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Aliases for RNF223 Gene

Aliases for RNF223 Gene

  • Ring Finger Protein 223 2 3 5

External Ids for RNF223 Gene

Previous GeneCards Identifiers for RNF223 Gene

  • GC01M001009

Summaries for RNF223 Gene

GeneCards Summary for RNF223 Gene

RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF225.

Additional gene information for RNF223 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene

Genomics for RNF223 Gene

Regulatory Elements for RNF223 Gene

Enhancers around RNF223 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNF223 Gene

Genomic Locations for RNF223 Gene
3,342 bases
Minus strand

Genomic View for RNF223 Gene

Genes around RNF223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF223 Gene

Proteins for RNF223 Gene

  • Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 223
    Protein Accession:
    Secondary Accessions:
    • B4DKI4

    Protein attributes for RNF223 Gene

    249 amino acids
    Molecular mass:
    26629 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF223 Gene

Post-translational modifications for RNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF223 Gene

Domains & Families for RNF223 Gene

Gene Families for RNF223 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF223 Gene

Suggested Antigen Peptide Sequences for RNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF223: view

No data available for UniProtKB/Swiss-Prot for RNF223 Gene

Function for RNF223 Gene

Phenotypes From GWAS Catalog for RNF223 Gene

Gene Ontology (GO) - Molecular Function for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF223: view

Phenotypes for RNF223 Gene

GenomeRNAi human phenotypes for RNF223:
genes like me logo Genes that share phenotypes with RNF223: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF223 Gene

Localization for RNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF223 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF223: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF223 Gene

Pathways & Interactions for RNF223 Gene

SuperPathways for RNF223 Gene

No Data Available

Interacting Proteins for RNF223 Gene

Gene Ontology (GO) - Biological Process for RNF223 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF223 Gene

Drugs & Compounds for RNF223 Gene

No Compound Related Data Available

Transcripts for RNF223 Gene

mRNA/cDNA for RNF223 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF223 Gene

Ring finger protein 223:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF223 Gene

No ASD Table

Relevant External Links for RNF223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF223 Gene

mRNA differential expression in normal tissues according to GTEx for RNF223 Gene

This gene is overexpressed in Esophagus - Mucosa (x21.0), Cervix - Ectocervix (x8.3), and Vagina (x7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF223 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF223 Gene:


SOURCE GeneReport for Unigene cluster for RNF223 Gene:

genes like me logo Genes that share expression patterns with RNF223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF223 Gene

Orthologs for RNF223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF223 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF223 33 34
  • 81.57 (n)
(Canis familiaris)
Mammalia RNF223 33 34
  • 81.17 (n)
(Mus musculus)
Mammalia Rnf223 33 16
  • 75.64 (n)
(Rattus norvegicus)
Mammalia Rnf223 33
  • 72.29 (n)
(Gallus gallus)
Aves RNF223 33 34
  • 59.94 (n)
(Anolis carolinensis)
Reptilia RNF223 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf223 33
  • 56.4 (n)
(Danio rerio)
Actinopterygii LOC101883831 33
  • 52.79 (n)
RNF223 34
  • 40 (a)
Species where no ortholog for RNF223 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF223 Gene

Gene Tree for RNF223 (if available)
Gene Tree for RNF223 (if available)

Paralogs for RNF223 Gene

Paralogs for RNF223 Gene

genes like me logo Genes that share paralogs with RNF223: view

Variants for RNF223 Gene

Sequence variations from dbSNP and Humsavar for RNF223 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000097429 -- 1,073,998(+) AACAC(A/G)GGCTG intron-variant
rs1000104885 -- 1,069,502(+) CCGGC(G/T)CCCCG upstream-variant-2KB, utr-variant-3-prime
rs1000293410 -- 1,072,154(+) TGCCC(C/T)CCAGC reference, missense
rs1000412084 -- 1,071,191(+) GCTTC(C/T)CTGGC utr-variant-3-prime
rs1000448295 -- 1,070,860(+) AGAAC(C/T)TTGGG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF223 Gene

Variant ID Type Subtype PubMed ID
nsv950451 CNV deletion 24416366
nsv945741 CNV duplication 23825009
nsv544947 CNV loss 21841781
nsv517709 CNV gain+loss 19592680
nsv509146 CNV insertion 20534489
nsv482937 CNV loss 15286789
nsv470680 CNV loss 18288195
nsv428334 CNV gain 18775914
nsv1160772 CNV duplication 26073780
nsv1160644 CNV deletion 26073780
nsv10161 CNV gain+loss 18304495
nsv1013524 CNV gain 25217958
nsv1003578 CNV gain 25217958
esv2762302 CNV gain 21179565
dgv5n100 CNV gain 25217958
dgv2n67 CNV gain 20364138

Variation tolerance for RNF223 Gene

Gene Damage Index Score: 3.97; 59.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF223 Gene

Disorders for RNF223 Gene

Relevant External Links for RNF223

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF223 Gene

Publications for RNF223 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for RNF223 Gene

Sources for RNF223 Gene

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