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Aliases for RNF24 Gene

Aliases for RNF24 Gene

  • Ring Finger Protein 24 2 3
  • G1L 3 6
  • Goliath-Like Protein (C3HC4 Type) 3

External Ids for RNF24 Gene

Summaries for RNF24 Gene

Entrez Gene Summary for RNF24 Gene

  • The protein encoded by this gene contains similarity to the Drosophila goliath protein and thus may function as a transcription factor. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for RNF24 Gene

RNF24 (Ring Finger Protein 24) is a Protein Coding gene. An important paralog of this gene is RNF122.

UniProtKB/Swiss-Prot for RNF24 Gene

  • May play a role in TRPCs intracellular trafficking.

Gene Wiki entry for RNF24 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF24 Gene

Genomics for RNF24 Gene

Genomic Location for RNF24 Gene

Start:
3,927,309 bp from pter
End:
4,015,582 bp from pter
Size:
88,274 bases
Orientation:
Minus strand

Genomic View for RNF24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF24 Gene

Regulatory Elements for RNF24 Gene

Proteins for RNF24 Gene

  • Protein details for RNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y225-RNF24_HUMAN
    Recommended name:
    RING finger protein 24
    Protein Accession:
    Q9Y225
    Secondary Accessions:
    • D3DVZ2
    • D3DVZ3
    • Q9UMH1

    Protein attributes for RNF24 Gene

    Size:
    148 amino acids
    Molecular mass:
    17210 Da
    Quaternary structure:
    • Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.

    Three dimensional structures from OCA and Proteopedia for RNF24 Gene

    Alternative splice isoforms for RNF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF24 Gene

Proteomics data for RNF24 Gene at MOPED

Post-translational modifications for RNF24 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys61 and Lys107

Other Protein References for RNF24 Gene

No data available for DME Specific Peptides for RNF24 Gene

Domains for RNF24 Gene

Gene Families for RNF24 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF24 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RNF24_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9Y225
genes like me logo Genes that share domains with RNF24: view

Function for RNF24 Gene

Molecular function for RNF24 Gene

UniProtKB/Swiss-Prot Function: May play a role in TRPCs intracellular trafficking.

Gene Ontology (GO) - Molecular Function for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF24: view

miRNA for RNF24 Gene

miRTarBase miRNAs that target RNF24

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF24 Gene

Localization for RNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF24 Gene

Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF24 Gene COMPARTMENTS Subcellular localization image for RNF24 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF24: view

Pathways for RNF24 Gene

SuperPathways for RNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF24 Gene

None

No data available for Pathways by source for RNF24 Gene

Transcripts for RNF24 Gene

Unigene Clusters for RNF24 Gene

Ring finger protein 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: -

Relevant External Links for RNF24 Gene

GeneLoc Exon Structure for
RNF24
ECgene alternative splicing isoforms for
RNF24

Expression for RNF24 Gene

mRNA expression in normal human tissues for RNF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF24 Gene

This gene is overexpressed in Whole Blood (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF24 Gene

SOURCE GeneReport for Unigene cluster for RNF24 Gene Hs.589884

genes like me logo Genes that share expressions with RNF24: view

Orthologs for RNF24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF24 36
  • 99.8 (n)
  • 100 (a)
RNF24 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF24 36
  • 95.27 (n)
  • 99.32 (a)
RNF24 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF24 36
  • 95.72 (n)
  • 100 (a)
RNF24 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf24 36
  • 92.57 (n)
  • 97.97 (a)
Rnf24 16
Rnf24 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF24 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF24 37
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF24 36
  • 83.56 (n)
  • 95.27 (a)
RNF24 37
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15788 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485988 36
  • 76.83 (n)
  • 89.02 (a)
Str.3540 36
zebrafish
(Danio rerio)
Actinopterygii rnf24 36
  • 75.9 (n)
  • 85.14 (a)
rnf24 37
  • 85 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToMany
Species with no ortholog for RNF24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF24 Gene

ENSEMBL:
Gene Tree for RNF24 (if available)
TreeFam:
Gene Tree for RNF24 (if available)

Paralogs for RNF24 Gene

Paralogs for RNF24 Gene

Selected SIMAP similar genes for RNF24 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF24: view

Variants for RNF24 Gene

Sequence variations from dbSNP and Humsavar for RNF24 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs14047 -- 3,933,568(+) AACAT(A/G)AGCCT utr-variant-3-prime
rs47794 -- 3,937,049(+) GGCCA(A/G)GATGC intron-variant
rs171345 -- 3,946,966(+) GGTGG(C/G)TGGAT intron-variant
rs241600 -- 3,930,623(-) AGTAT(A/C)CCCAG utr-variant-3-prime
rs241601 -- 3,930,643(-) CATCC(A/T)GATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF24 Gene

Variant ID Type Subtype PubMed ID
nsv828673 CNV Gain 20364138
nsv527924 CNV Gain 19592680
nsv912623 CNV Gain 21882294

Relevant External Links for RNF24 Gene

HapMap Linkage Disequilibrium report
RNF24

Disorders for RNF24 Gene

Relevant External Links for RNF24

Genetic Association Database (GAD)
RNF24
genes like me logo Genes that share disorders with RNF24: view

No data available for UniProtKB/Swiss-Prot for RNF24 Gene

Publications for RNF24 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PMID: 17850865) Lussier M.P. … Boulay G. (Cell Calcium 2008) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3

Products for RNF24 Gene

Sources for RNF24 Gene

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