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Aliases for RNF25 Gene

Aliases for RNF25 Gene

  • Ring Finger Protein 25 2 3
  • E3 Ubiquitin-Protein Ligase RNF25 3
  • Ring Finger Protein AO7 3
  • RING Finger Protein 25 4
  • EC 6.3.2.- 4
  • AO7 3

External Ids for RNF25 Gene

Previous GeneCards Identifiers for RNF25 Gene

  • GC02M217544
  • GC02M218249
  • GC02M219492
  • GC02M219731
  • GC02M219354
  • GC02M219236
  • GC02M211382
  • GC02M219528

Summaries for RNF25 Gene

Entrez Gene Summary for RNF25 Gene

  • The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF25 Gene

RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and NF-kappaB binding.

UniProtKB/Swiss-Prot for RNF25 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Gene Wiki entry for RNF25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF25 Gene

Genomics for RNF25 Gene

Regulatory Elements for RNF25 Gene

Genomic Location for RNF25 Gene

218,663,864 bp from pter
218,672,411 bp from pter
8,548 bases
Minus strand

Genomic View for RNF25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF25 Gene

Proteins for RNF25 Gene

  • Protein details for RNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF25
    Protein Accession:
    Secondary Accessions:
    • A8K0D6
    • Q53HQ5
    • Q9H874

    Protein attributes for RNF25 Gene

    459 amino acids
    Molecular mass:
    51219 Da
    Quaternary structure:
    • Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity). Interacts with RELA.

    Three dimensional structures from OCA and Proteopedia for RNF25 Gene

neXtProt entry for RNF25 Gene

Proteomics data for RNF25 Gene at MOPED

Post-translational modifications for RNF25 Gene

Other Protein References for RNF25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF25 Gene

Domains for RNF25 Gene

Gene Families for RNF25 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for RNF25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96BH1
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination
  • Contains 1 RWD domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF25: view

Function for RNF25 Gene

Molecular function for RNF25 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Enzyme Numbers (IUBMB) for RNF25 Gene

Gene Ontology (GO) - Molecular Function for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0051059 NF-kappaB binding IPI 12748188
genes like me logo Genes that share ontologies with RNF25: view

miRNA for RNF25 Gene

miRTarBase miRNAs that target RNF25

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF25 Gene

Localization for RNF25 Gene

Subcellular locations from

Jensen Localization Image for RNF25 Gene COMPARTMENTS Subcellular localization image for RNF25 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12748188
GO:0005829 cytosol IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF25 Gene

Pathways for RNF25 Gene

genes like me logo Genes that share pathways with RNF25: view

UniProtKB/Swiss-Prot Q96BH1-RNF25_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

Compounds for RNF25 Gene

(4) HMDB Compounds for RNF25 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with RNF25: view

Transcripts for RNF25 Gene

Unigene Clusters for RNF25 Gene

Ring finger protein 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10

Relevant External Links for RNF25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF25 Gene

mRNA expression in normal human tissues for RNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF25 Gene

SOURCE GeneReport for Unigene cluster for RNF25 Gene Hs.471403

genes like me logo Genes that share expressions with RNF25: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF25 Gene

Orthologs for RNF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF25 35
  • 98.91 (n)
  • 98.26 (a)
RNF25 36
  • 98 (a)
(Bos Taurus)
Mammalia RNF25 35
  • 86.46 (n)
  • 82.53 (a)
RNF25 36
  • 83 (a)
(Canis familiaris)
Mammalia RNF25 35
  • 90.05 (n)
  • 89.11 (a)
RNF25 36
  • 89 (a)
(Mus musculus)
Mammalia Rnf25 35
  • 84.58 (n)
  • 82.24 (a)
Rnf25 16
Rnf25 36
  • 82 (a)
(Monodelphis domestica)
Mammalia RNF25 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Rnf25 35
  • 84.88 (n)
  • 85.02 (a)
(Gallus gallus)
Aves RNF25 35
  • 57.96 (n)
  • 51.11 (a)
RNF25 36
  • 43 (a)
(Anolis carolinensis)
Reptilia RNF25 36
  • 47 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25335 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf25 35
  • 56.6 (n)
  • 51.04 (a)
Str.14059 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9261 35
(Danio rerio)
Actinopterygii -- 35
rnf25 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13344 36
  • 31 (a)
CG13344 37
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y53G8AR.5 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8459 36
  • 29 (a)
Species with no ortholog for RNF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF25 Gene

Gene Tree for RNF25 (if available)
Gene Tree for RNF25 (if available)

Paralogs for RNF25 Gene

No data available for Paralogs for RNF25 Gene

Variants for RNF25 Gene

Sequence variations from dbSNP and Humsavar for RNF25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1968346 -- 218,665,625(+) ATAAT(C/T)CCAGC intron-variant
rs2069333 -- 218,666,533(-) TGAAC(A/C)TTTTT intron-variant
rs2081744 -- 218,665,160(+) CATGG(C/G)CTGTT reference, missense
rs2243911 -- 218,664,625(+) GACCA(C/T)GATCA intron-variant
rs2303562 -- 218,664,524(+) TCCGC(A/C/T)GGGGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RNF25 Gene

Variant ID Type Subtype PubMed ID
nsv875862 CNV Gain 21882294

Relevant External Links for RNF25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF25 Gene

Disorders for RNF25 Gene

No disorders were found for RNF25 Gene.

No data available for UniProtKB/Swiss-Prot for RNF25 Gene

Publications for RNF25 Gene

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PMID: 12748188) Asamitsu K. … Okamoto T. (J. Biol. Chem. 2003) 2 3 4
  2. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick K.L. … Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3

Products for RNF25 Gene

Sources for RNF25 Gene

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