Aliases for RNF223 Gene
External Ids for RNF223 Gene
- HGNC: 40020
- Entrez Gene: 401934
- Ensembl: ENSG00000237330
- UniProtKB: E7ERA6
Previous GeneCards Identifiers for RNF223 Gene
- GC01M001009
Summaries for RNF223 Gene
GeneCards Summary for RNF223 Gene
RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF225.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene
Genomics for RNF223 Gene
Regulatory Elements for RNF223 Gene
Enhancers for RNF223 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RNF223 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for RNF223 Gene
- Chromosome:
- 1
- Start:
- 1,070,966 bp from pter
- End:
- 1,074,307 bp from pter
- Size:
- 3,342 bases
- Orientation:
- Minus strand
Genomic View for RNF223 Gene
Genes around RNF223 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.33 by Ensembl
- 1p36.33 by Entrez Gene
- 1p36.33 by HGNC
RNF223 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF223 Gene
Proteins for RNF223 Gene
-
Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- E7ERA6-RN223_HUMAN
- Recommended name:
- RING finger protein 223
- Protein Accession:
- E7ERA6
- B4DKI4
Protein attributes for RNF223 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 26629 Da
- Quaternary structure:
- No Data Available
Protein Expression for RNF223 Gene
Post-translational modifications for RNF223 Gene
Other Protein References for RNF223 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF223
- Origene Custom Protein Services for RNF223
- Search GeneTex for Proteins for RNF223
Assay Products
No data available for DME Specific Peptides for RNF223 Gene
Domains & Families for RNF223 Gene
Gene Families for RNF223 Gene
Protein Domains for RNF223 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF223 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
E7ERA6- Similarity:
-
- Contains 1 RING-type zinc finger.
Function for RNF223 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RNF223 Gene
- GenomeRNAi human phenotypes for RNF223:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RNF223
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- Search ViGene Biosciences for RNF223
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RNF223
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF223
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RNF223
-
ViGene Biosciences adenoviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF223 Gene
Localization for RNF223 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for RNF223 Gene
mRNA/cDNA for RNF223 Gene
- (3) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNF223 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RNF223
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF223
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for RNF223 Gene
mRNA differential expression in normal tissues according to GTEx for RNF223 Gene
This gene is overexpressed in Esophagus - Mucosa (x21.0), Cervix - Ectocervix (x8.3), and Vagina (x7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF223 Gene
NURSA nuclear receptor signaling pathways regulating expression of RNF223 Gene:
RNF223SOURCE GeneReport for Unigene cluster for RNF223 Gene:
Hs.568137Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNF223 Gene
Orthologs for RNF223 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RNF223 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RNF223 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Rnf223 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rnf223 34 |
|
||
| chicken (Gallus gallus) |
Aves | RNF223 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RNF223 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rnf223 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101883831 34 |
|
||
| RNF223 35 |
|
OneToOne |
- Species where no ortholog for RNF223 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RNF223 Gene
Variants for RNF223 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs111436748 | -- | 1,071,148(+) | CATGA(A/G)TGGAA | utr-variant-3-prime | |
| rs111517730 | -- | 1,067,784(+) | CGTGG(C/T)TGCAC | intron-variant, upstream-variant-2KB | |
| rs111600513 | -- | 1,071,185(+) | CAAGG(A/G)GCTTC | utr-variant-3-prime | |
| rs111617441 | -- | 1,065,287(+) | TGCGG(G/T)GCCCT | intron-variant, downstream-variant-500B | |
| rs111739447 | -- | 1,065,194(+) | TCTGC(A/G)GGGCC | intron-variant, downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv950451 | CNV | deletion | 24416366 |
| nsv945741 | CNV | duplication | 23825009 |
| nsv544947 | CNV | loss | 21841781 |
| nsv517709 | CNV | gain+loss | 19592680 |
| nsv509146 | CNV | insertion | 20534489 |
| nsv482937 | CNV | loss | 15286789 |
| nsv470680 | CNV | loss | 18288195 |
| nsv428334 | CNV | gain | 18775914 |
| nsv1160772 | CNV | duplication | 26073780 |
| nsv1160644 | CNV | deletion | 26073780 |
| nsv10161 | CNV | gain+loss | 18304495 |
| nsv1013524 | CNV | gain | 25217958 |
| nsv1003578 | CNV | gain | 25217958 |
| esv2762302 | CNV | gain | 21179565 |
| dgv5n100 | CNV | gain | 25217958 |
| dgv2n67 | CNV | gain | 20364138 |
Gene Damage Index Score:
3.97;
59.90% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RNF223 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF223
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF223 Gene
Disorders for RNF223 Gene
Relevant External Links for RNF223
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RNF223
No disorders were found for RNF223 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF223 Gene
Publications for RNF223 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
Products for RNF223 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF223
- Origene Custom Protein Services for RNF223
- Browse OriGene Inhibitory RNA Products For RNF223
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for RNF223
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RNF223
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for RNF223
- GenScript Custom Assay Services for RNF223
- GenScript Custom overexpressing Cell Line Services for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for RNF223
- ViGene Biosciences adenoviral particle packaged cDNA for RNF223 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- Search ViGene Biosciences for RNF223
- Horizon Cell Lines for RNF223
- Cyagen custom Knockout/knockin (KOKI) mouse models for RNF223
- VectorBuilder custom plasmid, inducible vectors for RNF223
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF223
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RNF223 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab