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Aliases for RNF222 Gene

Aliases for RNF222 Gene

  • Ring Finger Protein 222 2 3 5

External Ids for RNF222 Gene

Previous GeneCards Identifiers for RNF222 Gene

  • GC17M008235
  • GC17M008295
  • GC17M008188

Summaries for RNF222 Gene

GeneCards Summary for RNF222 Gene

RNF222 (Ring Finger Protein 222) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF222 Gene

Genomics for RNF222 Gene

Regulatory Elements for RNF222 Gene

Enhancers for RNF222 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF222 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF222 Gene

8,390,704 bp from pter
8,397,833 bp from pter
7,130 bases
Minus strand

Genomic View for RNF222 Gene

Genes around RNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF222 Gene

Proteins for RNF222 Gene

  • Protein details for RNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 222
    Protein Accession:

    Protein attributes for RNF222 Gene

    220 amino acids
    Molecular mass:
    23767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF222 Gene

Proteomics data for RNF222 Gene at MOPED

Post-translational modifications for RNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF222 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF222 Gene

Domains & Families for RNF222 Gene

Gene Families for RNF222 Gene

Protein Domains for RNF222 Gene

Suggested Antigen Peptide Sequences for RNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF222: view

Function for RNF222 Gene

Gene Ontology (GO) - Molecular Function for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with RNF222: view

Phenotypes for RNF222 Gene

GenomeRNAi human phenotypes for RNF222:
genes like me logo Genes that share phenotypes with RNF222: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF222 Gene

Localization for RNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF222 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF222 Gene COMPARTMENTS Subcellular localization image for RNF222 gene
Compartment Confidence
nucleus 5
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNF222 Gene

Pathways & Interactions for RNF222 Gene

SuperPathways for RNF222 Gene

No Data Available

Interacting Proteins for RNF222 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000343799 for RNF222 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF222: view

No data available for Pathways by source and SIGNOR curated interactions for RNF222 Gene

Drugs & Compounds for RNF222 Gene

No Compound Related Data Available

Transcripts for RNF222 Gene

mRNA/cDNA for RNF222 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF222 Gene

Ring finger protein 222:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF222 Gene

No ASD Table

Relevant External Links for RNF222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF222 Gene

mRNA expression in normal human tissues for RNF222 Gene

mRNA differential expression in normal tissues according to GTEx for RNF222 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.0), Skin - Not Sun Exposed (Suprapubic) (x8.4), Skin - Sun Exposed (Lower leg) (x7.8), Vagina (x6.0), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for RNF222 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF222 Gene

SOURCE GeneReport for Unigene cluster for RNF222 Gene Hs.526550

genes like me logo Genes that share expression patterns with RNF222: view

Protein tissue co-expression partners for RNF222 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF222 Gene

Orthologs for RNF222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF222 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF222 35
  • 87.68 (n)
  • 87.2 (a)
RNF222 36
  • 83 (a)
(Canis familiaris)
Mammalia RNF222 35
  • 88.23 (n)
  • 88.56 (a)
RNF222 36
  • 81 (a)
(Mus musculus)
Mammalia Rnf222 35
  • 85.47 (n)
  • 87.2 (a)
Rnf222 16
Rnf222 36
  • 87 (a)
(Pan troglodytes)
Mammalia RNF222 35
  • 99.09 (n)
  • 99.55 (a)
RNF222 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf222 35
  • 85.62 (n)
  • 89.1 (a)
(Monodelphis domestica)
Mammalia RNF222 36
  • 76 (a)
(Gallus gallus)
Aves LOC101749003 35
  • 64.32 (n)
  • 50.25 (a)
RNF222 36
  • 48 (a)
(Anolis carolinensis)
Reptilia RNF222 36
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732514 35
  • 55.22 (n)
  • 42.79 (a)
(Danio rerio)
Actinopterygii LOC101886437 35
  • 49.38 (n)
  • 39.68 (a)
RNF222 36
  • 38 (a)
Species with no ortholog for RNF222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF222 Gene

Gene Tree for RNF222 (if available)
Gene Tree for RNF222 (if available)

Paralogs for RNF222 Gene

No data available for Paralogs for RNF222 Gene

Variants for RNF222 Gene

Sequence variations from dbSNP and Humsavar for RNF222 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1391765 -- 8,394,148(-) CTGAC(A/G)TGACT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs2872230 -- 8,391,107(+) TGCAA(C/G)CTCCG downstream-variant-500B, utr-variant-3-prime
rs4792805 -- 8,397,596(+) CTCTC(C/T)CTCAT intron-variant
rs3930740 -- 8,391,641(+) ACTTA(C/T)GGACC utr-variant-3-prime
rs7207902 -- 8,397,183(+) TTTGT(C/G)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF222 Gene

Variant ID Type Subtype PubMed ID
dgv3057n71 CNV Loss 21882294
nsv1968 CNV Insertion 18451855
nsv509651 CNV Insertion 20534489

Variation tolerance for RNF222 Gene

Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF222 Gene

Disorders for RNF222 Gene

Relevant External Links for RNF222

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF222 Gene

Publications for RNF222 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 67
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for RNF222 Gene

Sources for RNF222 Gene