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RNF26 Gene

protein-coding   GIFtS: 49
GCID: GC11P119205

Ring Finger Protein 26

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 261 2
Ring Finger Protein With Leucine Zipper1 2

External Ids:    HGNC: 146461   Entrez Gene: 791022   Ensembl: ENSG000001734567   OMIM: 6061305   UniProtKB: Q9BY783   

Export aliases for RNF26 gene to outside databases

Previous GC identifers: GC11P121204 GC11P120717 GC11P119239 GC11P118743 GC11P118742 GC11P118710 GC11P115145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF26 Gene:
The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in
protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer
cell lines derived from different types of cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF26 Gene:
RNF26 (ring finger protein 26) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF26 gene promoter:
         Max1   Elk-1   NF-kappaB   CREB   AREB6   Max   deltaCREB   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF26 promoter sequence
   Search Chromatin IP Primers for RNF26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

RNF26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF26 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P119205:  view genomic region     (about GC identifiers)

Start:
119,205,237 bp from pter      End:
119,208,023 bp from pter
Size:
2,787 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78 (See protein sequence)
Recommended Name: RING finger protein 26  
Size: 433 amino acids; 47737 Da
Secondary accessions: Q542Y8

Explore the universe of human proteins at neXtProt for RNF26: NX_Q9BY78

Explore proteomics data for RNF26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114404.1  
    ENSEMBL proteins: 
     ENSP00000312439  

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    antibodies-online kits for RNF26 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9BY78

    ProtoNet protein and cluster: Q9BY78

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS11352657
         
    Find genes that share ontologies with RNF26           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for RNF26:
     Decreased cilium length  Decreased cilium length after   Decreased p24 protein expressi  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory 

    Animal Models:
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    miRNA
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    hsa-let-7e-5p (MIRT051481), hsa-mir-215-5p (MIRT024944), hsa-mir-935 (MIRT036664), hsa-mir-192-5p (MIRT026179), hsa-mir-324-5p (MIRT043248)

    Block miRNA regulation of human, mouse, rat RNF26 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF26 (see all 12):
    hsa-miR-3606 hsa-miR-1266 hsa-miR-448 hsa-miR-186* hsa-miR-4306 hsa-miR-1291 hsa-miR-3918 hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidRNF26 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF26_HUMAN, Q9BY78: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RNF26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF26: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF26

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for RNF26 (Q9BY783 ENSP000003124394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    UBE2Q1Q7Z7E83, ENSP000002922114I2D: score=2 STRING: ENSP00000292211
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with RNF26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF26



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF26 gene: 
    NM_032015.4  

    Unigene Cluster for RNF26:

    Ring finger protein 26
    Hs.524084  [show with all ESTs]
    Unigene Representative Sequence: NM_032015
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000311413(uc001pwh.3)
    miRNA
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    hsa-miR-3606 hsa-miR-1266 hsa-miR-448 hsa-miR-186* hsa-miR-4306 hsa-miR-1291 hsa-miR-3918 hsa-miR-197
    SwitchGear 3'UTR luciferase reporter plasmidRNF26 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF26
      QuantiTect SYBR Green Assays in human, mouse, rat RNF26
      QuantiFast Probe-based Assays in human, mouse, rat RNF26

    Additional mRNA sequence: 

    AB055622.1 AK075379.1 AK122642.1 AY545553.1 BC000058.2 BC007534.1 BX647424.1 

    13 DOTS entries:

    DT.91651223  DT.414698  DT.100828268  DT.120708424  DT.100030182  DT.100828264  DT.120708427  DT.95287233 
    DT.120708423  DT.120708451  DT.120708467  DT.100828266  DT.120708446 

    Selected AceView cDNA sequences (see all 85):

    C01689 AW006946 BQ005825 AI494225 BU728658 AI608679 CR610988 BQ678770 
    BU681104 CA416707 BF514612 NM_032015 CA446726 CK821090 AW516090 CA416744 
    BM981596 BU179819 AI655472 BI793232 AI348066 BE535369 AW173772 AL559247 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGGCAG
    RNF26 Expression
    About this image

    RNF26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524084

    UniProtKB/Swiss-Prot: RNF26_HUMAN, Q9BY78
    Tissue specificity: Ubiquitous. Up-regulated in several cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF26: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF26 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf261 , 5 ring finger protein 261, 5 84.43(n)1
    87.97(a)1
      9 (24.53 cM)5
    2132111  NM_153762.31  NP_717095.21 
     440663275 
    chicken
    (Gallus gallus)
    Aves RNF261 ring finger protein 26 60.42(n)
    50.69(a)
      769803  XM_004948037.1  XP_004948094.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.188352 Xenopus laevis transcribed sequences 87.16(n)    BG347108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187312 Transcribed sequence with moderate similarity to protein more 73.77(n)    BI705485.1 


    ENSEMBL Gene Tree for RNF26 (if available)
    TreeFam Gene Tree for RNF26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF26 (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477525761,2
    C--119203356(+) TTGGAG/TTAGTG 1 -- us2k10--------
    rs25118471,2
    C,F,A,H--119203359(-) ACTCAC/TTAATC 1 -- us2k120Minor allele frequency- T:0.16NS EA NA WA CSA 2318
    rs1419446421,2
    C--119203397(+) GTCCTA/GAACGA 1 -- us2k10--------
    rs613786521,2
    C,F--119203401(+) TAAACG/AAATGG 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs118240011,2
    C,F,A,H--119203505(+) CACAGC/TACGTT 1 -- us2k116Minor allele frequency- T:0.33NS EA NA WA CSA 796
    rs1458072741,2
    C--119203563(+) ACCCAA/C/TGAACC 1 -- us2k10--------
    rs1384474751,2
    --119203757(+) TGATTA/GATAAC 1 -- us2k10--------
    rs799849291,2
    F--119203792(+) AGATCC/TCTTAA 1 -- us2k11Minor allele frequency- T:0.05EA 120
    rs797503121,2
    F--119203795(+) TCCCTT/GAAGAG 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs764846491,2
    F--119203811(+) GGTACG/AGGCGA 1 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for RNF26 (119205237 - 119208023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RNF26:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522705CNV Loss19592680
    nsv898417CNV Loss21882294
    nsv898418CNV Loss21882294
    nsv826103CNV Gain20364138
    nsv826104CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF26
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606130    OMIM disorders: --


    Find genes that share disorders with RNF26           About GenesLikeMe

    Genetic Association Database (GAD): RNF26
    Human Genome Epidemiology (HuGE) Navigator: RNF26 (4 documents)

    Export disorders for RNF26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF26 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RNF26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. (PubMed id 11352657)1, 2, 3, 9 Katoh M. (Biochem. Biophys. Res. Commun. 2001)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    8. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79102 HGNC: 14646 AceView: RNF26 Ensembl:ENSG00000173456 euGenes: HUgn79102
    ECgene: RNF26 H-InvDB: RNF26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF26 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF26 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF26 gene:
    Search GeneIP for patents involving RNF26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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