Aliases for RNF223 Gene
External Ids for RNF223 Gene
- HGNC: 40020
- Entrez Gene: 401934
- Ensembl: ENSG00000237330
- UniProtKB: E7ERA6
Previous GeneCards Identifiers for RNF223 Gene
- GC01M001009
Summaries for RNF223 Gene
GeneCards Summary for RNF223 Gene
RNF223 (Ring Finger Protein 223) is a Protein Coding gene. An important paralog of this gene is RNF183.
Additional gene information for RNF223 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF223 Gene
Genomics for RNF223 Gene
GeneHancer (GH) Regulatory Elements for RNF223 Gene
Promoters and enhancers for RNF223 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RNF223 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RNF223 Gene
Genomic Locations for RNF223 Gene
- chr1:1,070,966-1,074,307
- (GRCh38/hg38)
- Size:
- 3,342 bases
- Orientation:
- Minus strand
- chr1:1,006,346-1,009,687
- (GRCh37/hg19)
Genomic View for RNF223 Gene
Genes around RNF223 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.33 by Ensembl
- 1p36.33 by Entrez Gene
- 1p36.33 by HGNC
RNF223 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for RNF223 Gene
Proteins for RNF223 Gene
-
Protein details for RNF223 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- E7ERA6-RN223_HUMAN
- Recommended name:
- RING finger protein 223
- Protein Accession:
- E7ERA6
- B4DKI4
Protein attributes for RNF223 Gene
- Size:
- 249 amino acids
- Molecular mass:
- 26629 Da
- Quaternary structure:
- No Data Available
Protein Expression for RNF223 Gene
Post-translational modifications for RNF223 Gene
No Post-translational modifications
Other Protein References for RNF223 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF223
- Origene Custom Protein Services for RNF223
- Search GeneTex for Proteins for RNF223
Assay Products
No data available for DME Specific Peptides for RNF223 Gene
Domains & Families for RNF223 Gene
Gene Families for RNF223 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for RNF223 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF223 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for RNF223 Gene
Function for RNF223 Gene
Phenotypes From GWAS Catalog for RNF223 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RNF223 Gene
- GenomeRNAi human phenotypes for RNF223:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
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- Search ViGene Biosciences for RNF223
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- genomics-online: gRNA clones - Search results for 21 available RNF223 gene related products
- Overview of 21 available RNF223 gene related products
- Applied Biological Materials CRISPR for RNF223
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 21 available RNF223 gene related products
- Overview of 21 available RNF223 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RNF223
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RNF223
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RNF223
-
ViGene Biosciences adenoviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNF223 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF223 Gene
Localization for RNF223 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF223 Gene
- Membrane; Single-pass membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF223 Gene
Transcripts for RNF223 Gene
mRNA/cDNA for RNF223 Gene
- (3) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNF223 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNF223
- genomics-online: gRNA clones - Search results for 21 available RNF223 gene related products
- Overview of 21 available RNF223 gene related products
- Applied Biological Materials CRISPR for RNF223
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for RNF223
miRNA Products
- Search ViGene Biosciences for RNF223
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for 21 available RNF223 gene related products
- Overview of 21 available RNF223 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNF223 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for RNF223
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF223
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RNF223
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RNF223 Gene
mRNA differential expression in normal tissues according to GTEx for RNF223 Gene
This gene is overexpressed in Esophagus - Mucosa (x21.0), Cervix - Ectocervix (x8.3), and Vagina (x7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF223 Gene
NURSA nuclear receptor signaling pathways regulating expression of RNF223 Gene:
RNF223SOURCE GeneReport for Unigene cluster for RNF223 Gene:
Hs.568137Primer Products
- genomics-online: primer clones - Search results for 21 available RNF223 gene related products
- Overview of 21 available RNF223 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF223 Gene
Orthologs for RNF223 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
cow (Bos Taurus) |
Mammalia | RNF223 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | RNF223 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Rnf223 33 16 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rnf223 33 |
|
||
chicken (Gallus gallus) |
Aves | RNF223 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | RNF223 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rnf223 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | LOC101883831 33 |
|
||
RNF223 34 |
|
OneToOne |
- Species where no ortholog for RNF223 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RNF223 Gene
Variants for RNF223 Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000097429 | -- | 1,073,998(-) | G/A/C | genic_upstream_transcript_variant, intron_variant | |
rs1000104885 | -- | 1,069,502(-) | T/G | 3_prime_UTR_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
rs1000293410 | -- | 1,072,154(-) | T/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs1000412084 | -- | 1,071,191(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant | |
rs1000448295 | -- | 1,070,860(-) | C/T | 3_prime_UTR_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2n67 | CNV | gain | 20364138 |
dgv5n100 | CNV | gain | 25217958 |
esv2762302 | CNV | gain | 21179565 |
nsv1003578 | CNV | gain | 25217958 |
nsv1013524 | CNV | gain | 25217958 |
nsv10161 | CNV | gain+loss | 18304495 |
nsv1160644 | CNV | deletion | 26073780 |
nsv1160772 | CNV | duplication | 26073780 |
nsv428334 | CNV | gain | 18775914 |
nsv470680 | CNV | loss | 18288195 |
nsv482937 | CNV | loss | 15286789 |
nsv509146 | CNV | insertion | 20534489 |
nsv517709 | CNV | gain+loss | 19592680 |
nsv544947 | CNV | loss | 21841781 |
nsv945741 | CNV | duplication | 23825009 |
nsv950451 | CNV | deletion | 24416366 |
Gene Damage Index Score:
3.97;
59.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF223 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF223
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF223 Gene
Disorders for RNF223 Gene
Additional Disease Information for RNF223
No disorders were found for RNF223 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF223 Gene
Publications for RNF223 Gene
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
Products for RNF223 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available RNF223 related products ranked by validation data
- antibodies-online: Search results for available RNF223 related products ranked by validation data
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Sources for RNF223 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew