Aliases for RNF223 Gene
External Ids for RNF223 Gene
- HGNC: 40020
- Entrez Gene: 401934
- Ensembl: ENSG00000237330
- UniProtKB: E7ERA6
Previous GeneCards Identifiers for RNF223 Gene
- GC01M001009
Summaries for RNF223 Gene
GeneCards Summary for RNF223 Gene
RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF225.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene
Genomics for RNF223 Gene
Regulatory Elements for RNF223 Gene
Enhancers for RNF223 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RNF223 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for RNF223 Gene
- Chromosome:
- 1
- Start:
- 1,070,966 bp from pter
- End:
- 1,074,307 bp from pter
- Size:
- 3,342 bases
- Orientation:
- Minus strand
Genomic View for RNF223 Gene
Genes around RNF223 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.33 by Ensembl
- 1p36.33 by Entrez Gene
- 1p36.33 by HGNC
RNF223 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF223 Gene
Proteins for RNF223 Gene
-
Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- E7ERA6-RN223_HUMAN
- Recommended name:
- RING finger protein 223
- Protein Accession:
- E7ERA6
- B4DKI4
Protein attributes for RNF223 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 26629 Da
- Quaternary structure:
- No Data Available
Protein Expression for RNF223 Gene
Post-translational modifications for RNF223 Gene
Other Protein References for RNF223 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for RNF223
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF223
- Origene Custom Protein Services for RNF223
- Search GeneTex for Proteins for RNF223
Assay Products
No data available for DME Specific Peptides for RNF223 Gene
Domains & Families for RNF223 Gene
Gene Families for RNF223 Gene
Protein Domains for RNF223 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF223 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
E7ERA6- Similarity:
-
- Contains 1 RING-type zinc finger.
Function for RNF223 Gene
Phenotypes for RNF223 Gene
- GenomeRNAi human phenotypes for RNF223:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- Search ViGene Biosciences for RNF223
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- OriGene clones in human for RNF223
- OriGene ORF clones in human,mouse for RNF223
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF223 Gene
Localization for RNF223 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 2 |
No data available for Gene Ontology (GO) - Cellular Components for RNF223 Gene
More details on SuperPathways for RNF223Transcripts for RNF223 Gene
mRNA/cDNA for RNF223 Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNF223 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- OriGene clones in human for RNF223
- OriGene ORF clones in human,mouse for RNF223
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
Flow Cytometry Products
Expression for RNF223 Gene
mRNA differential expression in normal tissues according to GTEx for RNF223 Gene
This gene is overexpressed in Esophagus - Mucosa (x21.0), Cervix - Ectocervix (x8.3), and Vagina (x7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RNF223 Gene
SOURCE GeneReport for Unigene cluster for RNF223 Gene Hs.568137
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF223 Gene
Orthologs for RNF223 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RNF223 35 |
|
||
| RNF223 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | RNF223 35 |
|
||
| RNF223 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Rnf223 35 |
|
||
| Rnf223 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Rnf223 35 |
|
||
| chicken (Gallus gallus) |
Aves | RNF223 35 |
|
||
| RNF223 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | RNF223 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rnf223 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101883831 35 |
|
||
| RNF223 36 |
|
OneToOne |
- Species with no ortholog for RNF223:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RNF223 Gene
Pseudogenes.org Pseudogenes for RNF223 Gene
Variants for RNF223 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4633229 | -- | 1,071,823(+) | TAATT(A/G)TCAGT | reference, synonymous-codon | |
| rs4326571 | -- | 1,071,610(+) | ACCCC(A/G)TCAGG | downstream-variant-500B | |
| rs4333796 | -- | 1,072,052(+) | CGGGC(A/G)CGGGC | reference, missense | |
| rs9442366 | -- | 1,073,854(+) | CACTG(C/T)GAGGC | intron-variant | |
| rs9442367 | -- | 1,074,098(+) | CTGCC(C/G)TGGCA | utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3e1 | CNV | Complex | 17122850 |
| nsv10161 | CNV | Gain+Loss | 18304495 |
| essv2408 | CNV | CNV | 17122850 |
| nsv517709 | CNV | Gain+Loss | 19592680 |
| nsv428334 | CNV | Gain | 18775914 |
| dgv2n67 | CNV | Gain | 20364138 |
| nsv871883 | CNV | Gain+Loss | 21882294 |
| dgv9n71 | CNV | Loss | 21882294 |
| nsv871547 | CNV | Loss | 21882294 |
| dgv10n71 | CNV | Loss | 21882294 |
| dgv11n71 | CNV | Loss | 21882294 |
| dgv12n71 | CNV | Loss | 21882294 |
| dgv13n71 | CNV | Loss | 21882294 |
| nsv509146 | CNV | Insertion | 20534489 |
| dgv15n71 | CNV | Loss | 21882294 |
| nsv871557 | CNV | Gain | 21882294 |
| nsv870874 | CNV | Loss | 21882294 |
| nsv871349 | CNV | Loss | 21882294 |
| nsv470680 | CNV | Loss | 18288195 |
Gene Damage Index Score:
3.97;
59.90% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF223 Gene
Disorders for RNF223 Gene
Relevant External Links for RNF223
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RNF223
No disorders were found for RNF223 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF223 Gene
Publications for RNF223 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 67
Products for RNF223 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Browse ELISAs
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF223
- Origene Custom Protein Services for RNF223
- Browse OriGene Inhibitory RNA Products For RNF223
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for RNF223
- OriGene clones in human for RNF223
- OriGene ORF clones in human,mouse for RNF223
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for RNF223
- GenScript Custom Assay Services for RNF223
- GenScript Custom overexpressing Cell Line Services for RNF223
- GenScript: Design CRISPR guide RNA sequences for RNF223
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RNF223
- ViGene Biosciences adenoviral particle packaged cDNA for RNF223 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
- Search ViGene Biosciences for RNF223
- Search ViGene Biosciences for RNF223
Sources for RNF223 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon