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Aliases for RNF26 Gene

Aliases for RNF26 Gene

  • Ring Finger Protein 26 2 3 5
  • Ring Finger Protein With Leucine Zipper 2

External Ids for RNF26 Gene

Previous GeneCards Identifiers for RNF26 Gene

  • GC11P121204
  • GC11P120717
  • GC11P119239
  • GC11P118743
  • GC11P118742
  • GC11P118710
  • GC11P115145
  • GC11P119205

Summaries for RNF26 Gene

Entrez Gene Summary for RNF26 Gene

  • The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF26 Gene

RNF26 (Ring Finger Protein 26) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF26 Gene

Genomics for RNF26 Gene

Regulatory Elements for RNF26 Gene

Enhancers for RNF26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G119336 1.3 ENCODE dbSUPER 84.8 +4.6 4564 5.3 PKNOX1 ATF1 ARNT ARID4B ZNF48 GLIS2 ZNF143 SP3 NCOA1 MXD4 RNF26 CBL ENSG00000245385 C1QTNF5 MFRP
GH11G119090 1.7 Ensembl ENCODE dbSUPER 22.3 -240.8 -240829 5.9 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 HINFP ARCN1 RNF26 ENSG00000254909 C2CD2L BCL9L RPL23AP64 UBE4A RPS25 IFT46
GH11G119314 1.4 ENCODE dbSUPER 21.8 -15.7 -15691 8.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ARID4B FEZF1 ZNF2 ZNF766 RNF26 CBL IFT46 RPS25 ENSG00000271751 GC11M119321 MIR6756
GH11G118398 1.6 Ensembl ENCODE dbSUPER 18.9 -933.7 -933702 5.1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207 ARCN1 RNF26 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A IFT46 BCL9L ENSG00000255384 KMT2A
GH11G118906 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -415.7 -415708 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC BCL9L CCDC84 CXCR5 DPAGT1 HMBS ENSG00000222529 FOXR1 C2CD2L ENSG00000254909 RNF26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF26 on UCSC Golden Path with GeneCards custom track

Promoters for RNF26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RNF26 Gene

119,334,500 bp from pter
119,337,314 bp from pter
2,815 bases
Plus strand

Genomic View for RNF26 Gene

Genes around RNF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF26 Gene

Proteins for RNF26 Gene

  • Protein details for RNF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 26
    Protein Accession:
    Secondary Accessions:
    • Q542Y8

    Protein attributes for RNF26 Gene

    433 amino acids
    Molecular mass:
    47737 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF26 Gene

Post-translational modifications for RNF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF26 Gene

Domains & Families for RNF26 Gene

Gene Families for RNF26 Gene

Protein Domains for RNF26 Gene


Suggested Antigen Peptide Sequences for RNF26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF26: view

No data available for UniProtKB/Swiss-Prot for RNF26 Gene

Function for RNF26 Gene

Gene Ontology (GO) - Molecular Function for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27368102
GO:0008270 zinc ion binding NAS 11352657
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 25254379
genes like me logo Genes that share ontologies with RNF26: view
genes like me logo Genes that share phenotypes with RNF26: view

Animal Model Products

CRISPR Products

miRNA for RNF26 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF26 Gene

Localization for RNF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF26 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF26 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 25254379
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF26: view

Pathways & Interactions for RNF26 Gene

SuperPathways for RNF26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IDA 27368102
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IDA 27368102
GO:0032479 regulation of type I interferon production IDA 25254379
GO:0050687 negative regulation of defense response to virus IDA 25254379
genes like me logo Genes that share ontologies with RNF26: view

No data available for Pathways by source and SIGNOR curated interactions for RNF26 Gene

Drugs & Compounds for RNF26 Gene

No Compound Related Data Available

Transcripts for RNF26 Gene

mRNA/cDNA for RNF26 Gene

(1) REFSEQ mRNAs :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF26 Gene

No ASD Table

Relevant External Links for RNF26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF26 Gene

Protein differential expression in normal tissues from HIPED for RNF26 Gene

This gene is overexpressed in Adrenal (46.7) and Heart (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF26 Gene

Protein tissue co-expression partners for RNF26 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF26 Gene:


SOURCE GeneReport for Unigene cluster for RNF26 Gene:


mRNA Expression by UniProt/SwissProt for RNF26 Gene:

Tissue specificity: Ubiquitous. Up-regulated in several cancer cell lines.

Evidence on tissue expression from TISSUES for RNF26 Gene

  • Nervous system(4.9)
  • Muscle(4.2)
  • Skin(3.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RNF26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF26 Gene

Orthologs for RNF26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF26 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF26 34 35
  • 99.69 (n)
(Canis familiaris)
Mammalia RNF26 34 35
  • 89.22 (n)
(Bos Taurus)
Mammalia RNF26 34 35
  • 88.76 (n)
(Mus musculus)
Mammalia Gm9008 35
  • 87 (a)
Rnf26 34 16 35
  • 84.43 (n)
(Rattus norvegicus)
Mammalia Rnf26 34
  • 83.73 (n)
(Gallus gallus)
Aves RNF26 34 35
  • 60.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf26 34
  • 49.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18835 34
(Danio rerio)
Actinopterygii rnf26 34 35
  • 50.84 (n)
Dr.18731 34
Species where no ortholog for RNF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF26 Gene

Gene Tree for RNF26 (if available)
Gene Tree for RNF26 (if available)

Paralogs for RNF26 Gene

No data available for Paralogs for RNF26 Gene

Variants for RNF26 Gene

Sequence variations from dbSNP and Humsavar for RNF26 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000151481 -- 119,335,003(+) CCTGG(A/G)TTGGA utr-variant-5-prime
rs1000274665 -- 119,334,651(+) GGGGA(C/T)AGGGG utr-variant-5-prime
rs1000889657 -- 119,333,296(+) CAGTC(C/T)TTCCT upstream-variant-2KB
rs1000899962 -- 119,337,353(+) GTCAA(-/G)GCAAC downstream-variant-500B
rs1001489294 -- 119,333,647(+) CGGGC(A/T)TGGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF26 Gene

Variant ID Type Subtype PubMed ID
nsv522705 CNV loss 19592680
nsv826103 CNV gain 20364138
nsv826104 CNV gain 20364138

Variation tolerance for RNF26 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF26 Gene

Disorders for RNF26 Gene

Relevant External Links for RNF26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF26 Gene

Publications for RNF26 Gene

  1. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. (PMID: 11352657) Katoh M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. (PMID: 27368102) Jongsma M.L. … Neefjes J. (Cell 2016) 3 64

Products for RNF26 Gene

Sources for RNF26 Gene

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