Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF25 Gene

protein-coding GIFtS: 51
GCID: GC02M219528

ring finger protein 25

Explore 2 diseases affiliated with
RNF25 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 25¹ ² ³
AO7¹ ²
FLJ13906¹
E3 Ubiquitin-Protein Ligase RNF25²
Ring Finger Protein AO7²
EC 6.3.2.-³

External Ids:	HGNC: 14662¹	Entrez Gene: 64320²	Ensembl: ENSG00000163481⁷	UniProtKB: Q96BH1³

Export aliases for RNF25 gene to outside databases

Previous GC identifers: GC02M217544 GC02M218249 GC02M219492 GC02M219731 GC02M219354 GC02M219236 GC02M211382

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF25:

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to

interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse

protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By

similarity). Stimulates transcription mediated by NF-kappa-B

Gene Wiki entry for RNF25

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF25 gene promoter:
AP-1 p53 RREB-1 ATF-2 Pax-2 E4BP4 FOXO4 ARP-1 c-Myb ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF25 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

RNF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF25 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M219528: view genomic region (about GC identifiers)

Start:	219,528,587 bp from pter	End:	219,537,134 bp from pter
Size:	8,548 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF25

Size: 459 amino acids; 51219 Da

Subunit: Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity).

Interacts with RELA

2 PDB 3D structures from and Proteopedia for RNF25:

2DAY (3D)

2DMF (3D)

Secondary accessions: A8K0D6 Q53HQ5 Q9H874

Explore the universe of human proteins at neXtProt for RNF25: NX_Q96BH1

Post-translational modifications:

Ubiquitinated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96BH1

RNF25 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_071898.2

ENSEMBL proteins:

ENSP00000295704 ENSP00000403582

Reactome Protein details: Q96BH1
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RNF25 OriGene Protein Over-expression Lysate: RNF25 OriGene Custom Protein Services for RNF25
	GenScript Custom Purified and Recombinant Proteins Services for RNF25
	Novus Biologicals RNF25 Proteins Novus Biologicals RNF25 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNF25

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12748188
GO:0005829	cytosol	IDA	12748188

RNF25 for ontologies About GeneDecksing

RNF25 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RNF25
	GenScript Custom Superior Antibodies Services for RNF25
	Novus Biologicals RNF25 Antibodies
	Search for Antibodies for RNF25 at Abcam
	Uscn Antibodies for RNF25
	Search ThermoFisher Antibodies for RNF25

Assay Products for RNF25:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNF25
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RNF25

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF25 for domains About GeneDecksing

4 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

IPR006575 RWD-domain

Graphical View of Domain Structure for InterPro Entry Q96BH1

ProtoNet protein and cluster: Q96BH1

3 Blocks protein families:

IPB000608 Ubiquitin-conjugating enzymes

IPB001841 Zn-finger

IPB006575 RWD

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates

ubiquitination

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 1 RWD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By

similarity). Stimulates transcription mediated by NF-kappa-B

Enzyme Number (IUBMB): EC 6.3.2.-¹

miRNA Products:		OriGene 3'-UTR Clone: RNF25 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF25
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RNF25
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF25 (see all 7) OriGene shRNA RFP: RNF25 OriGene siRNA: RNF25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF25

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNF25

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNF25 (NM_022453)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF25

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNF25
		Search LifeMap BioReagents cell lines for RNF25

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF25

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	ISS	--
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0051059	NF-kappaB binding	IPI	12748188

RNF25 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Tryptophan metabolism

Tryptophan metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for RNF25

	TNF-alpha/NF-kB Signaling Pathway
	Tryptophan metabolism

5 Reactome Pathways for RNF25

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Pathway: Protein modification; protein ubiquitination

RNF25 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RNF25

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/16 Interacting proteins for RNF25 (Q96BH1³ ENSP00000295704⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2D2	P62837³, ENSP00000381717⁴	I2D: score=2 STRING: ENSP00000381717
UBE2D3	P61077³, ENSP00000349722⁴	I2D: score=2 STRING: ENSP00000349722
UBE2L6	O14933³, ENSP00000287156⁴	I2D: score=2 STRING: ENSP00000287156
UBE2U	Q5VVX9³, ENSP00000360116⁴	I2D: score=2 STRING: ENSP00000360116
NKD2	Q969F2³, ENSP00000296849⁴	I2D: score=1 STRING: ENSP00000296849

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	ISS	--
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	12748188

RNF25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF25

4 HMDB Compounds for RNF25 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about RNF25

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF25 gene:

NM_022453.2

Unigene Cluster for RNF25:

