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RNF220 Gene

protein-coding   GIFtS: 50
GCID: GC01P044870

Ring Finger Protein 220

(Previous name: chromosome 1 open reading frame 164)
(Previous symbol: C1orf164)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 2201 2 3
C1orf1641 2 3
Chromosome 1 Open Reading Frame 1641
E3 Ubiquitin-Protein Ligase RNF2202
EC 6.3.2.-3

External Ids:    HGNC: 255521   Entrez Gene: 551822   Ensembl: ENSG000001871477   UniProtKB: Q5VTB93   

Export aliases for RNF220 gene to outside databases

Previous GC identifers: GC01P044644 GC01P042984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF220 Gene:
RNF220 (ring finger protein 220) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: RN220_HUMAN, Q5VTB9
Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By
similarity)

Gene Wiki entry for RNF220 (C1orf164) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF220 gene promoter:
         Elk-1   C/EBPbeta   FOXD1   POU6F1 (c2)   POU2F1   POU2F1a   SEF-1 (1)   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF220 promoter sequence
   Search Chromatin IP Primers for RNF220

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF220


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

RNF220 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF220 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044870:  view genomic region     (about GC identifiers)

Start:
44,870,866 bp from pter      End:
45,117,396 bp from pter
Size:
246,531 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN220_HUMAN, Q5VTB9 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF220  
Size: 566 amino acids; 62765 Da
Subunit: Interacts with SIN3B (By similarity)
Sequence caution: Sequence=BAA91704.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KPJ3 Q4KMX2 Q9NVP6

Explore the universe of human proteins at neXtProt for RNF220: NX_Q5VTB9

Explore proteomics data for RNF220 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated; leads to proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys362, Lys451
  • Modification sites at PhosphoSitePlus

  • See RNF220 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060620.2  
    ENSEMBL proteins: 
     ENSP00000347548   ENSP00000354872   ENSP00000411541   ENSP00000335580   ENSP00000388533  
     ENSP00000475383   ENSP00000361321   ENSP00000414640  
    Reactome Protein details: Q5VTB9

    RNF220 Human Recombinant Protein Products:

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    Novus Biologicals RNF220 Proteins
    Novus Biologicals RNF220 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF220

     
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    RNF220 Assay Products:

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    Search eBioscience for ELISAs for RNF220 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5VTB9

    ProtoNet protein and cluster: Q5VTB9

    UniProtKB/Swiss-Prot: RN220_HUMAN, Q5VTB9
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF220           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN220_HUMAN, Q5VTB9
    Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By
    similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RNF220           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF220:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF220
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF220

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF220
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF220

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF220:
    hsa-mir-93-5p (MIRT048901)

    Block miRNA regulation of human, mouse, rat RNF220 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF220 (see all 28):
    hsa-miR-3149 hsa-miR-30c hsa-miR-520d-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-30d hsa-miR-181a-2* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidRNF220 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF220

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    GenScript: all cDNA clones in your preferred vector: RNF220 (NM_018150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF220
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF220

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    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF220 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF220


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN220_HUMAN, Q5VTB9: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    nucleus2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with RNF220           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF220 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with RNF220           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RNF220
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RN220_HUMAN, Q5VTB9
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF220: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF220

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF220 (Q5VTB92, 3 ENSP000003475484) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930092, 3, ENSP000003435354MINT-2874127 I2D: score=4 STRING: ENSP00000343535
    SIN3BO751823, ENSP000003691314I2D: score=3 STRING: ENSP00000369131
    UBE2WQ96B023, ENSP000003974534I2D: score=1 STRING: ENSP00000397453
    UBE2E1P519653, ENSP000003037094I2D: score=2 STRING: ENSP00000303709
    UBE2E2Q96LR53, ENSP000003799314I2D: score=1 STRING: ENSP00000379931
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ISS--
    GO:0051865protein autoubiquitination ISS--

    Find genes that share ontologies with RNF220           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF220 (RN220)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF220 gene: 
    NM_018150.2  

    Unigene Cluster for RNF220:

    Ring finger protein 220
    Hs.456557  [show with all ESTs]
    Unigene Representative Sequence: AK124790
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000355387 ENST00000361799(uc001clv.1 uc001clw.1) ENST00000487332
    ENST00000470498 ENST00000496262 ENST00000453863 ENST00000335497 ENST00000440132
    ENST00000474064(uc010okz.2 uc001cma.1 uc001clx.2) ENST00000471494
    ENST00000488865 ENST00000497469 ENST00000475378 ENST00000484745 ENST00000474394
    ENST00000480686 ENST00000474956 ENST00000372247(uc010oky.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF220 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF220 (see all 28):
    hsa-miR-3149 hsa-miR-30c hsa-miR-520d-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-30d hsa-miR-181a-2* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidRNF220 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF220
    Predesigned siRNA for gene silencing in human, mouse, rat RNF220
    Clone
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    OriGene clones in human, mouse for RNF220 (see all 6)
    OriGene ORF clones in mouse, rat for RNF220
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF220 (NM_018150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF220
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF220
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF220
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF220
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF220
      QuantiTect SYBR Green Assays in human, mouse, rat RNF220
      QuantiFast Probe-based Assays in human, mouse, rat RNF220

