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Aliases for RNF224 Gene

Aliases for RNF224 Gene

  • Ring Finger Protein 224 2 3 5

External Ids for RNF224 Gene

Previous GeneCards Identifiers for RNF224 Gene

  • GC09P140122

Summaries for RNF224 Gene

GeneCards Summary for RNF224 Gene

RNF224 (Ring Finger Protein 224) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF224 Gene

Genomics for RNF224 Gene

Regulatory Elements for RNF224 Gene

Enhancers for RNF224 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF224 on UCSC Golden Path with GeneCards custom track

Promoters for RNF224 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF224 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF224 Gene

137,227,271 bp from pter
137,229,640 bp from pter
2,370 bases
Plus strand

Genomic View for RNF224 Gene

Genes around RNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF224 Gene

Proteins for RNF224 Gene

  • Protein details for RNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 224
    Protein Accession:

    Protein attributes for RNF224 Gene

    156 amino acids
    Molecular mass:
    16549 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF224 Gene

Proteomics data for RNF224 Gene at MOPED

Post-translational modifications for RNF224 Gene

No Post-translational modifications

Other Protein References for RNF224 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF224 Gene

Domains & Families for RNF224 Gene

Gene Families for RNF224 Gene

Protein Domains for RNF224 Gene

Suggested Antigen Peptide Sequences for RNF224 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF224: view

Function for RNF224 Gene

Phenotypes for RNF224 Gene

GenomeRNAi human phenotypes for RNF224:
genes like me logo Genes that share phenotypes with RNF224: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF224 Gene

Localization for RNF224 Gene

Subcellular locations from

Jensen Localization Image for RNF224 Gene COMPARTMENTS Subcellular localization image for RNF224 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF224 Gene

Pathways & Interactions for RNF224 Gene

SuperPathways for RNF224 Gene

No Data Available

Interacting Proteins for RNF224 Gene

Gene Ontology (GO) - Biological Process for RNF224 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF224 Gene

Drugs & Compounds for RNF224 Gene

No Compound Related Data Available

Transcripts for RNF224 Gene

mRNA/cDNA for RNF224 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF224 Gene

Ring finger protein 224:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF224 Gene

No ASD Table

Relevant External Links for RNF224 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF224 Gene

mRNA expression in normal human tissues for RNF224 Gene

mRNA differential expression in normal tissues according to GTEx for RNF224 Gene

This gene is overexpressed in Pituitary (x9.5) and Esophagus - Mucosa (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF224 Gene

SOURCE GeneReport for Unigene cluster for RNF224 Gene Hs.730186

genes like me logo Genes that share expression patterns with RNF224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF224 Gene

Orthologs for RNF224 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF224 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF224 35
  • 79.32 (n)
  • 72.26 (a)
RNF224 36
  • 64 (a)
(Canis familiaris)
Mammalia RNF224 35
  • 77.07 (n)
  • 75.18 (a)
RNF224 36
  • 74 (a)
(Mus musculus)
Mammalia Gm757 35
  • 77.62 (n)
  • 75.91 (a)
Rnf224 16
Gm757 36
  • 69 (a)
(Pan troglodytes)
Mammalia RNF224 35
  • 99.15 (n)
  • 98.08 (a)
RNF224 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Rnf224 35
  • 77.37 (n)
  • 78.1 (a)
(Gallus gallus)
Aves RNF224 35
  • 67.72 (n)
  • 64.57 (a)
(Anolis carolinensis)
Reptilia RNF224 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497669 35
  • 70.43 (n)
  • 70.97 (a)
(Danio rerio)
Actinopterygii LOC100334516 35
  • 60.98 (n)
  • 56.91 (a)
RNF224 36
  • 36 (a)
Species with no ortholog for RNF224:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF224 Gene

Gene Tree for RNF224 (if available)
Gene Tree for RNF224 (if available)

Paralogs for RNF224 Gene

No data available for Paralogs for RNF224 Gene

Variants for RNF224 Gene

Sequence variations from dbSNP and Humsavar for RNF224 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs114870709 -- 137,227,387(+) CCTGG(G/T)GGCAG upstream-variant-2KB
rs201045313 -- 137,227,506(+) CAACT(C/G)TGCTC upstream-variant-2KB
rs141892180 -- 137,227,445(+) CCAGC(A/G)GGGCT upstream-variant-2KB
rs201873579 -- 137,228,028(+) AGAGT(-/G)GGGGA intron-variant, utr-variant-5-prime
rs368169286 -- 137,227,923(+) GGGAG(C/T)GGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF224 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894639 CNV Loss 21882294
nsv894640 CNV Loss 21882294

Variation tolerance for RNF224 Gene

Gene Damage Index Score: 5.72; 73.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF224 Gene

Disorders for RNF224 Gene

Relevant External Links for RNF224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF224 Gene

Publications for RNF224 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 67

Products for RNF224 Gene

Sources for RNF224 Gene