Ring finger protein 25

Hs.471403 [show with all ESTs]

Unigene Representative Sequence: BC028167

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295704(uc002vit.3) ENST00000473034(uc010fvw.3) ENST00000474339

ENST00000463188 ENST00000423170 ENST00000497832

miRNA Products:		OriGene 3'-UTR Clone: RNF25 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF25
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RNF25
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF25 (see all 7) OriGene shRNA RFP: RNF25 OriGene siRNA: RNF25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF25

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNF25 (NM_022453)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF25

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNF25
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF25
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF25

Additional cDNA sequence:

AK023968.1 AK222525.1 AK289501.1 BC015612.2 BC028167.1

7 DOTS entries:

DT.112447 DT.99935205 DT.92429592 DT.100645481 DT.100801145 DT.121035332 DT.212370

24/130 AceView cDNA sequences (see all 130):

BC015612 BM709039 BM717814 BI914900 AU119027 AA447724 BM666406 BC028167

CR603654 NM_022453 BX354783 BX282015 BP370924 CR604874 CK725204 BG742306

CR617443 BM799598 CR624539 BM977954 BI831198 BX375518 BM804809 AA424903

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF25 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for RNF25

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTAAAGC

About this image

RNF25 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNF25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF25

SOURCE GeneReport for Unigene cluster: Hs.471403

SABiosciences Custom PCR Arrays for RNF25

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNF25
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF25
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF25

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF25

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF25 gene from 9/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnf25^{1 , 5}	ring finger protein 25^{1, 5}	84.87(n)¹ 82.89(a)¹		1 (38.54 cM)⁵ 57751¹ NM_021313.2¹ NP_067288.2¹ 74593748⁵
chicken (Gallus gallus)	Aves	RNF25¹	ring finger protein 25	59.29(n) 52.38(a)		424211 NM_001031259.1 NP_001026430.1
lizard (Anolis carolinensis)	Reptilia	RNF25⁶	--	40(a)	1 ↔ 1	1(88276793-88297597)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25335²	Xenopus laevis transcribed sequence with weak similarity more	72.58(n)		CB558881.1
zebrafish (Danio rerio)	Actinopterygii	BC055571.1²	--	75.59(n)		394158 BC055571.1
fruit fly (Drosophila melanogaster)	Insecta	CG13344^{1 , 3}	CG13344¹	36(a)³ 46.11(n)¹ 34.5(a)¹		50C6³ 36541¹ NM_137071.4¹ NP_610915.2¹
worm (Caenorhabditis elegans)	Secernentea	Y53G8AR.5⁶	Protein Y53G8AR.5	20(a)	1 ↔ 1	III(3297445-3302154)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G60300¹	ubiquitin-protein ligase RNF25	43.67(n) 29.89(a)		825201 NM_115894.4 NP_191589.3
rice (Oryza sativa)	Liliopsida	Os11g0565400¹	hypothetical protein	43.98(n) 33.13(a)		4350739 NM_001074640.2 NP_001068108.1

ENSEMBL Gene Tree for RNF25 (if available)
TreeFam Gene Tree for RNF25 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193118439^1,2		--	219528700(+)	`AGATTC/GCAGGC`	2	Q E	mis¹		0	--	--	--	--
rs201760175^1,2	C,	--	219528715(+)	`GGACTC/GCCTCC`	2	Q E	mis¹		1		EU	1323
rs138321594^1,2	C	--	219528732(+)	`CAGGCC/TGGTAT`	2	Q R	mis¹		1		NA	4032
rs11686957^1,2	C,F,H	--	219528760(+)	`CAGGCG/AAGGGT`	2	/R /C	mis¹		10		NS EA NA EU	6473
rs115343354^1,2	C,F,	--	219528762(+)	`GGCGAG/CGGTAG`	2	/P /R	mis¹		3		NA EU	5741
rs115609218^1,2	C,F,	--	219528775(+)	`AGAACC/TGGGTG`	2	S G	mis¹		1		EA	182
rs59377638^1,2	C,	--	219528784(+)	`TGTCCA/GGCCTT`	2	R W	mis¹		0	--	--	--	--
rs116018821^1,2	C,	--	219528795(+)	`TAGAGC/TGCTCC`	2	H R	mis¹		2		WA NA	4576
rs139628113^1,2	C,	--	219528816(+)	`AGTCCC/TGAGTC`	2	Q R	mis¹		1		NA	4388
rs113289861^1,2	C,F,	--	219528817(+)	`GTCCCG/AAGTCC`	2	/R /W	mis¹		4		CSA WA NA	4613

