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Aliases for RNF220 Gene

Aliases for RNF220 Gene

  • Ring Finger Protein 220 2 3
  • C1orf164 3 4
  • Chromosome 1 Open Reading Frame 164 2
  • E3 Ubiquitin-Protein Ligase RNF220 3
  • RING Finger Protein 220 4
  • EC 6.3.2.- 4

External Ids for RNF220 Gene

Previous HGNC Symbols for RNF220 Gene

  • C1orf164

Previous GeneCards Identifiers for RNF220 Gene

  • GC01P044644
  • GC01P044870
  • GC01P042984

Summaries for RNF220 Gene

GeneCards Summary for RNF220 Gene

RNF220 (Ring Finger Protein 220) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF220 Gene

  • E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).

Gene Wiki entry for RNF220 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF220 Gene

Genomics for RNF220 Gene

Regulatory Elements for RNF220 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF220 Gene

Start:
44,405,091 bp from pter
End:
44,651,724 bp from pter
Size:
246,634 bases
Orientation:
Plus strand

Genomic View for RNF220 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF220 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF220 Gene

Proteins for RNF220 Gene

  • Protein details for RNF220 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTB9-RN220_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF220
    Protein Accession:
    Q5VTB9
    Secondary Accessions:
    • B3KPJ3
    • B4DLZ9
    • E9PCS1
    • Q4KMX2
    • Q9NVP6

    Protein attributes for RNF220 Gene

    Size:
    566 amino acids
    Molecular mass:
    62765 Da
    Quaternary structure:
    • Interacts with SIN3B (By similarity). Interacts with CTNNB1 (via Armadillo repeats 2-8) (PubMed:25266658). Interacts with USP7 (via MATH domain) (PubMed:25266658).
    SequenceCaution:
    • Sequence=BAA91704.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF220 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF220 Gene

Proteomics data for RNF220 Gene at MOPED

Post-translational modifications for RNF220 Gene

  • Auto-ubiquitinated; leads to proteasomal degradation.
  • Ubiquitination at Lys362 and Lys451
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF220 Gene

No data available for DME Specific Peptides for RNF220 Gene

Domains for RNF220 Gene

Gene Families for RNF220 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF220 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VTB9

UniProtKB/Swiss-Prot:

RN220_HUMAN :
  • Q5VTB9
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF220: view

Function for RNF220 Gene

Molecular function for RNF220 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).

Enzyme Numbers (IUBMB) for RNF220 Gene

Gene Ontology (GO) - Molecular Function for RNF220 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding IPI 25266658
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF220: view

Phenotypes for RNF220 Gene

GenomeRNAi human phenotypes for RNF220:
genes like me logo Genes that share phenotypes with RNF220: view

Animal Model Products

CRISPR Products

miRNA for RNF220 Gene

miRTarBase miRNAs that target RNF220

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF220

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF220 Gene

Localization for RNF220 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF220 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF220 Gene COMPARTMENTS Subcellular localization image for RNF220 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF220 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with RNF220: view

Pathways for RNF220 Gene

genes like me logo Genes that share pathways with RNF220: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q5VTB9-RN220_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF220 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0051865 protein autoubiquitination ISS --
GO:0090263 positive regulation of canonical Wnt signaling pathway IMP 25266658
genes like me logo Genes that share ontologies with RNF220: view

Transcripts for RNF220 Gene

Unigene Clusters for RNF220 Gene

Ring finger protein 220:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF220

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF220 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12: - - - -
SP13: - - -
SP14:

ExUns: 17d ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RNF220 Gene

GeneLoc Exon Structure for
RNF220
ECgene alternative splicing isoforms for
RNF220

Expression for RNF220 Gene

mRNA expression in normal human tissues for RNF220 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF220 Gene

SOURCE GeneReport for Unigene cluster for RNF220 Gene Hs.456557

genes like me logo Genes that share expressions with RNF220: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF220 Gene

Orthologs for RNF220 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF220 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF220 35
  • 99.76 (n)
  • 100 (a)
RNF220 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF220 35
  • 93.88 (n)
  • 99.12 (a)
RNF220 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF220 35
  • 94.76 (n)
  • 99.29 (a)
RNF220 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf220 35
  • 92.23 (n)
  • 97.88 (a)
Rnf220 16
Rnf220 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF220 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF220 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf220 35
  • 91.81 (n)
  • 98.41 (a)
chicken
(Gallus gallus)
Aves RNF220 35
  • 83.07 (n)
  • 95.03 (a)
RNF220 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 95 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf220.1 35
  • 78.28 (n)
  • 90.64 (a)
Str.11999 35
zebrafish
(Danio rerio)
Actinopterygii rnf220a 36
  • 80 (a)
OneToOne
rnf220b 35
  • 66.85 (n)
  • 65.5 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003744 35
  • 46.79 (n)
  • 40.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4813 35
  • 50 (n)
  • 41.41 (a)
CG4813 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4958 36
  • 41 (a)
OneToOne
Species with no ortholog for RNF220:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF220 Gene

ENSEMBL:
Gene Tree for RNF220 (if available)
TreeFam:
Gene Tree for RNF220 (if available)

Paralogs for RNF220 Gene

No data available for Paralogs for RNF220 Gene

Variants for RNF220 Gene

Sequence variations from dbSNP and Humsavar for RNF220 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2822 -- 44,651,628(-) CACCA(C/T)AGGGC utr-variant-3-prime
rs69141 -- 44,573,533(-) TGCTC(C/T)TGATC intron-variant
rs149844 -- 44,604,893(+) TGTAG(C/G)CATGA intron-variant
rs156155 -- 44,575,717(-) cgtct(A/G)tacta intron-variant
rs156255 -- 44,553,265(-) CTAAG(A/C)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF220 Gene

Variant ID Type Subtype PubMed ID
nsv829715 CNV Gain 17160897
nsv461395 CNV Gain 19166990
esv272636 CNV Insertion 20981092
esv267525 CNV Insertion 20981092
esv2747708 CNV Deletion 23290073
esv1005212 CNV Deletion 20482838
nsv744 CNV Insertion 18451855
dgv41e199 CNV Deletion 23128226
esv2747719 CNV Deletion 23290073
esv24516 CNV Loss 19812545
esv2747730 CNV Deletion 23290073
esv2747741 CNV Deletion 23290073
esv1001605 CNV Insertion 20482838

Relevant External Links for RNF220 Gene

HapMap Linkage Disequilibrium report
RNF220

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF220 Gene

Disorders for RNF220 Gene

Relevant External Links for RNF220

Genetic Association Database (GAD)
RNF220
Human Genome Epidemiology (HuGE) Navigator
RNF220
genes like me logo Genes that share disorders with RNF220: view

No data available for UniProtKB/Swiss-Prot for RNF220 Gene

Publications for RNF220 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for RNF220 Gene

Sources for RNF220 Gene

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