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Aliases for RNF224 Gene

Aliases for RNF224 Gene

  • Ring Finger Protein 224 2 3 5

External Ids for RNF224 Gene

Previous GeneCards Identifiers for RNF224 Gene

  • GC09P140122

Summaries for RNF224 Gene

GeneCards Summary for RNF224 Gene

RNF224 (Ring Finger Protein 224) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF224 Gene

Genomics for RNF224 Gene

Regulatory Elements for RNF224 Gene

Enhancers for RNF224 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F137233 1.6 FANTOM5 ENCODE 5.8 +11.0 11035 9.9 CREB3L1 MLX DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC TBX21 IL9RP1 NDOR1 DPH7 TMEM203 NELFB LCN15 ABCA2 TOR4A UAP1L1 RNF224
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF224 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF224 Gene

137,227,271 bp from pter
137,229,640 bp from pter
2,370 bases
Plus strand

Genomic View for RNF224 Gene

Genes around RNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF224 Gene

Proteins for RNF224 Gene

  • Protein details for RNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 224
    Protein Accession:

    Protein attributes for RNF224 Gene

    156 amino acids
    Molecular mass:
    16549 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF224 Gene

Post-translational modifications for RNF224 Gene

No Post-translational modifications

Other Protein References for RNF224 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF224 Gene

Domains & Families for RNF224 Gene

Gene Families for RNF224 Gene

Protein Domains for RNF224 Gene

Suggested Antigen Peptide Sequences for RNF224 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF224: view

Function for RNF224 Gene

Gene Ontology (GO) - Molecular Function for RNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF224: view

Phenotypes for RNF224 Gene

GenomeRNAi human phenotypes for RNF224:
genes like me logo Genes that share phenotypes with RNF224: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF224 Gene

Localization for RNF224 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF224 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF224 Gene

Pathways & Interactions for RNF224 Gene

SuperPathways for RNF224 Gene

No Data Available

Interacting Proteins for RNF224 Gene

Gene Ontology (GO) - Biological Process for RNF224 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF224 Gene

Transcripts for RNF224 Gene

mRNA/cDNA for RNF224 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF224 Gene

Ring finger protein 224:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF224 Gene

No ASD Table

Relevant External Links for RNF224 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF224 Gene

mRNA differential expression in normal tissues according to GTEx for RNF224 Gene

This gene is overexpressed in Pituitary (x9.5) and Esophagus - Mucosa (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF224 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF224 Gene:


SOURCE GeneReport for Unigene cluster for RNF224 Gene:

genes like me logo Genes that share expression patterns with RNF224: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNF224 Gene

Orthologs for RNF224 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF224 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF224 34 35
  • 99.15 (n)
(Bos Taurus)
Mammalia RNF224 34 35
  • 79.32 (n)
(Mus musculus)
Mammalia Gm757 34 35
  • 77.62 (n)
Rnf224 16
(Rattus norvegicus)
Mammalia Rnf224 34
  • 77.37 (n)
(Canis familiaris)
Mammalia RNF224 34 35
  • 77.07 (n)
(Gallus gallus)
Aves RNF224 34
  • 67.72 (n)
(Anolis carolinensis)
Reptilia RNF224 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497669 34
  • 70.43 (n)
(Danio rerio)
Actinopterygii LOC100334516 34
  • 60.98 (n)
RNF224 35
  • 36 (a)
Species where no ortholog for RNF224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF224 Gene

Gene Tree for RNF224 (if available)
Gene Tree for RNF224 (if available)

Paralogs for RNF224 Gene

No data available for Paralogs for RNF224 Gene

Variants for RNF224 Gene

Sequence variations from dbSNP and Humsavar for RNF224 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs111388752 -- 137,229,360(+) TGGTG(A/C)GGACA upstream-variant-2KB, utr-variant-3-prime
rs112668723 -- 137,226,692(+) AAGAG(A/G)GTGGT intron-variant, upstream-variant-2KB
rs113409152 -- 137,228,271(+) AGGGC(A/G/T)CCCTG utr-variant-5-prime
rs113732689 -- 137,228,968(+) CACTC(A/G)GCAGC upstream-variant-2KB, reference, missense
rs114070088 -- 137,228,228(+) GACTC(A/C)CGTGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF224 Gene

Variant ID Type Subtype PubMed ID
nsv951207 CNV deletion 24416366
nsv616007 CNV loss 21841781
nsv524322 CNV loss 19592680
nsv1161918 CNV duplication 26073780
esv2422220 CNV deletion 17116639
dgv13011n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
dgv13009n54 CNV loss 21841781

Variation tolerance for RNF224 Gene

Gene Damage Index Score: 5.72; 73.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF224 Gene

Disorders for RNF224 Gene

Relevant External Links for RNF224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF224 Gene

Publications for RNF224 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64

Products for RNF224 Gene

Sources for RNF224 Gene

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