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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF223 Gene

protein-coding   GIFtS: 29
GCID: GC01M001009

Ring Finger Protein 223
  Search for RNF223
at
MalaCards
 

Aliases
for RNF223 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Ring Finger Protein 2231 2

External Ids:    HGNC: 400201   Entrez Gene: 4019342   Ensembl: ENSG000002373307   UniProtKB: E7ERA63   

Export aliases for RNF223 gene to outside databases


Summaries
for RNF223 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for RNF223 Gene: 
RNF223 (ring finger protein 223) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF183.


Genomic Views
for RNF223 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004350.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RNF223
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RNF223

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF223


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

RNF223 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF223 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001009:  view genomic region     (about GC identifiers)

Start:
 1,006,346 bp from pter      End:
 1,009,687 bp from pter
Size:
 3,342 bases      Orientation:
 minus strand

Proteins
for RNF223 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6 (See protein sequence)
Recommended Name: RING finger protein 223  
Size: 249 amino acids; 26629 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B4DKI4

Explore the universe of human proteins at neXtProt for RNF223: NX_E7ERA6

Explore proteomics data for RNF223 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_E7ERA6

    • RNF223 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF223 Protein Expression
    REFSEQ proteins: NP_001192181.1  
    ENSEMBL proteins: 
     ENSP00000410533  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    RNF223 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF223 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry E7ERA6

    ProtoNet protein and cluster: E7ERA6

    UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6
    Similarity: Contains 1 RING-type zinc finger


    RNF223 for domains           About GeneDecksing


    Function
    for RNF223 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF223 for ontologies           About GeneDecksing


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    Pathways & Interactions
    for RNF223 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF223

    Drugs & Compounds
    for RNF223 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RNF223 (RN223)

    Search CenterWatch for drugs/clinical trials and news about RNF223 / RN223

    Transcripts
    for RNF223 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for RNF223 gene: 
    NM_001205252.1  

    Unigene Cluster for RNF223:

    Ring finger protein 223
    Hs.568137  [show with all ESTs]
    Unigene Representative Sequence: AK296576
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000453464(uc021oen.1)
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    Additional mRNA sequence: AK296576.1 

    1 DOTS entry:

    DT.75109241 

    GeneLoc Exon Structure


    Expression
    for RNF223 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF223 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCGTCCCC
    RNF223 Expression
    About this image


    See RNF223 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.568137
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    In Situ
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    Orthologs
    for RNF223 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNF223 gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnf2231 , 5 RIKEN cDNA 9930005F22 gene5
    ring finger 2231    		 75.9(n)1
    77.51(a)1    		   4 (88.44 cM)5
    1000457781  NM_001220499.11  NP_001207428.11 
     1561321705 
    chicken
    (Gallus gallus)    		 Aves RNF2231 ring finger protein 223 59.38(n)
    52.1(a)    		   419428  XM_417589.2  XP_417589.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF2236
    		 Uncharacterized protein
    		 49(a)
    		 1 ↔ 1
    		 GL343647.1(43538-44377)
    zebrafish
    (Danio rerio)    		 Actinopterygii RNF2236
    rnf1836
    		 ring finger protein 183
    		 42(a)
    16(a)
    		 1 ↔ 1
    possible ortholog
    		 23(24289254-24289914)
    15(34182738-34188950)


    ENSEMBL Gene Tree for RNF223 (if available)
    TreeFam Gene Tree for RNF223 (if available)

    Paralogs
    for RNF223 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF223 gene
    RNF1832  LOC6468622  

    RNF223 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF223
    PGOHUM00000259437


    Genomic Variants
    for RNF223 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 SNPs in RNF223 are shown (see all 105)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1869754121,2
    		--998888(+) GCTGAA/GGCTAT 1 -- us2k10--------
    rs1915263421,2
    		--998893(+) GGCTAC/TGGTGA 1 -- us2k10--------
    rs1843738141,2
    		--998896(+) TATGGG/TGACTC 1 -- us2k10--------
    rs729004991,2
    		C,F--1006644(+) TGTACG/AAGCCT 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1912698101,2
    		--1006741(+) CACCTA/CCCCGG 1 -- ds50010--------
    rs1858507551,2
    		--1006799(+) CACCAC/TGATGC 1 -- ds50010--------
    rs1427746111,2
    		--1006804(+) CGATGC/TCCGGT 1 -- ds50010--------
    rs43265711,2
    		C,F,H--1006990(+) ACCCCA/GTCAGG 1 -- ds500113Minor allele frequency- G:0.15NA WA CSA EA 376
    rs115778291,2
    		H--1007065(+) GAGTCC/TTCAGA 1 -- ds50010--------
    rs1159083301,2
    		C,F--1007131(+) TTGGGA/C/TCCCCC 2 -- ut311NA 120

    HapMap Linkage Disequilibrium report for RNF223 (1006346 - 1009687 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for RNF223 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509146CNV Insertion20534489
    nsv470680CNV Loss18288195
    dgv9n71CNV Loss21882294
    nsv870874CNV Loss21882294
    dgv12n71CNV Loss21882294
    nsv871349CNV Loss21882294
    dgv10n71CNV Loss21882294
    dgv13n71CNV Loss21882294
    dgv11n71CNV Loss21882294
    nsv871547CNV Loss21882294

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    Disorders / Diseases
    for RNF223 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for RNF223 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF223 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF223)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for RNF223 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNF223 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401934 HGNC: 40020 Ensembl:ENSG00000237330 euGenes: HUgn401934 ECgene: RNF223
    H-InvDB: RNF223

    Other Databases showing RNF223 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF223 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF223 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF223 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF223 gene:
    Search GeneIP for patents involving RNF223

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

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