    Additional mRNA sequence: 

    AF151080.1 AK001459.1 AK025744.1 AK056424.1 AK124790.1 AK225180.1 AK293411.1 AK296038.1 
    AK297228.1 BC000279.1 BC034221.1 BC062600.1 BC073835.1 BC098266.1 BC098300.1 BC105790.1 
    BC128534.1 

    Selected DOTS entries (see all 28):

    DT.100797112  DT.100840037  DT.92438503  DT.100797113  DT.97854211  DT.97774368  DT.92438498  DT.454858 
    DT.92438497  DT.95134795  DT.121353012  DT.121353056  DT.97794134  DT.100028723  DT.100652060  DT.100674085 
    DT.121352914  DT.109248  DT.121352937  DT.75178881  DT.100797118  DT.121352904  DT.121352913  DT.121353002 

    Selected AceView cDNA sequences (see all 402):

    BQ924538 BC034221 CR604881 BM793846 BF970497 BU154020 AI655446 T33117 
    CR618869 CD675916 BI862139 BI768029 AW593185 BQ673859 BI766670 BQ276399 
    BG773834 AI346571 BM761254 NM_018150 BX360392 AW250022 BE791061 AW611878 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF220 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ·
    SP1:        -     -     -     -     -                                   -     -                 -                 -     -                 -                 -   
    SP2:        -     -     -     -     -                                   -     -                 -                 -     -                 -                 -   
    SP3:                                                                                                                                      -                 -   
    SP4:                                                                                                              -     -                 -                     
    SP5:                                                                                                                                                            

    ExUns: 17d ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
    SP1:  -     -                             -                     
    SP2:  -     -                             -                     
    SP3:  -     -                             -                     
    SP4:                                                            
    SP5:                                      -                     


    ECgene alternative splicing isoforms for RNF220

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF220 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTAAACCA
    RNF220 Expression
    About this image


    RNF220 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    RNF220 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF220 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.456557
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF220: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF220
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF220
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    QuantiFast Probe-based Assays in human, mouse, rat RNF220
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF220

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF220 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf2201 , 5 ring finger protein 2201, 5 92.23(n)1
    97.88(a)1
      4 (53.44 cM)5
    667431  NM_025739.21  NP_080015.31 
     1172714635 
    chicken
    (Gallus gallus)
    Aves RNF2201 ring finger protein 220 83.07(n)
    95.03(a)
      424580  NM_001109987.1  NP_001103457.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    95(a)
    75(a)
    many → 1
    many → 1
    4(109620012-109620641)
    4(109868620-109970448)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.119992 Transcribed sequence with moderate similarity to protein more 82(n)    142021170 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf220b1 ring finger protein 220b 66.85(n)
    65.5(a)
      558091  XM_681262.5  XP_686354.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48131 CG4813 50(n)
    41.41(a)
      42690  NM_142831.3  NP_651088.1 


    ENSEMBL Gene Tree for RNF220 (if available)
    TreeFam Gene Tree for RNF220 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF220 (see all 4966)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3701809431,2
    C--43012111(+) CTTTT-/CTTTTTT 1 -- int11Minor allele frequency- CT:0.00NA 2
    rs120827441,2
    --44868988(+) TAGAGC/GCTAAC 1 -- us2k10--------
    rs1874884411,2
    C--44869059(+) CAGGCA/GTGGTG 1 -- us2k10--------
    rs1919345111,2
    C--44869061(+) GGCGTG/TGTGGC 1 -- us2k10--------
    rs1848021271,2
    --44869149(+) CCAACA/GTGGTG 1 -- us2k10--------
    rs1488098371,2
    C--44869184(+) TTTGGG/TCATGG 1 -- us2k10--------
    rs1415778411,2
    C--44869239(+) AGAATC/TGCTTG 1 -- us2k10--------
    rs1508941141,2
    --44869247(+) TTGAAC/TTCGGG 1 -- us2k10--------
    rs1474169011,2
    C--44869331(+) AAAAA-/TAAATA 1 -- us2k10--------
    rs1877162561,2
    --44869586(+) GACAAC/TTTATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF220 (44870866 - 45117396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF220 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747741CNV Deletion23290073
    dgv41e199CNV Deletion23128226
    esv1005212CNV Deletion20482838
    esv2747730CNV Deletion23290073
    esv2747719CNV Deletion23290073
    esv2747708CNV Deletion23290073
    esv272636CNV Insertion20981092
    esv1001605CNV Insertion20482838
    esv267525CNV Insertion20981092
    nsv744CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF220           About GenesLikeMe

    Genetic Association Database (GAD): RNF220
    Human Genome Epidemiology (HuGE) Navigator: RNF220 (4 documents)

    Export disorders for RNF220 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF220 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with RNF220)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55182 HGNC: 25552 AceView: FLJ10597 Ensembl:ENSG00000187147 euGenes: HUgn55182
    ECgene: RNF220 H-InvDB: RNF220

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF220 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF220 gene:
    Search GeneIP for patents involving RNF220

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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