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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF24 Gene

protein-coding   GIFtS: 46
GCID: GC20M003912

Ring Finger Protein 24

  Search for RNF24
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 241 2
G1L2 5
Goliath-Like Protein (C3HC4 Type)2

External Ids:    HGNC: 137791   Entrez Gene: 112372   Ensembl: ENSG000001012367   OMIM: 6124895   UniProtKB: Q9Y2253   

Export aliases for RNF24 gene to outside databases

Previous GC identifers: GC20M003901 GC20M003861 GC20M003908 GC20M003860


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF24 Gene:
The protein encoded by this gene contains similarity to the Drosophila goliath protein and thus may function as a
transcription factor. Multiple alternatively spliced transcript variants that encode different isoforms have been
found for this gene. (provided by RefSeq, Aug 2008)

GeneCards Summary for RNF24 Gene: 
RNF24 (ring finger protein 24) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF122.

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225
Function: May play a role in TRPCs intracellular trafficking

Gene Wiki entry for RNF24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF24 gene promoter:
         Egr-2   AREB6   FOXJ2 (long isoform)   HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF24 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

RNF24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003912:  view genomic region     (about GC identifiers)

Start:
3,912,068 bp from pter      End:
3,996,229 bp from pter
Size:
84,162 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225 (See protein sequence)
Recommended Name: RING finger protein 24  
Size: 148 amino acids; 17210 Da
Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7
Subcellular location: Golgi apparatus membrane; Single-pass membrane protein
1 PDB 3D structure from and Proteopedia for RNF24:
2EP4 (3D)    
Secondary accessions: D3DVZ2 D3DVZ3 Q9UMH1
Alternative splicing: 2 isoforms:  Q9Y225-1   Q9Y225-2   

Explore the universe of human proteins at neXtProt for RNF24: NX_Q9Y225

Explore proteomics data for RNF24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y225

  • RNF24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF24 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001127809.1  NP_001127810.1  NP_009150.1  

    ENSEMBL proteins: 
     ENSP00000336753   ENSP00000351166   ENSP00000444711   ENSP00000388550  

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    Cloud-Clone Corp. Proteins for RNF24 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--

    RNF24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y225

    ProtoNet protein and cluster: Q9Y225

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225
    Similarity: Contains 1 RING-type zinc finger


    RNF24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF24_HUMAN, Q9Y225
    Function: May play a role in TRPCs intracellular trafficking

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF24 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RNF24 (ENSP000003885504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF24

    Search CenterWatch for drugs/clinical trials and news about RNF24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF24 gene (3 alternative transcripts): 
    NM_001134337.1  NM_001134338.1  NM_007219.3  

    Unigene Cluster for RNF24:

    Ring finger protein 24
    Hs.589884  [show with all ESTs]
    Unigene Representative Sequence: NM_007219
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336095(uc002wkh.2) ENST00000358395(uc002wkj.2) ENST00000545616(uc002wki.2)
    ENST00000432261
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF151081.1 AL079313.1 AL096778.1 BC000213.2 BC039584.1 BT007406.1 

    10 DOTS entries:

    DT.213065  DT.92424596  DT.100780353  DT.95096008  DT.120834387  DT.120834453  DT.120834411  DT.92008744 
    DT.92013051  DT.95073251 

    24/120 AceView cDNA sequences (see all 120):

    BU164445 AW732459 CR599255 BT007406 CR616881 BU191159 BC039584 CR626646 
    AI269590 CR605832 AA134351 BU753511 BM699152 AI189598 AL449893 CR617392 
    BM931812 CA433068 AW665448 AL079313 AI379183 AI215604 BP347933 AA327926 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF24    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:              -                                                   
    SP2:              -     -                                             
    SP3:                    -                                             


    ECgene alternative splicing isoforms for RNF24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTGTGG
    RNF24 Expression
    About this image


    See RNF24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF24

    SOURCE GeneReport for Unigene cluster: Hs.589884
        SABiosciences Expression via Pathway-Focused PCR Array including RNF24: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF24 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf241 , 5 ring finger protein 241, 5 92.57(n)1
    97.97(a)1
      2 (63.32 cM)5
    519021  NM_178607.41  NP_848722.11 
     1312980645 
    chicken
    (Gallus gallus)
    Aves LOC1008576051 RING finger protein 24-like 83.56(n)
    95.27(a)
      100857605  XM_003641262.1  XP_003641310.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157882 Xenopus laevis transcribed sequence with moderate similarity more 84.05(n)    BJ042570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf241 ring finger protein 24 75.9(n)
    85.14(a)
      492480  NM_001007352.1  NP_001007353.1 


    ENSEMBL Gene Tree for RNF24 (if available)
    TreeFam Gene Tree for RNF24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF24 gene
    RNF1222  
    4 SIMAP similar genes for RNF24 using alignment to 2 protein entries:     RNF24_HUMAN (see all proteins):
    RNF122    RNF13    RNF167    RNF149

    RNF24 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1737 SNPs in RNF24 are shown (see all 1737)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1508065351,2
    --3911652(+) GTGGCA/GAAGAA 3 -- int10--------
    rs1143152941,2
    F--3911693(+) ATACTG/CACCCA 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1152116171,2
    C,F--3911716(+) GTCAGG/ACTGGT 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1919442541,2
    --3911792(+) CACCCA/GTGGAG 3 -- int10--------
    rs1159200211,2
    F--3911830(+) TAACCC/TATAGC 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1832062541,2
    --3911862(+) TGAGCC/TGCTTA 3 -- int10--------
    rs735743001,2
    C,F--3911952(+) CAACTC/GCTGAA 3 -- int12Minor allele frequency- G:0.03WA 120
    rs1497603131,2
    C--3912056(+) ATAAAA/TAAAGG 3 -- int10--------
    rs1873729581,2
    --3912154(+) AGATGC/TGCAGG 3 -- ut310--------
    rs38039621,2
    C,F,H--3912188(+) TGCAGG/AGAGCA 3 -- ut31 ese310Minor allele frequency- A:0.02NS EA NA 1030

    HapMap Linkage Disequilibrium report for RNF24 (3912068 - 3996229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF24:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912623CNV Gain21882294
    nsv527924CNV Gain19592680
    nsv828673CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNF24 for disorders           About MalaCards
    OMIM gene information: 612489    OMIM disorders: --


    RNF24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF24

    Export disorders for RNF24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF24 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RNF24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PubMed id 17850865)1, 2 Lussier M.P.... Boulay G. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11237 HGNC: 13779 AceView: RNF24 Ensembl:ENSG00000101236 euGenes: HUgn11237
    ECgene: RNF24 H-InvDB: RNF24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF24 gene:
    Search GeneIP for patents involving RNF24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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