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Aliases for RNF223 Gene

Aliases for RNF223 Gene

  • Ring Finger Protein 223 2 3

External Ids for RNF223 Gene

Previous GeneCards Identifiers for RNF223 Gene

  • GC01M001009

Summaries for RNF223 Gene

GeneCards Summary for RNF223 Gene

RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF225.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene

Genomics for RNF223 Gene

Genomic Location for RNF223 Gene

Start:
1,070,966 bp from pter
End:
1,074,307 bp from pter
Size:
3,342 bases
Orientation:
Minus strand

Genomic View for RNF223 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF223 Gene

No data available for Regulatory Elements for RNF223 Gene

Proteins for RNF223 Gene

  • Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E7ERA6-RN223_HUMAN
    Recommended name:
    RING finger protein 223
    Protein Accession:
    E7ERA6
    Secondary Accessions:
    • B4DKI4

    Protein attributes for RNF223 Gene

    Size:
    249 amino acids
    Molecular mass:
    26629 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF223 Gene

Proteomics data for RNF223 Gene at MOPED

Post-translational modifications for RNF223 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF223 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF223 Gene

Domains for RNF223 Gene

Gene Families for RNF223 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF223 Gene

Suggested Antigen Peptide Sequences for RNF223 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

E7ERA6

UniProtKB/Swiss-Prot:

RN223_HUMAN :
  • E7ERA6
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF223: view

Function for RNF223 Gene

Gene Ontology (GO) - Molecular Function for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF223: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF223 Gene

Localization for RNF223 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for RNF223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF223: view

No data available for Subcellular locations from COMPARTMENTS for RNF223 Gene

Pathways for RNF223 Gene

SuperPathways for RNF223 Gene

No Data Available

Interacting Proteins for RNF223 Gene

Gene Ontology (GO) - Biological Process for RNF223 Gene

None

No data available for Pathways by source for RNF223 Gene

Transcripts for RNF223 Gene

mRNA/cDNA for RNF223 Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF223 Gene

Ring finger protein 223:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF223

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF223 Gene

No ASD Table

Relevant External Links for RNF223 Gene

GeneLoc Exon Structure for
RNF223
ECgene alternative splicing isoforms for
RNF223

Expression for RNF223 Gene

mRNA expression in normal human tissues for RNF223 Gene

mRNA differential expression in normal tissues according to GTEx for RNF223 Gene

This gene is overexpressed in Esophagus - Mucosa (21.0), Cervix - Ectocervix (8.3), and Vagina (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RNF223 Gene

SOURCE GeneReport for Unigene cluster for RNF223 Gene Hs.568137

genes like me logo Genes that share expressions with RNF223: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RNF223 Gene

Orthologs for RNF223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF223 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF223 35
  • 81.57 (n)
  • 80.08 (a)
RNF223 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF223 35
  • 81.17 (n)
  • 81.61 (a)
RNF223 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf223 35
  • 75.64 (n)
  • 76.71 (a)
Rnf223 16
rat
(Rattus norvegicus)
Mammalia Rnf223 35
  • 72.29 (n)
  • 73.9 (a)
chicken
(Gallus gallus)
Aves RNF223 35
  • 59.94 (n)
  • 52.75 (a)
RNF223 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF223 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf223 35
  • 56.4 (n)
  • 55.81 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883831 35
  • 52.79 (n)
  • 46.82 (a)
RNF223 36
  • 40 (a)
OneToOne
Species with no ortholog for RNF223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF223 Gene

ENSEMBL:
Gene Tree for RNF223 (if available)
TreeFam:
Gene Tree for RNF223 (if available)

Paralogs for RNF223 Gene

Paralogs for RNF223 Gene

Pseudogenes.org Pseudogenes for RNF223 Gene

genes like me logo Genes that share paralogs with RNF223: view

Variants for RNF223 Gene

Sequence variations from dbSNP and Humsavar for RNF223 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4326571 -- 1,071,610(+) ACCCC(A/G)TCAGG downstream-variant-500B
rs4333796 -- 1,072,052(+) CGGGC(A/G)CGGGC reference, missense
rs4633229 -- 1,071,823(+) TAATT(A/G)TCAGT synonymous-codon, reference
rs9442366 -- 1,073,854(+) CACTG(C/T)GAGGC intron-variant
rs9442367 -- 1,074,098(+) CTGCC(C/G)TGGCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF223 Gene

Variant ID Type Subtype PubMed ID
dgv3e1 CNV Complex 17122850
nsv10161 CNV Gain+Loss 18304495
essv2408 CNV CNV 17122850
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871883 CNV Gain+Loss 21882294
dgv9n71 CNV Loss 21882294
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv13n71 CNV Loss 21882294
nsv509146 CNV Insertion 20534489
dgv15n71 CNV Loss 21882294
nsv871557 CNV Gain 21882294
nsv870874 CNV Loss 21882294
nsv871349 CNV Loss 21882294
nsv470680 CNV Loss 18288195

Relevant External Links for RNF223 Gene

HapMap Linkage Disequilibrium report
RNF223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF223 Gene

Disorders for RNF223 Gene

No disorders were found for RNF223 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNF223 Gene

Publications for RNF223 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for RNF223 Gene

Sources for RNF223 Gene

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