Aliases for RNF25 Gene
External Ids for RNF25 Gene
Previous GeneCards Identifiers for RNF25 Gene
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF25 Gene
RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Diseases associated with RNF25 include Congenital Epulis. Among its related pathways are Immune System and superpathway of tryptophan utilization. GO annotations related to this gene include ligase activity and NF-kappaB binding.
UniProtKB/Swiss-Prot for RNF25 Gene
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.