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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF24 Gene

protein-coding GIFtS: 47
GCID: GC20M003912

ring finger protein 24

Explore 1 disease affiliated with
RNF24 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 24¹ ²
G1L¹ ² ⁵
Goliath-Like Protein (C3HC4 Type)²

External Ids:	HGNC: 13779¹	Entrez Gene: 11237²	Ensembl: ENSG00000101236⁷	OMIM: 612489⁵	UniProtKB: Q9Y225³

Export aliases for RNF24 gene to outside databases

Previous GC identifers: GC20M003901 GC20M003861 GC20M003908 GC20M003860

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF24:

The protein encoded by this gene contains similarity to the Drosophila goliath protein and thus may function as a

transcription factor. Multiple alternatively spliced transcript variants that encode different isoforms have been

found for this gene. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225

Function: May play a role in TRPCs intracellular trafficking

Gene Wiki entry for RNF24

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF24 gene promoter:
Egr-2 AREB6 FOXJ2 (long isoform) HTF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF24 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF24

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF24

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

RNF24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF24 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M003912: view genomic region (about GC identifiers)

Start:	3,912,068 bp from pter	End:	3,996,229 bp from pter
Size:	84,162 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225 (See protein sequence)

Recommended Name: RING finger protein 24

Size: 148 amino acids; 17210 Da

Subunit: Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7

Subcellular location: Golgi apparatus membrane; Single-pass membrane protein

1 PDB 3D structure from and Proteopedia for RNF24:

2EP4 (3D)

Secondary accessions: D3DVZ2 D3DVZ3 Q9UMH1

Alternative splicing: 2 isoforms: Q9Y225-1 Q9Y225-2

Explore the universe of human proteins at neXtProt for RNF24: NX_Q9Y225

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y225

RNF24 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001127809.1 NP_001127810.1 NP_009150.1

ENSEMBL proteins:

ENSP00000336753 ENSP00000351166 ENSP00000444711 ENSP00000388550

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

RNF24 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF24 for domains About GeneDecksing

2 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q9Y225

ProtoNet protein and cluster: Q9Y225

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RNF24_HUMAN, Q9Y225

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RNF24_HUMAN, Q9Y225

Function: May play a role in TRPCs intracellular trafficking

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

RNF24 for ontologies About GeneDecksing

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF24

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNF24 (ENSP00000388550⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RNF24 gene (3 alternative transcripts):

NM_001134337.1 NM_001134338.1 NM_007219.3

Unigene Cluster for RNF24:

Ring finger protein 24

Hs.589884 [show with all ESTs]

Unigene Representative Sequence: NM_007219

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336095(uc002wkh.2) ENST00000358395(uc002wkj.2) ENST00000545616(uc002wki.2)

ENST00000432261

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Additional cDNA sequence:

AF151081.1 AL079313.1 AL096778.1 BC000213.2 BC039584.1 BT007406.1

10 DOTS entries:

DT.213065 DT.92424596 DT.100780353 DT.95096008 DT.120834387 DT.120834453 DT.120834411 DT.92008744

DT.92013051 DT.95073251

24/120 AceView cDNA sequences (see all 120):

AI189598 AW732459 AA327926 AI698319 AW070389 AL449738 BM683945 T32656

BC039584 AI609826 CR616881 BM931812 BU164445 BM669814 AW665448 AI146409

CR626646 CR599255 AI215604 CA433068 AA431287 CA449147 AL449893 AI379183

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF24 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c
SP1:					-
SP2:					-		-
SP3:							-

ECgene alternative splicing isoforms for RNF24

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCACTGTGG

About this image

RNF24 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNF24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF24

SOURCE GeneReport for Unigene cluster: Hs.589884

SABiosciences Expression via Pathway-Focused PCR Array including RNF24:

Ubiquitin Ligases in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF24 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100857605¹	RING finger protein 24-like	83.56(n) 95.27(a)		100857605 XM_003641262.1 XP_003641310.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.15788²	Xenopus laevis transcribed sequence with moderate similarity more	84.05(n)		BJ042570.1
zebrafish (Danio rerio)	Actinopterygii	rnf24¹	ring finger protein 24	75.9(n) 85.14(a)		492480 NM_001007352.1 NP_001007353.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	zinc finger, C3HC4 type domain containing protein (see all 10)	9(a) 9(a) (see all 10)	many ↔ many many ↔ many (see all 10)	11(1751235-1751891) 11(1773368-1774024)

ENSEMBL Gene Tree for RNF24 (if available)
TreeFam Gene Tree for RNF24 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF24 gene

RNF122²

4 SIMAP similar genes for RNF24 using alignment to 2 protein entries: RNF24_HUMAN (see all proteins):

RNF122 RNF13 RNF167 RNF149

RNF24 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150806535^1,2		--	3911652(+)	`GTGGCA/GAAGAA`	3	--	int¹		0	--	--	--	--
rs114315294^1,2	F	--	3911693(+)	`ATACTG/CACCCA`	3	--	int¹		1		WA	118
rs115211617^1,2	C,F	--	3911716(+)	`GTCAGG/ACTGGT`	3	--	int¹		1		WA	118
rs191944254^1,2		--	3911792(+)	`CACCCA/GTGGAG`	3	--	int¹		0	--	--	--	--
rs115920021^1,2	F	--	3911830(+)	`TAACCC/TATAGC`	3	--	int¹		1		WA	118
rs183206254^1,2		--	3911862(+)	`TGAGCC/TGCTTA`	3	--	int¹		0	--	--	--	--
rs73574300^1,2	C	--	3911952(+)	`CAACTC/GCTGAA`	3	--	int¹		2		WA	120
rs149760313^1,2		--	3912056(+)	`ATAAAA/TAAAGG`	3	--	int¹		0	--	--	--	--
rs187372958^1,2		--	3912154(+)	`AGATGC/TGCAGG`	3	--	ut3¹		0	--	--	--	--
rs3803962^1,2	C,F,H	--	3912188(+)	`TGCAGG/AGAGCA`	3	--	ut3¹ ese³		10		NS EA NA	1030

HapMap Linkage Disequilibrium report for RNF24 (3912068 - 3996229 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF24
1 CNV: 90445

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF24 for disorders           About GeneDecksing

OMIM gene information: 612489    OMIM disorders: --

1 disease for RNF24:    About MalaCards

malaria

Export disorders for RNF24 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF24)

Utopia: connect your pdf to the dynamic
world of online information

RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PubMed id 17850865)^{1, 2} Lussier M.P.... Boulay G. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)¹ Zhang Q.-H.... Chen Z. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11237	HGNC: 13779	AceView: RNF24	Ensembl:ENSG00000101236	euGenes: HUgn11237
ECgene: RNF24	H-InvDB: RNF24

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNF24	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF24 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNF24 gene:
Search GeneIP for patents involving RNF24

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF24
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	GenScript Custom Purified and Recombinant Proteins Services for RNF24		GenScript cDNA clones with any tag delivered in your preferred vector for RNF24
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF24

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF24

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNF24 gene at Home site.

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RNF24 Gene

ring finger protein 24

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RNF24 Gene

ring finger protein 24

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