Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF222 Gene

Aliases for RNF222 Gene

  • Ring Finger Protein 222 2 3

External Ids for RNF222 Gene

Previous GeneCards Identifiers for RNF222 Gene

  • GC17M008235
  • GC17M008295
  • GC17M008188

Summaries for RNF222 Gene

GeneCards Summary for RNF222 Gene

RNF222 (Ring Finger Protein 222) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF222 Gene

Genomics for RNF222 Gene

Regulatory Elements for RNF222 Gene

Genomic Location for RNF222 Gene

Start:
8,390,704 bp from pter
End:
8,397,826 bp from pter
Size:
7,123 bases
Orientation:
Minus strand

Genomic View for RNF222 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF222 Gene

Proteins for RNF222 Gene

  • Protein details for RNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCQ9-RN222_HUMAN
    Recommended name:
    RING finger protein 222
    Protein Accession:
    A6NCQ9
    Secondary Accessions:

    Protein attributes for RNF222 Gene

    Size:
    220 amino acids
    Molecular mass:
    23767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF222 Gene

Proteomics data for RNF222 Gene at MOPED

Post-translational modifications for RNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF222 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF222 Gene

Domains for RNF222 Gene

Gene Families for RNF222 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF222 Gene

Suggested Antigen Peptide Sequences for RNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCQ9

UniProtKB/Swiss-Prot:

RN222_HUMAN :
  • A6NCQ9
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF222: view

Function for RNF222 Gene

Gene Ontology (GO) - Molecular Function for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF222

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF222 Gene

Localization for RNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF222 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF222 Gene COMPARTMENTS Subcellular localization image for RNF222 gene
Compartment Confidence
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF222: view

Pathways for RNF222 Gene

SuperPathways for RNF222 Gene

No Data Available

Interacting Proteins for RNF222 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343799%0d%0a9606.ENSP00000356480%0d%0a
Selected Interacting proteins: ENSP00000343799 for RNF222 Gene via STRING

Symbol External ID(s) Details
RNF2

Gene Ontology (GO) - Biological Process for RNF222 Gene

None

No data available for Pathways by source for RNF222 Gene

Transcripts for RNF222 Gene

mRNA/cDNA for RNF222 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF222 Gene

Ring finger protein 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF222

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF222 Gene

No ASD Table

Relevant External Links for RNF222 Gene

GeneLoc Exon Structure for
RNF222
ECgene alternative splicing isoforms for
RNF222

Expression for RNF222 Gene

mRNA expression in normal human tissues for RNF222 Gene

mRNA differential expression in normal tissues according to GTEx for RNF222 Gene

This gene is overexpressed in Esophagus - Mucosa (22.0), Skin - Not Sun Exposed (Suprapubic) (8.4), Skin - Sun Exposed (Lower leg) (7.8), Vagina (6.0), and Cervix - Ectocervix (4.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNF222 Gene

SOURCE GeneReport for Unigene cluster for RNF222 Gene Hs.526550

genes like me logo Genes that share expressions with RNF222: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF222 Gene

Orthologs for RNF222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF222 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF222 35
  • 99.09 (n)
  • 99.55 (a)
RNF222 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF222 35
  • 87.68 (n)
  • 87.2 (a)
RNF222 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF222 35
  • 88.23 (n)
  • 88.56 (a)
RNF222 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf222 35
  • 85.47 (n)
  • 87.2 (a)
Rnf222 16
Rnf222 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF222 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf222 35
  • 85.62 (n)
  • 89.1 (a)
chicken
(Gallus gallus)
Aves LOC101749003 35
  • 64.32 (n)
  • 50.25 (a)
RNF222 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF222 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732514 35
  • 55.22 (n)
  • 42.79 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886437 35
  • 49.38 (n)
  • 39.68 (a)
RNF222 36
  • 38 (a)
OneToOne
Species with no ortholog for RNF222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF222 Gene

ENSEMBL:
Gene Tree for RNF222 (if available)
TreeFam:
Gene Tree for RNF222 (if available)

Paralogs for RNF222 Gene

No data available for Paralogs for RNF222 Gene

Variants for RNF222 Gene

Sequence variations from dbSNP and Humsavar for RNF222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1391765 -- 8,394,148(-) CTGAC(A/G)TGACT intron-variant
rs2872230 -- 8,391,107(+) TGCAA(C/G)CTCCG utr-variant-3-prime
rs3930740 -- 8,391,641(+) ACTTA(C/T)GGACC utr-variant-3-prime
rs4792805 -- 8,397,596(+) CTCTC(C/T)CTCAT intron-variant
rs6503111 -- 8,395,228(+) CTCTT(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF222 Gene

Variant ID Type Subtype PubMed ID
dgv3057n71 CNV Loss 21882294
nsv1968 CNV Insertion 18451855
nsv509651 CNV Insertion 20534489

Relevant External Links for RNF222 Gene

HapMap Linkage Disequilibrium report
RNF222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF222 Gene

Disorders for RNF222 Gene

No disorders were found for RNF222 Gene.

No data available for UniProtKB/Swiss-Prot for RNF222 Gene

Publications for RNF222 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RNF222 Gene

Sources for RNF222 Gene

Back to Top

Content