1 AY545553.1 BC000058.2 BC007534.1 BX647424.1 13 DOTS entries: DT.91651223 DT.414698 DT.100828268 DT.120708424 DT.100030182 DT.100828264 DT.120708427 DT.95287233 DT.120708423 DT.120708451 DT.120708467 DT.100828266 DT.120708446 24/85 AceView cDNA sequences (see all 85): AI608679 CA416744 BQ678770 BI793232 AW516090 BU681104 AW006946 BU179819 BM981596 CR610988 BQ005825 CA416707 AI494225 NM_032015 BF514612 CA446726 C01689 AI655472 CK821090 BU728658 CA449620 AW173772 AI445271 BG823296
GeneLoc Exon Structure
|
Expression
for RNF26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGGGCAG
About this image
See RNF26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF26
SOURCE GeneReport for Unigene clusters: Hs.524084 Hs.727631
UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78Tissue specificity: Ubiquitous. Up-regulated in several cancer cell lines
SABiosciences Expression via Pathway-Focused PCR Array including RNF26:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF26
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF26 |
Orthologs
for RNF26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF26 gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rnf261 , 5 |
ring finger protein 261, 5 |
84.59(n)1
88.21(a)1 |
|
9 (24.53 cM)5
2132111 NM_153762.31 NP_717095.21
440663275 |
chicken
(Gallus gallus) |
Aves |
RNF261 |
ring finger protein 26 |
60.94(n)
51.51(a) |
|
769803 XM_001233109.2 XP_001233110.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.188352 |
Xenopus laevis transcribed sequences |
87.16(n) |
|
BG347108.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.187312 |
Transcribed sequence with moderate similarity to protein more |
73.77(n) |
|
BI705485.1 |
ENSEMBL Gene Tree for RNF26 (if available)
TreeFam Gene Tree for RNF26 (if available) |
Paralogs
for RNF26 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNF26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF26 (119205237 - 119208023 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF26: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF26 |
|
Disorders
/ Diseases
for RNF26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RNF26 for disorders About MalaCards
RNF26 for disorders About GeneDecksing
OMIM gene information: 606130
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RNF26 (4 documents)
Export disorders for RNF26 gene to outside databases
|
Publications
for RNF26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF26 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF26) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. (PubMed id 11352657)1, 2, 3, 9 Katoh M. (2001)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNF26 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF26 gene:
Search GeneIP for patents involving RNF26
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 | | | RNF26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF26 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF26 |
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