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Aliases for RNF223 Gene

Aliases for RNF223 Gene

  • Ring Finger Protein 223 2 3 5

External Ids for RNF223 Gene

Previous GeneCards Identifiers for RNF223 Gene

  • GC01M001009

Summaries for RNF223 Gene

GeneCards Summary for RNF223 Gene

RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF225.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene

Genomics for RNF223 Gene

Regulatory Elements for RNF223 Gene

Enhancers for RNF223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001071 0.8 Ensembl ENCODE 11.8 +1.0 1023 3.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ZNF207 FOS MCM3 ENSG00000272512 RNF223 C1orf159 TTLL10 LOC105378948
GH01F001066 1.2 FANTOM5 Ensembl ENCODE 11.6 +5.5 5526 4.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000229905 WBP1LP6 ENSG00000235146 LOC100287934 ENSG00000272512 CICP3 MIR6727 LINC01786 RNF223 LINC00115
GH01F001077 1.6 FANTOM5 Ensembl ENCODE 11.1 -6.3 -6289 5.4 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000272512 RNF223 C1orf159 LOC101928626 TTLL10 ENSG00000237094 GC01M001107
GH01F001061 1 Ensembl ENCODE 10.9 +10.7 10677 4.1 MLX CREB3L1 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC ENSG00000240731 CCNL2 MIR6727 FAM87B LINC00115 ENSG00000229905 WBP1LP6 ENSG00000235146 ENSG00000272512 LOC100287934
GH01F001124 1.2 FANTOM5 ENCODE 6 -50.9 -50874 2.0 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 C1orf159 SLC35E2 RNF223 GC01M001125
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNF223 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF223 Gene

1,070,966 bp from pter
1,074,307 bp from pter
3,342 bases
Minus strand

Genomic View for RNF223 Gene

Genes around RNF223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF223 Gene

Proteins for RNF223 Gene

  • Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 223
    Protein Accession:
    Secondary Accessions:
    • B4DKI4

    Protein attributes for RNF223 Gene

    249 amino acids
    Molecular mass:
    26629 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF223 Gene

Post-translational modifications for RNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF223 Gene

Domains & Families for RNF223 Gene

Gene Families for RNF223 Gene

Protein Domains for RNF223 Gene

Suggested Antigen Peptide Sequences for RNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF223: view

Function for RNF223 Gene

Gene Ontology (GO) - Molecular Function for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF223: view

Phenotypes for RNF223 Gene

GenomeRNAi human phenotypes for RNF223:
genes like me logo Genes that share phenotypes with RNF223: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF223 Gene

Localization for RNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF223 Gene COMPARTMENTS Subcellular localization image for RNF223 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF223: view

Pathways & Interactions for RNF223 Gene

SuperPathways for RNF223 Gene

No Data Available

Interacting Proteins for RNF223 Gene

Gene Ontology (GO) - Biological Process for RNF223 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF223 Gene

Transcripts for RNF223 Gene

mRNA/cDNA for RNF223 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF223 Gene

Ring finger protein 223:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF223 Gene

No ASD Table

Relevant External Links for RNF223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF223 Gene

mRNA expression in normal human tissues for RNF223 Gene

mRNA differential expression in normal tissues according to GTEx for RNF223 Gene

This gene is overexpressed in Esophagus - Mucosa (x21.0), Cervix - Ectocervix (x8.3), and Vagina (x7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF223 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF223 Gene:


SOURCE GeneReport for Unigene cluster for RNF223 Gene:

genes like me logo Genes that share expression patterns with RNF223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNF223 Gene

Orthologs for RNF223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF223 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF223 34 35
  • 81.57 (n)
(Canis familiaris)
Mammalia RNF223 34 35
  • 81.17 (n)
(Mus musculus)
Mammalia Rnf223 34 16
  • 75.64 (n)
(Rattus norvegicus)
Mammalia Rnf223 34
  • 72.29 (n)
(Gallus gallus)
Aves RNF223 34 35
  • 59.94 (n)
(Anolis carolinensis)
Reptilia RNF223 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf223 34
  • 56.4 (n)
(Danio rerio)
Actinopterygii LOC101883831 34
  • 52.79 (n)
RNF223 35
  • 40 (a)
Species where no ortholog for RNF223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF223 Gene

Gene Tree for RNF223 (if available)
Gene Tree for RNF223 (if available)

Paralogs for RNF223 Gene

Paralogs for RNF223 Gene

genes like me logo Genes that share paralogs with RNF223: view

Variants for RNF223 Gene

Sequence variations from dbSNP and Humsavar for RNF223 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111436748 -- 1,071,148(+) CATGA(A/G)TGGAA utr-variant-3-prime
rs111517730 -- 1,067,784(+) CGTGG(C/T)TGCAC intron-variant, upstream-variant-2KB
rs111600513 -- 1,071,185(+) CAAGG(A/G)GCTTC utr-variant-3-prime
rs111617441 -- 1,065,287(+) TGCGG(G/T)GCCCT intron-variant, downstream-variant-500B
rs111739447 -- 1,065,194(+) TCTGC(A/G)GGGCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNF223 Gene

Variant ID Type Subtype PubMed ID
dgv2n67 CNV gain 20364138
dgv5n100 CNV gain 25217958
esv2762302 CNV gain 21179565
nsv1003578 CNV gain 25217958
nsv1013524 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1160644 CNV deletion 26073780
nsv1160772 CNV duplication 26073780
nsv428334 CNV gain 18775914
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv509146 CNV insertion 20534489
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv945741 CNV duplication 23825009
nsv950451 CNV deletion 24416366

Variation tolerance for RNF223 Gene

Gene Damage Index Score: 3.97; 59.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF223 Gene

Disorders for RNF223 Gene

Relevant External Links for RNF223

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF223 Gene

Publications for RNF223 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for RNF223 Gene

Sources for RNF223 Gene

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