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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF24 Gene

protein-coding   GIFtS: 47
GCID: GC20M003912

ring finger protein 24
 Explore 1 disease affiliated with
RNF24 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF24    

Aliases
for RNF24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 241 2
G1L1 2 5
Goliath-Like Protein (C3HC4 Type)2

External Ids:    HGNC: 137791   Entrez Gene: 112372   Ensembl: ENSG000001012367   OMIM: 6124895   UniProtKB: Q9Y2253   

Export aliases for RNF24 gene to outside databases

Previous GC identifers: GC20M003901 GC20M003861 GC20M003908 GC20M003860


Summaries
for RNF24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNF24:
The protein encoded by this gene contains similarity to the Drosophila goliath protein and thus may function as a
transcription factor. Multiple alternatively spliced transcript variants that encode different isoforms have been
found for this gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225
Function: May play a role in TRPCs intracellular trafficking

Gene Wiki entry for RNF24


Genomic Views
for RNF24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF24 gene promoter:
         Egr-2   AREB6   FOXJ2 (long isoform)   HTF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF24 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

RNF24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF24 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003912:  view genomic region     (about GC identifiers)

Start:
 3,912,068 bp from pter      End:
 3,996,229 bp from pter
Size:
 84,162 bases      Orientation:
 minus strand

Proteins
for RNF24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225 (See protein sequence)
Recommended Name: RING finger protein 24  
Size: 148 amino acids; 17210 Da
Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7
Subcellular location: Golgi apparatus membrane; Single-pass membrane protein
1 PDB 3D structure from and Proteopedia for RNF24:
2EP4 (3D)    
Secondary accessions: D3DVZ2 D3DVZ3 Q9UMH1
Alternative splicing: 2 isoforms:  Q9Y225-1   Q9Y225-2   

Explore the universe of human proteins at neXtProt for RNF24: NX_Q9Y225

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y225

    • RNF24 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001127809.1  NP_001127810.1  NP_009150.1  

    ENSEMBL proteins: 
     ENSP00000336753   ENSP00000351166   ENSP00000444711   ENSP00000388550  

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    Novus Biologicals RNF24 Proteins
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNF24

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--


    RNF24 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF24 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y225

    ProtoNet protein and cluster: Q9Y225

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225
    Function: May play a role in TRPCs intracellular trafficking

    miRNA
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    hsa-miR-194* hsa-miR-4254 hsa-miR-520f hsa-miR-15a hsa-miR-570 hsa-miR-877* hsa-miR-1276 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: RNF24 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    RNF24 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RNF24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF24

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RNF24 (ENSP000003885504) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for RNF24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF24
    Search CenterWatch for drugs/clinical trials and news about RNF24 

    Transcripts
    for RNF24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF24 gene (3 alternative transcripts): 
    NM_001134337.1  NM_001134338.1  NM_007219.3  

    Unigene Cluster for RNF24:

    Ring finger protein 24
    Hs.589884  [show with all ESTs]
    Unigene Representative Sequence: NM_007219
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336095(uc002wkh.2) ENST00000358395(uc002wkj.2) ENST00000545616(uc002wki.2)
    ENST00000432261

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF24 (see all 45):
    hsa-miR-194* hsa-miR-4254 hsa-miR-520f hsa-miR-15a hsa-miR-570 hsa-miR-877* hsa-miR-1276 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: RNF24 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF24 (see all 7)
    OriGene shRNA RFP: RNF24
    OriGene siRNA: RNF24
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF24
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): RNF24 (NM_001134338)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF24

    Additional cDNA sequence: 

    AF151081.1 AL079313.1 AL096778.1 BC000213.2 BC039584.1 BT007406.1 

    10 DOTS entries:

    DT.213065  DT.92424596  DT.100780353  DT.95096008  DT.120834387  DT.120834453  DT.120834411  DT.92008744 
    DT.92013051  DT.95073251 

    24/120 AceView cDNA sequences (see all 120):

