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Aliases for RNF224 Gene

Aliases for RNF224 Gene

  • Ring Finger Protein 224 2 3

External Ids for RNF224 Gene

Previous GeneCards Identifiers for RNF224 Gene

  • GC09P140122

Summaries for RNF224 Gene

GeneCards Summary for RNF224 Gene

RNF224 (Ring Finger Protein 224) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF224 Gene

Genomics for RNF224 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF224 Gene

137,227,271 bp from pter
137,229,638 bp from pter
2,368 bases
Plus strand

Genomic View for RNF224 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF224 Gene

No data available for Regulatory Elements for RNF224 Gene

Proteins for RNF224 Gene

  • Protein details for RNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 224
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RNF224 Gene

    156 amino acids
    Molecular mass:
    16549 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF224 Gene

Proteomics data for RNF224 Gene at MOPED

Post-translational modifications for RNF224 Gene

No Post-translational modifications

Other Protein References for RNF224 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF224 Gene

Domains for RNF224 Gene

Gene Families for RNF224 Gene

Protein Domains for RNF224 Gene

Suggested Antigen Peptide Sequences for RNF224 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF224: view

Function for RNF224 Gene

Gene Ontology (GO) - Molecular Function for RNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF224: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF224 Gene

Localization for RNF224 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNF224 Gene

Pathways for RNF224 Gene

SuperPathways for RNF224 Gene

No Data Available

Interacting Proteins for RNF224 Gene

Gene Ontology (GO) - Biological Process for RNF224 Gene


No data available for Pathways by source for RNF224 Gene

Transcripts for RNF224 Gene

mRNA/cDNA for RNF224 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF224 Gene

Ring finger protein 224:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF224 Gene

No ASD Table

Relevant External Links for RNF224 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF224 Gene

mRNA expression in normal human tissues for RNF224 Gene

mRNA differential expression in normal tissues according to GTEx for RNF224 Gene

This gene is overexpressed in Pituitary (9.5) and Esophagus - Mucosa (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNF224 Gene

SOURCE GeneReport for Unigene cluster for RNF224 Gene Hs.730186

genes like me logo Genes that share expressions with RNF224: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RNF224 Gene

Orthologs for RNF224 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF224 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF224 35
  • 79.32 (n)
  • 72.26 (a)
RNF224 36
  • 64 (a)
(Canis familiaris)
Mammalia RNF224 35
  • 77.07 (n)
  • 75.18 (a)
RNF224 36
  • 74 (a)
(Mus musculus)
Mammalia Gm757 35
  • 77.62 (n)
  • 75.91 (a)
Gm757 16
Gm757 36
  • 69 (a)
(Pan troglodytes)
Mammalia RNF224 35
  • 99.15 (n)
  • 98.08 (a)
RNF224 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Rnf224 35
  • 77.37 (n)
  • 78.1 (a)
(Gallus gallus)
Aves RNF224 35
  • 67.72 (n)
  • 64.57 (a)
(Anolis carolinensis)
Reptilia RNF224 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497669 35
  • 70.43 (n)
  • 70.97 (a)
(Danio rerio)
Actinopterygii LOC100334516 35
  • 60.98 (n)
  • 56.91 (a)
RNF224 36
  • 36 (a)
Species with no ortholog for RNF224:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF224 Gene

Gene Tree for RNF224 (if available)
Gene Tree for RNF224 (if available)

Paralogs for RNF224 Gene

No data available for Paralogs for RNF224 Gene

Variants for RNF224 Gene

Sequence variations from dbSNP and Humsavar for RNF224 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6606565 -- 137,228,680(-) AGTCT(C/G)TCCTC reference, missense
rs7021080 -- 137,227,119(-) TCCTC(A/G)CCTTG upstream-variant-2KB
rs7022129 -- 137,227,812(-) TTCCC(C/T)CCTGG utr-variant-5-prime
rs7023977 -- 137,227,309(-) CAAGG(C/T)GGGGA upstream-variant-2KB
rs28540759 -- 137,228,182(+) AAACG(A/G)GAGCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF224 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894639 CNV Loss 21882294
nsv894640 CNV Loss 21882294

Relevant External Links for RNF224 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF224 Gene

Disorders for RNF224 Gene

No disorders were found for RNF224 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNF224 Gene

Publications for RNF224 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for RNF224 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RNF224
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RNF224
    • Block miRNA regulation of RNF224 using miScript Target Protectors

    Sources for RNF224 Gene

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