RNF223 Gene
protein-coding GIFtS: 28
GCID: GC01M001009
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Ring Finger Protein 223
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Aliases
for RNF223 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
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| Aliases |
|---|
| Ring Finger Protein 2231 2 |
Export aliases for RNF223 gene to outside databases |
Summaries
for RNF223 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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GeneCards Summary for RNF223 Gene:
RNF223 (ring finger protein 223) is a protein-coding gene. An important paralog of this gene is RNF183.
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Genomic Views
for RNF223 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000001.11 NC_018912.2 NT_032977.10
Regulatory elements:
 Search for regulatory transcription factor binding sites for RNF223
Other transcription factors
Search Chromatin IP Primers for RNF223
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF223 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33RNF223 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001009: view genomic region
(about GC identifiers)
Start:
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1,006,346 bp from pter |
End:
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1,009,687 bp from pter |
Size:
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3,342 bases |
Orientation:
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minus strand |
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Proteins
for RNF223 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6 (See
protein sequence)Recommended Name: RING finger protein 223 Size: 249 amino acids; 26629 Da
Secondary accessions: B4DKI4Explore the universe of human proteins at neXtProt for RNF223: NX_E7ERA6
Explore proteomics data for RNF223 at MOPED
See RNF223 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_001192181.1
ENSEMBL proteins: ENSP00000410533
RNF223 Human Recombinant
Protein Products:RNF223 Antibody
Products:RNF223 Assay Products: |
Domains /
Families
for RNF223 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
RNF: RING-type (C3HC4) zinc fingers
3 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry E7ERA6ProtoNet protein and cluster: E7ERA6 UniProtKB/Swiss-Prot: RN223_HUMAN, E7ERA6Similarity: Contains 1 RING-type zinc finger
RNF223 for domains About GeneDecksing
|
Function
for RNF223 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 3 molecular function terms: About this table
RNF223 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for RNF223 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for RNF223  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF223 |
Localization
for RNF223 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot RN223_HUMAN, E7ERA6: Membrane; Single-pass membrane protein (Potential)Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral component of membrane |
IEA | -- |
RNF223 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF223 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF223
Interactions:
Search GeneGlobe Interaction Network for RNF223
|
Drugs & Compounds
for RNF223 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for RNF223 (RN223)
|
Transcripts
for RNF223 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for RNF223 gene: NM_001205252.1 Unigene Cluster for RNF223: Ring finger protein 223 Hs.568137 [show with all ESTs]Unigene Representative Sequence: AK2965761 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000453464(uc021oen.1)
Primer
Products: |  | Browse OriGene qPCR
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNF223 | | | QuantiTect SYBR Green Assays in human, mouse, rat RNF223 | | | QuantiFast Probe-based Assays in human, mouse, rat RNF223 |
Additional mRNA sequence: AK296576.1 1 DOTS entry: DT.75109241
GeneLoc Exon Structure
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Expression
for RNF223 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNF223 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGCGTCCCC
About this image RNF223 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  About this image
SOURCE GeneReport for Unigene cluster: Hs.568137
Custom PCR Arrays for RNF223
Primer
Products: | | Browse OriGene qPCR
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNF223 | | | QuantiTect SYBR Green Assays in human, mouse, rat RNF223 | | | QuantiFast Probe-based Assays in human, mouse, rat RNF223 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF223 |
Orthologs
for RNF223 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for RNF223 gene from Selected species (see all 8) About this table
ENSEMBL Gene Tree for RNF223 (if available)
TreeFam Gene Tree for RNF223 (if available) |
Paralogs
for RNF223 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for RNF223 gene
- RNF1832 LOC6468622
RNF223 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RNF223
PGOHUM00000259437
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Genomic Variants
for RNF223 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF223 (1006346 - 1009687 bp)
Structural Variations
Database of Genomic Variants (DGV) Selected variations for RNF223 (see all 19): About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing RNF223 |
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Disorders
/ Diseases
for RNF223 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus | -- |
Publications
for RNF223 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for RNF223 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNF223) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
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External Searches for RNF223 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing RNF223 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing RNF223 gene
(According to HUGE)
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Specialized Databases showing RNF223 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RNF223 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for RNF223 gene:
Search GeneIP for patents involving RNF223
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF223 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | Block miRNA regulation of human, mouse, rat RNF223 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing RNF223 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF223 | | Predesigned siRNA for gene silencing in human, mouse, rat RNF223 | | | QuantiFast Probe-based Assays in human, mouse, rat RNF223 | | QuantiTect SYBR Green Assays in human, mouse, rat RNF223 | | | Custom PCR Arrays for RNF223 | | Search Chromatin IP Primers for RNF223 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNF223 | | Search GeneGlobe Interaction Network for RNF223 | | | Search Regulatory tfbs for RNF223 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF223 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for RNF223 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF223 |
| | | | LSBio Antibodies in human, mouse, rat for RNF223 |
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