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RNF223 Gene

protein-coding GIFtS: 28
GCID: GC01M001009

Ring Finger Protein 223

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ring Finger Protein 223¹ ²

External Ids:	HGNC: 40020¹	Entrez Gene: 401934²	Ensembl: ENSG00000237330⁷	UniProtKB: E7ERA6³

Export aliases for RNF223 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF223 Gene:

RNF223 (ring finger protein 223) is a protein-coding gene. An important paralog of this gene is RNF183.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000001.10 NC_018912.2 NT_032977.10

Regulatory elements:

Search for regulatory transcription factor binding sites for RNF223
Other transcription factors

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Epigenetics:

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Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33

RNF223 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF223 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001009: view genomic region (about GC identifiers)

Start:	1,006,346 bp from pter	End:	1,009,687 bp from pter
Size:	3,342 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6 (See protein sequence)

Recommended Name: RING finger protein 223

Size: 249 amino acids; 26629 Da

Secondary accessions: B4DKI4

Explore the universe of human proteins at neXtProt for RNF223: NX_E7ERA6

Explore proteomics data for RNF223 at MOPED

See RNF223 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001192181.1

ENSEMBL proteins:

ENSP00000410533

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

RNF: RING-type (C3HC4) zinc fingers

3 InterPro protein domains:

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry E7ERA6

ProtoNet protein and cluster: E7ERA6

UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6

Similarity: Contains 1 RING-type zinc finger

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(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	--	--

Find genes that share ontologies with RNF223 About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

RN223_HUMAN, E7ERA6: Membrane; Single-pass membrane protein (Potential)

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	IEA	--

Find genes that share ontologies with RNF223 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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REFSEQ mRNAs for RNF223 gene:

NM_001205252.1

Unigene Cluster for RNF223:

Ring finger protein 223

Hs.568137 [show with all ESTs]

Unigene Representative Sequence: AK296576

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000453464(uc021oen.1)

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Additional mRNA sequence: AK296576.1

1 DOTS entry:

DT.75109241

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNF223 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGCGTCCCC

About this image

RNF223 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RNF223 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.568137

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RNF223 gene from Selected species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnf223^{1 , 5}	RIKEN cDNA 9930005F22 gene⁵ ring finger 223¹	75.64(n)¹ 76.71(a)¹		4 (88.44 cM)⁵ 100045778¹ NM_001220499.1¹ NP_001207428.1¹ 156132170⁵
chicken (Gallus gallus)	Aves	RNF223¹	ring finger protein 223	59.94(n) 52.75(a)		419428 XM_417589.3 XP_417589.1
lizard (Anolis carolinensis)	Reptilia	RNF223⁶	ring finger protein 223	49(a)	1 ↔ 1	GL343647.1(43538-44377)
tropical clawed frog (Xenopus tropicalis)	Amphibia	rnf223¹	ring finger protein 223	56.4(n) 55.81(a)		100492332 XM_004916525.1 XP_004916582.1
zebrafish (Danio rerio)	Actinopterygii	LOC101883831¹	RING finger protein 223-like	52.79(n) 46.82(a)		101883831 XM_005162206.1 XP_005162263.1

ENSEMBL Gene Tree for RNF223 (if available)
TreeFam Gene Tree for RNF223 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RNF223 gene

RNF183² LOC646862²

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1 Pseudogenes.org Pseudogene for RNF223
PGOHUM00000259437

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186975412^1,2		--	998888(+)	`GCTGAA/GGCTAT`	1	--	us2k¹		0	--	--	--	--
rs191526342^1,2		--	998893(+)	`GGCTAC/TGGTGA`	1	--	us2k¹		0	--	--	--	--
rs184373814^1,2		--	998896(+)	`TATGGG/TGACTC`	1	--	us2k¹		0	--	--	--	--
rs72900499^1,2	C,F	--	1006644(+)	`TGTACG/AAGCCT`	1	--	ds500¹		1		WA	2
rs191269810^1,2		--	1006741(+)	`CACCTA/CCCCGG`	1	--	ds500¹		0	--	--	--	--
rs185850755^1,2		--	1006799(+)	`CACCAC/TGATGC`	1	--	ds500¹		0	--	--	--	--
rs142774611^1,2		--	1006804(+)	`CGATGC/TCCGGT`	1	--	ds500¹		0	--	--	--	--
rs4326571^1,2	C,F,H	--	1006990(+)	`ACCCCA/GTCAGG`	1	--	ds500¹		13		NA WA CSA EA	376
rs11577829^1,2	H	--	1007065(+)	`GAGTCC/TTCAGA`	1	--	ds500¹		0	--	--	--	--
rs115908330^1,2	C,F	--	1007131(+)	`TTGGGA/C/TCCCCC`	2	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for RNF223 (1006346 - 1009687 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for RNF223 (see all 19): About this table

Variant ID	Type	Subtype	PubMed ID
nsv509146	CNV	Insertion	20534489
nsv470680	CNV	Loss	18288195
dgv9n71	CNV	Loss	21882294
nsv870874	CNV	Loss	21882294
dgv12n71	CNV	Loss	21882294
nsv871349	CNV	Loss	21882294
dgv10n71	CNV	Loss	21882294
dgv13n71	CNV	Loss	21882294
dgv11n71	CNV	Loss	21882294
nsv871547	CNV	Loss	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNF223 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNF223)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (Nature 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 401934	HGNC: 40020	Ensembl:ENSG00000237330	euGenes: HUgn401934	ECgene: RNF223
H-InvDB: RNF223

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNF223	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF223 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNF223 gene:
Search GeneIP for patents involving RNF223

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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RNF223 Gene

Ring Finger Protein 223

Aliases
for RNF223 gene

Summaries
for RNF223 gene

Genomic Views
for RNF223 gene

Proteins
for RNF223 gene

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RNF223 Gene

Ring Finger Protein 223

Aliasesfor RNF223 gene

Summariesfor RNF223 gene

Genomic Viewsfor RNF223 gene

Proteinsfor RNF223 gene

RNF223 Human Recombinant Protein Products:

RNF223 Antibody Products:

RNF223 Assay Products:

Domains /Familiesfor RNF223 gene

Functionfor RNF223 gene

Localizationfor RNF223 gene

Pathways & Interactionsfor RNF223 gene

Drugs & Compoundsfor RNF223 gene

Transcriptsfor RNF223 gene

Expression for RNF223 gene

Orthologsfor RNF223 gene

Paralogsfor RNF223 gene

Genomic Variantsfor RNF223 gene

Disorders / Diseasesfor RNF223 gene

Publicationsfor RNF223 gene

External Searches for RNF223 gene

Genome Databases showing RNF223 gene

Other Databases showing RNF223 gene

Specialized Databases showing RNF223 gene

Intellectual Propertyfor RNF223 gene

Productsfor RNF223 gene

View Random Gene

Aliases
for RNF223 gene

Summaries
for RNF223 gene

Genomic Views
for RNF223 gene

Proteins
for RNF223 gene

Domains /
Families
for RNF223 gene

Function
for RNF223 gene

Localization
for RNF223 gene

Pathways & Interactions
for RNF223 gene

Drugs & Compounds
for RNF223 gene

Transcripts
for RNF223 gene

Expression
for RNF223 gene

Orthologs
for RNF223 gene

Paralogs
for RNF223 gene

Genomic Variants
for RNF223 gene

Disorders / Diseases
for RNF223 gene

Publications
for RNF223 gene

Intellectual Property
for RNF223 gene

Products
for RNF223 gene