    AI189598 AW732459 AA327926 AI698319 AW070389 AL449738 BM683945 T32656 
    BC039584 AI609826 CR616881 BM931812 BU164445 BM669814 AW665448 AI146409 
    CR626646 CR599255 AI215604 CA433068 AA431287 CA449147 AL449893 AI379183 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF24    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:              -                                                   
    SP2:              -     -                                             
    SP3:                    -                                             


    ECgene alternative splicing isoforms for RNF24

    Expression
    for RNF24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACTGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RNF24 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RNF24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF24

    SOURCE GeneReport for Unigene cluster: Hs.589884
        SABiosciences Expression via Pathway-Focused PCR Array including RNF24: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF24

    Orthologs
    for RNF24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF24 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008576051 RING finger protein 24-like 83.56(n)
    95.27(a)    		   100857605  XM_003641262.1  XP_003641310.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.157882 Xenopus laevis transcribed sequence with moderate similarity more 84.05(n)    BJ042570.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rnf241 ring finger protein 24 75.9(n)
    85.14(a)    		   492480  NM_001007352.1  NP_001007353.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 zinc finger, C3HC4 type domain containing protein
    (see all 10)    		 9(a)
    9(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 11(1751235-1751891)
    11(1773368-1774024)


    ENSEMBL Gene Tree for RNF24 (if available)
    TreeFam Gene Tree for RNF24 (if available) 

    Paralogs
    for RNF24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF24 gene
    RNF1222  
    4 SIMAP similar genes for RNF24 using alignment to 2 protein entries:     RNF24_HUMAN (see all proteins):
    RNF122    RNF13    RNF167    RNF149

    RNF24 for paralogs           About GeneDecksing



    Genomic Variants
    for RNF24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1464 NCBI SNPs in RNF24 are shown (see all 1464)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1508065351,2
    		--3911652(+) GTGGCA/GAAGAA 3 -- int10--------
    rs1143152941,2
    		F,--3911693(+) ATACTG/CACCCA 3 -- int11Minor allele frequency- C:0.03WA 118
    rs1152116171,2
    		C,F,--3911716(+) GTCAGG/ACTGGT 3 -- int11Minor allele frequency- A:0.02WA 118
    rs1919442541,2
    		--3911792(+) CACCCA/GTGGAG 3 -- int10--------
    rs1159200211,2
    		F,--3911830(+) TAACCC/TATAGC 3 -- int11Minor allele frequency- T:0.03WA 118
    rs1832062541,2
    		--3911862(+) TGAGCC/TGCTTA 3 -- int10--------
    rs735743001,2
    		C,--3911952(+) CAACTC/GCTGAA 3 -- int12Minor allele frequency- G:0.03WA 120
    rs1497603131,2
    		--3912056(+) ATAAAA/TAAAGG 3 -- int10--------
    rs1873729581,2
    		--3912154(+) AGATGC/TGCAGG 3 -- ut310--------
    rs38039621,2
    		C,F,H,--3912188(+) TGCAGG/AGAGCA 3 -- ut31 ese310Minor allele frequency- A:0.02NS EA NA 1030

    HapMap Linkage Disequilibrium report for RNF24 (3912068 - 3996229 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RNF24
         1 CNV: 90445

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    Disorders / Diseases
    for RNF24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF24 for disorders           About GeneDecksing

    OMIM gene information: 612489    OMIM disorders: --

    1 disease for RNF24:    About MalaCards
    malaria


    Export disorders for RNF24 gene to outside databases

    Publications
    for RNF24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF24 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PubMed id 17850865)1, 2 Lussier M.P.... Boulay G. (2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1 Zhang Q.-H.... Chen Z. (2000)

    External Searches for RNF24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNF24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11237 HGNC: 13779 AceView: RNF24 Ensembl:ENSG00000101236 euGenes: HUgn11237
    ECgene: RNF24 H-InvDB: RNF24

    Other Databases showing RNF24 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF24 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF24 gene:
    Search GeneIP for patents involving RNF24

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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