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Aliases for RNF222 Gene

Aliases for RNF222 Gene

  • Ring Finger Protein 222 2 3 5

External Ids for RNF222 Gene

Previous GeneCards Identifiers for RNF222 Gene

  • GC17M008235
  • GC17M008295
  • GC17M008188
  • GC17M008395

Summaries for RNF222 Gene

GeneCards Summary for RNF222 Gene

RNF222 (Ring Finger Protein 222) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF222 Gene

Genomics for RNF222 Gene

Regulatory Elements for RNF222 Gene

Enhancers for RNF222 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008417 1.7 FANTOM5 Ensembl ENCODE 12.2 -21.8 -21768 5.2 PKNOX1 ARNT MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 SP5 NFYC PIK3R5 RNF222 SPDYE4 RNU7-43P MYH10 NDEL1 PER1 CTC1 VAMP2 BORCS6
GH17F008478 1.4 Ensembl ENCODE 10.8 -82.4 -82415 2.5 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RPL26 RNU7-43P MYH10 ENSG00000212206 RNF222 ODF4 SPDYE4 NDEL1 GC17P008478 PIR54625
GH17F008375 1.1 ENCODE 11.9 +21.3 21333 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 DEK ODF4 LOC105371523 KRBA2 MIR6883 RNF222 ENSG00000212206 SNORD10 PIR59981
GH17F008921 1.4 FANTOM5 Ensembl ENCODE 9.3 -525.6 -525639 3.2 HDGF ESRRA ZNF146 TBL1XR1 RELA GATA3 ZNF366 POLR2A GATA2 CREM PIK3R5 RNF222 NDEL1 GC17M008877
GH17F008680 1.3 VISTA Ensembl ENCODE 9.9 -283.3 -283339 2.3 FEZF1 ZNF2 RAD21 ZNF316 ZNF547 ZNF26 SCRT2 KLF8 MAFK ZNF202 PFAS CNTROB LOC105371523 CTC1 MYH10 SPDYE4 RNF222 LOC105371525 LOC105371526
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF222 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF222 Gene

8,390,704 bp from pter
8,397,833 bp from pter
7,130 bases
Minus strand

Genomic View for RNF222 Gene

Genes around RNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF222 Gene

Proteins for RNF222 Gene

  • Protein details for RNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 222
    Protein Accession:

    Protein attributes for RNF222 Gene

    220 amino acids
    Molecular mass:
    23767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF222 Gene

Post-translational modifications for RNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF222 Gene

No data available for DME Specific Peptides for RNF222 Gene

Domains & Families for RNF222 Gene

Gene Families for RNF222 Gene

Protein Domains for RNF222 Gene

Suggested Antigen Peptide Sequences for RNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF222: view

Function for RNF222 Gene

Gene Ontology (GO) - Molecular Function for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IBA --
GO:0008270 zinc ion binding IEA --
GO:0032184 SUMO polymer binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF222: view

Phenotypes for RNF222 Gene

GenomeRNAi human phenotypes for RNF222:
genes like me logo Genes that share phenotypes with RNF222: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF222 Gene

Localization for RNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF222 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF222 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0033768 SUMO-targeted ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with RNF222: view

Pathways & Interactions for RNF222 Gene

SuperPathways for RNF222 Gene

No Data Available

Interacting Proteins for RNF222 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: A6NCQ9-RN222_HUMAN ENSP00000343799 for RNF222 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0033234 negative regulation of protein sumoylation IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with RNF222: view

No data available for Pathways by source and SIGNOR curated interactions for RNF222 Gene

Transcripts for RNF222 Gene

mRNA/cDNA for RNF222 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF222 Gene

Ring finger protein 222:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF222 Gene

No ASD Table

Relevant External Links for RNF222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF222 Gene

mRNA differential expression in normal tissues according to GTEx for RNF222 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.0), Skin - Not Sun Exposed (Suprapubic) (x8.4), Skin - Sun Exposed (Lower leg) (x7.8), Vagina (x6.0), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for RNF222 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF222 Gene

Protein tissue co-expression partners for RNF222 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF222 Gene:


SOURCE GeneReport for Unigene cluster for RNF222 Gene:

genes like me logo Genes that share expression patterns with RNF222: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF222 Gene

Orthologs for RNF222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF222 34 35
  • 99.09 (n)
(Canis familiaris)
Mammalia RNF222 34 35
  • 88.23 (n)
(Bos Taurus)
Mammalia RNF222 34 35
  • 87.68 (n)
(Rattus norvegicus)
Mammalia Rnf222 34
  • 85.62 (n)
(Mus musculus)
Mammalia Rnf222 34 16 35
  • 85.47 (n)
(Monodelphis domestica)
Mammalia RNF222 35
  • 76 (a)
(Gallus gallus)
Aves LOC101749003 34
  • 64.32 (n)
RNF222 35
  • 48 (a)
(Anolis carolinensis)
Reptilia RNF222 35
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732514 34
  • 55.22 (n)
(Danio rerio)
Actinopterygii LOC101886437 34
  • 49.38 (n)
RNF222 35
  • 38 (a)
Species where no ortholog for RNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF222 Gene

Gene Tree for RNF222 (if available)
Gene Tree for RNF222 (if available)

Paralogs for RNF222 Gene

No data available for Paralogs for RNF222 Gene

Variants for RNF222 Gene

Sequence variations from dbSNP and Humsavar for RNF222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111619986 -- 8,394,458(+) TTGAG(-/T)AGGGA intron-variant, upstream-variant-2KB
rs111694990 -- 8,394,685(+) CGCCC(A/G)CCTCG intron-variant, upstream-variant-2KB
rs112317192 -- 8,395,125(+) GCTCC(A/G)AATCT intron-variant, upstream-variant-2KB
rs112506995 -- 8,398,801(+) AAGAA(C/T)TGCTT upstream-variant-2KB
rs113200442 -- 8,397,493(+) CACCT(A/G)GGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF222 Gene

Variant ID Type Subtype PubMed ID
nsv509651 CNV insertion 20534489
nsv1968 CNV insertion 18451855

Variation tolerance for RNF222 Gene

Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF222 Gene

Disorders for RNF222 Gene

Relevant External Links for RNF222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF222 Gene

Publications for RNF222 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for RNF222 Gene

Sources for RNF222 Gene

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