HapMap Linkage Disequilibrium report for RNF25 (219528587 - 219537134 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF25: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF25

DNA2.0 Custom Variant and Variant Library Synthesis for RNF25

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF25 for disorders About GeneDecksing

2 diseases for RNF25: About MalaCards

scrub typhus typhus

Export disorders for RNF25 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF25 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with RNF25)

Utopia: connect your pdf to the dynamic
world of online information

RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PubMed id 12748188)^{1, 2, 3} Asamitsu K....Okamoto T. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)^{1, 9} Lorick K.L....Weissman A.M. (1999)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)¹ Altun M....Kessler B.M. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64320	HGNC: 14662	AceView: RNF25	Ensembl:ENSG00000163481	euGenes: HUgn64320
ECgene: RNF25	H-InvDB: RNF25

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNF25	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNF25 gene:
Search GeneIP for patents involving RNF25

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RNF25
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF25		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF25
	OriGene Protein Over-expression Lysate for RNF25		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RNF25		OriGene 3'-UTR Clone for RNF25
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF25
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for RNF25		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RNF25		OriGene Custom Protein Services for RNF25
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF25
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF25
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF25
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF25
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF25
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF25

	GenScript Custom Purified and Recombinant Proteins Services for RNF25		GenScript cDNA clones with any tag delivered in your preferred vector for RNF25
	GenScript Custom Assay Services for RNF25		GenScript Custom Superior Antibodies Services for RNF25
	GenScript Custom overexpressing Cell Line Services for RNF25		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RNF25 promoter
	Search Chromatin IP Primers for RNF25
	RT² qPCR Primer Assay in human, mouse, rat RNF25
	GNC Network for RNF25
	SABiosciences Custom PCR Arrays for RNF25

Search Tocris compounds for RNF25

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RNF25 antibodies
	RNF25 proteins
	RNF25 lysates

	Search for Antibodies for RNF25 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RNF25
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RNF25 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RNF25

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF25

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RNF25
	SwitchGear Promoter luciferase reporter plasmids for RNF25

Search ThermoFisher Antibodies for RNF25

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF25

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNF25 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RNF25 Gene

ring finger protein 25

Aliases
for RNF25 gene

Summaries
for RNF25 gene

Genomic Views
for RNF25 gene

Proteins
for RNF25 gene

Protein Domains /
Families
for RNF25 gene

Function
for RNF25 gene

Pathways & Interactions
for RNF25 gene

Drugs & Compounds
for RNF25 gene

Transcripts
for RNF25 gene

Expression
for RNF25 gene

Orthologs
for RNF25 gene

Paralogs
for RNF25 gene

Genomic Variants
for RNF25 gene

Disorders / Diseases
for RNF25 gene

Publications
for RNF25 gene

External Searches for RNF25 gene

Genome Databases showing RNF25 gene

Other Databases showing RNF25 gene

Specialized Databases showing RNF25 gene

Intellectual Property
for RNF25 gene

Products
for RNF25 gene

View Random Gene

Advanced Search

Export list of displayed genes

RNF25 Gene

ring finger protein 25

Aliasesfor RNF25 gene

Summariesfor RNF25 gene

Genomic Viewsfor RNF25 gene

Proteinsfor RNF25 gene

Protein Domains /Familiesfor RNF25 gene

Functionfor RNF25 gene

Pathways & Interactionsfor RNF25 gene

Drugs & Compoundsfor RNF25 gene

Transcriptsfor RNF25 gene

Expression for RNF25 gene

Orthologsfor RNF25 gene

Paralogsfor RNF25 gene

Genomic Variantsfor RNF25 gene

Disorders / Diseasesfor RNF25 gene

Publicationsfor RNF25 gene

External Searches for RNF25 gene

Genome Databases showing RNF25 gene

Other Databases showing RNF25 gene

Specialized Databases showing RNF25 gene

Intellectual Propertyfor RNF25 gene

Productsfor RNF25 gene

View Random Gene

Aliases
for RNF25 gene

Summaries
for RNF25 gene

Genomic Views
for RNF25 gene

Proteins
for RNF25 gene

Protein Domains /
Families
for RNF25 gene

Function
for RNF25 gene

Pathways & Interactions
for RNF25 gene

Drugs & Compounds
for RNF25 gene

Transcripts
for RNF25 gene

Expression
for RNF25 gene

Orthologs
for RNF25 gene

Paralogs
for RNF25 gene

Genomic Variants
for RNF25 gene

Disorders / Diseases
for RNF25 gene

Publications
for RNF25 gene

Intellectual Property
for RNF25 gene

Products
for RNF25 gene